WO1996006946A1 - Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to a solid surface - Google Patents
Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to a solid surface Download PDFInfo
- Publication number
- WO1996006946A1 WO1996006946A1 PCT/US1995/010630 US9510630W WO9606946A1 WO 1996006946 A1 WO1996006946 A1 WO 1996006946A1 US 9510630 W US9510630 W US 9510630W WO 9606946 A1 WO9606946 A1 WO 9606946A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dna
- nucleic acid
- film
- electrode
- label
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95930881A EP0777741A4 (en) | 1994-08-26 | 1995-08-25 | Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to a solid surface |
AU34103/95A AU703344B2 (en) | 1994-08-26 | 1995-08-25 | Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to a solid surface |
JP8508822A JPH10509025A (en) | 1994-08-26 | 1995-08-25 | Biosensor and method for electrogenerated chemiluminescent detection of nucleic acids adsorbed on solid surface |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29663094A | 1994-08-26 | 1994-08-26 | |
US08/296,630 | 1994-08-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996006946A1 true WO1996006946A1 (en) | 1996-03-07 |
Family
ID=23142843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1995/010630 WO1996006946A1 (en) | 1994-08-26 | 1995-08-25 | Biosensor for and method of electrogenerated chemiluminescent detection of nucleic acid adsorbed to a solid surface |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0777741A4 (en) |
JP (1) | JPH10509025A (en) |
AU (1) | AU703344B2 (en) |
CA (1) | CA2198489A1 (en) |
WO (1) | WO1996006946A1 (en) |
Cited By (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0755458A1 (en) * | 1995-02-09 | 1997-01-29 | Igen, Inc. | Electrogenerated chemiluminescence labels for analysis and/or referencing |
WO1998045475A1 (en) * | 1997-04-09 | 1998-10-15 | Cis Bio International | System for detecting nucleic acid hybridisation, preparation method and application thereof |
US6066448A (en) * | 1995-03-10 | 2000-05-23 | Meso Sclae Technologies, Llc. | Multi-array, multi-specific electrochemiluminescence testing |
US6140045A (en) * | 1995-03-10 | 2000-10-31 | Meso Scale Technologies | Multi-array, multi-specific electrochemiluminescence testing |
US6207369B1 (en) | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
WO2001042508A2 (en) * | 1999-12-09 | 2001-06-14 | Motorola, Inc. | Methods and compositions relating to electrical detection of nucleic acid reactions |
US6518024B2 (en) | 1999-12-13 | 2003-02-11 | Motorola, Inc. | Electrochemical detection of single base extension |
EP1322787A1 (en) * | 2000-10-05 | 2003-07-02 | Virginia Tech Intellectual Properties, Inc. | Bio-chip, photoluminescent methods for identifying biological material, and apparatuses for use with such methods and bio-chips |
US6673533B1 (en) | 1995-03-10 | 2004-01-06 | Meso Scale Technologies, Llc. | Multi-array multi-specific electrochemiluminescence testing |
US6824669B1 (en) | 2000-02-17 | 2004-11-30 | Motorola, Inc. | Protein and peptide sensors using electrical detection methods |
US6977151B2 (en) | 1996-11-05 | 2005-12-20 | Clinical Micro Sensors, Inc. | Electrodes linked via conductive oligomers to nucleic acids |
US7138121B2 (en) | 2003-01-23 | 2006-11-21 | Spangler Brenda D | Biosensors utilizing dendrimer-immobilized ligands and there use thereof |
US7361470B2 (en) | 2003-05-13 | 2008-04-22 | Trustees Of Boston College | Electrocatalytic nucleic acid hybridization detection |
WO2006076047A3 (en) * | 2004-08-06 | 2009-04-09 | Trustees Boston College | Electrocatalytic nucleic acid hybridization detection |
EP2186910A2 (en) | 1997-12-23 | 2010-05-19 | Meso Scale Technologies LLC | Methods and compositions for improved luminescence assays using microparticles |
US7935481B1 (en) | 1999-07-26 | 2011-05-03 | Osmetech Technology Inc. | Sequence determination of nucleic acids using electronic detection |
