WO1996020698A3 - Surface-modified nanoparticles and method of making and using same - Google Patents

Surface-modified nanoparticles and method of making and using same Download PDF

Info

Publication number
WO1996020698A3
WO1996020698A3 PCT/US1996/000476 US9600476W WO9620698A3 WO 1996020698 A3 WO1996020698 A3 WO 1996020698A3 US 9600476 W US9600476 W US 9600476W WO 9620698 A3 WO9620698 A3 WO 9620698A3
Authority
WO
WIPO (PCT)
Prior art keywords
nanoparticles
cells
agents
delivery
segments
Prior art date
Application number
PCT/US1996/000476
Other languages
French (fr)
Other versions
WO1996020698A2 (en
Inventor
Robert J Levy
Vinod D Labhasetwar
Cunxian S Song
Original Assignee
Univ Michigan
Robert J Levy
Vinod D Labhasetwar
Cunxian S Song
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan, Robert J Levy, Vinod D Labhasetwar, Cunxian S Song filed Critical Univ Michigan
Priority to JP8521279A priority Critical patent/JPH10511957A/en
Priority to AT96903476T priority patent/ATE252894T1/en
Priority to DE69630514T priority patent/DE69630514D1/en
Priority to AU47556/96A priority patent/AU4755696A/en
Priority to EP96903476A priority patent/EP0805678B1/en
Publication of WO1996020698A2 publication Critical patent/WO1996020698A2/en
Publication of WO1996020698A3 publication Critical patent/WO1996020698A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

Biodegradable controlled release nanoparticles as sustained release bioactive agent delivery vehicles include surface modifying agents to target binding of the nanoparticles to tissues or cells of living systems, to enhance nanoparticle sustained release properties, and to protect nanoparticle-incorporated bioactive agents. Unique methods of making small (10 nm to 15 nm, and preferably 20 nm to 35 nm) nanoparticles having a narrow size distribution which can be surface-modified after the nanoparticles are formed is described. Techniques for modifying the surface include a lyophilization technique to produce a physically adsorbed coating and epoxy-derivatization to functionalize the surface of the nanoparticles to covalently bind molecules of interest. The manoparticles may also comprise hydroxy-terminated or epoxide-terminated and/or activated multiblock copolymers, having hydrophobic segments which may be polycaprolactone and hydrophilic segments. The nanoparticles are useful for local intravascular administration of smooth muscle inhibitors and antithrombogenic agents as part of interventional cardiac or vascular catheterization such as a balloon angioplasty procedure; direct application to tissues and/or cells for gene therapy, such as the delivery of osteotropic genes or gene segments into bone progenitor cells; or oral administration in an enteric capsule for delivery of protein/peptide based vaccines.
PCT/US1996/000476 1995-01-05 1996-01-04 Surface-modified nanoparticles and method of making and using same WO1996020698A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP8521279A JPH10511957A (en) 1995-01-05 1996-01-04 Surface-modified nanoparticles and methods for their production and use
AT96903476T ATE252894T1 (en) 1995-01-05 1996-01-04 SURFACE-MODIFIED NANOPARTICLES AND METHODS FOR THEIR PRODUCTION AND USE
DE69630514T DE69630514D1 (en) 1995-01-05 1996-01-04 SURFACE-MODIFIED NANOPARTICLES AND METHOD FOR THEIR PRODUCTION AND USE
AU47556/96A AU4755696A (en) 1995-01-05 1996-01-04 Surface-modified nanoparticles and method of making and using same
EP96903476A EP0805678B1 (en) 1995-01-05 1996-01-04 Surface-modified nanoparticles and method of making and using same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36954195A 1995-01-05 1995-01-05
US38989395A 1995-02-16 1995-02-16
US08/369,541 1995-02-16
US08/389,893 1995-02-16

Publications (2)

