WO1995014127A1 - Composite materials using bone bioactive glass and ceramic fibers - Google Patents
Composite materials using bone bioactive glass and ceramic fibers Download PDFInfo
- Publication number
- WO1995014127A1 WO1995014127A1 PCT/US1994/013152 US9413152W WO9514127A1 WO 1995014127 A1 WO1995014127 A1 WO 1995014127A1 US 9413152 W US9413152 W US 9413152W WO 9514127 A1 WO9514127 A1 WO 9514127A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fibers
- bone
- composite
- bioactive
- mesh
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C4/00—Compositions for glass with special properties
- C03C4/0007—Compositions for glass with special properties for biologically-compatible glass
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/3094—Designing or manufacturing processes
- A61F2/30965—Reinforcing the prosthesis by embedding particles or fibres during moulding or dipping
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/32—Joints for the hip
- A61F2/36—Femoral heads ; Femoral endoprostheses
- A61F2/3662—Femoral shafts
- A61F2/367—Proximal or metaphyseal parts of shafts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/025—Other specific inorganic materials not covered by A61L27/04 - A61L27/12
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/10—Ceramics or glasses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L27/422—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of carbon
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/443—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with carbon fillers
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
- A61L27/446—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
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- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C13/00—Fibre or filament compositions
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- D—TEXTILES; PAPER
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- D03D—WOVEN FABRICS; METHODS OF WEAVING; LOOMS
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- D03D15/242—Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the material of the fibres or filaments constituting the yarns or threads inorganic, e.g. basalt
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- D—TEXTILES; PAPER
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- D03D15/50—Woven fabrics characterised by the material, structure or properties of the fibres, filaments, yarns, threads or other warp or weft elements used characterised by the properties of the yarns or threads
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- D—TEXTILES; PAPER
- D03—WEAVING
- D03D—WOVEN FABRICS; METHODS OF WEAVING; LOOMS
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A—HUMAN NECESSITIES
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
- A61F2/30771—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves
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- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C2213/00—Glass fibres or filaments
- C03C2213/02—Biodegradable glass fibres
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- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2101/00—Inorganic fibres
- D10B2101/02—Inorganic fibres based on oxides or oxide ceramics, e.g. silicates
- D10B2101/06—Glass
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- D—TEXTILES; PAPER
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- D—TEXTILES; PAPER
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- D10B2101/00—Inorganic fibres
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- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
- Y10T442/30—Woven fabric [i.e., woven strand or strip material]
- Y10T442/3179—Woven fabric is characterized by a particular or differential weave other than fabric in which the strand denier or warp/weft pick count is specified
- Y10T442/322—Warp differs from weft
- Y10T442/3228—Materials differ
- Y10T442/3236—Including inorganic strand material
Definitions
- the present invention relates to composites made from fibers comprised of bioactive glass and the use of such composites to form implantable surfaces.
- the present invention relates to composites comprised of bone bioactive glass or ceramic fibers intermingled with structural fibers such as carbon fibers in a matrix of a polymeric material .
- Low modulus composite materials have been employed as femoral components of hip implants to reduce stress shielding of the bone and consequently reduce bone tissue resorption.
- composite implants are stabilized in their bony bed by a press fit. With this method of stabilization, however, optimum stress distribution effects are not fully realized.
- porous polymer coatings and particulate bioactive coatings.
- Implants using porous polymer coatings seek to achieve fixation through mechanical interlocking between the implant and surrounding bone tissue, while the bioactive coatings are designed to attain fixation through a chemical bond between the implant and bone.
- Implant surfaces coated with polysulfone particles in an effort to create a porous coating which would behave similarly to a porous metal coating are disclosed in M. Spector, et al . , "Porous Polymers for Biological Fixation,” Clin . Ortho . Rel . Res . , 235:207-218 (1988) . Although it is disclosed that some bone growth was evident, the majority of the tissue ' about the implant surface was fibrous. The porous polymer did not enhance the bone tissue growth in any way.
