WO1996007397A3 - Delivery of solid drug compositions - Google Patents

Delivery of solid drug compositions Download PDF

Info

Publication number
WO1996007397A3
WO1996007397A3 PCT/IB1995/000778 IB9500778W WO9607397A3 WO 1996007397 A3 WO1996007397 A3 WO 1996007397A3 IB 9500778 W IB9500778 W IB 9500778W WO 9607397 A3 WO9607397 A3 WO 9607397A3
Authority
WO
WIPO (PCT)
Prior art keywords
solid drug
delivery
drug compositions
microplunger
needle
Prior art date
Application number
PCT/IB1995/000778
Other languages
French (fr)
Other versions
WO1996007397A2 (en
Inventor
Roland Cherif-Cheikh
Original Assignee
Scras
Cherif Cheikh Roland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scras, Cherif Cheikh Roland filed Critical Scras
Priority to AT95930675T priority Critical patent/ATE230977T1/en
Priority to DK95930675T priority patent/DK0778767T3/en
Priority to JP50935696A priority patent/JP4072867B2/en
Priority to AU33981/95A priority patent/AU712916B2/en
Priority to KR10-2001-7005475A priority patent/KR100491424B1/en
Priority to BR9508688A priority patent/BR9508688A/en
Priority to EP95930675A priority patent/EP0778767B1/en
Priority to CA 2198916 priority patent/CA2198916C/en
Priority to DE1995629415 priority patent/DE69529415T2/en
Publication of WO1996007397A2 publication Critical patent/WO1996007397A2/en
Publication of WO1996007397A3 publication Critical patent/WO1996007397A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF] (Somatoliberin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14248—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body of the skin patch type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/14244—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M2005/14268—Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body with a reusable and a disposable component
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A61M5/31531—Microsyringes, e.g. having piston bore diameter close or equal to needle shaft diameter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31573—Accuracy improving means
    • A61M5/31575—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
    • A61M5/31595—Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking

Abstract

This invention relates to the parenteral administration of solid drug compositions. In particular, this invention relates to a syringe-like device for delivering solid drug cylinders including a syringe barrel, a needle, and a microplunger and piston assembly, wherein said microplunger pushes said solid drug cylinder out of said needle and into a patient and said piston pushes on said microplunger. <IMAGE>
PCT/IB1995/000778 1994-09-02 1995-08-31 Delivery of solid drug compositions WO1996007397A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AT95930675T ATE230977T1 (en) 1994-09-02 1995-08-31 ADMINISTRATION OF SOLID MEDICINAL PREPARATIONS
DK95930675T DK0778767T3 (en) 1994-09-02 1995-08-31 Delivery of solid drug preparations
JP50935696A JP4072867B2 (en) 1994-09-02 1995-08-31 Supply of solid drug composition
AU33981/95A AU712916B2 (en) 1994-09-02 1995-08-31 Delivery of solid drug compositions
KR10-2001-7005475A KR100491424B1 (en) 1994-09-02 1995-08-31 Delivery of Solid Drug Compositions
BR9508688A BR9508688A (en) 1994-09-02 1995-08-31 Release of solid drug compositions
EP95930675A EP0778767B1 (en) 1994-09-02 1995-08-31 Delivery of solid drug compositions
CA 2198916 CA2198916C (en) 1994-09-02 1995-08-31 Delivery of solid drug compositions
DE1995629415 DE69529415T2 (en) 1994-09-02 1995-08-31 ADMINISTRATION OF SOLID DRUG PREPARATIONS

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/300,713 1994-09-02
US08/300,713 US5582591A (en) 1994-09-02 1994-09-02 Delivery of solid drug compositions
US31746594A 1994-10-04 1994-10-04
US08/317,465 1994-10-04

Publications (2)

Publication Number Publication Date
WO1996007397A2 WO1996007397A2 (en) 1996-03-14
WO1996007397A3 true WO1996007397A3 (en) 1996-08-15