Publication Number Publication Date
WO1996020698A2 WO1996020698A2 (en) 1996-07-11
WO1996020698A3 true WO1996020698A3 (en) 1998-01-22

Family

ID=27004624

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/000476 WO1996020698A2 (en) 1995-01-05 1996-01-04 Surface-modified nanoparticles and method of making and using same

Country Status (7)

Country Link
EP (1) EP0805678B1 (en)
JP (1) JPH10511957A (en)
AT (1) ATE252894T1 (en)
AU (1) AU4755696A (en)
CA (1) CA2207961A1 (en)
DE (1) DE69630514D1 (en)
WO (1) WO1996020698A2 (en)

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
US8835610B2 (en) 2009-03-05 2014-09-16 Abbvie Inc. IL-17 binding proteins
US8834913B2 (en) 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
US8841417B2 (en) 2010-05-14 2014-09-23 Abbvie Inc. IL-1 binding proteins
US8852625B2 (en) 2006-04-26 2014-10-07 Micell Technologies, Inc. Coatings containing multiple drugs
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US8900651B2 (en) 2007-05-25 2014-12-02 Micell Technologies, Inc. Polymer films for medical device coating
US8911789B2 (en) 2006-10-17 2014-12-16 Carnegie Mellon University Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
US8986686B2 (en) 2002-06-14 2015-03-24 Medimmune, Llc Stabilized liquid anti-RSV antibody formulations
US8992992B2 (en) 2003-12-19 2015-03-31 The University Of North Carolina At Chapel Hill Methods for fabricating isolated micro- or nano-structures using soft or imprint lithography
US9004791B2 (en) 2010-04-30 2015-04-14 The Procter & Gamble Company Package for multiple personal care compositions
US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
US9173824B2 (en) 2011-05-17 2015-11-03 The Procter & Gamble Company Mascara and applicator
US9212294B2 (en) 2012-10-11 2015-12-15 Nanocomposix, Inc. Silver nanoplate compositions and methods
US9216145B2 (en) 2009-10-27 2015-12-22 The Procter & Gamble Company Semi-permanent cosmetic concealer
US9283274B2 (en) 2009-10-06 2016-03-15 Medimmune Limited RSV specific binding molecule
US9371374B2 (en) 2013-03-14 2016-06-21 Abbott Laboratories HCV core lipid binding domain monoclonal antibodies
US9421260B2 (en) 2010-08-27 2016-08-23 Sienna Biopharmaceuticals, Inc. Thermal treatment of acne with nanoparticles with coatings that facilitate selective removal from the skin surface
US9433516B2 (en) 2007-04-17 2016-09-06 Micell Technologies, Inc. Stents having controlled elution
US9486431B2 (en) 2008-07-17 2016-11-08 Micell Technologies, Inc. Drug delivery medical device
US9505829B2 (en) 2010-08-19 2016-11-29 Zoetis Belgium S.A. Anti-NGF antibodies and their use
US9510856B2 (en) 2008-07-17 2016-12-06 Micell Technologies, Inc. Drug delivery medical device
US9539593B2 (en) 2006-10-23 2017-01-10 Micell Technologies, Inc. Holder for electrically charging a substrate during coating
US9592293B2 (en) 2006-09-08 2017-03-14 Abbvie Inc. Interleukin-13 binding proteins

Families Citing this family (371)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981568A (en) * 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
ES2098188B1 (en) * 1995-05-11 1997-12-16 Univ Santiago Compostela DEVELOPMENT OF NANOPARTICLES BASED ON HYDROPHILIC POLYMERS.
US20010009904A1 (en) * 1997-12-30 2001-07-26 Jon A. Wolff Process of delivering a polynucleotide to a cell via the vascular system
WO1998001160A2 (en) * 1996-07-10 1998-01-15 Danbiosyst Uk Limited Compositions suitable for delivery of genes to epithelial cells
US6649192B2 (en) * 1996-07-29 2003-11-18 Universidade De Santiago De Compostela Application of nanoparticles based on hydrophilic polymers as pharmaceutical forms
ES2114502B1 (en) * 1996-07-29 1999-07-01 Univ Santiago Compostela APPLICATION OF NANOPARTICLES BASED ON HYDROPHILIC POLYMERS AS PHARMACEUTICAL FORMS.
