WO1996018892A1 - Automated electrophoresis and fluorescence detection apparatus and method - Google Patents
Automated electrophoresis and fluorescence detection apparatus and method Download PDFInfo
- Publication number
- WO1996018892A1 WO1996018892A1 PCT/US1995/015951 US9515951W WO9618892A1 WO 1996018892 A1 WO1996018892 A1 WO 1996018892A1 US 9515951 W US9515951 W US 9515951W WO 9618892 A1 WO9618892 A1 WO 9618892A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- excitation
- detection
- gel
- electromagnetic radiation
- fluorophore
- Prior art date
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/849,662 US6005663A (en) | 1994-12-12 | 1995-12-12 | Automated electrophoresis and fluorescence detection apparatus and method |
JP8519158A JPH10512045A (en) | 1994-12-12 | 1995-12-12 | Apparatus and method for automated electrophoresis and fluorescence detection |
EP95943037A EP0797771A1 (en) | 1994-12-12 | 1995-12-12 | Automated electrophoresis and fluorescence detection apparatus and method |
AU44191/96A AU4419196A (en) | 1994-12-12 | 1995-12-12 | Automated electrophoresis and fluorescence detection apparatus and method |
US08/819,910 US6014213A (en) | 1994-12-12 | 1997-03-18 | High dynamic range apparatus for separation and detection of polynucleotide fragments |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/353,932 | 1994-12-12 | ||
US08/353,932 US5710628A (en) | 1994-12-12 | 1994-12-12 | Automated electrophoresis and fluorescence detection apparatus and method |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/819,910 Continuation-In-Part US6014213A (en) | 1994-12-12 | 1997-03-18 | High dynamic range apparatus for separation and detection of polynucleotide fragments |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996018892A1 true WO1996018892A1 (en) | 1996-06-20 |
Family
ID=23391202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1995/015951 WO1996018892A1 (en) | 1994-12-12 | 1995-12-12 | Automated electrophoresis and fluorescence detection apparatus and method |
Country Status (6)
Country | Link |
---|---|
US (2) | US5710628A (en) |
EP (1) | EP0797771A1 (en) |
JP (1) | JPH10512045A (en) |
AU (1) | AU4419196A (en) |
CA (1) | CA2207488A1 (en) |
WO (1) | WO1996018892A1 (en) |
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WO1998041854A1 (en) * | 1997-03-18 | 1998-09-24 | Visible Genetics Inc. | High dynamic range apparatus for separation and detection of polynucleotide fragments |
US6064754A (en) * | 1996-11-29 | 2000-05-16 | Oxford Glycosciences (Uk) Ltd. | Computer-assisted methods and apparatus for identification and characterization of biomolecules in a biological sample |
US6225067B1 (en) | 1999-04-13 | 2001-05-01 | BIOMéRIEUX, INC. | Methods and devices for performing analysis of a nucleic acid sample |
US6438259B1 (en) * | 1997-06-24 | 2002-08-20 | Large Scale Biology Corporation | Computer-assisted methods and apparatus for identification and characterization of biomolecules |
US6459994B1 (en) | 1998-05-29 | 2002-10-01 | Oxford Glycosciences (Uk) Ltd | Methods for computer-assisted isolation of proteins |
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US5936730A (en) * | 1998-09-08 | 1999-08-10 | Motorola, Inc. | Bio-molecule analyzer with detector array and filter device |
US7501245B2 (en) * | 1999-06-28 | 2009-03-10 | Helicos Biosciences Corp. | Methods and apparatuses for analyzing polynucleotide sequences |
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US6760668B1 (en) | 2000-03-24 | 2004-07-06 | Bayer Healthcare Llc | Method for alignment of DNA sequences with enhanced accuracy and read length |