Family

ID=26971933

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1995/000778 WO1996007397A2 (en) 1994-09-02 1995-08-31 Delivery of solid drug compositions

Country Status (16)

Country Link
US (2) US5582591A (en)
EP (3) EP0778767B1 (en)
JP (1) JP4072867B2 (en)
KR (1) KR100491424B1 (en)
CN (1) CN1212830C (en)
AT (3) ATE378082T1 (en)
AU (1) AU712916B2 (en)
BR (1) BR9508688A (en)
CA (1) CA2198916C (en)
DE (3) DE69535645T2 (en)
DK (2) DK0778767T3 (en)
ES (3) ES2188669T3 (en)
HK (1) HK1067870A1 (en)
PT (2) PT1270032E (en)
WO (1) WO1996007397A2 (en)
ZA (1) ZA957356B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9173992B2 (en) 2006-03-13 2015-11-03 Novo Nordisk A/S Secure pairing of electronic devices using dual means of communication
US9399094B2 (en) 2006-06-06 2016-07-26 Novo Nordisk A/S Assembly comprising skin-mountable device and packaging therefore

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837276A (en) * 1994-09-02 1998-11-17 Delab Apparatus for the delivery of elongate solid drug compositions
US5980945A (en) * 1996-01-16 1999-11-09 Societe De Conseils De Recherches Et D'applications Scientifique S.A. Sustained release drug formulations
DK0914102T3 (en) 1996-05-24 2006-01-09 Angiotech Pharm Inc Preparations and methods for treating or preventing diseases of the body canals
FR2756493B1 (en) 1996-12-02 2001-04-13 Delab DEVICE FOR LOCAL ADMINISTRATION OF SOLID OR SEMI-SOLID FORMULATIONS
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
SE9700423D0 (en) * 1997-02-07 1997-02-07 Astra Ab Disposable inhalers
FR2783433B1 (en) * 1998-09-18 2001-02-16 Delab SYRINGES FOR THE ADMINISTRATION OF PASTY OR SEMI-SOLID FORMULATIONS
GB2345010B (en) 1998-12-17 2002-12-31 Electrosols Ltd A delivery device
WO2000062759A1 (en) * 1999-04-16 2000-10-26 Novo Nordisk A/S Dry, mouldable drug formulation
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US8465468B1 (en) * 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US20020156453A1 (en) * 1999-10-14 2002-10-24 Pettis Ronald J. Method and device for reducing therapeutic dosage
DK1242055T3 (en) * 1999-12-23 2008-07-21 Pfizer Prod Inc Hydrogel controlled dosage form for drugs
US20010041869A1 (en) * 2000-03-23 2001-11-15 Causey James D. Control tabs for infusion devices and methods of using the same
US20040175360A1 (en) * 2000-06-29 2004-09-09 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
US20050008683A1 (en) * 2000-06-29 2005-01-13 Becton Dickinson And Company Method for delivering interferons to the intradermal compartment
WO2002005744A1 (en) * 2000-07-14 2002-01-24 Novo Nordisk A/S Method of moulding a pharmaceutical composition in a packaging material
BR0116972A (en) * 2001-04-13 2004-12-21 Becton Dickinson Co Methods and devices for administering substances to the intradermal skin layer for systemic absorption
US20050010193A1 (en) * 2002-05-06 2005-01-13 Laurent Philippe E. Novel methods for administration of drugs and devices useful thereof
US20030073609A1 (en) * 2001-06-29 2003-04-17 Pinkerton Thomas C. Enhanced pharmacokinetic profile of intradermally delivered substances
WO2003002069A2 (en) 2001-06-29 2003-01-09 Becton, Dickinson And Company Intradermal delivery of vaccines and gene therapeutic agents via microcannula
US20040120964A1 (en) * 2001-10-29 2004-06-24 Mikszta John A. Needleless vaccination using chimeric yellow fever vaccine-vectored vaccines against heterologous flaviviruses
US8454997B2 (en) 2001-12-18 2013-06-04 Novo Nordisk A/S Solid dose micro implant
US20060264886A9 (en) * 2002-05-06 2006-11-23 Pettis Ronald J Method for altering insulin pharmacokinetics
CA2484265C (en) 2002-05-06 2012-08-07 Becton, Dickinson And Company Method and device for controlling drug pharmacokinetics
US20090035260A1 (en) * 2002-07-29 2009-02-05 Therapicon Srl Enhanced nasal composition of active peptide
JP2005537054A (en) * 2002-08-30 2005-12-08 ベクトン・ディキンソン・アンド・カンパニー Methods for controlling the pharmacokinetics of immunomodulatory compounds
BR0314111A (en) * 2002-09-12 2005-07-26 Childrens Hosp Medical Center Method and device for painless medication injection
MXPA05007181A (en) 2002-12-31 2006-04-07 Altus Pharmaceuticals Inc Human growth hormone crystals and methods for preparing them.
AU2004232858B2 (en) 2003-04-23 2009-07-09 Mannkind Corporation Hydraulically actuated pump for long duration medicament administration
JP2007500251A (en) * 2003-06-13 2007-01-11 ベクトン・ディキンソン・アンド・カンパニー Improved intradermal delivery of biologically active agents