DE59707744D1 (en) * 1996-10-23 2002-08-22 Sueddeutsche Kalkstickstoff METHOD FOR PRODUCING BIOLOGICALLY ACTIVE POLYMERNANOPARTICLE-NUCLEIC ACID CONJUGATES
US6387700B1 (en) 1996-11-04 2002-05-14 The Reagents Of The University Of Michigan Cationic peptides, Cys-Trp-(LYS)n, for gene delivery
PT991403E (en) * 1997-01-30 2003-08-29 Chiron Corp USE OF MICROPARTICLES WITH ADSORVED ANTIGEN TO STIMULATE IMMUNE RESPONSES
EP0860167A1 (en) * 1997-01-30 1998-08-26 Robert Gurny RNA-and DNA- based active agents in nanoparticles
US6884435B1 (en) * 1997-01-30 2005-04-26 Chiron Corporation Microparticles with adsorbent surfaces, methods of making same, and uses thereof
EP1275380A1 (en) * 1997-01-30 2003-01-15 Chiron Corporation Use of microparticles with adsorbed antigen to stimulate immune responses
EP0975340B2 (en) * 1997-03-31 2009-10-28 Boston Scientific Limited Therapeutic inhibitor of vascular smooth muscle cells
AU7133898A (en) * 1997-04-18 1998-11-13 Vertex Pharmaceuticals Incorporated Nanosized aspartyl protease inhibitors
US5885609A (en) * 1997-05-23 1999-03-23 Northeastern University Biocompatible articles and method for making same
US6254890B1 (en) * 1997-12-12 2001-07-03 Massachusetts Institute Of Technology Sub-100nm biodegradable polymer spheres capable of transporting and releasing nucleic acids
JP2002508337A (en) * 1997-12-12 2002-03-19 マックス−デルブルック−セントラム フュール モレクラーレ メディツィン Drugs for gene therapy of tumors, neurodegeneration, cardiovascular and autoimmune diseases
US6395253B2 (en) * 1998-04-23 2002-05-28 The Regents Of The University Of Michigan Microspheres containing condensed polyanionic bioactive agents and methods for their production
KR19990085365A (en) * 1998-05-16 1999-12-06 허영섭 Biodegradable polymer microspheres capable of continuously controlled controlled release and preparation method thereof
WO2000000180A1 (en) * 1998-06-29 2000-01-06 White Spot Ag Utilization of growth factors for the production of medicaments
IL125336A0 (en) * 1998-07-14 1999-03-12 Yissum Res Dev Co Compositions for inhibition and treatment of restinosis
US7008645B2 (en) * 1998-07-14 2006-03-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method of inhibiting restenosis using bisphosphonates
PT1100468E (en) * 1998-07-29 2006-07-31 Chiron Corp MICROPARTICLES WITH ADSORVENT SURFACES, PROCESSES OF MANUFACTURE AND USE OF THE SAME
ATE322285T1 (en) * 1998-09-01 2006-04-15 Elan Corp Plc METHOD FOR INDUCING THE CELLULAR IMMUNE RESPONSE AND PARENTERAL VACCINE COMPOSITIONS THEREFOR
US7087236B1 (en) 1998-09-01 2006-08-08 Merrion Research I Limited Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof
ATE452651T1 (en) * 1998-09-01 2010-01-15 Merrion Res Iii Ltd ORAL VACCINE COMPOSITION
US6689121B1 (en) * 1998-09-24 2004-02-10 C. R. Bard, Inc. Systems and methods for treating ischemia
US6251079B1 (en) 1998-09-30 2001-06-26 C. R. Bard, Inc. Transthoracic drug delivery device
US8236352B2 (en) 1998-10-01 2012-08-07 Alkermes Pharma Ireland Limited Glipizide compositions
US8293277B2 (en) * 1998-10-01 2012-10-23 Alkermes Pharma Ireland Limited Controlled-release nanoparticulate compositions