US6436641B1 (en) * | 2000-04-17 | 2002-08-20 | Visible Genetics Inc. | Method and apparatus for DNA sequencing |
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US7445893B2 (en) * | 2002-04-12 | 2008-11-04 | Primera Biosystems, Inc. | Sampling method for amplification reaction analysis |
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US20040185477A1 (en) * | 2003-01-10 | 2004-09-23 | Sention Inc. | Methods of detecting differences in genomic sequence representation |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2411361A1 (en) * | 1974-03-09 | 1975-09-11 | Messerschmitt Boelkow Blohm | Contrast signal generator for electrophoretic cell - using low-weight system of UV light source and photocells uses optical fibres |
US4343991A (en) * | 1979-05-25 | 1982-08-10 | Olympus Optical Co., Ltd. | Sample detector |
WO1987007719A1 (en) * | 1986-06-03 | 1987-12-17 | Europäisches Laboratorium Für Molekularbiologie (E | Apparatus for the detection of substances which can be excited for photon emission |
EP0454286A2 (en) * | 1990-01-26 | 1991-10-30 | The Board Of Trustees Of The Leland Stanford Junior University | Rectangular capillaries for capillary electrophoresis |
WO1994003631A1 (en) * | 1992-08-10 | 1994-02-17 | Biometric Imaging Inc. | Differential separation assay methods and test kits |
US5324401A (en) * | 1993-02-05 | 1994-06-28 | Iowa State University Research Foundation, Inc. | Multiplexed fluorescence detector system for capillary electrophoresis |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3916197A (en) * | 1973-11-28 | 1975-10-28 | Particle Technology Inc | Method and apparatus for classifying biological cells |
JPS55164336A (en) * | 1979-06-08 | 1980-12-22 | Olympus Optical Co Ltd | Inspecting material detecting method |
US5171534A (en) * | 1984-01-16 | 1992-12-15 | California Institute Of Technology | Automated DNA sequencing technique |
US5207880A (en) * | 1984-03-29 | 1993-05-04 | The Board Of Regents Of The University Of Nebraska | DNA sequencing |
US4729947A (en) * | 1984-03-29 | 1988-03-08 | The Board Of Regents Of The University Of Nebraska | DNA sequencing |
US5230781A (en) * | 1984-03-29 | 1993-07-27 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes |
US5360523A (en) * | 1984-03-29 | 1994-11-01 | Li-Cor, Inc. | DNA sequencing |
US5268486A (en) * | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
US4811218A (en) * | 1986-06-02 | 1989-03-07 | Applied Biosystems, Inc. | Real time scanning electrophoresis apparatus for DNA sequencing |
US4823007A (en) * | 1986-12-15 | 1989-04-18 | Norand Corporation | DNA sequencing gel reading system and method |
JPH0799353B2 (en) * | 1987-03-31 | 1995-10-25 | 株式会社島津製作所 | Nucleotide sequencer |
JP2550106B2 (en) * | 1987-10-30 | 1996-11-06 | 株式会社日立製作所 | Optical dispersion detection type electrophoretic device |
US5045172A (en) * | 1987-11-25 | 1991-09-03 | Princeton Biochemicals, Inc. | Capillary electrophoresis apparatus |
US5246866A (en) * | 1987-12-23 | 1993-09-21 | Hitachi Software Engineering Co., Ltd. | Method for transcription of a DNA sequence |
US4930893A (en) * | 1988-03-25 | 1990-06-05 | Molecular Dynamics | Electrophoresis imaging system |
US4927265A (en) * | 1988-04-29 | 1990-05-22 | 501 Microphoretic Systems, Inc. | Detector for fluorescence and absorption spectroscopy |
US4962020A (en) * | 1988-07-12 | 1990-10-09 | President And Fellows Of Harvard College | DNA sequencing |
US5006210A (en) * | 1989-02-06 | 1991-04-09 | Iowa State University Research Foundation, Inc. | Means and method for capillary zone electrophoresis with laser-induced indirect fluorescence detection |