JP2007503435A (en) * 2003-08-26 2007-02-22 ベクトン・ディキンソン・アンド・カンパニー Intradermal delivery of therapeutics
IL157981A (en) 2003-09-17 2014-01-30 Elcam Medical Agricultural Cooperative Ass Ltd Auto-injector
ITMI20040235A1 (en) * 2004-02-13 2004-05-13 Therapicon Srl PHARMACEUTICAL PREPARATION FOR THE ORAL CABLE
US7670314B2 (en) * 2004-02-17 2010-03-02 Children's Hospital Medical Center Injection device for administering a vaccine
WO2005091922A2 (en) * 2004-03-03 2005-10-06 Becton, Dickinson And Company Methods and devices for improving delivery of a substance to skin
IL160891A0 (en) 2004-03-16 2004-08-31 Auto-mix needle
WO2005115360A2 (en) * 2004-05-11 2005-12-08 Becton, Dickinson And Company Formulations of anti-pain agents and methods of using the same
WO2006014425A1 (en) 2004-07-02 2006-02-09 Biovalve Technologies, Inc. Methods and devices for delivering glp-1 and uses thereof
US20080262444A1 (en) 2005-01-31 2008-10-23 Bioserentach Co., Ltd. Percutaneously Absorbable Preparation, Percutaneously Absorbable Preparation Holding Sheet, and Percutaneously Absorbable Preparation Holding Equipment
DE502005002757D1 (en) * 2005-03-24 2008-03-20 Disetronic Licensing Ag Device for the dosed administration of a fluid product
EP1704885A1 (en) * 2005-03-24 2006-09-27 Disetronic Licensing AG Device for the dosed administration of a fluid product
EP1704883B1 (en) * 2005-03-24 2008-11-12 Disetronic Licensing AG Device for the dosed administration of a fluid product
ATE413896T1 (en) * 2005-03-24 2008-11-15 Disetronic Licensing Ag DEVICE FOR THE DOSED ADMINISTRATION OF A FLUID PRODUCT
US8113244B2 (en) * 2006-02-09 2012-02-14 Deka Products Limited Partnership Adhesive and peripheral systems and methods for medical devices
WO2007075839A2 (en) * 2005-12-19 2007-07-05 Diobex, Inc. Glucagon injector for emergency treatment of hypoglycemia
JP2009532117A (en) 2006-03-30 2009-09-10 ヴァレリタス，エルエルシー Multi-cartridge fluid dispensing device
US8668676B2 (en) * 2006-06-19 2014-03-11 Allergan, Inc. Apparatus and methods for implanting particulate ocular implants
EP2043502B1 (en) * 2006-07-13 2014-03-12 St. Jude Medical AB Information management in devices implanted in a patient
US20080097335A1 (en) * 2006-08-04 2008-04-24 Allergan, Inc. Ocular implant delivery assemblies
US20100063448A1 (en) * 2007-03-06 2010-03-11 Novo Nordisk A/S Pump assembly comprising actuator system
US8529521B2 (en) * 2007-04-23 2013-09-10 Ultimed Inc. Low-dosage syringe
US8409140B2 (en) 2007-08-17 2013-04-02 Medtronic Minimed, Inc. Injection apparatus
US8986253B2 (en) 2008-01-25 2015-03-24 Tandem Diabetes Care, Inc. Two chamber pumps and related methods
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
US8650937B2 (en) 2008-09-19 2014-02-18 Tandem Diabetes Care, Inc. Solute concentration measurement device and related methods
US8545554B2 (en) 2009-01-16 2013-10-01 Allergan, Inc. Intraocular injector
US9250106B2 (en) 2009-02-27 2016-02-02 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
AU2010217760B2 (en) 2009-02-27 2015-04-09 Tandem Diabetes Care, Inc. Methods and devices for determination of flow reservoir volume
US20120109046A1 (en) * 2009-03-27 2012-05-03 Novo Nordisk A/S Solid dose delivery device
CA2769030C (en) 2009-07-30 2016-05-10 Tandem Diabetes Care, Inc. Infusion pump system with disposable cartridge having pressure venting and pressure feedback
US20110251481A1 (en) * 2009-10-15 2011-10-13 Strobl Geoffrey S Piezoelectrically-Driven Power Injector
EP2452638A1 (en) * 2010-11-15 2012-05-16 forteq Nidau AG Device for injecting solids
WO2012125999A2 (en) * 2011-03-17 2012-09-20 Emory University Delivery devices and methods for delivering therapeutic agents
US9180242B2 (en) 2012-05-17 2015-11-10 Tandem Diabetes Care, Inc. Methods and devices for multiple fluid transfer
US9173998B2 (en) 2013-03-14 2015-11-03 Tandem Diabetes Care, Inc. System and method for detecting occlusions in an infusion pump
US20150080845A1 (en) * 2013-03-14 2015-03-19 Allergan, Inc. Polymer system for securing implants in syringe needles
GB2545880A (en) * 2015-10-20 2017-07-05 Glide Pharmaceutical Tech Ltd Solid formulation
EP3658203B1 (en) 2017-07-25 2022-08-31 Amgen Inc. Drug delivery device with gear module and related method of assembly
US11585042B2 (en) 2020-09-30 2023-02-21 Haier Us Appliance Solutions, Inc. Dryer appliance with additive dispenser
GB202200706D0 (en) * 2022-01-20 2022-03-09 Cambridge Univ Hospitals Nhs Foundation Trust A surgical instrument

