WO1994027628A1 - Enteral nutritional product - Google Patents
Enteral nutritional product Download PDFInfo
- Publication number
- WO1994027628A1 WO1994027628A1 PCT/US1994/005415 US9405415W WO9427628A1 WO 1994027628 A1 WO1994027628 A1 WO 1994027628A1 US 9405415 W US9405415 W US 9405415W WO 9427628 A1 WO9427628 A1 WO 9427628A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nutritional product
- product
- blend
- range
- fatty acids
- Prior art date
Links
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 55
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 30
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 16
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 16
- 229960003080 taurine Drugs 0.000 claims abstract description 15
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 13
- 229930195729 fatty acid Natural products 0.000 claims abstract description 13
- 239000000194 fatty acid Substances 0.000 claims abstract description 13
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- 239000007788 liquid Substances 0.000 claims abstract description 10
- 229960004203 carnitine Drugs 0.000 claims abstract description 8
- 235000020665 omega-6 fatty acid Nutrition 0.000 claims abstract description 4
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 claims abstract 3
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims abstract 2
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 claims abstract 2
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Definitions
- the present invention relates to an enteral nutritional supplement, for example for persons with cancer who are not currently undergoing radiation therapy and/or chemotherapy.
- Cancer patients typically undergo intermittent periods of chemotherapy and/or radiation therapy during which their nutritional needs are different from the periods between therapy treatments. It is preferred that when the patient is not receiving intensive therapy a well balanced enteral diet be consumed. However, decreased appetite and changes in taste perceptions due to therapies may result in inadequate nutritional intake. Therefore, the consumption of an enteral nutritional supplement may be required.
- the nutritional product of the present invention is formulated to provide enteral nutritional supplementation, for example for a person afflicted with cancer, during a period of time when the person is not undergoing intensive chemotherapy and/or radiation therapy. That is to say, the enteral nutritional product of the present invention is intended either as a nutritional supplement, or as a sole source of nutrition.
- the quantity of this supplement consumed per day may be in the range of 1 to 10 8 fluid ounce servings, or as recommended by an attending physician to meet the specific metabolic needs of the patient.
- the nutritional regimen should be one which takes into consideration the problems of diarrhea, vomiting, anorexia and damage to the intestinal architecture which can occur during such periods of therapy.
- the nutritional product of the present invention contains ⁇ - carotene, carnitine and taurine, while the general nutritional supplement provides none of these nutrients.
- /3-carotene is a carotenoid compound that has pro-vitamin A activity.
- 0-carotene is not associated with toxicity and, therefore, may be used as a source of retinol equivalents in the diet without inducing toxicity concerns.
- Vitamin A has been shown to reverse some of the immunosuppression associated with thermal injury and radiation injury.
- Favorable effects on the immune system also have been observed with 3-carotene supplementation.
- the nutritional product of the present invention contains about 4,900 to 5,700 ⁇ g per liter (about 1,160 to 1,350 ⁇ g per 8 ounce serving) of /3-carotene).
- the nutritional product of the present invention contains about 84.5 to 109.8 mg per liter (about 20 to 26 mg per 8 fluid ounces) of carnitine.
- the nutritional product of the present invention contains about 84.5 to 109.8 mg per liter (about 20 to 26 mg per 8 fluid ounces) of taurine.
- dietary fiber and/or “total dietary fiber” is understood to mean plant material that is undigested by human alimentary enzymes. Dietary fiber is known to be beneficial in regulating bowel function in diarrhea. Inclusion of dietary fiber in the diet also stimulates the renewal of intestinal epithelial cells and ucosal growth.
- the nutritional product of the present invention contains about 10.6 to 13.5 grams per liter (2.5 to 3.2 grams per 8 fluid ounces) of dietary fiber.
- the dietary fiber system comprises by weight about 50% soy polysaccharide, 42.5% gum arabic, and 7.5% carboxymethylcellulose (CMC).
- CMC carboxymethylcellulose
- any suitable source of dietary fiber may be used without varying from the scope of the invention.
- the specifications for acronutrients, trace and ultratrace minerals in the nutritional product of the present invention are presented in Table 2.
- the specifications for vitamins and conditionally essential nutrients in the nutritional product of the present invention are presented in Table 3.
- the nutritional product of the present invention has a fat blend which comprises canola oil, medium chain triglycerides (MCT oil), high oleic safflower oil and fish oil.
- a fish oil which is suitable for use in the nutritional product of the present invention is manufactured from sardines and has been obtained from Mochida International in Shinjuku-ku, Tokyo, Japan.