US7521068B2 (en) 1998-11-12 2009-04-21 Elan Pharma International Ltd. Dry powder aerosols of nanoparticulate drugs
AU3471400A (en) * 1999-01-19 2000-08-07 Children's Hospital Of Philadelphia, The Compositions and methods for controlled delivery of virus vectors
JP2003503308A (en) * 1999-02-02 2003-01-28 セーフサイエンス インコーポレイテッド Gene therapy delivery systems and methods
CA2361421A1 (en) 1999-02-03 2000-08-10 Biosante Pharmaceuticals, Inc. Therapeutic calcium phosphate particles and methods of manufacture and use
EP1471034A3 (en) * 1999-02-03 2005-03-02 Biosante Pharmaceuticals, Inc. Therapeutic calcium phosphate particles and methods of manufacture and use
EP1163001A2 (en) * 1999-03-24 2001-12-19 The Secretary of State for Defence Vaccine composition
US6620170B1 (en) 1999-04-26 2003-09-16 C. R. Bard, Inc. Devices and methods for treating ischemia by creating a fibrin plug
US6719805B1 (en) 1999-06-09 2004-04-13 C. R. Bard, Inc. Devices and methods for treating tissue
US6770740B1 (en) 1999-07-13 2004-08-03 The Regents Of The University Of Michigan Crosslinked DNA condensate compositions and gene delivery methods
US6277082B1 (en) 1999-07-22 2001-08-21 C. R. Bard, Inc. Ischemia detection system
US6629987B1 (en) 1999-07-30 2003-10-07 C. R. Bard, Inc. Catheter positioning systems
DE19961939A1 (en) * 1999-12-22 2001-06-28 Cognis Deutschland Gmbh Nanoscale cationic compounds having specific particle size are useful for the production of cosmetic or pharmaceutical compositions
US7229619B1 (en) 2000-11-28 2007-06-12 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
WO2002043660A2 (en) 2000-11-28 2002-06-06 Mediummune, Inc Methods of administering/dosing anti-rsv antibodies for prophylaxis and treatment
US7527807B2 (en) * 2000-06-21 2009-05-05 Cubist Pharmaceuticals, Inc. Compositions and methods for increasing the oral absorption of antimicrobials
US7829100B2 (en) 2000-09-12 2010-11-09 Teagarden Dirk L Pharmaceutical composition having modified carrier
AUPR011700A0 (en) 2000-09-14 2000-10-05 Austin Research Institute, The Composition comprising immunogenic virus sized particles (VSP)
US7198795B2 (en) 2000-09-21 2007-04-03 Elan Pharma International Ltd. In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions
RU2257198C2 (en) 2000-09-28 2005-07-27 Чирон Корпорейшн Microparticle composition and methods for their preparing
WO2002061129A2 (en) * 2000-11-15 2002-08-08 Minerva Biotechnologies Corporation Oligonucleotide identifiers
US6818216B2 (en) 2000-11-28 2004-11-16 Medimmune, Inc. Anti-RSV antibodies
US6855493B2 (en) 2000-11-28 2005-02-15 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
US7179900B2 (en) 2000-11-28 2007-02-20 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
EP2341060B1 (en) 2000-12-12 2019-02-20 MedImmune, LLC Molecules with extended half-lives, compositions and uses thereof
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
JP4510383B2 (en) 2001-05-23 2010-07-21 田辺三菱製薬株式会社 Composition for repairing cartilage disease
MXPA03010679A (en) 2001-05-23 2004-03-02 Tanabe Seiyaku Co Compositions for promoting healing of bone fracture.