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2239989A1 (en) * 1973-08-08 1975-03-07 Aries Robert Pellets for subcutaneous treatment of animals - pref. implanted from a cartridge contg. several, by means of an injection force
EP0049068A1 (en) * 1980-09-30 1982-04-07 Minnesota Mining And Manufacturing Company Solid dose ballistic projectile
US4451253A (en) * 1980-12-18 1984-05-29 Harman Sherman M Means and method for administering medicinals
EP0134318A2 (en) * 1983-06-10 1985-03-20 Connaught Laboratories Limited Controlled release of injectable and implantable insulin compositions
EP0230647A2 (en) * 1985-12-27 1987-08-05 Sumitomo Pharmaceuticals Company, Limited Method for producing a sustained release formulation
EP0403032A2 (en) * 1987-03-16 1990-12-19 Monsanto Company Method for prolonged release of somatotropin
JPH04244031A (en) * 1990-07-18 1992-09-01 Korea Advanced Inst Of Sci Technol Auto-release-regulation type insulin pharmaceuticals
WO1994022423A1 (en) * 1993-04-07 1994-10-13 Bukh Meditec A/S Drug administration system
WO1995022314A1 (en) * 1994-02-18 1995-08-24 Innovac Co. Inoculation of animals with dried, pelleted biological materials