- a disadvantage of using fish oil is that is should be stored under nitrogen with refrigeration until used to minimize oxidation and even then has a fairly short storage life.
- the fish oil comprises, by weight, about 10% of the oil blend.
- the fish oil and canola oil are important components of the oil blend because they are rich in n-3 fatty acids.
- the fatty acid profile of the nutritional product of the present invention is presented in Table 4.
- An especially desirable feature of this fatty acid profile is that, by weight, the ratio of the sum of the n-6 fatty acids to the sum of the n-3 fatty acids is in the range of 1.37 to 1.730.
- Such a characteristic of the fatty acid profile is desirable because, for example, a larger portion of the fatty acids being from the n-3 group tends to result in decreased production in the cancer patient of cytokines which promote cachexia.
- Fat content in the nutritional product of the present invention is in the range of about 39.0 to 43.0 g per liter (9.2 to 10.1 g per 8 fluid oz.).
- Linoleic (18:2n-6) 13.7-16.0
- Protein is provided in the nutritional product of the present invention by a combination of a soy protein isolate and sodium caseinate.
- a soy protein isolate that has been used to manufacture a nutritional product according to the present invention is PP750 which is a slightly hydrolyzed soy protein isolate which has obtained from Protein Technologies International, St. Louis, Missouri, U.S.A..
- the nutritional product may be manufactured using an intact soy protein isolate, the resultant viscosity of the nutritional product may be unacceptably high.
- the protein content of a nutritional product according to the present invention is about 55.0 to 76.0 grams per liter (13.0 to 18.0 grams per 8 fluid ounces). This level of protein is desirable in the nutritional product because it provides an excellent calorie to nitrogen ratio and high levels of all essential amino acids.
- the amino acid profile of the nutritional product of the present invention is presented in Table 5.
- Carbohydrates are provided in the nutritional product of the invention by sucrose and hydrolyzed cornstarch, but it is understood that any suitable source(s) of carbohydrates may be used.
- the nutritional product of the present invention contains about 180 to 200 g per liter (42.5 to 47.2 g per 8 fluid oz.) of carbohydrates.
- the caloric density of the nutritional product of the present invention is about 1.20 to 1.50 calories/ml, preferably about 1.30 to 1.40 calories/ml. This relatively high caloric density is desirable because it provides high caloric, vitamin and nutrient values in a low volume of the product for patients who may have reduced intake capacity.
- the osmolality of the nutritional product of the present invention is about 300 to 700 mos /kg water, preferably about 400 to 625 mosm/kg water.
- This osmolality value is designed to deliver low osmotic load to nutrient ratios, reducing osmotic load while delivering maximal nutrient concentration with a low risk of diarrhea.
- the viscosity of the nutritional product of the present invention is about 30 to 80 cps, preferably about 40 to 65 cps.
- the embodiment which contains oat fiber has a viscosity of about 30.1 to 41.0 cps, while the embodiment which does not contain oat fiber has a viscosity of about 38.9 - 63.2 cps.
- This range of viscosities allows the nutritional product to be ingested either orally or via a feeding tube (e.g. nasogastric, gastrostomy, jejunostomy, or any other suitable enteral route).
- This nutritional product is not designed for delivery through a central line into the bloodstream. While this nutritional product has only been manufactured in a liquid form, it is understood that it could be manufactured in a powdered form, for reconstitution with an appropriate liquid, without departing from the scope of the present invention.
- a nutritional product in accordance with the present invention has been produced using the preceding Bill of Materials and the manufacturing process described below. However, it is understood that the manufacturing process may be altered based upon available equipment and other variables.
- An oil blend containing dietary fiber is prepared by the following procedure.
- the canola oil, medium chain triglycerides and high oleic safflower oil are placed together in a blend tank and the resulting oil blend is heated to a temperature in the range of about 43-52 ⁇ C.
- the soy lecithin, oil soluble vitamin premix, Vitamin A palmitate and beta carotene are added to the oil blend.
- While maintaining the temperature of the oil blend in the range of 43-52 ⁇ C the fish oil is added thereto.
- a protein slurry is prepared by the following procedure. Place about 199.3 kg of water in a vessel and heat the water to a temperature in the range of about 60-71°C. Add the oat fiber to the water. When the oat fiber has been dispersed, add the sodium caseinate to the heated water. After the protein has been dissolved, maintain the temperature of the resultant slurry in the range of about 43-54°C. Add the remainder of the soy protein isolate to the slurry, and continue to maintain the slurry at a temperature in the range of about 43-54°C until it is combined with additional product ingredients.
- An oat fiber which is suitable for use in the practice of the present invention comprises ground up oat hulls that have been treated in the manner taught in U.S. Patent No. 4,806,875, and may be obtained from Opta Food Ingredients, Inc. of Cambridge, Massachusetts, U.S.A.