IL160570A0 (en) 2001-09-26 2004-07-25 Baxter Int Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
FR2836381B1 (en) * 2002-02-22 2004-09-10 Oreal POLYESTER POLYOL-BASED NANOCAPSULES, AND COSMETIC OR DERMATOLOGICAL COMPOSITIONS CONTAINING THEM
DE10209860A1 (en) * 2002-03-06 2003-09-25 Hemofarm Konzern A D Hydrophobic nano-drops with bound hemoglobin molecules in the hydrophilic phase contain emulsion as blood substitute
AU2003221497A1 (en) 2002-03-13 2003-09-22 Novartis Ag Pharmaceutical microparticles
JP2003342196A (en) * 2002-05-31 2003-12-03 Mukku:Kk Composition for intravenous injection, method of production for the same and its preparation
US7425618B2 (en) 2002-06-14 2008-09-16 Medimmune, Inc. Stabilized anti-respiratory syncytial virus (RSV) antibody formulations
CA2492488A1 (en) * 2002-07-16 2004-01-22 Elan Pharma International, Ltd. Liquid dosage compositions of stable nanoparticulate active agents
FR2842737B1 (en) * 2002-07-25 2006-01-27 Centre Nat Rech Scient PARTICLES COATED ON THE SURFACE OF HYALURONANE OR ONE OF ITS DERIVATIVES AND THEIR USE AS BIOLOGICAL VECTORS FOR ACTIVE MATERIALS
AU2003262650B2 (en) 2002-08-14 2009-10-29 Macrogenics, Inc. FcgammaRIIB-specific antibodies and methods of use thereof
JP2006511593A (en) 2002-09-09 2006-04-06 トライジェン・リミテッド Boronate and its use in the treatment of thrombosis
US7659061B2 (en) 2002-11-19 2010-02-09 Pharmacia & Upjohn Company Pharmaceutical compositions having a modified vehicle
EP1587540B1 (en) 2003-01-09 2021-09-15 MacroGenics, Inc. IDENTIFICATION AND ENGINEERING OF ANTIBODIES WITH VARIANT Fc REGIONS AND METHODS OF USING SAME
US7700100B2 (en) 2003-01-13 2010-04-20 Macrogenics, Inc. FcγRIIB fusion proteins and compositions thereof
WO2004084871A1 (en) * 2003-03-26 2004-10-07 Ltt Bio-Pharma Co., Ltd. Intravenous nanoparticles for targenting drug delivery and sustained drug release
ES2391087T3 (en) 2003-04-11 2012-11-21 Medimmune, Llc Recombinant IL-9 antibodies and uses thereof
CA2528007C (en) 2003-06-02 2012-03-27 Chiron Corporation Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen
US10517883B2 (en) 2003-06-27 2019-12-31 Zuli Holdings Ltd. Method of treating acute myocardial infarction
ES2232287B1 (en) * 2003-07-04 2006-11-01 Advanced In Vitro Cell Technologies, S.L. POLYOXYETHYLATE DERIVATIVES NANOPARTICLES.
US7326571B2 (en) 2003-07-17 2008-02-05 Boston Scientific Scimed, Inc. Decellularized bone marrow extracellular matrix
AU2004286198C1 (en) 2003-08-18 2011-02-24 Medimmune, Llc Humanization of antibodies
WO2005058961A2 (en) 2003-12-12 2005-06-30 Amgen Inc. Antibodies specific for human galanin, and uses thereof
US9040090B2 (en) 2003-12-19 2015-05-26 The University Of North Carolina At Chapel Hill Isolated and fixed micro and nano structures and methods thereof
EP1719523A4 (en) * 2004-02-26 2009-07-15 Japan Science & Tech Agency Protein drug sustained-release microparticle preparation for injection and process for producing the same
ES2246694B1 (en) 2004-04-29 2007-05-01 Instituto Cientifico Y Tecnologico De Navarra, S.A. PEGILATED NANOPARTICLES.