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2513014A (en) * 1946-11-18 1950-06-27 Abbott Lab Apparatus for implanting medicinal pellets subcutaneously
US3995631A (en) * 1971-01-13 1976-12-07 Alza Corporation Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
US3760806A (en) * 1971-01-13 1973-09-25 Alza Corp Helical osmotic dispenser with non-planar membrane
US4177256A (en) * 1973-04-25 1979-12-04 Alza Corporation Osmotic bursting drug delivery device
US3995632A (en) * 1973-05-04 1976-12-07 Alza Corporation Osmotic dispenser
US4142526A (en) * 1974-12-23 1979-03-06 Alza Corporation Osmotic releasing system with means for changing release therefrom
US4273122A (en) * 1976-11-12 1981-06-16 Whitney Douglass G Self contained powered injection system
US4086914A (en) * 1977-02-11 1978-05-02 Edwin Bailey Moore Implant injector
US4263910A (en) * 1978-09-27 1981-04-28 Eli Lilly And Company Implantate package, system and method
US4313439A (en) * 1980-03-24 1982-02-02 Biotek, Inc. Automated, spring-powered medicament infusion system
EP0047013B1 (en) * 1980-09-02 1986-01-22 Medtronic, Inc. Subcutaneously implantable lead with drug dispenser means
US4327725A (en) * 1980-11-25 1982-05-04 Alza Corporation Osmotic device with hydrogel driving member
US4340054A (en) * 1980-12-29 1982-07-20 Alza Corporation Dispenser for delivering fluids and solids
US4525164A (en) * 1981-04-24 1985-06-25 Biotek, Inc. Wearable medication infusion system with arcuated reservoir
US4529401A (en) * 1982-01-11 1985-07-16 Cardiac Pacemakers, Inc. Ambulatory infusion pump having programmable parameters
DE3317536A1 (en) * 1983-05-13 1984-11-15 Siemens AG, 1000 Berlin und 8000 München Metering device for a medicament
US4753636A (en) * 1983-08-02 1988-06-28 Endocon, Inc. Subcutaneous implant kit
EP0139286B1 (en) * 1983-10-14 1991-08-21 Sumitomo Pharmaceuticals Company, Limited Prolonged sustained-release preparations
US4685903A (en) * 1984-01-06 1987-08-11 Pacesetter Infusion, Ltd. External infusion pump apparatus
US4595583A (en) * 1984-03-19 1986-06-17 Alza Corporation Delivery system controlled administration of beneficial agent to ruminants
GB8423749D0 (en) * 1984-09-19 1984-10-24 Sutherland I A Powered infusion apparatus
US4720384A (en) * 1985-05-03 1988-01-19 E. I. Du Pont De Nemours And Company Manufacture of hollow fine tubular drug delivery systems
US4655766A (en) * 1985-08-01 1987-04-07 Alza Corporation Fluid imbibing pump with self-regulating skin patch
US4661103A (en) * 1986-03-03 1987-04-28 Engineering Development Associates, Ltd. Multiple implant injector
US4723958A (en) * 1986-05-23 1988-02-09 Merck & Co., Inc. Pulsatile drug delivery system
EP0255123A3 (en) * 1986-07-30 1988-04-20 Sumitomo Pharmaceuticals Company, Limited Solid preparation administering instrument
US4693706A (en) * 1986-08-11 1987-09-15 Mark L. Anderson Two compartment mixing syringe
US4994028A (en) * 1987-03-18 1991-02-19 Endocon, Inc. Injector for inplanting multiple pellet medicaments
DE3855054T2 (en) * 1987-05-26 1996-07-18 Sumitomo Pharma Device for the administration of solid preparations
FR2618329B1 (en) * 1987-07-22 1997-03-28 Dow Corning Sa METHOD OF MANUFACTURING A RING CAPABLE OF ENSURING THE RELEASE OF A THERAPEUTIC AGENT, AND RING MANUFACTURED BY THIS METHOD
DE3802158A1 (en) * 1987-08-11 1989-02-23 Hoechst Ag DEVICE FOR APPLICATION OF IMPLANTS
US4936827A (en) * 1988-04-11 1990-06-26 Ivy Laboratories, Inc. Implanter applicator
US4834704A (en) * 1988-04-13 1989-05-30 Eaton Corporation Injectable infusion pump apparatus for implanting long-term dispensing module and medication in an animal and method therefor
US4976966A (en) * 1988-12-29 1990-12-11 Alza Corporation Delayed release osmotically driven fluid dispenser
US5226895A (en) * 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
US5284479A (en) * 1989-08-30 1994-02-08 N.V. Nederlandsche Apparatenfabriek Nedap Implanter
US5086787A (en) * 1989-12-06 1992-02-11 Medtronic, Inc. Steroid eluting intramuscular lead
US5030216A (en) * 1989-12-15 1991-07-09 Alza Corporation Osmotically driven syringe
KR930008048B1 (en) * 1991-06-05 1993-08-25 윤영우 Interruptor without any relation with requester
IL105553A (en) * 1992-05-06 1998-01-04 Janssen Pharmaceutica Inc Solid dosage form comprising a porous network of matrix forming material which disperses rapidly in water
JPH0631181A (en) * 1992-07-06 1994-02-08 Stonehard Assoc Inc Production of highly diffused finely powdered metal carrying catalyst