US4960999A (en) * | 1989-02-13 | 1990-10-02 | Kms Fusion, Inc. | Scanning and storage of electrophoretic records |
US5062942A (en) * | 1989-04-12 | 1991-11-05 | Hitachi, Ltd. | Fluorescence detection type electrophoresis apparatus |
JP2853745B2 (en) * | 1989-04-12 | 1999-02-03 | 株式会社日立製作所 | Light detection electrophoresis device |
JPH083481B2 (en) * | 1989-06-07 | 1996-01-17 | 日立ソフトウェアエンジニアリング株式会社 | Fluorescent electrophoresis pattern reader |
US4981977A (en) * | 1989-06-09 | 1991-01-01 | Carnegie-Mellon University | Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups |
US5108179A (en) * | 1989-08-09 | 1992-04-28 | Myers Stephen A | System and method for determining changes in fluorescence of stained nucleic acid in electrophoretically separated bands |
US5274240A (en) * | 1990-01-12 | 1993-12-28 | The Regents Of The University Of California | Capillary array confocal fluorescence scanner and method |
US5091652A (en) * | 1990-01-12 | 1992-02-25 | The Regents Of The University Of California | Laser excited confocal microscope fluorescence scanner and method |
US5307148A (en) * | 1990-04-05 | 1994-04-26 | Hitachi, Ltd. | Fluorescence detection type electrophoresis apparatus |
US5104512A (en) * | 1990-05-14 | 1992-04-14 | Labintelligence, Inc. | Gel electrophoresis system |
JP2814408B2 (en) * | 1990-05-22 | 1998-10-22 | 日立ソフトウェアエンジニアリング 株式会社 | Fluorescent pattern reading device and fluorescent pattern reading method |
JPH0743353B2 (en) * | 1990-05-31 | 1995-05-15 | 株式会社島津製作所 | Fluorescence detection type gel electrophoresis device |
US5119316A (en) * | 1990-06-29 | 1992-06-02 | E. I. Du Pont De Nemours And Company | Method for determining dna sequences |
JP2508404B2 (en) * | 1990-10-30 | 1996-06-19 | 株式会社島津製作所 | Nucleotide sequencer |
JP2814409B2 (en) * | 1990-11-30 | 1998-10-22 | 日立ソフトウェアエンジニアリング 株式会社 | Multicolor electrophoresis pattern reader |
US5162654A (en) * | 1991-02-01 | 1992-11-10 | Wisconsin Alumni Research Foundation | Detection apparatus for electrophoretic gels |
JPH04271800A (en) * | 1991-02-28 | 1992-09-28 | Hitachi Ltd | Apparatus for detection of gene and method therefor |
US5420691A (en) * | 1991-03-15 | 1995-05-30 | Matsushita Electric Industrial Co., Ltd. | Electric component observation system |
JP2873884B2 (en) * | 1991-03-22 | 1999-03-24 | 日立ソフトウェアエンジニアリング 株式会社 | Multicolor electrophoresis pattern reader |
US5205917A (en) * | 1991-05-07 | 1993-04-27 | Glyko, Inc. | Fluorophore assisted carbohydrate electrophoresis diagnosis |
US5419825A (en) * | 1991-07-29 | 1995-05-30 | Shimadzu Corporation | Base sequencing apparatus |
US5365455A (en) * | 1991-09-20 | 1994-11-15 | Vanderbilt University | Method and apparatus for automatic nucleic acid sequence determination |
US5208466A (en) * | 1991-10-08 | 1993-05-04 | Beckman Instruments, Inc. | Apparatus and method for aligning capillary column and detection optics |
JP2815506B2 (en) * | 1992-04-14 | 1998-10-27 | 株式会社日立製作所 | Light detection type electrophoresis device |
DE592060T1 (en) * | 1992-10-09 | 1994-12-08 | Univ Nebraska | Digital DNS typing. |
EP0626578B1 (en) * | 1993-05-26 | 1998-07-29 | Hitachi Electronics Engineering Co., Ltd. | Apparatus for gel electrophoresis |
US5439578A (en) * | 1993-06-03 | 1995-08-08 | The Governors Of The University Of Alberta | Multiple capillary biochemical analyzer |
US5710628A (en) * | 1994-12-12 | 1998-01-20 | Visible Genetics Inc. | Automated electrophoresis and fluorescence detection apparatus and method |
-
1994
- 1994-12-12 US US08/353,932 patent/US5710628A/en not_active Expired - Lifetime
-
1995
- 1995-12-12 AU AU44191/96A patent/AU4419196A/en not_active Abandoned
