WO1995003315A3 - Saccharides, their synthesis and use - Google Patents

Saccharides, their synthesis and use Download PDF

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Publication number
WO1995003315A3
WO1995003315A3 PCT/GB1994/001575 GB9401575W WO9503315A3 WO 1995003315 A3 WO1995003315 A3 WO 1995003315A3 GB 9401575 W GB9401575 W GB 9401575W WO 9503315 A3 WO9503315 A3 WO 9503315A3
Authority
WO
WIPO (PCT)
Prior art keywords
conjugate
sugar2
sugar1
polysaccharide
derived
Prior art date
Application number
PCT/GB1994/001575
Other languages
French (fr)
Other versions
WO1995003315A2 (en
Inventor
Colin Campion
Mezher Hussein Ali
Michael Glen Orchard
Stephen Martin Courtney
Rajesh Bhikhu Parekh
Original Assignee
Oxford Glycosystems Ltd
Colin Campion
Mezher Hussein Ali
Michael Glen Orchard
Stephen Martin Courtney
Rajesh Bhikhu Parekh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939315112A external-priority patent/GB9315112D0/en
Priority claimed from GB939315111A external-priority patent/GB9315111D0/en
Priority claimed from GB939315113A external-priority patent/GB9315113D0/en
Priority claimed from GB939315114A external-priority patent/GB9315114D0/en
Priority claimed from GB939318037A external-priority patent/GB9318037D0/en
Application filed by Oxford Glycosystems Ltd, Colin Campion, Mezher Hussein Ali, Michael Glen Orchard, Stephen Martin Courtney, Rajesh Bhikhu Parekh filed Critical Oxford Glycosystems Ltd
Priority to AU71934/94A priority Critical patent/AU7193494A/en
Publication of WO1995003315A2 publication Critical patent/WO1995003315A2/en
Publication of WO1995003315A3 publication Critical patent/WO1995003315A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Abstract

A library comprises at least six different sugar-containing molecules selected from (i) carbohydrates each derived from at least two saccharide monomers, and (ii) glycoconjugates. Such a library may comprise disaccharides or linear or branched trisaccharides. It may be prepared from a compound having at least two OH groups which are modified by independently-removable blocking groups. A novel process comprises synthesising a polysaccharide of the formula sugarn, n representing the number of mono- and/or oligo-saccharide units from which the polysaccharide may be derived, comprises the steps of coupling sugar2 with a conjugate of the formula Q-sugar1, Q being a removable lipophilic or polymeric material, in a solvent for the conjugate; adding a non-solvent for the resultant conjugate Q-sugar1-sugar2; repeating the said steps n-2 times, as necessary, selecting the sugar to be coupled independently each time; and removing Q from the resultant coupled conjugate.
PCT/GB1994/001575 1993-07-21 1994-07-21 Saccharides, their synthesis and use WO1995003315A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU71934/94A AU7193494A (en) 1993-07-21 1994-07-21 Saccharides, their synthesis and use

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
GB939315112A GB9315112D0 (en) 1993-07-21 1993-07-21 Saccharides
GB939315111A GB9315111D0 (en) 1993-07-21 1993-07-21 Saccharides
GB9315111.6 1993-07-21
GB9315112.4 1993-07-21
GB939315113A GB9315113D0 (en) 1993-07-21 1993-07-21 Saccharides,glycoconjugates and their use
GB939315114A GB9315114D0 (en) 1993-07-21 1993-07-21 Glycoconjugates
GB9315114.0 1993-07-21
GB9315113.2 1993-07-21
GB939318037A GB9318037D0 (en) 1993-08-31 1993-08-31 Multi-functional compounds and their use
GB9318037.0 1993-08-31

Publications (2)

Publication Number Publication Date
WO1995003315A2 WO1995003315A2 (en) 1995-02-02
WO1995003315A3 true WO1995003315A3 (en) 1995-06-01