US8140148B2 (en) | 1998-01-20 | 2012-03-20 | Boston Scientific Scimed Ltd. | Readable probe array for in vivo use |
US8888969B2 (en) | 2008-09-02 | 2014-11-18 | The Governing Council Of The University Of Toronto | Nanostructured microelectrodes and biosensing devices incorporating the same |
US9151746B2 (en) | 1999-04-21 | 2015-10-06 | Osmetech Technology, Inc. | Use of microfluidic systems in the electrochemical detection of target analytes |
US9580742B2 (en) | 2011-03-10 | 2017-02-28 | Shana O. Kelley | Diagnostic and sample preparation devices and methods |
WO2017153336A1 (en) | 2016-03-07 | 2017-09-14 | F. Hoffmann-La Roche Ag | Detection of anti-p53 antibodies |
WO2018141768A1 (en) | 2017-02-02 | 2018-08-09 | Roche Diagnostics Gmbh | Immunoassay using at least two pegylated analyte-specific binding agents |
WO2019201901A1 (en) | 2018-04-18 | 2019-10-24 | F. Hoffmann-La Roche Ag | Novel anti-thymidine kinase antibodies |
WO2020043868A1 (en) | 2018-08-31 | 2020-03-05 | F. Hoffmann-La Roche Ag | Thymidine kinase (tk-1) in prognostic indices for dlbcl |
CN111272742A (en) * | 2020-03-06 | 2020-06-12 | 安徽大学 | Electrochemiluminescence sensor based on metal organic gel composite material and metal organic framework and preparation and detection methods thereof |
WO2021013781A1 (en) | 2019-07-22 | 2021-01-28 | F. Hoffmann-La Roche Ag | Substance p as blood biomarker for the non-invasive diagnosis of endometriosis |
WO2021013786A1 (en) | 2019-07-22 | 2021-01-28 | F. Hoffmann-La Roche Ag | S100a6 as blood biomarker for the non-invasive diagnosis of endometriosis |
WO2021013785A1 (en) | 2019-07-22 | 2021-01-28 | F. Hoffmann-La Roche Ag | S100a9 as blood biomarker for the non-invasive diagnosis of endometriosis |
WO2021013784A1 (en) | 2019-07-22 | 2021-01-28 | F. Hoffmann-La Roche Ag | S100a8 as blood biomarker for the non-invasive diagnosis of endometriosis |
WO2021013783A1 (en) | 2019-07-22 | 2021-01-28 | F. Hoffmann-La Roche Ag | S100a12 as blood biomarker for the non-invasive diagnosis of endometriosis |
WO2021094409A1 (en) | 2019-11-15 | 2021-05-20 | F. Hoffmann-La Roche Ag | Derivatization of beta-lactam antibiotics for massspec measurements in patient samples |
WO2022090455A1 (en) | 2020-11-02 | 2022-05-05 | F. Hoffmann-La Roche Ag | Sars-cov-2 nucleocapsid antibodies |
US11366110B2 (en) | 2011-01-11 | 2022-06-21 | The Governing Council Of The University Of Toronto | Protein detection method |
US11391733B2 (en) | 2015-08-20 | 2022-07-19 | Roche Diagnostics Operations, Inc. | Particle-based immunoassay using a pegylated analyte-specific binding agent |
WO2022207685A1 (en) | 2021-04-01 | 2022-10-06 | F. Hoffmann-La Roche Ag | Psp94 as blood biomarker for the non-invasive diagnosis of endometriosis |
WO2022207628A1 (en) | 2021-03-30 | 2022-10-06 | F. Hoffmann-La Roche Ag | Scf as blood biomarker for the non-invasive diagnosis of endometriosis |
WO2022243210A1 (en) | 2021-05-17 | 2022-11-24 | F. Hoffmann-La Roche Ag | sFRP4 AS BLOOD BIOMARKER FOR THE NON-INVASIVE DIAGNOSIS OF ADENOMYOSIS |
CN115414930A (en) * | 2022-08-26 | 2022-12-02 | 重庆医科大学 | Ru(bpy) 32+ Anode or cathode coreactant and method of making same |
WO2023072904A1 (en) | 2021-10-26 | 2023-05-04 | F. Hoffmann-La Roche Ag | Monoclonal antibodies specific for sars-cov-2 rbd |
WO2023131594A1 (en) | 2022-01-05 | 2023-07-13 | F. Hoffmann-La Roche Ag | Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm) |
WO2023247752A1 (en) | 2022-06-23 | 2023-12-28 | F. Hoffmann-La Roche Ag | Method for diagnosing endometriosis and for classifying the stage of endometriosis |
WO2024017985A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
WO2024017982A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Leukotriene a4 hydrolase (lta4h) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
WO2024017983A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Meteorin-like protein (metrnl) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
