WO1994012670A3 - Process for typing of hcv isolates - Google Patents

Process for typing of hcv isolates Download PDF

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Publication number
WO1994012670A3
WO1994012670A3 PCT/EP1993/003325 EP9303325W WO9412670A3 WO 1994012670 A3 WO1994012670 A3 WO 1994012670A3 EP 9303325 W EP9303325 W EP 9303325W WO 9412670 A3 WO9412670 A3 WO 9412670A3
Authority
WO
WIPO (PCT)
Prior art keywords
hcv
probe
nucleotide
isolate
hcv isolates
Prior art date
Application number
PCT/EP1993/003325
Other languages
French (fr)
Other versions
WO1994012670A2 (en
Inventor
Geert Maertens
Lieven Stuyver
Rudi Rossau
Heuverswyn Hugo Van
Original Assignee
Innogenetics Nv
Geert Maertens
Lieven Stuyver
Rudi Rossau
Heuverswyn Hugo Van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26132445&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1994012670(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to JP51276794A priority Critical patent/JP4251407B2/en
Priority to CA2128528A priority patent/CA2128528C/en
Priority to DK94901891T priority patent/DK0637342T3/en
Priority to DE69324678T priority patent/DE69324678T2/en
Priority to US08/256,568 priority patent/US5846704A/en
Priority to EP94901891A priority patent/EP0637342B1/en
Priority to AU56282/94A priority patent/AU681612B2/en
Application filed by Innogenetics Nv, Geert Maertens, Lieven Stuyver, Rudi Rossau, Heuverswyn Hugo Van filed Critical Innogenetics Nv
Publication of WO1994012670A2 publication Critical patent/WO1994012670A2/en
Publication of WO1994012670A3 publication Critical patent/WO1994012670A3/en
Priority to GR990401727T priority patent/GR3030641T3/en
Priority to US09/899,302 priority patent/US6887985B2/en
Priority to US09/899,044 priority patent/US6548244B2/en
Priority to US09/899,082 priority patent/US6891026B2/en
Priority to US10/822,711 priority patent/US7258982B2/en
Priority to US11/826,099 priority patent/US8101351B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/706—Specific hybridization probes for hepatitis
    • C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Degasification And Air Bubble Elimination (AREA)
  • Treatment Of Water By Oxidation Or Reduction (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

Abstract

The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for classifying said isolate according to the percentage of homology with other HCV isolates, comprising the steps of: contacting said sample in which the ribonucleotides or deoxyribonucleotides have been made accessible, if need be, under suitable denaturation, with at least one probe from about 10 to about 40 nucleotides, with said probe being liable to hybridize to a region being in the domain extending from nucleotide at position -291 to nucleotide at position -66 of the 5' untranslated region of one of the HCV isolates represented by their cDNA sequences, with said numbering of position beginning with the first ATG codon of the open reading frame encoding the HCV polyprotein, or with said probe being complementary to the above-defined probes; detecting the complexes possibly formed between said probe and the nucleotide sequence of the HCV isolate to be identified.
PCT/EP1993/003325 1992-11-27 1993-11-26 Process for typing of hcv isolates WO1994012670A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
JP51276794A JP4251407B2 (en) 1992-11-27 1993-11-26 HCV isolate typing method
CA2128528A CA2128528C (en) 1992-11-27 1993-11-26 Process for typing of hcv isolates
DK94901891T DK0637342T3 (en) 1992-11-27 1993-11-26 Method for typing HCV isolates
DE69324678T DE69324678T2 (en) 1992-11-27 1993-11-26 METHOD FOR TYPING HCV ISOLATES
US08/256,568 US5846704A (en) 1992-11-27 1993-11-26 Process for typing of HCV isolates
EP94901891A EP0637342B1 (en) 1992-11-27 1993-11-26 Process for typing of hcv isolates
AU56282/94A AU681612B2 (en) 1992-11-27 1993-11-26 Process for typing of hcv isolates
GR990401727T GR3030641T3 (en) 1992-11-27 1999-06-30 Process for typing of hcv isolates.
US09/899,082 US6891026B2 (en) 1992-11-27 2001-07-06 Process for typing of HCV isolates
US09/899,044 US6548244B2 (en) 1992-11-27 2001-07-06 Process for typing HCV isolates
US09/899,302 US6887985B2 (en) 1992-11-27 2001-07-06 Process for typing of HCV isolates
US10/822,711 US7258982B2 (en) 1992-11-27 2004-04-13 Process for typing of HCV isolates
US11/826,099 US8101351B2 (en) 1992-11-27 2007-07-12 Process for typing of HCV isolates