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2239989A1 (en) * 1973-08-08 1975-03-07 Aries Robert Pellets for subcutaneous treatment of animals - pref. implanted from a cartridge contg. several, by means of an injection force
EP0049068A1 (en) * 1980-09-30 1982-04-07 Minnesota Mining And Manufacturing Company Solid dose ballistic projectile
US4451253A (en) * 1980-12-18 1984-05-29 Harman Sherman M Means and method for administering medicinals
EP0134318A2 (en) * 1983-06-10 1985-03-20 Connaught Laboratories Limited Controlled release of injectable and implantable insulin compositions
EP0230647A2 (en) * 1985-12-27 1987-08-05 Sumitomo Pharmaceuticals Company, Limited Method for producing a sustained release formulation
EP0403032A2 (en) * 1987-03-16 1990-12-19 Monsanto Company Method for prolonged release of somatotropin
JPH04244031A (en) * 1990-07-18 1992-09-01 Korea Advanced Inst Of Sci Technol Auto-release-regulation type insulin pharmaceuticals
WO1994022423A1 (en) * 1993-04-07 1994-10-13 Bukh Meditec A/S Drug administration system
WO1995022314A1 (en) * 1994-02-18 1995-08-24 Innovac Co. Inoculation of animals with dried, pelleted biological materials

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 9242, Derwent World Patents Index; Class B04, AN 92-124827 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9173992B2 (en) 2006-03-13 2015-11-03 Novo Nordisk A/S Secure pairing of electronic devices using dual means of communication
US9399094B2 (en) 2006-06-06 2016-07-26 Novo Nordisk A/S Assembly comprising skin-mountable device and packaging therefore