- Composite system of calcium phosphate ceramic powder pressed onto a polymer surface and then cured are also known. See P. Boone, et al. , "Bone Attachment of HA Coated Polymers,” J “ . Biomed. Mater. Res .
- An implantable bone fixation device comprised of an absorbable polymer and a calcium phosphate ceramic powder filler material is disclosed in U.S. Patent No. , 781,183--Casey et al .
- the device disclosed is a temporary load bearing device which resorbs upon implantation.
- the calcium phosphate particles are added for strength and also resorb, therefore this device is not fixed to bone tissue through the chemical bonding of bioactive material or porous ingrowth.
- Structural fibers will improve certain mechanical properties of composite materials.
- U.S. Patent No. 4,239, 113--Gross et al discloses a composition of methylmethacrylate polymers and a bioactive ceramic powder combined with vitreous mineral fibers less than 20 millimeters long. This device is used as a grouting material to bond implants to bone tissue. The chopped fibers are not specifically tailored or designed for mechanical property optimization.
- a similar composition is disclosed in U.S. Patent 4, 131, 597--Bluethgen et al . , which mentions the use of glass or carbon fibers to add strength to the composite.
- This patent does not specifically discuss placing fibers to achieve bone bonding regionally. Also, no method of optimization of material properties through arrangement of the structural fibers is suggested. Finally, the method of fixation to be achieved by the disclosed material is not explained.
- bone bioactive glass or ceramic fibers are useful as a chemical bonding vehicle in combination with a structural three-dimensional braided fiber substrate.
- the bioactive fibers enhance bone growth and bond to surrounding bone tissue.
- These bone bioactive glass or ceramic fibers are interwoven in the three dimensional braid with carbon fibers and infiltrated with a thermoplastic polymer to form a three-dimensional bioactive composite material .
- the glass fibers are preferably concentrated on the outer surface of the composite so as to be exposed to physiological fluids upon implantation. This leaves the carbon fibers concentrated in the center region of the implant material to bear the majority of the load.
- the stress transfer achieved by interfacial bonding between the implant and bone, combined with the "matched modulus" of the composite implant, provides near optimal stress distribution in the bone, thereby improving long term stability and fixation.
- FIG. 1 is an illustration of the apparatus used to draw bone bioactive glass or ceramic fibers used in the present invention.
- FIG. 2 is a photomicrograph of a section of bone showing ingrowth achieved in an implant.
- FIG. 3 is a photomicrograph of a section of bone similar to FIG. 2, but taken at higher magnification.
- FIG. 4 is a cross-section of a composite fiber braid made in accordance with the present invention.
- FIG. 5 is a schematic illustrating the orientation and placement of fibers in a textile woven from bone bioactive glass or ceramic fibers and structural fibers in accordance with the present invention.
- FIG. 6 is an elevation view of a hip prosthesis made in accordance with the present invention.
- the uniquely constructed composite material of the present invention is able to maintain continuity from the interface of the structural substrate and the carbon fiber/polymer interface, and to the interface between the bioactive surface and the bioactive glass fiber/polymer interface.
- the bioactive section of the implant material is integrally incorporated into the substrate through a braided interface. Because of this construction there is an increased bond surface between the bioactive material and the polymer that imparts a higher degree of integrity to the bioactive composite material as compared to a particulate coating on the surface of a polymeric composite, such as that found in the prior art. Thus, the likelihood of delamination of the bioactive material from the polymer is greatly reduced.
- the present invention provides interfacial bonding between the polymer and bioactive coating, overcoming the main limitation of the prior art.
- the configuration of the fiber architecture results in the load being applied to a central portion of the composite, which is preferably comprised of strong, inert fibers such as carbon fibers or other biocompatible fibers integrated with the bioactive fiber surface. Stress is therefore transferred from the inert structural fibers to the bioactive fibers at the implant surface.
- the integration also serves to increase the mechanical integrity of the material system and prevent delamination within the composite structure.
- a composition of bone bioactive glass or ceramic fibers is preferred.