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP92403222 1992-11-27
EP92403222.0 1992-11-27
EP93402129 1993-08-31
EP93402129.6 1993-08-31

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US08/256,568 A-371-Of-International US5846704A (en) 1992-11-27 1993-11-26 Process for typing of HCV isolates
US08256568 A-371-Of-International 1993-11-26
US09/038,369 Continuation US6171784B1 (en) 1992-11-27 1998-03-10 Process for typing of HCV isolates
US09/044,665 Division US6051696A (en) 1992-11-27 1998-03-19 Process for typing of HCV isolates

Publications (2)

Publication Number Publication Date
WO1994012670A2 WO1994012670A2 (en) 1994-06-09
WO1994012670A3 true WO1994012670A3 (en) 1994-07-21

Family

ID=26132445

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1993/003325 WO1994012670A2 (en) 1992-11-27 1993-11-26 Process for typing of hcv isolates

Country Status (13)

Country Link
US (8) US5846704A (en)
EP (3) EP0637342B1 (en)
JP (2) JP4251407B2 (en)
AT (2) ATE179459T1 (en)
AU (1) AU681612B2 (en)
CA (1) CA2128528C (en)
DE (2) DE69334357D1 (en)
DK (1) DK0637342T3 (en)
ES (1) ES2133529T3 (en)
GR (1) GR3030641T3 (en)
HK (1) HK1047961A1 (en)
SG (1) SG46456A1 (en)
WO (1) WO1994012670A2 (en)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG46456A1 (en) * 1992-11-27 1998-02-20 Innogenetics Nv Process for typing of hcv isolates
US7258977B1 (en) 1992-11-27 2007-08-21 Innogenetics N.V. Process for typing of HCV isolates
EP0688488A1 (en) * 1993-03-05 1995-12-27 MANKOVITZ, Roy J. Apparatus and method using compressed codes for television program record scheduling
US7255997B1 (en) * 1993-04-27 2007-08-14 N.V. Innogenetics S.A. Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents
BR9405334A (en) 1993-04-27 1999-05-25 Innogenetics Nv New hepatitis c virus genotype sequences and their use as therapeutic and diagnostic agents
US5830635A (en) * 1995-03-31 1998-11-03 Agnello; Vincent Method of detecting hepatitis C virus in tissues
US20020081577A1 (en) * 1995-06-06 2002-06-27 Robert L. Kilkuskie Oligonucleotides speciific for hepatitis c virus
JPH11502727A (en) 1996-01-26 1999-03-09 イノジェネティックス・ナムローゼ・フェンノートシャップ Methods for detecting drug-induced mutations in the reverse transcriptase gene
ZA973367B (en) 1996-04-19 1997-11-18 Innogenetics Nv Method for typing and detecting HBV.
FR2750505B1 (en) * 1996-06-27 1998-10-16 Appligene Oncor PROCESS FOR THE PREPARATION OF ANALYSIS MEDIA FOR CHEMICAL OR BIOLOGICAL SUBSTANCES HAVING ORDERED SET OF REACTION AREAS
WO1998029736A1 (en) 1996-12-31 1998-07-09 Genometrix Incorporated Multiplexed molecular analysis apparatus and method
US7101672B2 (en) * 1998-05-05 2006-09-05 Third Wave Technologies, Inc. Target-dependent reactions using structure-bridging oligonucleotides
IL122299A (en) * 1997-11-25 2003-11-23 Broadcom Corp Video encoding device
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
WO1999060158A1 (en) * 1998-05-19 1999-11-25 Laboratory Of Molecular Biophotonics Solid phase for detecting nucleic acid and method for detecting nucleic acid
AR020608A1 (en) 1998-07-17 2002-05-22 United Video Properties Inc A METHOD AND A PROVISION TO SUPPLY A USER REMOTE ACCESS TO AN INTERACTIVE PROGRAMMING GUIDE BY A REMOTE ACCESS LINK
DK1942668T3 (en) 1998-07-17 2017-09-04 Rovi Guides Inc Interactive television program guide system with multiple devices in a household
AU2006203092B2 (en) * 1999-02-03 2009-11-12 Ortho-Clinical Diagnostics, Inc. Oligonucleotide primers for efficient detection of hepatitis C virus (HCV) and methods of use thereof
US6638714B1 (en) * 1999-02-03 2003-10-28 Ortho-Clinical Diagnostics, Inc. Oligonucleotide primers for efficient detection of hepatitis C virus (HCV) and methods of use thereof
US6623919B1 (en) * 1999-02-03 2003-09-23 Ortho-Clinical Diagnostics, Inc Oligonucleotide primers for efficient multiplex detection of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) and methods of use thereof
GB0016836D0 (en) 2000-07-07 2000-08-30 Lee Helen Improved dipstick assays (1)
US6586584B2 (en) 2001-01-29 2003-07-01 Becton, Dickinson And Company Sequences and methods for detection of Hepatitis C virus
RU2229719C2 (en) * 2001-03-27 2004-05-27 Кабусики Кайся Тосиба Detection of nucleic acid associated with disease
AU2002311897A1 (en) * 2001-05-09 2002-11-18 Third Wave Technologies, Inc. Nucleic acid detection in pooled samples
US7196183B2 (en) * 2001-08-31 2007-03-27 Innogenetics N.V. Hepatitis C virus genotype, and its use as prophylactic, therapeutic and diagnostic agent