- the oat fiber is eliminated and, as indicated in the Bill of Materials, a larger quantity of soy polysaccharide is used.
- a larger quantity of soy polysaccharide is used.
- only about 30% of the soy protein isolate is added to the oil blend and the remainder of the soy protein isolate is added to this protein slurry. If there is no oat fiber in the formulation, but more soy polysaccharide, (all of which must be added to the oil blend), not as much soy protein isolate can be accommodated in the oil blend, so more soy protein isolate is added to the protein slurry in place of the oat fiber.
- a carbohydrate/mineral slurry is prepared by the following procedure. Place about 71.7 kg of water in a vessel and heat the water to a temperature in the range of about 60-71°C. (Note in the all- soy polysaccharide alternative embodiment about 62.2 kg of water is used.) Add to the water the magnesium chloride, potassium citrate, potassium chloride and potassium iodide. Agitate the resultant mixture until these ingredients have been dissolved/suspended, and the mixture is uniform in appearance. Add the ultra trace mineral/trace mineral (UTM/TM) premix to the mixture.
- UDM/TM ultra trace mineral/trace mineral
- the UTM/TM premix contains zinc sulfate, ferrous sulfate, manganese sulfate, copper sulfate, sodium selenite, chromium chloride, sodium molybdate and citric acid, with sucrose used as a diluent).
- the slurry should be green in color.
- the magnesium phosphate, calcium carbonate and tricalcium phosphate are then added to the slurry.
- the sucrose and hydrolyzed cornstarch are added to the slurry, and the slurry is agitated until these ingredients have been dissolved.
- the resultant carbohydrate/mineral slurry is continuously agitated and maintained at a temperature in the range of about 60-71°C until it is combined with additional product ingredients.
- the three slurries/blends which have been prepared are then blended together by the following procedure. Combine the protein slurry with the oil blend containing dietary fiber with agitation. To the resultant blend add the carbohydrate/mineral slurry, and mix the blend thoroughly. Adjust the temperature of the resultant product blend to be in the range of about 49-57°C. The pH of the product blend should be in the range of 6.45 - 6.70, and if necessary IN potassium hydroxide is added to bring the pH of the product blend into the specified range.
- the product blend is processed as follows:
- the product blend is emulsified with a homogenizer at about 900-1100 psig.
- the product blend is heated by steam injection to a temperature in the range of about 144-148°C and held at this temperature for about 5 seconds.
- the product blend is flash cooled to a temperature in the range of about 120-122°C.
- the product blend is further cooled to a temperature in the range of about 71-79°C.
- the product blend is held at a temperature in the range of about 74-85°C for 16 seconds.
- the nutritional product of the present invention is manufactured on a large scale that rather than adding the fish oil to the oil blend, the fish oil should be metered into the product blend at a constant rate just prior to emulsification to improve dispersion of the fish oil throughout the final blend.
- dilution water is added to the blend. If a vanilla flavored product is being produced add 27.4 kg of dilution water; if a strawberry flavored product is being produced add 33.1 kg of dilution water.
- a vitamin solution is prepared by the following procedure. About 9.2 kg of water is placed in a vessel and adjusted to a temperature in the range of about 10-43°C. The ascorbic acid is added to the water which is agitated until the ascorbic acid is dissolved therein. The resultant solution is neutralized with 45% potassium hydroxide. The choline chloride, L- carnitine and taurine are added to the solution and blended until dissolved.
- a flavor solution is prepared and added to the product blend with agitation. If a vanilla flavored product is being manufactured, add (a) the natural and artificial vanilla and (b) the artificial creamy vanilla to 10.2 kg of water. If a strawberry flavored product is being manufactured add the artificial strawberry to 3.3 kg of water.
- a color-in water solution is prepared by mixing the FD&C Red #3 in about 1.8 kg of water. The color-in-water solution is then added to the product blend with agitation.
- the resultant nutritional product of the present invention may then be placed in suitable containers, for example 8 ounce cans, which are then sealed with suitable closures.
- suitable containers for example 8 ounce cans, which are then sealed with suitable closures.
- the product should be sealed in containers within 48 hours after completion of the standardization/flavoring procedures.
- the nutritional product may then be sterilized using suitable procedures which are well known in the art.
