WO1996005514A3 - Messanordnung und verfahren zur durchführung luminometrischer reihenanalysen sowie mehrfachküvette zur aufnahme von flüssigkeitsproben hierfür - Google Patents

Messanordnung und verfahren zur durchführung luminometrischer reihenanalysen sowie mehrfachküvette zur aufnahme von flüssigkeitsproben hierfür Download PDF

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Publication number
WO1996005514A3
WO1996005514A3 PCT/EP1995/003188 EP9503188W WO9605514A3 WO 1996005514 A3 WO1996005514 A3 WO 1996005514A3 EP 9503188 W EP9503188 W EP 9503188W WO 9605514 A3 WO9605514 A3 WO 9605514A3
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WO
WIPO (PCT)
Prior art keywords
liquid samples
reaction partners
carrying
carrier particles
vessel
Prior art date
Application number
PCT/EP1995/003188
Other languages
English (en)
French (fr)
Other versions
WO1996005514A2 (de
Inventor
Hermann Leistner
Hans Schiessl
Original Assignee
Stratec Elektronik Gmbh
Hermann Leistner
Hans Schiessl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stratec Elektronik Gmbh, Hermann Leistner, Hans Schiessl filed Critical Stratec Elektronik Gmbh
Priority to JP50701896A priority Critical patent/JP3238155B2/ja
Priority to DE59505449T priority patent/DE59505449D1/de
Priority to EP95930445A priority patent/EP0774123B1/de
Priority to US08/793,090 priority patent/US5985671A/en
Publication of WO1996005514A2 publication Critical patent/WO1996005514A2/de
Publication of WO1996005514A3 publication Critical patent/WO1996005514A3/de

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • Y10T436/114165—Automated chemical analysis with conveyance of sample along a test line in a container or rack with step of insertion or removal from test line
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/113332—Automated chemical analysis with conveyance of sample along a test line in a container or rack
    • Y10T436/114998—Automated chemical analysis with conveyance of sample along a test line in a container or rack with treatment or replacement of aspirator element [e.g., cleaning, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Abstract

Die Erfindung bezieht sich auf eine Meßanordnung und ein Verfahren zur Durchführung luminometrischer Reihenanalysen an zu untersuchende Reaktionskomponenten und diese bindende magnetisierbare Trägerpartikel enthaltenden Flüssigproben (12). Die Proben werden in Küvetteneinheiten (30) einer Mehrfachküvette (14) in einer Förderstrecke (16) zu einer Meßstation (18) transportiert, wo die Konzentration der nachzuweisenden Zielsubstanz mittels einer Lumineszenzmessung bestimmt wird. Zur Entfernung überschüssiger, die Messung verfälschender Reaktionskomponenten werden die Mehrfachküvetten (14) an mehreren rotierenden Dauermagneten (20-27) vorbeitransportiert, die mit ihrem keulenförmigen Magnetfeld (80) die Küvetteneinheiten (30) nacheinander und von einander gegenüberliegenden Wandbereichen (40, 44) her durchdringen. Dabei werden die Trägerpartikel auf Spiralbahnen durch die Probenflüssigkeit gezogen und als Pellet (92) konzentriert. Die von den Trägerpartikeln abgelösten überschüssigen Reaktionskomponenten können dann in einem Spül- und Absaugprozeß entfernt werden.
PCT/EP1995/003188 1994-08-17 1995-08-11 Messanordnung und verfahren zur durchführung luminometrischer reihenanalysen sowie mehrfachküvette zur aufnahme von flüssigkeitsproben hierfür WO1996005514A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP50701896A JP3238155B2 (ja) 1994-08-17 1995-08-11 発光測定による直列分析を実施するための測定装置及び方法並びに直列分析のための液体試料を収容する多重容器
DE59505449T DE59505449D1 (de) 1994-08-17 1995-08-11 Messanordnung und verfahren zur durchführung luminometrischer reihenanalysen sowie mehrfachküvette zur aufnahme von flüssigkeitsproben hierfür
EP95930445A EP0774123B1 (de) 1994-08-17 1995-08-11 Messanordnung und verfahren zur durchführung luminometrischer reihenanalysen sowie mehrfachküvette zur aufnahme von flüssigkeitsproben hierfür
US08/793,090 US5985671A (en) 1994-08-17 1995-08-11 Measuring system and method for performing luminometric series analyses as well as multiple cuvette for receiving liquid samples therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4429155A DE4429155A1 (de) 1994-08-17 1994-08-17 Meßanordnung und Verfahren zur Durchführung luminometrischer Reihenanalysen sowie Mehrfachküvette zur Aufnahme von Flüssigkeitsproben hierfür
DEP4429155.8 1994-08-17

Publications (2)

Publication Number Publication Date
WO1996005514A2 WO1996005514A2 (de) 1996-02-22
WO1996005514A3 true WO1996005514A3 (de) 1996-05-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1995/003188 WO1996005514A2 (de) 1994-08-17 1995-08-11 Messanordnung und verfahren zur durchführung luminometrischer reihenanalysen sowie mehrfachküvette zur aufnahme von flüssigkeitsproben hierfür

Country Status (6)

Country Link
US (2) US5985671A (de)
EP (2) EP0893692B1 (de)
JP (1) JP3238155B2 (de)
AT (2) ATE178140T1 (de)
DE (3) DE4429155A1 (de)
WO (1) WO1996005514A2 (de)

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Also Published As

Publication number Publication date
ATE210300T1 (de) 2001-12-15
JPH10504389A (ja) 1998-04-28
US6333008B1 (en) 2001-12-25
US5985671A (en) 1999-11-16
WO1996005514A2 (de) 1996-02-22
EP0774123A2 (de) 1997-05-21
EP0774123B1 (de) 1999-03-24
EP0893692A1 (de) 1999-01-27
DE59505449D1 (de) 1999-04-29
JP3238155B2 (ja) 2001-12-10
DE4429155A1 (de) 1996-02-22
EP0893692B1 (de) 2001-12-05
DE59509917D1 (de) 2002-01-17
ATE178140T1 (de) 1999-04-15

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