- the preferred composition leads to a slowly reacting glass while maintaining the ability to be fabricated.
- a slow reaction rate is desired because a large surface area of glass is exposed to physiological solutions during implantation with glass in a fibrous configuration.
- a bioactive glass that quickly degrades may lead to an adverse inflammatory response, impeding bone growth and bonding.
- the tradeoff is that since the glass must be drawn into continuous fibers it cannot be too viscous or too fluid, or the fibers would break upon drawing. Describing the compositional range for materials capable of being drawn into bioactive glass or ceramic fibers thus involves bioactivity versus manufacturability.
- a most preferred composition that can be successfully drawn into fibers while maintaining bioactivity is: 52% Si0 2; 30% Na 2 0; 15% CaO; 3% P 2 0 5 .
- experimental trials showed that a composition of 52% Si0 2 ; 32% CaO; 3% P 2 0 5 ; 13% Na 2 0 would be bioactive, however, it is difficult to draw this composition of glass into fibers. This is because the CaO and the P 2 0 5 work against fiberization, while the Na 2 0 and Si0 2 work for it. It was also found that a composition of 52% Si0 2 ; 27%
- glass compositions used with the present invention will be comprised of 40-60% Si0 2 ; 10-21% CaO; 0-4% P 2 0 5 ; and 19-30% NaO.
- a more preferred range will be comprised of 45-55% Si0 2 15-20% CaO; 25-35% Na 2 0; and 0-3% P 2 0 5 by mole.
- the most preferred composition on the criteria of slow reaction rate and the ability to be manufactured is 52% Si0 2 , 30% Na 2 0, 15% CaO, and 3% P 2 0 5 by mole.
- Modifiers which may be added to the base composition include: 0-3% K 2 0; 0-2% MgO; 0-.2% A1 2 0 3 ; and 0-3% F 2 .
- such modifiers may be added in small quantities to vary the properties and process parameters without severely affecting the bioactivity or ability of the material to be manufactured.
- EXAMPLE I The most preferred glass fiber composition disclosed immediately above (52% Si0 2 , 30% Na 2 0, 15% CaO, and 3% P 2 0 5 (in mole %) ) was prepared from powders. The powders were weighed, mixed, and melted at 1350°C for two hours in a silica crucible.
- the glass drawing apparatus used for this Example is shown in FIG. 1 and includes a resistance heated platinum crucible 50 with an orifice at the bottom. Glass shards were placed into the crucible 50 and melted at approximately 1150°C. The viscous melt formed a meniscus at the crucible orifice 52.
- the glass meniscus was gently touched with a glass rod and the glass rod was quickly, yet smoothly, pulled from the crucible orifice 52 to form a glass fiber 100 from the melt.
- the fiber 100 was manually pulled and attached to the take-up wheel 60 spinning at 300-500 rpm, as determined by the speed control 72 attached tot he motor 70 that rotates the take-up wheel 60.
- a smooth, continuous glass fiber 10-13 microns in diameter was obtained.
- Polymer plates were manufactured using a closed die and a hot press.
- the polymer (polysulfone) was weighed and dried in an oven at 163°C for two hours to drive out excess moisture.
- the mold was cleaned with ethanol and sprayed with teflon mold release.
- the thermoplastic powder was poured into the mold and the mold was placed in the hot press.
- the press was heated to 260°C and pressure was then applied to 14,000 lbs and released. This was repeated twice.
- the mold was then heated to 300°C and a pressure of 620 psi was maintained for thirty minutes. At this time the pressure was released and the mold was air cooled.
- the same processing parameters were followed to make plates of a composite material.
- the polymer was first mixed with chopped glass fibers and then processed with the closed die in the hot press, as described above.
- Plugs 4 mm in diameter and 3 mm thick were machined out of both the polymer plates and the plates that included the chopped bioactive fibers using a core drill tip.
- the samples were then cleaned with soap and water to remove cutting fluids, and ultrasonically cleaned in ethanol and deionized water, being dried after each cleaning.