US7877273B2 (en) * 2002-01-08 2011-01-25 Fredric David Abramson System and method for evaluating and providing nutrigenomic data, information and advice
GB0200526D0 (en) * 2002-01-11 2002-02-27 Science And Technology The Methods
FR2855832B1 (en) 2003-06-03 2007-09-14 Biomerieux Sa DIAGNOSTIC AND / OR PROGNOSTIC METHOD OF SEPTIC SYNDROME
FR2857375B1 (en) 2003-07-10 2007-11-09 Biomerieux Sa PROCESS FOR THE DETECTION AND / OR IDENTIFICATION OF STAPHYLOCOCCUS GENE BACTERIA
EP1536024B1 (en) * 2003-08-29 2016-08-17 Fujirebio Europe N.V. New hepatitis c virus clade and phototype sequences thereof
US8124747B2 (en) * 2003-08-29 2012-02-28 Innogenetics HCV clade and prototype sequences thereof
CA2552949C (en) * 2004-01-07 2012-10-02 Third Wave Technologies, Inc. Determination of hepatitis c virus genotype
US20090209432A1 (en) * 2004-04-06 2009-08-20 Flinders Technologies Pty. Ltd. Detecting targets using nucleic acids having both a variable region and a conserved region
US8806533B1 (en) 2004-10-08 2014-08-12 United Video Properties, Inc. System and method for using television information codes
FR2881437B1 (en) 2005-01-31 2010-11-19 Biomerieux Sa METHOD FOR THE DIAGNOSIS / PROGNOSIS OF A SEPTIC SYNDROME
US8927208B2 (en) 2005-03-30 2015-01-06 Labo Bio-Medical Investments B.V. Identification of beta-papillomavirus DNA by type-specific reverse hybridization
US7919242B2 (en) * 2005-06-30 2011-04-05 Roche Molecular Systems, Inc. Light emission modifiers and their uses in nucleic acid detection, amplification and analysis
WO2007059348A2 (en) * 2005-11-17 2007-05-24 Third Wave Technologies, Inc. Compositions and methods for detecting an hcv-1 subtype
WO2007087310A2 (en) * 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Nucleic acid analysis using sequence tokens
FR2906537A1 (en) 2006-09-28 2008-04-04 Biomerieux Sa METHOD FOR IN VITRO DIAGNOSIS OF BRONCHO-PULMONARY CANCER BY DETECTION OF ALTERNATIVE MAJORITY TRANSCRIPTS OF KLK8 GENE ENCODING KALLICREIN 8 AND USE THEREOF FOR THE PROGNOSIS OF SURVIVAL
EP2463389A1 (en) 2006-10-20 2012-06-13 Innogenetics N.V. Methodology for analysis of sequence variations within the HCV NS5B genomic region
EP2121991A2 (en) 2006-10-20 2009-11-25 Innogenetics N.V. Methodology for analysis of sequence variations within the hcv ns3/4a genomic region
US8418206B2 (en) 2007-03-22 2013-04-09 United Video Properties, Inc. User defined rules for assigning destinations of content
EP2236624B1 (en) * 2007-08-09 2012-11-07 Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Institut Molekulyarnoi Biologi Im. V.A. Engelgardta Rossiiskoi Akademii Nauk Method for identifying the genotype and subtype of hepatitis c virus on a biological microchip
US8601526B2 (en) 2008-06-13 2013-12-03 United Video Properties, Inc. Systems and methods for displaying media content and media guidance information
US8258283B2 (en) * 2008-12-29 2012-09-04 Lg Life Sciences Ltd. Method for detection of HCV at the real time PCR with intercalating dye
US20100240049A1 (en) 2009-01-16 2010-09-23 Cepheid Methods of Detecting Cervical Cancer
EP2379752B1 (en) 2009-01-19 2015-09-30 Biomérieux S.A. Methods for determining the susceptibility of a subject to contract a nosocomial infection and for establishing a prognose of evolution of septic syndrome
US20100323344A1 (en) * 2009-06-18 2010-12-23 Ferguson Monique R Detection of hepatitis C virus RNA
US9204193B2 (en) 2010-05-14 2015-12-01 Rovi Guides, Inc. Systems and methods for media detection and filtering using a parental control logging application
EP2576815B1 (en) 2010-06-04 2018-02-14 Biomérieux Method for the prognosis of colorectal cancer
US9110079B2 (en) 2010-09-29 2015-08-18 Biomerieux Method and kit for establishing an in vitro prognosis on a patient exhibiting SIRS
FR2970975B1 (en) 2011-01-27 2016-11-04 Biomerieux Sa METHOD AND KIT FOR DETERMINING IN VITRO THE IMMUNE STATUS OF AN INDIVIDUAL
WO2012129758A1 (en) 2011-03-25 2012-10-04 Biomerieux Method and kit for determining in vitro probability for individual to suffer from colorectal cancer
ES2640570T3 (en) * 2012-10-18 2017-11-03 F. Hoffmann-La Roche Ag Double probe assay for HCV detection
FR3000966B1 (en) 2013-01-11 2016-10-28 Biomerieux Sa METHOD FOR ESTABLISHING IN VITRO A PROGNOSIS OF SEVERITY IN A SEPTIC SHOCK PATIENT
US10072300B2 (en) 2013-05-21 2018-09-11 Biomerieux Kit for the prognosis of colorectal cancer
CA3040907A1 (en) * 2016-10-19 2018-04-26 Gen-Probe Incorporated Compositions and methods for detecting or quantifying hepatitis c virus
EP3643792B1 (en) 2018-10-24 2021-09-15 Fujirebio Europe N.V. Detection and analysis of sequence variations in a target nucleic acid