US7534449B2 (en) * 2004-07-01 2009-05-19 Yale University Targeted and high density drug loaded polymeric materials
JP2008507540A (en) 2004-07-21 2008-03-13 チューレン ユニバーシティ ヘルス サイエンス センター Treatment of renal dysfunction and multiple myeloma using PACAP compounds
WO2006047639A2 (en) 2004-10-27 2006-05-04 Medimmune, Inc. Modulation of antibody specificity by tailoring the affinity to cognate antigens
US20090041812A1 (en) 2004-11-01 2009-02-12 Bell Steve J D Therapeutic Calcium Phosphate Particles in Use for Aesthetic of Cosmetic Medicine, and Methods of Manufacture and Use
WO2007013893A2 (en) 2004-11-15 2007-02-01 Novartis Vaccines And Diagnostics Inc. Immunogenic compositions containing anthrax antigen, biodegradable polymer microparticles, and polynucleotide-containing immunological adjuvant
CA2600085A1 (en) * 2005-03-09 2006-09-14 Toray Industries, Inc. Microparticle and pharmaceutical preparation
AU2006227377B2 (en) 2005-03-18 2013-01-31 Medimmune, Llc Framework-shuffling of antibodies
AU2006236439B2 (en) 2005-04-15 2012-05-03 Macrogenics, Inc. Covalent diabodies and uses thereof
WO2006128121A2 (en) 2005-05-27 2006-11-30 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
EP1893647A2 (en) 2005-06-23 2008-03-05 MedImmune, Inc. Antibody formulations having optimized aggregation and fragmentation profiles
WO2007011708A2 (en) 2005-07-15 2007-01-25 Micell Technologies, Inc. Stent with polymer coating containing amorphous rapamycin
AU2006270221B2 (en) 2005-07-15 2012-01-19 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology
LT2573114T (en) 2005-08-10 2016-10-10 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
EP2500352A1 (en) 2005-08-19 2012-09-19 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
EP2500356A3 (en) 2005-08-19 2012-10-24 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
TWI388344B (en) * 2005-08-23 2013-03-11 Celsion Corp Methods of storing nanoparticle formulations
CN101277974A (en) 2005-09-30 2008-10-01 阿伯特有限及两合公司 Binding domains of proteins of the repulsive guidance molecule (RGM) protein family and functional fragments thereof, and their use
SG10201706600VA (en) 2005-11-30 2017-09-28 Abbvie Inc Monoclonal antibodies and uses thereof
WO2008051245A2 (en) 2005-12-02 2008-05-02 Novartis Ag Nanoparticles for use in immunogenic compositions
WO2007074604A1 (en) 2005-12-26 2007-07-05 Ltt Bio-Pharma Co., Ltd. Nanoparticle containing water-soluble non-peptidic low molecular weight substance
US20070166800A1 (en) * 2006-01-13 2007-07-19 Haixiang Lin Immunogenic substances comprising a polyinosinic acid-polycytidilic acid based adjuvant
WO2007109244A2 (en) * 2006-03-21 2007-09-27 Morehouse School Of Medicine Novel nanoparticles for delivery of active agents
CA2655080A1 (en) 2006-06-14 2007-12-21 Macrogenics, Inc. Methods for the treatment of autoimmune disorders using monoclonal antibodies with reduced toxicity
AU2007281876B2 (en) 2006-06-26 2013-09-05 Macrogenics, Inc. FcgammaRIIB-specific antibodies and methods of use thereof
DK2484696T3 (en) 2006-08-28 2017-10-02 Kyowa Hakko Kirin Co Ltd Antagonistic hLIGHT-specific human monoclonal antibodies
US20110021592A1 (en) * 2006-09-14 2011-01-27 Shlomo Magdassi Organic nanoparticles obtained from microemulsions by solvent evaporation
EP2407548A1 (en) 2006-10-16 2012-01-18 MedImmune, LLC Molecules with reduced half-lives, compositions and uses thereof
JP5603598B2 (en) 2007-01-08 2014-10-08 ミセル テクノロジーズ、インコーポレイテッド Stent with biodegradable layer
US11426494B2 (en) 2007-01-08 2022-08-30 MT Acquisition Holdings LLC Stents having biodegradable layers