US11971407B2 (en) | 2016-03-07 | 2024-04-30 | Roche Diagnostics Operations, Inc. | Detection of anti-p53 antibodies |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2006075497A1 (en) * | 2004-12-21 | 2008-06-12 | 国立大学法人京都大学 | Probe unit, nucleotide region identification apparatus, and nucleotide region identification method |
Citations (5)
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---|---|---|---|---|
US3591838A (en) * | 1967-12-28 | 1971-07-06 | Matsushita Electronics Corp | Semiconductor device having an alloy electrode and its manufacturing method |
US5019343A (en) * | 1989-12-15 | 1991-05-28 | W. R. Grace & Co.-Conn. | Control of corrosion in aqueous systems using certain phosphonomethyl amines |
US5124022A (en) * | 1989-08-23 | 1992-06-23 | Aluminum Company Of America | Electrolytic capacitor and method of making same |
US5238808A (en) * | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
WO1993022678A2 (en) * | 1992-04-23 | 1993-11-11 | Massachusetts Institute Of Technology | Optical and electrical methods and apparatus for molecule detection |
-
1995
- 1995-08-25 CA CA002198489A patent/CA2198489A1/en not_active Abandoned
- 1995-08-25 WO PCT/US1995/010630 patent/WO1996006946A1/en not_active Application Discontinuation
- 1995-08-25 EP EP95930881A patent/EP0777741A4/en not_active Withdrawn
- 1995-08-25 JP JP8508822A patent/JPH10509025A/en active Pending
- 1995-08-25 AU AU34103/95A patent/AU703344B2/en not_active Ceased
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3591838A (en) * | 1967-12-28 | 1971-07-06 | Matsushita Electronics Corp | Semiconductor device having an alloy electrode and its manufacturing method |
US5238808A (en) * | 1984-10-31 | 1993-08-24 | Igen, Inc. | Luminescent metal chelate labels and means for detection |
US5124022A (en) * | 1989-08-23 | 1992-06-23 | Aluminum Company Of America | Electrolytic capacitor and method of making same |
US5019343A (en) * | 1989-12-15 | 1991-05-28 | W. R. Grace & Co.-Conn. | Control of corrosion in aqueous systems using certain phosphonomethyl amines |
WO1993022678A2 (en) * | 1992-04-23 | 1993-11-11 | Massachusetts Institute Of Technology | Optical and electrical methods and apparatus for molecule detection |
Non-Patent Citations (2)
Title |
---|
ANALYTICAL CHEMISTRY, Volume 66, Number 6, issued 15 March 1994, H. SU et al., "Interfacial Nucleic Acid Hybridization Studied by Random Primer 32P Labeling and Liquid-Phase Acoustic Network Analysis", pages 769-77. * |
See also references of EP0777741A4 * |
Cited By (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0755458A4 (en) * | 1995-02-09 | 2000-07-26 | Igen Int Inc | Electrogenerated chemiluminescence labels for analysis and/or referencing |
EP0755458A1 (en) * | 1995-02-09 | 1997-01-29 | Igen, Inc. | Electrogenerated chemiluminescence labels for analysis and/or referencing |
US6066448A (en) * | 1995-03-10 | 2000-05-23 | Meso Sclae Technologies, Llc. | Multi-array, multi-specific electrochemiluminescence testing |
US6673533B1 (en) | 1995-03-10 | 2004-01-06 | Meso Scale Technologies, Llc. | Multi-array multi-specific electrochemiluminescence testing |
US6090545A (en) * | 1995-03-10 | 2000-07-18 | Meso Scale Technologies, Llc. | Multi-array, multi-specific electrochemiluminescence testing |
US7015046B2 (en) | 1995-03-10 | 2006-03-21 | Mesoscale Technologies, Llc. | Multi-array, multi-specific electrochemiluminescence testing |
US6140045A (en) * | 1995-03-10 | 2000-10-31 | Meso Scale Technologies | Multi-array, multi-specific electrochemiluminescence testing |
US6207369B1 (en) | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
US7824925B2 (en) | 1995-03-10 | 2010-11-02 | Meso Scale Technology Llp | Multi-array, multi-specific electrochemiluminescence testing |
US8722323B2 (en) | 1995-03-10 | 2014-05-13 | Meso Scale Technologies Llp | Multi-array, multi-specific electrochemiluminescence testing |
US8541168B1 (en) | 1995-03-10 | 2013-09-24 | Jacob Wohlstadter | Multi-array, multi-specific electrochemiluminescence testing |
