WO1994028780A3 - Methods of preparing gas and gaseous precursor-filled microspheres - Google Patents

Methods of preparing gas and gaseous precursor-filled microspheres Download PDF

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Publication number
WO1994028780A3
WO1994028780A3 PCT/US1994/005792 US9405792W WO9428780A3 WO 1994028780 A3 WO1994028780 A3 WO 1994028780A3 US 9405792 W US9405792 W US 9405792W WO 9428780 A3 WO9428780 A3 WO 9428780A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
gaseous precursor
filled microspheres
preparing gas
filled liposomes
Prior art date
Application number
PCT/US1994/005792
Other languages
French (fr)
Other versions
WO1994028780A2 (en
Inventor
Evan C Unger
Thomas A Fritz
Terry Matsunaga
Varadarajan Ramaswami
David Yellowhair
Guanli Wu
Original Assignee
Evan C Unger
Thomas A Fritz
Terry Matsunaga
Varadarajan Ramaswami
David Yellowhair
Guanli Wu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27491252&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1994028780(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/076,239 external-priority patent/US5469854A/en
Priority claimed from US08/160,232 external-priority patent/US5542935A/en
Priority to DE69432219T priority Critical patent/DE69432219T2/en
Priority to AU70431/94A priority patent/AU683900B2/en
Priority to JP50183995A priority patent/JP4274387B2/en
Priority to AT94919208T priority patent/ATE233574T1/en
Priority to DE122007000024C priority patent/DE122007000024I2/en
Application filed by Evan C Unger, Thomas A Fritz, Terry Matsunaga, Varadarajan Ramaswami, David Yellowhair, Guanli Wu filed Critical Evan C Unger
Priority to EP94919208A priority patent/EP0712293B1/en
Priority to CA002164845A priority patent/CA2164845C/en
Priority to DK94919208T priority patent/DK0712293T3/en
Publication of WO1994028780A2 publication Critical patent/WO1994028780A2/en
Publication of WO1994028780A3 publication Critical patent/WO1994028780A3/en
Priority to NL300267C priority patent/NL300267I2/en
Priority to LU91325C priority patent/LU91325I2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3145—Filters incorporated in syringes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/812—Liposome comprising an antibody, antibody fragment, antigen, or other specific or nonspecific immunoeffector
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/829—Liposomes, e.g. encapsulation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y10S977/907—Liposome
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/927—Diagnostic contrast agent
    • Y10S977/929—Ultrasound contrast agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
PCT/US1994/005792 1993-06-11 1994-05-20 Methods of preparing gas and gaseous precursor-filled microspheres WO1994028780A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
DK94919208T DK0712293T3 (en) 1993-06-11 1994-05-20 Process for preparing gas-filled lipid microspheres and gas-filled lipid microspheres
CA002164845A CA2164845C (en) 1993-06-11 1994-05-20 Methods of preparing gas and gaseous precursor-filled microspheres
EP94919208A EP0712293B1 (en) 1993-06-11 1994-05-20 Method of preparing gas-filled lipid microspheres and gas-filled lipid microspheres
AU70431/94A AU683900B2 (en) 1993-06-11 1994-05-20 Methods of preparing gaseous precursor-filled microspheres
JP50183995A JP4274387B2 (en) 1993-06-11 1994-05-20 Process for producing microspheres filled with gas and gas precursor
AT94919208T ATE233574T1 (en) 1993-06-11 1994-05-20 METHOD FOR PRODUCING GAS-FILLED LIPID MICROPARTICLES AND GAS-FILLED LIPID MICROPARTICLES
DE122007000024C DE122007000024I2 (en) 1993-06-11 1994-05-20 METHOD FOR PRODUCING GAS-FILLED LIPID MICROPARTICLES AND GAS-FILLED LIPID MICROPARTICLES
DE69432219T DE69432219T2 (en) 1993-06-11 1994-05-20 METHOD FOR PRODUCING GAS-FILLED LIPID MICROPARTICLES AND GAS-FILLED LIPID MICROPARTICLES
NL300267C NL300267I2 (en) 1993-06-11 2007-03-13 Process for preparing gas-filled lipid microspheres and gas-filled lipid microspheres.
LU91325C LU91325I2 (en) 1993-06-11 2007-03-16 Luminity (medical product) the product is lipid microspheres containing perflutren

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US08/076,239 1993-06-11
US08/076,239 US5469854A (en) 1989-12-22 1993-06-11 Methods of preparing gas-filled liposomes
US15967493A 1993-11-30 1993-11-30
US08/159,687 US5585112A (en) 1989-12-22 1993-11-30 Method of preparing gas and gaseous precursor-filled microspheres
US08/159,674 1993-11-30
US08/160,232 US5542935A (en) 1989-12-22 1993-11-30 Therapeutic delivery systems related applications
US08/159,687 1993-11-30
US08/160,232 1993-11-30

Publications (2)

Publication Number Publication Date
WO1994028780A2 WO1994028780A2 (en) 1994-12-22
WO1994028780A3 true WO1994028780A3 (en) 1995-02-02

Family

ID=27491252

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/005792 WO1994028780A2 (en) 1993-06-11 1994-05-20 Methods of preparing gas and gaseous precursor-filled microspheres

Country Status (14)

Country Link
US (4) US5585112A (en)
EP (2) EP1252885A3 (en)
JP (2) JP4274387B2 (en)
CN (1) CN1125654C (en)
AT (1) ATE233574T1 (en)
AU (1) AU683900B2 (en)
CA (1) CA2164845C (en)
DE (2) DE122007000024I2 (en)
DK (1) DK0712293T3 (en)
ES (1) ES2193161T3 (en)
LU (1) LU91325I2 (en)
NL (1) NL300267I2 (en)
PT (1) PT712293E (en)
WO (1) WO1994028780A2 (en)

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