- 1995-12-12 WO PCT/US1995/015951 patent/WO1996018892A1/en not_active Application Discontinuation
- 1995-12-12 EP EP95943037A patent/EP0797771A1/en not_active Withdrawn
- 1995-12-12 CA CA002207488A patent/CA2207488A1/en not_active Abandoned
- 1995-12-12 US US08/849,662 patent/US6005663A/en not_active Expired - Lifetime
- 1995-12-12 JP JP8519158A patent/JPH10512045A/en not_active Ceased
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2411361A1 (en) * | 1974-03-09 | 1975-09-11 | Messerschmitt Boelkow Blohm | Contrast signal generator for electrophoretic cell - using low-weight system of UV light source and photocells uses optical fibres |
US4343991A (en) * | 1979-05-25 | 1982-08-10 | Olympus Optical Co., Ltd. | Sample detector |
WO1987007719A1 (en) * | 1986-06-03 | 1987-12-17 | Europäisches Laboratorium Für Molekularbiologie (E | Apparatus for the detection of substances which can be excited for photon emission |
EP0454286A2 (en) * | 1990-01-26 | 1991-10-30 | The Board Of Trustees Of The Leland Stanford Junior University | Rectangular capillaries for capillary electrophoresis |
WO1994003631A1 (en) * | 1992-08-10 | 1994-02-17 | Biometric Imaging Inc. | Differential separation assay methods and test kits |
US5324401A (en) * | 1993-02-05 | 1994-06-28 | Iowa State University Research Foundation, Inc. | Multiplexed fluorescence detector system for capillary electrophoresis |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998008978A1 (en) * | 1996-08-27 | 1998-03-05 | Visible Genetics Inc. | Apparatus and method for performing sequencing of nucleic acid polymers |
US6064754A (en) * | 1996-11-29 | 2000-05-16 | Oxford Glycosciences (Uk) Ltd. | Computer-assisted methods and apparatus for identification and characterization of biomolecules in a biological sample |
US6278794B1 (en) | 1996-11-29 | 2001-08-21 | Oxford Glycosciences (Uk) Ltd | Computer-assisted isolation and characterization of proteins |
US6480618B1 (en) | 1996-11-29 | 2002-11-12 | Oxford Glycosciences (Uk) Ltd. | Robotic device for removing selected portions of a polyacrylamide gel |
WO1998041854A1 (en) * | 1997-03-18 | 1998-09-24 | Visible Genetics Inc. | High dynamic range apparatus for separation and detection of polynucleotide fragments |
US6438259B1 (en) * | 1997-06-24 | 2002-08-20 | Large Scale Biology Corporation | Computer-assisted methods and apparatus for identification and characterization of biomolecules |
US6507664B1 (en) * | 1997-06-24 | 2003-01-14 | Large Scale Biology Corporation | Two-dimensional gels for separation, identification and characterization of biomolecules |
US6643391B2 (en) * | 1997-06-24 | 2003-11-04 | Large Scale Proteomics Corporation | Apparatus for computer-assisted isolation and characterization of proteins |
US6459994B1 (en) | 1998-05-29 | 2002-10-01 | Oxford Glycosciences (Uk) Ltd | Methods for computer-assisted isolation of proteins |
US6225067B1 (en) | 1999-04-13 | 2001-05-01 | BIOMéRIEUX, INC. | Methods and devices for performing analysis of a nucleic acid sample |
US6235479B1 (en) | 1999-04-13 | 2001-05-22 | Bio Merieux, Inc. | Methods and devices for performing analysis of a nucleic acid sample |
WO2004046711A1 (en) * | 2002-11-18 | 2004-06-03 | Interlab S.R.L. | Automatic device for positioning and cooling within a migration chamber of a strip for electrophoretic analyses |
Also Published As
Publication number | Publication date |
---|---|
JPH10512045A (en) | 1998-11-17 |
CA2207488A1 (en) | 1996-06-20 |
US5710628A (en) | 1998-01-20 |
AU4419196A (en) | 1996-07-03 |
US6005663A (en) | 1999-12-21 |
EP0797771A1 (en) | 1997-10-01 |
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