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0461863A1 (en) * 1990-06-12 1991-12-18 Immuno Japan Inc. Oligonucleotide primers, and their application for high-fidelity detection of non-A, non-B hepatitis virus
EP0469348A2 (en) * 1990-07-11 1992-02-05 SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. cDNA sequence and detection of hepatits C virus
WO1992002642A1 (en) * 1990-08-10 1992-02-20 Chiron Corporation Nanbv diagnostics: polynucleotides useful for screening for hepatitis c virus
WO1992019743A2 (en) * 1991-05-08 1992-11-12 Chiron Corporation Hcv genomic sequences for diagnostics and therapeutics

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8810400D0 (en) * 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
JPH02167081A (en) * 1988-12-21 1990-06-27 Tetsuo Nakamura Genome rna of hepatitis virus of non-a, non-b type, cdna and viral antigen protein
US5176994A (en) * 1988-12-21 1993-01-05 Immuno Japan Inc. Non-A, Non-B hepatitis virus genome RNA, cDNA and virus antigen protein
US5629158A (en) 1989-03-22 1997-05-13 Cemu Bitecknik Ab Solid phase diagnosis of medical conditions
US5043272A (en) * 1989-04-27 1991-08-27 Life Technologies, Incorporated Amplification of nucleic acid sequences using oligonucleotides of random sequence as primers
JP2802125B2 (en) * 1989-06-23 1998-09-24 キヤノン株式会社 Nucleic acid detection method
US5372928A (en) * 1989-09-15 1994-12-13 Chiron Corporation Hepatitis C virus isolates
GB8924989D0 (en) * 1989-11-06 1989-12-28 Scotgen Ltd Method and device for the detection of antibiotic resistance
US5252743A (en) * 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5629153A (en) * 1990-01-10 1997-05-13 Chiron Corporation Use of DNA-dependent RNA polymerase transcripts as reporter molecules for signal amplification in nucleic acid hybridization assays
US5620852A (en) 1990-11-14 1997-04-15 Hri Research, Inc. Nucleic acid preparation methods
DE69132843T2 (en) * 1990-12-06 2002-09-12 Affymetrix Inc N D Ges D Staat Identification of nucleic acids in samples
EP0511559A1 (en) * 1991-04-30 1992-11-04 F.Hoffmann-La Roche & Co. Aktiengesellschaft Oligonucleotide probe reagent
US6190864B1 (en) * 1991-05-08 2001-02-20 Chiron Corporation HCV genomic sequences for diagnostics and therapeutics
US5428145A (en) * 1991-08-09 1995-06-27 Immuno Japan, Inc. Non-A, non-B, hepatitis virus genome, polynucleotides, polypeptides, antigen, antibody and detection systems
ATE241704T1 (en) * 1991-08-27 2003-06-15 Hoffmann La Roche PRIMERS AND BUT FOR DETECTING HEPATITIS C
EP0532258A2 (en) * 1991-09-09 1993-03-17 Immuno Japan Inc. Oligonucleotides and determination system of HCV genotypes
JPH06502770A (en) 1991-09-12 1994-03-31 シーダーズ−サイナイ・メディカル・センター Direct detection method for hepatitis C virus RNA
US5173994A (en) * 1992-01-14 1992-12-29 The United States Of America As Represented By The Secretary Of Agriculture Fiber cleaning apparatus with air flow deflector
WO1993023569A1 (en) * 1992-05-11 1993-11-25 Ribozyme Pharmaceuticals, Inc. Method and reagent for inhibiting viral replication
SG46456A1 (en) 1992-11-27 1998-02-20 Innogenetics Nv Process for typing of hcv isolates
JPH06153961A (en) 1992-11-27 1994-06-03 Imuno Japan:Kk Partial gene of hepatitis c virus and method for detecting gene of hepatitis c virus in high sensitivity
US5820852A (en) * 1996-11-26 1998-10-13 The Proctor & Gamble Company Oral compositions containing fluoride, pyrophosphate, and peroxide