US20080175874A1 (en) * 2007-01-19 2008-07-24 The Procter & Gamble Company Applied care compositions comprising functionalized nano-particles
DE102007005191A1 (en) 2007-01-29 2008-07-31 Rüdiger Marcus Dr. Dr. Flaig Molecular drug transport system for producing medicine for specific transmission of incorporated active substance molecules into living cells in vitro and in vivo, has additional binding forces
DE102007005190A1 (en) 2007-01-29 2008-07-31 Flaig, Rüdiger Marcus, Dr. Dr. Peptide useful for specifically killing cells comprises a sequence capable of coupling to a specific-binding molecule, an oligomerization sequence and a sequence for binding a cytotoxic component
JP4621218B2 (en) * 2007-02-09 2011-01-26 有限会社バイオ研 Th1 inducer and method for producing the same
US10265407B2 (en) 2007-02-15 2019-04-23 Yale University Modular nanodevices for smart adaptable vaccines
EP2121048B9 (en) 2007-02-19 2016-02-24 Marine Polymer Technologies, Inc. Hemostatic compositions and therapeutic regimens
WO2008132727A2 (en) * 2007-04-26 2008-11-06 Technion Research And Development Foundation Ltd Oral delivery of proteins and peptides
EP1997830A1 (en) 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV specific binding molecules and means for producing them
JP5718637B2 (en) 2007-06-21 2015-05-13 マクロジェニクス，インコーポレーテッド Covalently bonded diabody and its use
CN101952312A (en) 2007-07-31 2011-01-19 米迪缪尼有限公司 Multispecific epitope binding proteins and uses thereof
CN101868180A (en) 2007-10-09 2010-10-20 圣路易斯华盛顿州立大学 Particles for imaging
WO2009049089A1 (en) 2007-10-09 2009-04-16 Washington University In St. Louis Ligand directed toroidal nanoparticles for therapy and diagnostic imaging
DE102007054049A1 (en) 2007-11-13 2009-05-14 Flaig, Rüdiger Marcus, Dr. Dr. System for drug transport into trypanosomal cells comprises a ktenate matrix with targeting molecules in the form of antibody Fc fragments
KR100961880B1 (en) * 2007-12-12 2010-06-09 중앙대학교 산학협력단 Manufacturing method of functional drug nanoparticles using milling and functional drug nanoparticle formulation manufactured thereby
AU2009205995B2 (en) 2008-01-18 2014-04-03 Medimmune, Llc Cysteine engineered antibodies for site-specific conjugation
HUE035331T2 (en) 2008-02-22 2018-05-02 Toray Industries Microparticles and pharmaceutical compositions thereof
US20110070284A1 (en) * 2008-02-22 2011-03-24 Musculoskeletal Transplant Foundation Biologic matrices comprising anti-infective methods and compositions related thereto
SG192523A1 (en) 2008-04-17 2013-08-30 Micell Technologies Inc Stents having bioabsorbable layers
WO2009134769A1 (en) * 2008-04-28 2009-11-05 Novartis Ag Nanoparticles for use in pharmaceutical compositions
MX2010011955A (en) 2008-04-29 2011-01-21 Abbott Lab Dual variable domain immunoglobulins and uses thereof.
KR101005562B1 (en) 2008-05-01 2011-01-05 한국생명공학연구원 Preparation method of homogeneous sized polymer nanoparticles containing water-insoluble drugs
CN104558178A (en) 2008-05-09 2015-04-29 Abbvie公司 Antibodies to receptor of advanced glycation end products (rage) and uses thereof
NZ589436A (en) 2008-06-03 2012-12-21 Abbott Lab Dual variable domain immunoglobulins and uses thereof
US9035027B2 (en) 2008-06-03 2015-05-19 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
WO2010005726A2 (en) 2008-06-16 2010-01-14 Bind Biosciences Inc. Therapeutic polymeric nanoparticles with mtor inhibitors and methods of making and using same
KR101706178B1 (en) 2008-06-16 2017-02-15 화이자 인코포레이티드 Drug loaded polymeric nanoparticles and methods of making and using same