EP2284536A2 (en) | 1996-09-17 | 2011-02-16 | Meso Scale Technologies, LLC. | Multi-array, multi-specific electrochemiluminescence testing |
US6977151B2 (en) | 1996-11-05 | 2005-12-20 | Clinical Micro Sensors, Inc. | Electrodes linked via conductive oligomers to nucleic acids |
US6210932B1 (en) | 1997-04-09 | 2001-04-03 | Cis Bio International | System for detecting nucleic acid hybridization, preparation method and application thereof |
FR2762013A1 (en) * | 1997-04-09 | 1998-10-16 | Cis Bio Int | NUCLEIC ACID HYBRIDIZATION DETECTION SYSTEMS, PROCESS FOR PREPARING THEM AND USES THEREOF |
WO1998045475A1 (en) * | 1997-04-09 | 1998-10-15 | Cis Bio International | System for detecting nucleic acid hybridisation, preparation method and application thereof |
EP2284277A1 (en) | 1997-12-23 | 2011-02-16 | Meso Scale Technologies, LLC | Methods and apparatus for improved luminescence assays using a soluble polymer having a ligand and a plurality of electrochemiluminescent labels |
EP2186910A2 (en) | 1997-12-23 | 2010-05-19 | Meso Scale Technologies LLC | Methods and compositions for improved luminescence assays using microparticles |
US8140148B2 (en) | 1998-01-20 | 2012-03-20 | Boston Scientific Scimed Ltd. | Readable probe array for in vivo use |
US9557295B2 (en) | 1999-04-21 | 2017-01-31 | Osmetech Technology, Inc. | Use of microfluidic systems in the electrochemical detection of target analytes |
US9151746B2 (en) | 1999-04-21 | 2015-10-06 | Osmetech Technology, Inc. | Use of microfluidic systems in the electrochemical detection of target analytes |
US7935481B1 (en) | 1999-07-26 | 2011-05-03 | Osmetech Technology Inc. | Sequence determination of nucleic acids using electronic detection |
WO2001042508A2 (en) * | 1999-12-09 | 2001-06-14 | Motorola, Inc. | Methods and compositions relating to electrical detection of nucleic acid reactions |
WO2001042508A3 (en) * | 1999-12-09 | 2002-03-14 | Motorola Inc | Methods and compositions relating to electrical detection of nucleic acid reactions |
US6518024B2 (en) | 1999-12-13 | 2003-02-11 | Motorola, Inc. | Electrochemical detection of single base extension |
US6824669B1 (en) | 2000-02-17 | 2004-11-30 | Motorola, Inc. | Protein and peptide sensors using electrical detection methods |
EP1322787A1 (en) * | 2000-10-05 | 2003-07-02 | Virginia Tech Intellectual Properties, Inc. | Bio-chip, photoluminescent methods for identifying biological material, and apparatuses for use with such methods and bio-chips |
EP1322787A4 (en) * | 2000-10-05 | 2005-06-15 | Virginia Tech Intell Prop | Bio-chip, photoluminescent methods for identifying biological material, and apparatuses for use with such methods and bio-chips |
US7138121B2 (en) | 2003-01-23 | 2006-11-21 | Spangler Brenda D | Biosensors utilizing dendrimer-immobilized ligands and there use thereof |
US7741033B2 (en) * | 2003-05-13 | 2010-06-22 | Trustees Of Boston College | Electrocatalytic nucleic acid hybridization detection |
US7361470B2 (en) | 2003-05-13 | 2008-04-22 | Trustees Of Boston College | Electrocatalytic nucleic acid hybridization detection |
WO2006076047A3 (en) * | 2004-08-06 | 2009-04-09 | Trustees Boston College | Electrocatalytic nucleic acid hybridization detection |
US9791402B2 (en) | 2008-09-02 | 2017-10-17 | The Governing Council Of The University Of Toronto | Nanostructured microelectrodes and biosensing devices incorporating the same |
US8888969B2 (en) | 2008-09-02 | 2014-11-18 | The Governing Council Of The University Of Toronto | Nanostructured microelectrodes and biosensing devices incorporating the same |
US10274453B2 (en) | 2008-09-02 | 2019-04-30 | The Governing Council Of The University Of Toronto | Nanostructured microelectrodes and biosensing devices incorporating the same |
US11366110B2 (en) | 2011-01-11 | 2022-06-21 | The Governing Council Of The University Of Toronto | Protein detection method |
US10301666B2 (en) | 2011-03-10 | 2019-05-28 | General Atomics | Diagnostic and sample preparation devices and methods |