Also Published As

Publication number Publication date
US5616123A (en) 1997-04-01
ATE378082T1 (en) 2007-11-15
EP0778767B1 (en) 2003-01-15
DK0778767T3 (en) 2003-04-07
DE69533709D1 (en) 2004-12-02
DE69535645T2 (en) 2008-10-30
CA2198916C (en) 2008-07-22
AU3398195A (en) 1996-03-27
ZA957356B (en) 1996-04-02
EP1498150B1 (en) 2007-11-14
PT1498150E (en) 2008-02-19
KR20030096434A (en) 2003-12-31
ATE230977T1 (en) 2003-02-15
DE69535645D1 (en) 2007-12-27
ES2295745T3 (en) 2008-04-16
CN1212830C (en) 2005-08-03
DE69529415D1 (en) 2003-02-20
US5582591A (en) 1996-12-10
KR100491424B1 (en) 2005-05-24
EP1270032B1 (en) 2004-10-27
DK1270032T3 (en) 2005-01-31
PT1270032E (en) 2005-02-28
ES2230431T3 (en) 2005-05-01
DE69533709T2 (en) 2005-10-20
BR9508688A (en) 1997-10-28
ATE280599T1 (en) 2004-11-15
JP4072867B2 (en) 2008-04-09
JPH10508293A (en) 1998-08-18
EP0778767A2 (en) 1997-06-18
DE69529415T2 (en) 2003-11-13
ES2188669T3 (en) 2003-07-01
AU712916B2 (en) 1999-11-18
HK1067870A1 (en) 2005-04-22
EP1270032A1 (en) 2003-01-02
CN1165477A (en) 1997-11-19
CA2198916A1 (en) 1996-03-14
WO1996007397A2 (en) 1996-03-14
EP1498150A1 (en) 2005-01-19

Similar Documents

Publication Publication Date Title
WO1996007397A3 (en) Delivery of solid drug compositions
AU7178498A (en) Prefillable syringes, plungers and injectors for use therewith
WO1995022991A3 (en) Block copolymers
IT8809543A0 (en) PISTON FOR SYRINGES WHICH AUTOMATICALLY MAKES THE HYPODERMIC NEEDLE, MODIFIED FOR THIS PURPOSE, HARMFUL AFTER USE
EP1097727A3 (en) Needleless injector drug capsule and adaptor for filling the same
WO2003009884A3 (en) Elongated syringe
CA2369952A1 (en) Injector device and method for its operation
ATE314104T1 (en) DRUG ADMINISTRATION DEVICE HAVING A CURVED PISTON ROD
ATE299723T1 (en) PRE-FILLED SYRINGES AND INJECTORS FOR USE WITH THEM
CA2183389A1 (en) Medical syringe
EP1944047A3 (en) Syringe barrel and cylinder holder
EP0904792A3 (en) Syringe holder with integral dose divider
BR9702089A (en) Combination comprising a medical serine and an extensible, self-retracting medical needle device and process for using a pre-filled syringe
AU4826893A (en) Syringe with incrementally actuated plunger
EP0830868A3 (en) Prefilled syringe for medical purpose
AU2001293688A1 (en) A medication delivery system with improved dose accuracy
AU6485594A (en) Device for administering implants
CA2506998A1 (en) Prefilled syringe
IT1279684B1 (en) SYRINGE FOR HYPODERMIC INJECTIONS.
BR9106274A (en) APPLICATOR TO ADMINISTER MEDICATION
TW353024B (en) Method of sterilizing prefilled syringe medicines
AU4098793A (en) Disposable injection syringe
AR016768A1 (en) PHARMACEUTICAL COMPOSITION OF 5- (4- (2- (N-METHYL-N- (2-PIRIDIL) AMINO) ETOXI) BENCIL) TIAZOLIDIN-2-4-DIONA AND AN INSULIN SECRETAGOG AND THE SAME FOR MEDICINAL PREPARATION
WO2003035136A3 (en) System for administering a drug delivery device
AU1542901A (en) Apparatus for the inoculation of medications in animals

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 95195472.5

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AM AT AU BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LT LU LV MD MG MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TT UA UG US UZ VN

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): KE MW SD SZ UG AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AM AT AU BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LT LU LV MD MG MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TT UA UG US UZ VN

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): KE MW SD SZ UG AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 1995930675

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2198916

Country of ref document: CA

Ref document number: 2198916

Country of ref document: CA

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1019970701392

Country of ref document: KR

WWP Wipo information: published in national office

Ref document number: 1995930675

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1019970701392

Country of ref document: KR

WWR Wipo information: refused in national office

Ref document number: 1019970701392

Country of ref document: KR

WWG Wipo information: grant in national office

Ref document number: 1995930675

Country of ref document: EP