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94917991A EP0700303A4 (en) | 1993-05-28 | 1994-05-11 | Enteral nutritional product |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6906793A | 1993-05-28 | 1993-05-28 | |
US6926593A | 1993-05-28 | 1993-05-28 | |
US069,067 | 1993-05-28 | ||
US069,265 | 1993-05-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994027628A1 true WO1994027628A1 (en) | 1994-12-08 |
Family
ID=26749648
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1994/005415 WO1994027628A1 (en) | 1993-05-28 | 1994-05-11 | Enteral nutritional product |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0700303A4 (en) |
CA (1) | CA2162042C (en) |
WO (1) | WO1994027628A1 (en) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0721742A1 (en) * | 1995-01-13 | 1996-07-17 | Clintec Nutrition Company, An Illinois Partnership | Nutrition for elderly patients |
EP0755634A2 (en) * | 1995-07-26 | 1997-01-29 | Hans-Günter Berner GmbH | Nutritional supplement |
WO2001084961A2 (en) * | 2000-05-08 | 2001-11-15 | N.V. Nutricia | Preparation for the prevention and/or treatment of vascular disorders |
DE19733892C2 (en) * | 1996-09-09 | 2002-06-20 | Hadasit Med Res Service | Anti-irradiation method |
KR100368011B1 (en) * | 2000-03-23 | 2003-01-14 | 조금호 | An enteral solution fortified with taurine |
EP0705539B1 (en) * | 1994-10-06 | 2003-01-22 | Friesland Brands B.V. | A food for pregnant and lactating women |
US7208180B2 (en) | 2000-05-08 | 2007-04-24 | N.V. Nutricia | Method and preparation for the preventing and/or treating vascular disorders and secondary disorders associated therewith |
EP1800675A1 (en) * | 2005-12-23 | 2007-06-27 | Nutricia N.V. | Composition comprising polyunsaturated fatty acids, proteins and manganese and/or molybden for improving membrane composition |
JP2010513226A (en) * | 2006-10-19 | 2010-04-30 | ネステク ソシエテ アノニム | Long-term nutrition supply for the elderly |
EP2340825A3 (en) * | 2001-11-14 | 2011-09-07 | N.V. Nutricia | Method and preparation preventing and/or treating neurodegenerative or neurological disorders using a neurotransmitter precursor |
CN113841889A (en) * | 2021-08-10 | 2021-12-28 | 许昌学院 | Cell absorption combined functional nutrient |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5085883A (en) * | 1991-06-27 | 1992-02-04 | Abbott Laboratories | Blend of dietary fiber for nutritional products |
US5223285A (en) * | 1992-03-31 | 1993-06-29 | Abbott Laboratories | Nutritional product for pulmonary patients |
-
1994
- 1994-05-11 WO PCT/US1994/005415 patent/WO1994027628A1/en not_active Application Discontinuation
- 1994-05-11 EP EP94917991A patent/EP0700303A4/en not_active Withdrawn
- 1994-05-11 CA CA002162042A patent/CA2162042C/en not_active Expired - Fee Related
Patent Citations (2)
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---|---|---|---|---|
US5085883A (en) * | 1991-06-27 | 1992-02-04 | Abbott Laboratories | Blend of dietary fiber for nutritional products |
US5223285A (en) * | 1992-03-31 | 1993-06-29 | Abbott Laboratories | Nutritional product for pulmonary patients |
Non-Patent Citations (3)
Title |
---|
Abstract, R.A. KARMALI, "Eicosonoids in Neoplasia", Prev. Med., Volume 16, No. 4, issued July 1987, Medline Abstract No. 87317457, pages 493-502, see entire Abstract. * |
Nutrition in Clinical Practice, Volume 3, issued October 1988, JOANNE KOUBA, "Nutritional Care of the Individual with Cancer", pages 175-182, especially page 180. * |
See also references of EP0700303A4 * |
Cited By (34)
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EP0705539B1 (en) * | 1994-10-06 | 2003-01-22 | Friesland Brands B.V. | A food for pregnant and lactating women |
US5589468A (en) * | 1995-01-13 | 1996-12-31 | Clintec Nutrition Co. | Method for providing nutrition to elderly patients |
US5686429A (en) * | 1995-01-13 | 1997-11-11 | Nestec Ltd | Method for providing nutrition to elderly patients |
USRE36288E (en) * | 1995-01-13 | 1999-08-31 | Nestec Ltd. | Method for providing nutrition to elderly patients |
USRE37020E1 (en) * | 1995-01-13 | 2001-01-16 | Nestec, Ltd. | Method for providing nutrition to elderly patients |