- the implants were sterilized with ethylene oxide.
- One bioactive glass fiber/polysulfone and one control polysulfone plug were implanted bilaterally in the medial proximal aspect of the tibia using aseptic techniques. Each rabbit served as its own control . Five rabbits were euthanized at three weeks and five at six weeks. The retrieved tibiae were immersed in formalin fixative for two weeks.
- the sections were rinsed in deionized water and gross sectioned with a low speed blade saw using 70% ethanol as cutting fluid.
- the sections were dehydrated according to a graded alcohol immersion plan from 70% ethanol to 100% absolute ethanol over a two week period. Following dehydration, the specimens were sectioned perpendicular to the implant long axis into approximately 1 mm thick sections.
- the sections were infiltrated with Spurr's embedding media according to a graded infiltration sequence in a vacuum desiccator using polyethylene embedding molds.
- the Spurr's infiltration cycle was as follows: 25% Spurr's*/75% ethanol 2 days (change day 2)
- the specimens were then cured for 2 days in an oven at 21°C. Following embedding, the specimens were sectioned to approximately 0.5 mm thick sections using a low speed diamond wafered rotating blade saw. These sections were ground and polished using 800 and 1200 grit paper to a final section thickness of about 50 ⁇ m. The sections were stained using Villanueva Mineralized bone Stain (Polyscientific, New York) .
- the composite material shows very close apposition to bone in areas of high fiber concentration. In these areas, bone bioactive glass or ceramic fibers are partially resorbed, more clearly seen in FIG. 3, taken at 1000X.
- FIG. 3 taken at 1000X.
- the polysulfone implants show bone tissue surrounding the plug, but with an interposing layer between the implant and bone tissue.
- the foregoing Example shows that the bioactive glass fiber/polysulfone plugs made in accordance with the present invention achieve a bond between surrounding bone tissue and the glass fibers at the implant surface.
- the bonded fibers are partially resorbed with bone tissue replacing the glass. Consequently, the method of glass fiber fixation to bone is not only by chemical bonding, but also by micromechanical interlocking. Additionally, there appears to be a bond between the adjacent polymer and surrounding bone tissue. This would lead to increased areas of fixation between the composite and bone beyond that of the fiber itself.
- the bond between polysulfone and bone may be due to a calcium phosphate layer being precipitated onto the adjacent polymer surface as it was being precipitated onto the glass fiber. Once this calcium phosphate layer is formed, the polymer itself may act as a substrate for bone growth.
- Similar findings after implantation of a titanium fiber/bioactive glass composite in dogs will be recently reported. L. Van Hove, E. Schepers and P. Ducheyne, "Titanium Fiber Reinforced Bioactive Glass composite Implants," Bioceramics, Vol. 6; (P. Ducheyne and D. Christiansen, Eds.), Butterworth-Heinemann Ltd. (in press). This study shows bone growth over a titanium fiber which was between two islands of bioactive glass.
- Another aspect of the present invention is the optimization of the amount of fiber used in the composite.
- previous bioactive polymeric composites had used continuous particle coatings on the surface of polymers or polymeric composites with a bioactive powder dispersed through the polymer matrix. It has been determined having surface area partially covered by bioactive glass in a composite form leads to bone bonding in vivo .
- a calcium phosphate layer is the substrate for bone growth.
- the desirable development of a calcium phosphate layer on a non-bioactive material is possible if the material is in close apposition to the bioactive glass. Consequently, it has been found that a composite with only a partial bioactive surface would still achieve bonding.
- the proportion of bioactive surface area exposed should be greater than 30% of the total surface area and the bioactive material should be homogeneously distributed over the surface of the composite to maintain the 30% surface area of bioactive material over the entire surface desired for fixation.
- the present invention also relates to composite materials formed of woven, intermingled or juxtaposed elongated fibers of both a bioactive material and another material chosen for its structural properties. These two fibers are combined in a polymeric matrix.
- the following Examples will illustrate embodiments of this aspect of the present invention.
