WO1995006431A3 - A robust accurate non-invasive analyte monitor - Google Patents

A robust accurate non-invasive analyte monitor Download PDF

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Publication number
WO1995006431A3
WO1995006431A3 PCT/US1994/009694 US9409694W WO9506431A3 WO 1995006431 A3 WO1995006431 A3 WO 1995006431A3 US 9409694 W US9409694 W US 9409694W WO 9506431 A3 WO9506431 A3 WO 9506431A3
Authority
WO
WIPO (PCT)
Prior art keywords
wavelengths
tissue
sub
region
differential absorption
Prior art date
Application number
PCT/US1994/009694
Other languages
French (fr)
Other versions
WO1995006431A2 (en
Inventor
Mark R Robinson
Original Assignee
Mark R Robinson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mark R Robinson filed Critical Mark R Robinson
Priority to CA002174719A priority Critical patent/CA2174719C/en
Priority to EP94929111A priority patent/EP0683641A4/en
Priority to AU78286/94A priority patent/AU7828694A/en
Publication of WO1995006431A2 publication Critical patent/WO1995006431A2/en
Publication of WO1995006431A3 publication Critical patent/WO1995006431A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
    • G01N21/3151—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths using two sources of radiation of different wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
    • G01N21/359—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/062—LED's
    • G01N2201/0621—Supply

Abstract

An improved method and apparatus for determining noninvasive in vivo determination one or more unknown values of the concentration of an analyte in human tissue. The method includes: (1) irradiating the tissue with infrared energy (400 nm-2400 nm) having at least several wavelengths in a given range of wavelengths so that there is differential absorption of at least some of the wavelengths by the tissue as a function of the wavelengths and the known characteristic, the differential absorption causing intensity variations of the wavelengths incident from the tissue; (2) providing a first path through the tissue which is optimized for a first sub-region of the range of wavelengths to maximize the differential absorption by a least some of the wavelengths in the first sub-region; (3) providing a second path through the tissue which is optimized for a second sub-region of the range, to maximize the differential absorption by at least some of the wavelengths in the second sub-region;
PCT/US1994/009694 1993-08-24 1994-08-24 A robust accurate non-invasive analyte monitor WO1995006431A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002174719A CA2174719C (en) 1993-08-24 1994-08-24 A robust accurate non-invasive analyte monitor
EP94929111A EP0683641A4 (en) 1993-08-24 1994-08-24 A robust accurate non-invasive analyte monitor.
AU78286/94A AU7828694A (en) 1993-08-24 1994-08-24 A robust accurate non-invasive analyte monitor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11137793A 1993-08-24 1993-08-24
US08/111,377 1993-08-24

Publications (2)

Publication Number Publication Date
WO1995006431A2 WO1995006431A2 (en) 1995-03-09
WO1995006431A3 true WO1995006431A3 (en) 1995-04-20

Family

ID=22338169

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/009694 WO1995006431A2 (en) 1993-08-24 1994-08-24 A robust accurate non-invasive analyte monitor

Country Status (5)

Country Link
US (2) US5830132A (en)
EP (1) EP0683641A4 (en)
AU (1) AU7828694A (en)
CA (1) CA2174719C (en)
WO (1) WO1995006431A2 (en)

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EP0683641A4 (en) 1998-07-15
US6278889B1 (en) 2001-08-21
AU7828694A (en) 1995-03-22
EP0683641A1 (en) 1995-11-29

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