Family

ID=27517197

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1994/001575 WO1995003315A2 (en) 1993-07-21 1994-07-21 Saccharides, their synthesis and use

Country Status (2)

Country Link
AU (1) AU7193494A (en)
WO (1) WO1995003315A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5789385A (en) * 1993-06-16 1998-08-04 Glycomed Incorporated Sialyl Lewisx mimetics containing phenyl backbones
US5837689A (en) * 1993-06-16 1998-11-17 Glycomed Incorporated Sialyl lewis-x mimetics containing naphthyl backbones
US5593853A (en) * 1994-02-09 1997-01-14 Martek Corporation Generation and screening of synthetic drug libraries
WO1996027379A1 (en) * 1995-03-08 1996-09-12 The Scripps Research Institute Carbopeptoids and carbonucleotoids
AU2341397A (en) * 1996-03-21 1997-10-10 Princeton University Carbohydrate-based ligand library, assay and method
EP0898575B1 (en) 1996-04-17 2004-12-29 KÖSTER, Hubert, Dr. A combinatorial protecting group strategy for multifunctional molecules
DE19621177A1 (en) 1996-05-24 1997-11-27 Basf Ag Carbohydrate derivatives and their synthesis on solid phase
DE19642751A1 (en) * 1996-10-16 1998-04-23 Deutsches Krebsforsch Saccharide library
US6756489B1 (en) * 1997-08-08 2004-06-29 Aventis Pharma Deutschland Gmbh Substituted tetrahydropyrane derivatives, method for producing same, their use as medicine or diagnostic agent, as well as medicine containing same
WO2000042067A1 (en) * 1999-01-12 2000-07-20 Princeton University Saccharides linked to compounds that bind cell-surface peptides or proteins
CA2365250A1 (en) * 1999-02-17 2000-08-24 Glycominds Ltd. Combinatorial complex carbohydrate libraries and methods for the manufacture and uses thereof
AUPS213802A0 (en) * 2002-05-03 2002-06-06 Alchemia Pty Ltd Disaccharides for drug discovery

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000091A1 (en) * 1990-07-02 1992-01-09 Bioligand, Inc. Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
WO1992009300A1 (en) * 1990-11-21 1992-06-11 Iterex Pharmaceuticals Ltd. Partnership Synthesis of equimolar multiple oligomer mixtures, especially of oligopeptide mixtures
WO1993006121A1 (en) * 1991-09-18 1993-04-01 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992000091A1 (en) * 1990-07-02 1992-01-09 Bioligand, Inc. Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
WO1992009300A1 (en) * 1990-11-21 1992-06-11 Iterex Pharmaceuticals Ltd. Partnership Synthesis of equimolar multiple oligomer mixtures, especially of oligopeptide mixtures
WO1993006121A1 (en) * 1991-09-18 1993-04-01 Affymax Technologies N.V. Method of synthesizing diverse collections of oligomers

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DOUGLAS S.P. ET AL: "Polymer-supported solution synthesis of oligosaccharides", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 113, no. 13, June 1991 (1991-06-01), GASTON, PA US, pages 5095 - 5097 *
KANDIL A.A. ET AL: "Synthesis of fragments of the capsular polysaccharide of Haemophilus Influenza type b on a soluble polymeric support", SYNLETT, no. 7, July 1992 (1992-07-01), STUTTGART DE, pages 555 - 557 *
MIZUOCHI T. ET AL: "A Library of Oligosaccharide Probes (Neoglycolipids) from N-Glycosylated Proteins Reveals That Conglutinin Binds to Certain Complex-type as Well as High Mannose-type Oligosaccharide chains", JOURNAL OF BIOLOGICAL CHEMISTRY., vol. 264, no. 23, 15 August 1989 (1989-08-15), BALTIMORE US, pages 13834 - 13839 *

Also Published As

Publication number Publication date
AU7193494A (en) 1995-02-20
WO1995003315A2 (en) 1995-02-02

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