- One manner by which the location and density of fibers within a composite can be controlled is by forming a braid of one or more types of fibers and impregnating the braid with a filler material, such as a polymer.
- a filler material such as a polymer.
- continuous bone bioactive glass or ceramic fibers are grouped into 5000 filament fiber bundles.
- the fiber bundles (or "tow") are interwoven with carbon fibers into a braided textile preform.
- the bone bioactive glass or ceramic fibers are made in accordance with the composition formulation set forth above.
- a preferred construction has glass fibers 100 woven into a three dimensional tube about a central, but separate, carbon fiber core 110.
- the two braids are woven simultaneously while the carbon fibers in the core 110 and glass fibers 100 at the carbon/glass interface are interwoven, overlaid or otherwise intermingled. This results in structural interlocking and brings continuity to the structure, even before the polymer is infiltrated.
- the carbon fibers in the core 110 are commingled with polymer and unidirectional thick polymer fibers are intermingled with the glass fibers 100 in the outer region of the preform.
- the hybrid preform is then processed in a closed die using a hot press, as described above.
- the amount of polymer is calculated to give the final total volume fraction desired, thus no additional polymer is added before processing.
- the resulting composite does not need to be injection molded due to the placement of the polymer fibers so as to achieve uniform polymer distribution throughout the fibrous preform.
- the final composite is machined to expose bioactive glass 100 fibers at the surface.
- the present invention is also directed to the integration of a bioactive phase in fibrous form into a carbon fiber, three dimensional structural reinforcement network. This results in a delamination resistant, interpenetrating fibrous network which allows bone tissue ingrowth.
- thermoplastic matrix in filamentous form is co-mingled with the reinforcement fibers.
- the thermoplastic fibers are uniformly distributed through out the structure.
- a composite can be formed with bioactive fibers and by the application of heat and pressure to melt the thermoplastic according to well-established regimens known in the art.
- the quantity and distribution of the bioactive phase can be controlled so that a preferred concentration of the bioactive fibers it disposed near the surface of the structure.
- the thermal and mechanical properties of the composite system can be further tailored by changing the fiber volume fraction and fiber orientation distribution.
- two or three dimensional fiber architectures can be selected and fabricated into net shape or near-net shape fibrous assemblies by weaving, knitting or braiding techniques, such as those disclosed in F.K. Ko, "Preform Fiber Architecture for Ceramic Matrix Composites," Bull . Am. Cer. Soc . (Feb. 1989) .
- a three dimensional hybrid mesh will be provided as a specific example. It should be noted, however, that the same principles can be applied to cylindrical shapes and other complex structural shapes as seen in the three dimensional braiding loom design diagram illustrated in FIG. 5.
- the X' s represent the bone bioactive glass or ceramic fibers, the number and distribution of which can vary, and the O's are a structural fiber, preferably carbon fibers, which also may be provided in large and small bundles.
- the vertical rows of the loom are called “tracks” whereas the horizontal rows of the loom are “columns.”
- a three dimensional braided structure is fabricated on the alternate motions of tracks and columns of bundles of fibers attached to a carrier based on the movement instructions indicated in the track and column direction in an alternate manner.
- An “0" means no movement
- a "1" means moving in the positive direction by one carrier position
- a "-1" means moving the carrier in the opposite direction of the other half of the carrier in the same direction.
- a "2" means moving two carrier positions.
- the integration of the bone bioactive glass or ceramic fibers into the carbon fiber in an interfacial region is accommodate by the position of the carrier in track/column coordinates 6/6, 6/7; 7/7, 7/8; 8/6, 8/7; 9/7, 9/8; 10/6, 10/7; 11/7, 11/8; 12/6, 12/7; 13/7, 13/8 being exchanged after each cycle of track/column movement .
- the fiber orientation and fiber volume fraction can be designed. Knowing the fiber and matrix material properties, the elastic properties in the form of a stiffness matrix [C] can be established for the composite. Finite element analysis can also be performed to assess the stress-strain response of the implant under a set of boundary conditions. This preform design, micromechanics analysis and structural mechanics analysis can be performed in an iterative manner to optimize the design of the implant and predict the performance capability of the structure.