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0461863A1 (en) * 1990-06-12 1991-12-18 Immuno Japan Inc. Oligonucleotide primers, and their application for high-fidelity detection of non-A, non-B hepatitis virus
EP0469348A2 (en) * 1990-07-11 1992-02-05 SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. cDNA sequence and detection of hepatits C virus
WO1992002642A1 (en) * 1990-08-10 1992-02-20 Chiron Corporation Nanbv diagnostics: polynucleotides useful for screening for hepatitis c virus
WO1992019743A2 (en) * 1991-05-08 1992-11-12 Chiron Corporation Hcv genomic sequences for diagnostics and therapeutics

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BUKH, J. ET AL: "sequence analysis of the noncoding region of hepatitis c virus", PROC. NATL. ACAD. SCI USA, vol. 89, June 1992 (1992-06-01), WASHINGTON, pages 4942 - 4946 *
HU, K-Q. ET AL: "direct detection of circulating hepatitis c virus rna.", JOURNAL OF CLINICAL INVESTIGATION, vol. 89, June 1992 (1992-06-01), NEW YORK US, pages 2040 - 2045 *
LEE, C-H. ET AL: "identification of hepatitis c virus with a nonconserved sequence of the 5' untranslated region.", JOURNAL OF CLINICAL MICROBIOLOGY, vol. 30, no. 6, June 1992 (1992-06-01), WASHINGTON USA, pages 1602 - 1604 *
OKAMOTO, H. ET AL: "typing hepatitis c virus by polymerase chain reaction", JOURNAL OF GENERAL VIROLOGY, vol. 73, no. 3, March 1992 (1992-03-01), GB, pages 673 - 679 *

Also Published As

Publication number Publication date
CA2128528A1 (en) 1994-06-09
DE69334357D1 (en) 2011-06-09
DE69324678T2 (en) 1999-12-09
US20040191768A1 (en) 2004-09-30
EP0905258A2 (en) 1999-03-31
US6051696A (en) 2000-04-18
US20020106638A1 (en) 2002-08-08
EP1197568A3 (en) 2004-04-14
AU681612B2 (en) 1997-09-04
JPH07503143A (en) 1995-04-06
HK1047961A1 (en) 2003-03-14
US6171784B1 (en) 2001-01-09
US20020168626A1 (en) 2002-11-14
DK0637342T3 (en) 1999-11-01
US20030036053A1 (en) 2003-02-20
ES2133529T3 (en) 1999-09-16
US6495670B1 (en) 2002-12-17
AU5628294A (en) 1994-06-22
DE69324678D1 (en) 1999-06-02
US7258982B2 (en) 2007-08-21
ATE179459T1 (en) 1999-05-15
WO1994012670A2 (en) 1994-06-09
JP2005040145A (en) 2005-02-17
EP0637342A1 (en) 1995-02-08
EP0905258A3 (en) 2001-01-31
US6891026B2 (en) 2005-05-10
SG46456A1 (en) 1998-02-20
ATE507312T1 (en) 2011-05-15
EP1197568A2 (en) 2002-04-17
JP4251407B2 (en) 2009-04-08
CA2128528C (en) 2012-02-14
US5846704A (en) 1998-12-08
US6548244B2 (en) 2003-04-15
US6887985B2 (en) 2005-05-03
EP0637342B1 (en) 1999-04-28
EP1197568B1 (en) 2011-04-27
GR3030641T3 (en) 1999-10-29

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