US9580742B2 (en) | 2011-03-10 | 2017-02-28 | Shana O. Kelley | Diagnostic and sample preparation devices and methods |
US11391733B2 (en) | 2015-08-20 | 2022-07-19 | Roche Diagnostics Operations, Inc. | Particle-based immunoassay using a pegylated analyte-specific binding agent |
WO2017153336A1 (en) | 2016-03-07 | 2017-09-14 | F. Hoffmann-La Roche Ag | Detection of anti-p53 antibodies |
US11971407B2 (en) | 2016-03-07 | 2024-04-30 | Roche Diagnostics Operations, Inc. | Detection of anti-p53 antibodies |
WO2018141768A1 (en) | 2017-02-02 | 2018-08-09 | Roche Diagnostics Gmbh | Immunoassay using at least two pegylated analyte-specific binding agents |
US11099180B2 (en) | 2017-02-02 | 2021-08-24 | Roche Diagnostics Operations, Inc. | Immunoassay using at least two pegylated analyte-specific binding agents |
WO2019201901A1 (en) | 2018-04-18 | 2019-10-24 | F. Hoffmann-La Roche Ag | Novel anti-thymidine kinase antibodies |
WO2020043868A1 (en) | 2018-08-31 | 2020-03-05 | F. Hoffmann-La Roche Ag | Thymidine kinase (tk-1) in prognostic indices for dlbcl |
WO2021013781A1 (en) | 2019-07-22 | 2021-01-28 | F. Hoffmann-La Roche Ag | Substance p as blood biomarker for the non-invasive diagnosis of endometriosis |
WO2021013786A1 (en) | 2019-07-22 | 2021-01-28 | F. Hoffmann-La Roche Ag | S100a6 as blood biomarker for the non-invasive diagnosis of endometriosis |
WO2021013784A1 (en) | 2019-07-22 | 2021-01-28 | F. Hoffmann-La Roche Ag | S100a8 as blood biomarker for the non-invasive diagnosis of endometriosis |
WO2021013783A1 (en) | 2019-07-22 | 2021-01-28 | F. Hoffmann-La Roche Ag | S100a12 as blood biomarker for the non-invasive diagnosis of endometriosis |
WO2021013785A1 (en) | 2019-07-22 | 2021-01-28 | F. Hoffmann-La Roche Ag | S100a9 as blood biomarker for the non-invasive diagnosis of endometriosis |
WO2021094409A1 (en) | 2019-11-15 | 2021-05-20 | F. Hoffmann-La Roche Ag | Derivatization of beta-lactam antibiotics for massspec measurements in patient samples |
CN111272742B (en) * | 2020-03-06 | 2022-11-08 | 安徽大学 | Electrochemiluminescence sensor based on metal organic gel composite material and metal organic framework and preparation and detection methods thereof |
CN111272742A (en) * | 2020-03-06 | 2020-06-12 | 安徽大学 | Electrochemiluminescence sensor based on metal organic gel composite material and metal organic framework and preparation and detection methods thereof |
WO2022090455A1 (en) | 2020-11-02 | 2022-05-05 | F. Hoffmann-La Roche Ag | Sars-cov-2 nucleocapsid antibodies |
WO2022207628A1 (en) | 2021-03-30 | 2022-10-06 | F. Hoffmann-La Roche Ag | Scf as blood biomarker for the non-invasive diagnosis of endometriosis |
WO2022207685A1 (en) | 2021-04-01 | 2022-10-06 | F. Hoffmann-La Roche Ag | Psp94 as blood biomarker for the non-invasive diagnosis of endometriosis |
WO2022243210A1 (en) | 2021-05-17 | 2022-11-24 | F. Hoffmann-La Roche Ag | sFRP4 AS BLOOD BIOMARKER FOR THE NON-INVASIVE DIAGNOSIS OF ADENOMYOSIS |
WO2023072904A1 (en) | 2021-10-26 | 2023-05-04 | F. Hoffmann-La Roche Ag | Monoclonal antibodies specific for sars-cov-2 rbd |
WO2023131594A1 (en) | 2022-01-05 | 2023-07-13 | F. Hoffmann-La Roche Ag | Derivatization of compounds in patient samples for therapeutic drug monitoring (tdm) |
WO2023247752A1 (en) | 2022-06-23 | 2023-12-28 | F. Hoffmann-La Roche Ag | Method for diagnosing endometriosis and for classifying the stage of endometriosis |
WO2024017985A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Fibroblast growth factor binding protein 1 (fgfbp1) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
WO2024017982A1 (en) | 2022-07-22 | 2024-01-25 | F. Hoffmann-La Roche Ag | Leukotriene a4 hydrolase (lta4h) as (blood) biomarker for the diagnosis of polycystic ovarian syndrome |
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EP0777741A1 (en) | 1997-06-11 |
CA2198489A1 (en) | 1996-03-07 |
EP0777741A4 (en) | 1999-01-13 |
AU3410395A (en) | 1996-03-22 |
JPH10509025A (en) | 1998-09-08 |
AU703344B2 (en) | 1999-03-25 |
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