- FIG. 6 illustrates a hip implant prosthesis 200 as an example of a composite structure that can be constructed using the present invention.
- the surface, or part of the surface of the prosthesis 200 can be covered with grooves 210 or other surface irregularities.
- the proximal circumferential third of the prosthesis 220 have grooves. These features aid in the macroscopic aspects of bone fixation and have been shown to be beneficial.
- the grooves 210 are most preferably formed by molding the preform to the desired texture, rather than machining a smooth surface .
- the present invention also permits bioactive and structural fibers to be localized to achieve a local fixation using a bioactive surface.
- the fibers can be varied so that the bioactivity is concentrated at a particular section or portion of an implant, device or prosthesis.
- the hip prosthesis 200 would most preferably have the bioactive fibers concentrated in the proximal one third 220 of the implant device. It has been shown that proximal stress transfer in a total hip arthroplasty is better achieved by using a material with fixation to bone in this region.
- the bone bioactive glass or ceramic fiber can be selected from bioactive glass or glass-ceramic materials, including calcium phosphate ceramic fibers.
- the polymer system used may be any polymer which bonds to the bone bioactive glass or ceramic fibers, is biocompatible, and does not inhibit the bioactivity of the fibers in vivo. Examples of such polymer systems are polysulfone, polyetheretherketone (PEEK) , and polyetherketoneketone (PEKK) .
- the structural fiber can be any inert fiber that fits the constraints of biocompatibility and exhibits the ability to bond to the chosen polymer.
- such fibers include inert high strength glass, aramid fibers, and inert ceramic fibers, such as alumina.
- the fiber orientation and type of weave may be varied for different applications and can be pre-selected and optimized using well known analysis techniques.
- the disclosed hybrid woven bioactive composite can be constructed not only as the three dimensional braided textile structure discussed above, but any woven textile structure such as a two-dimensional braid, fiber interlock weave, or laminated composite, among others.
- the present invention may be adapted to many applications where material shape, strength, stiffness, and fixation to bone are among the design parameters .
- fibrous composites of biocompatible materials can be made into bioactive composites by incorporating bone bioactive glass or ceramic fibers into the weave at the bone contact surface.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
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JP51455795A JPH09505345A (en) | 1993-11-15 | 1994-11-14 | Composite material consisting of bone bioactive glass and ceramic fibers |
EP19950901248 EP0730681B1 (en) | 1993-11-15 | 1994-11-14 | Composite materials using bone bioactive glass and ceramic fibers |
AT95901248T ATE222735T1 (en) | 1993-11-15 | 1994-11-14 | COMPOSITES BASED ON BONE BIOACTIVE GLASS AND CERAMIC FIBERS |
AU10564/95A AU700443C (en) | 1993-11-15 | 1994-11-14 | Composite materials using bone bioactive glass and ceramic fibers |
DE1994631254 DE69431254T2 (en) | 1993-11-15 | 1994-11-14 | COMPOSITIONS BASED ON BONE BIOACTIVE GLASS AND CERAMIC FIBERS |
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US08/152,962 | 1993-11-15 | ||
US08/152,962 US5468544A (en) | 1993-11-15 | 1993-11-15 | Composite materials using bone bioactive glass and ceramic fibers |