EP0721742A1 (en) * | 1995-01-13 | 1996-07-17 | Clintec Nutrition Company, An Illinois Partnership | Nutrition for elderly patients |
EP0755634A2 (en) * | 1995-07-26 | 1997-01-29 | Hans-Günter Berner GmbH | Nutritional supplement |
EP0755634A3 (en) * | 1995-07-26 | 1997-08-20 | Hans Guenther Berner Gmbh | Nutritional supplement |
DE19733892C2 (en) * | 1996-09-09 | 2002-06-20 | Hadasit Med Res Service | Anti-irradiation method |
KR100368011B1 (en) * | 2000-03-23 | 2003-01-14 | 조금호 | An enteral solution fortified with taurine |
EP1911442A3 (en) * | 2000-05-08 | 2008-05-21 | N.V. Nutricia | Preparation for the prevention and/or treatment of dementia syndromes |
EP2292210A1 (en) * | 2000-05-08 | 2011-03-09 | N.V. Nutricia | Preparation for the prevention and/or treatment of dementia syndromes |
US7208180B2 (en) | 2000-05-08 | 2007-04-24 | N.V. Nutricia | Method and preparation for the preventing and/or treating vascular disorders and secondary disorders associated therewith |
US7226916B1 (en) | 2000-05-08 | 2007-06-05 | N.V. Nutricia | Preparation for the prevention and/or treatment of vascular disorders |
US8865687B2 (en) | 2000-05-08 | 2014-10-21 | N.V. Nutricia | Preparation for the prevention and/or treatment of vascular disorders |
EP1911442A2 (en) * | 2000-05-08 | 2008-04-16 | N.V. Nutricia | Preparation for the prevention and/or treatment of vascular disorders |
WO2001084961A2 (en) * | 2000-05-08 | 2001-11-15 | N.V. Nutricia | Preparation for the prevention and/or treatment of vascular disorders |
EP2070519A1 (en) * | 2000-05-08 | 2009-06-17 | N.V. Nutricia | Preparation for the prevention and/or treatment of dementia syndromes |
US7560447B2 (en) | 2000-05-08 | 2009-07-14 | N.V. Nutricia | Preparation for the prevention and/or treatment of vascular disorders |
US8377912B2 (en) | 2000-05-08 | 2013-02-19 | N. V. Nutricia | Preparation for the prevention and/or treatment of vascular disorders |
US7772217B2 (en) | 2000-05-08 | 2010-08-10 | N.V. Nutricia | Preparation for the prevention and/or treatment of vascular disorders |
WO2001084961A3 (en) * | 2000-05-08 | 2002-08-15 | Nutricia Nv | Preparation for the prevention and/or treatment of vascular disorders |
EP2316426A1 (en) * | 2000-05-08 | 2011-05-04 | N.V. Nutricia | Preparation for the prevention and/or treatment of dementia syndromes |
EP2340825A3 (en) * | 2001-11-14 | 2011-09-07 | N.V. Nutricia | Method and preparation preventing and/or treating neurodegenerative or neurological disorders using a neurotransmitter precursor |
EP2338483A3 (en) * | 2001-11-14 | 2012-05-23 | N.V. Nutricia | Method and preparation preventing and/or treating neurodegenerative or neurological disorders using choline |
US9504712B2 (en) | 2001-11-14 | 2016-11-29 | N.V. Nutricia | Preparation for improving the action of receptors |
US9844525B2 (en) | 2001-11-14 | 2017-12-19 | N.V. Nutricia | Preparation for improving the action of receptors |
EP2342975A2 (en) | 2005-12-23 | 2011-07-13 | N.V. Nutricia | Composition for improving membrane composition and functioning of cells |
EP1800675A1 (en) * | 2005-12-23 | 2007-06-27 | Nutricia N.V. | Composition comprising polyunsaturated fatty acids, proteins and manganese and/or molybden for improving membrane composition |
EP2342975A3 (en) * | 2005-12-23 | 2014-10-22 | N.V. Nutricia | Composition for improving membrane composition and functioning of cells |
US9446014B2 (en) | 2005-12-23 | 2016-09-20 | N. V. Nutricia | Composition for improving membrane composition and functioning of cells |
US9463176B2 (en) | 2005-12-23 | 2016-10-11 | N.V. Nutricia | Composition for improving membrane composition and functioning of cells |
JP2010513226A (en) * | 2006-10-19 | 2010-04-30 | ネステク ソシエテ アノニム | Long-term nutrition supply for the elderly |
CN113841889A (en) * | 2021-08-10 | 2021-12-28 | 许昌学院 | Cell absorption combined functional nutrient |
Also Published As
Publication number | Publication date |
---|---|
CA2162042A1 (en) | 1994-12-08 |
EP0700303A4 (en) | 1996-08-21 |
EP0700303A1 (en) | 1996-03-13 |
CA2162042C (en) | 1999-02-23 |
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