WO1995001203A3 - Implantable membrane encapsulation apparatus - Google Patents

Implantable membrane encapsulation apparatus Download PDF

Info

Publication number
WO1995001203A3
WO1995001203A3 PCT/US1994/007015 US9407015W WO9501203A3 WO 1995001203 A3 WO1995001203 A3 WO 1995001203A3 US 9407015 W US9407015 W US 9407015W WO 9501203 A3 WO9501203 A3 WO 9501203A3
Authority
WO
WIPO (PCT)
Prior art keywords
fitting
individual
membrane
implantable
cavity
Prior art date
Application number
PCT/US1994/007015
Other languages
French (fr)
Other versions
WO1995001203A2 (en
Inventor
John F Mills
Edward J Doherty
Tyrone F Hazlett
Keith E Dionne
Nicholas F Warner
Brian M Cain
David H Rein
Original Assignee
Cytotherapeutics Inc
John F Mills
Edward J Doherty
Tyrone F Hazlett
Keith E Dionne
Nicholas F Warner
Brian M Cain
David H Rein
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytotherapeutics Inc, John F Mills, Edward J Doherty, Tyrone F Hazlett, Keith E Dionne, Nicholas F Warner, Brian M Cain, David H Rein filed Critical Cytotherapeutics Inc
Priority to JP7503551A priority Critical patent/JPH09502620A/en
Priority to AU72490/94A priority patent/AU688776B2/en
Priority to NZ269041A priority patent/NZ269041A/en
Priority to EP94921989A priority patent/EP0708670A4/en
Publication of WO1995001203A2 publication Critical patent/WO1995001203A2/en
Publication of WO1995001203A3 publication Critical patent/WO1995001203A3/en
Priority to US08/477,308 priority patent/US5932460A/en
Priority to NO955274A priority patent/NO955274L/en
Priority to FI956218A priority patent/FI956218A/en
Priority to KR1019950705923A priority patent/KR960703343A/en
Priority to US09/016,223 priority patent/US6123700A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Abstract

A sealed, implantable, encapsulation device (20) for diffusing a biologically active product or function to an individual which includes a substantially non-porous fitting (32) including an inner surface (33) defining an access port (34). A permselective, porous, membrane (21), having an interior surface (22), cooperates with the fitting inner surface (33) to form a storage cavity (23) therebetween. The membrane interior surface (22) is in substantially cell-tight dry sealing engagement with fitting (32) to seal cavity (23). Living cells (24) are disposed in the cavity (23) which are capable of secreting the biologically active product to an individual. The membrane (21) is of a material capable of permitting the passage of substances between the individual and cells required to provide the biological product or function. A plug member (35) is positioned in the access port (34) and seated in cell-tight sealing engagement with the fitting inner surface (33). A method for sealing the implantable encapsulation device (20) is also provided.
PCT/US1994/007015 1993-06-23 1994-06-22 Implantable membrane encapsulation apparatus WO1995001203A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP7503551A JPH09502620A (en) 1993-06-23 1994-06-22 Method and device for sealing an implantable membrane capsule device
AU72490/94A AU688776B2 (en) 1993-06-23 1994-06-22 Method and apparatus for sealing implantable, membrane encapsulation devices
NZ269041A NZ269041A (en) 1993-06-23 1994-06-22 Implantable encapsulation device having a cell-tight dry seal at an opening thereof
EP94921989A EP0708670A4 (en) 1993-06-23 1994-06-22 Method and apparatus for sealing implantable, membrane encapsulation devices
US08/477,308 US5932460A (en) 1993-06-23 1995-06-06 Method and apparatus for sealing implantable, membrane encapsulation devices containing living cells
NO955274A NO955274L (en) 1993-06-23 1995-12-22 Method and apparatus for sealing implantable membrane encapsulation devices
FI956218A FI956218A (en) 1993-06-23 1995-12-22 Method and apparatus for closing an implantable encapsulation device
KR1019950705923A KR960703343A (en) 1993-06-23 1995-12-23 METHOD AND APPARATUS FOR SEALING IMPLANTABLE, MEMBRANE ENCAPSULATION DEVICES
US09/016,223 US6123700A (en) 1993-06-23 1998-01-30 Method and apparatus for sealing implantable membrane encapsulation devices

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8240793A 1993-06-23 1993-06-23
US08/082,407 1993-06-23

Related Parent Applications (2)

Application Number Title Priority Date Filing Date
US8240793A Continuation-In-Part 1993-06-23 1993-06-23
US8340793A Continuation-In-Part 1993-06-25 1993-06-25

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US08/477,308 Division US5932460A (en) 1993-06-23 1995-06-06 Method and apparatus for sealing implantable, membrane encapsulation devices containing living cells
US08/488,560 Division US5713887A (en) 1993-06-23 1995-06-06 Method and apparatus for sealing implantable, membrane encapsulation devices

Publications (2)

Publication Number Publication Date
WO1995001203A2 WO1995001203A2 (en) 1995-01-12
WO1995001203A3 true WO1995001203A3 (en) 1995-02-16

Family

ID=22171016

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/007015 WO1995001203A2 (en) 1993-06-23 1994-06-22 Implantable membrane encapsulation apparatus

Country Status (11)

Country Link
US (6) US5932460A (en)
EP (1) EP0708670A4 (en)
JP (1) JPH09502620A (en)
KR (1) KR960703343A (en)
CN (1) CN1129402A (en)
AU (1) AU688776B2 (en)
CA (1) CA2166116A1 (en)
FI (1) FI956218A (en)
NO (1) NO955274L (en)
NZ (1) NZ269041A (en)
WO (1) WO1995001203A2 (en)

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Also Published As

Publication number Publication date
US5738673A (en) 1998-04-14
AU688776B2 (en) 1998-03-19
US6123700A (en) 2000-09-26
EP0708670A4 (en) 1998-07-01
FI956218A0 (en) 1995-12-22
CN1129402A (en) 1996-08-21
NO955274D0 (en) 1995-12-22
AU7249094A (en) 1995-01-24
WO1995001203A2 (en) 1995-01-12
NO955274L (en) 1996-02-15
KR960703343A (en) 1996-08-17
FI956218A (en) 1996-02-22
US5713887A (en) 1998-02-03
US5653688A (en) 1997-08-05
US5653687A (en) 1997-08-05
JPH09502620A (en) 1997-03-18
NZ269041A (en) 1998-02-26
US5932460A (en) 1999-08-03
EP0708670A1 (en) 1996-05-01
CA2166116A1 (en) 1995-01-12

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