US08/436,585 US5645934A (en) | 1993-11-15 | 1995-05-08 | Composite materials using bone bioactive glass and ceramic fibers |
US46342895A | 1995-06-05 | 1995-06-05 | |
US08/461,109 US6121172A (en) | 1993-11-15 | 1995-06-05 | Composite materials using bone bioactive glass and ceramic fibers |
US08/463,009 US5721049A (en) | 1993-11-15 | 1995-06-05 | Composite materials using bone bioactive glass and ceramic fibers |
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PCT/US1996/006439 WO1996036368A2 (en) | 1993-11-15 | 1996-05-08 | Composite materials using bone bioactive glass and ceramic fibers |
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US (2) | US5468544A (en) |
EP (2) | EP0730681B1 (en) |
JP (2) | JPH09505345A (en) |
AT (2) | ATE222735T1 (en) |
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CA (2) | CA2176707A1 (en) |
DE (2) | DE69431254T2 (en) |
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US6413538B1 (en) | 1996-03-18 | 2002-07-02 | The Trustees Of The University Of Pennsylvania | Bioactive glass or ceramic substrates having bound cell adhesion molecules |
WO1997035000A1 (en) * | 1996-03-18 | 1997-09-25 | The Trustees Of The University Of Pennsylvania | Bioactive material substrate for enhanced cellular attachment and function |
EP0951248A1 (en) * | 1996-11-01 | 1999-10-27 | The Johns Hopkins University | Orthopedic implant |
EP0951248A4 (en) * | 1996-11-01 | 2000-11-02 | Univ Johns Hopkins | Orthopedic implant |
AU761459B2 (en) * | 1998-12-11 | 2003-06-05 | Vivoxid Oy | A novel bioactive product and its use |
US6517857B2 (en) | 1998-12-11 | 2003-02-11 | Ylaenen Heimo | Bioactive product and its use |
WO2000035509A1 (en) * | 1998-12-11 | 2000-06-22 | Ylaenen Heimo | A novel bioactive product and its use |
US8597675B2 (en) | 2006-09-25 | 2013-12-03 | Orthovita, Inc. | Bioactive load-bearing composites |
US8968797B2 (en) | 2006-09-25 | 2015-03-03 | Orthovita, Inc. | Bioactive load-bearing composites |
US9381275B2 (en) | 2006-09-25 | 2016-07-05 | Orthovita, Inc. | Bioactive load-bearing composites |
US10195308B2 (en) | 2006-09-25 | 2019-02-05 | Orthovita, Inc. | Bioactive load-bearing composites |
US9662821B2 (en) | 2008-12-30 | 2017-05-30 | Orthovita, Inc. | Bioactive composites of polymer and glass and method for making same |
US10307511B2 (en) | 2008-12-30 | 2019-06-04 | Orthovita, Inc. | Bioactive composites of polymer and glass and method for making same |
WO2015021519A1 (en) | 2013-08-12 | 2015-02-19 | Fundação Universidade Federal De São Carlos | Vitreous composition, bioactive vitreous fibres and fabrics, and articles |
Also Published As
Publication number | Publication date |
---|---|
WO1996036368A3 (en) | 1996-12-19 |
JPH09505345A (en) | 1997-05-27 |
EP0871504B1 (en) | 2002-10-16 |
AU701236B2 (en) | 1999-01-21 |
IL111446A (en) | 1998-09-24 |
ES2186780T3 (en) | 2003-05-16 |
DE69431254T2 (en) | 2003-04-30 |
ATE222735T1 (en) | 2002-09-15 |
AU1056495A (en) | 1995-06-06 |
CA2176707A1 (en) | 1995-05-26 |
EP0730681B1 (en) | 2002-08-28 |
EP0871504A2 (en) | 1998-10-21 |
DE69431254D1 (en) | 2002-10-02 |
IL111446A0 (en) | 1994-12-29 |
DE69624376T2 (en) | 2003-07-03 |
ES2181762T3 (en) | 2003-03-01 |
JPH11506948A (en) | 1999-06-22 |
AU5731396A (en) | 1996-11-29 |
WO1996036368A2 (en) | 1996-11-21 |
EP0730681A4 (en) | 1998-07-15 |
CA2218086A1 (en) | 1996-11-21 |
DE69624376D1 (en) | 2002-11-21 |
ATE226098T1 (en) | 2002-11-15 |
US5645934A (en) | 1997-07-08 |
AU700443B2 (en) | 1999-01-07 |
EP0730681A1 (en) | 1996-09-11 |
EP0871504A4 (en) | 2000-08-16 |
US5468544A (en) | 1995-11-21 |
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