EP2309991B1 (en) 2008-06-16 2019-03-06 Pfizer Inc Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same
EP2310049A4 (en) 2008-07-08 2013-06-26 Abbvie Inc Prostaglandin e2 binding proteins and uses thereof
NZ590074A (en) 2008-07-08 2012-12-21 Abbott Lab Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
JP2012506900A (en) 2008-10-28 2012-03-22 ウニベルシダーデ デ サンティアゴ デ コンポステラ Nanoparticle systems prepared from anionic polymers
US8563041B2 (en) 2008-12-12 2013-10-22 Bind Therapeutics, Inc. Therapeutic particles suitable for parenteral administration and methods of making and using same
EA201100765A1 (en) 2008-12-15 2012-04-30 Бинд Биосаиэнсис Long-term circulation nanoparticles
PL2786762T3 (en) 2008-12-19 2019-09-30 Macrogenics, Inc. Covalent diabodies and uses thereof
US8030026B2 (en) 2009-02-24 2011-10-04 Abbott Laboratories Antibodies to troponin I and methods of use thereof
US8283162B2 (en) 2009-03-10 2012-10-09 Abbott Laboratories Antibodies relating to PIVKAII and uses thereof
CA2757276C (en) 2009-04-01 2017-06-06 Micell Technologies, Inc. Coated stents
EA201890311A1 (en) 2009-05-27 2018-10-31 Селекта Байосайенсиз, Инк. POLYMERIC COMPOUNDS - IMMUNE MODULATING REMEDIES
US20120134984A1 (en) 2009-06-01 2012-05-31 Olga Lubman Molecules with extended half-lives and uses thereof
RU2012101999A (en) 2009-06-22 2013-07-27 МЕДИММЬЮН, ЭлЭлСи Fc RECOMBINED SITES FOR SITE-SPECIFIC CONJUGATION
CA3062005C (en) 2009-08-21 2022-02-15 Novan, Inc. Topical gels comprising nitric oxide-releasing polysiloxane macromolecules and uses thereof
WO2011022680A2 (en) 2009-08-21 2011-02-24 Novan, Inc. Wound dressings, methods of using the same and methods of forming the same
CA2771575A1 (en) 2009-08-29 2011-03-03 Abbott Laboratories Therapeutic dll4 binding proteins
CA2772628A1 (en) 2009-09-01 2011-03-10 Abbott Laboratories Dual variable domain immunoglobulins and uses thereof
CA2768968A1 (en) * 2009-09-29 2011-04-07 Eyegate Pharmaceuticals, Inc. Positively-charged poly (d,l-lactide-co-glycolide) nanoparticles and fabrication methods of the same
TR201804897T4 (en) 2009-10-07 2018-06-21 Macrogenics Inc POLYPEPTIDES CONTAINING FC REGION WITH ADVANCED EFFECTOR FUNCTION DUE TO CHANGES OF FUCOSILATION SIZE AND METHODS FOR THEIR USE
AR078651A1 (en) 2009-10-15 2011-11-23 Abbott Lab IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME
US10034829B2 (en) 2010-10-27 2018-07-31 Noxell Corporation Semi-permanent mascara compositions
US9237992B2 (en) 2009-10-27 2016-01-19 The Procter & Gamble Company Two-step mascara product
UY32979A (en) 2009-10-28 2011-02-28 Abbott Lab IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME
TW201121568A (en) 2009-10-31 2011-07-01 Abbott Lab Antibodies to receptor for advanced glycation end products (RAGE) and uses thereof
WO2011054001A2 (en) 2009-11-02 2011-05-05 The Administrators Of The Tulane Analogs of pitutary adenylate cyclase-activating polypeptide (pacap) and methods for their use
CN102656190A (en) 2009-12-08 2012-09-05 雅培股份有限两合公司 Monoclonal antibodies against the RGM A protein for use in the treatment of retinal nerve fiber layer degeneration
JP5891175B2 (en) 2009-12-11 2016-03-22 バインド セラピューティックス インコーポレイテッド Stable formulation against lyophilization of therapeutic particles
EP2515942B1 (en) 2009-12-15 2020-02-12 Pfizer Inc. Therapeutic polymeric nanoparticle compositions with high glass transition temperature or high molecular weight copolymers
US9808500B2 (en) 2009-12-17 2017-11-07 Washington University Antithrombotic nanoparticle
JP2013514999A (en) * 2009-12-17 2013-05-02 ワシントン・ユニバーシティ Antithrombogenic nanoparticles
EP2531140B1 (en) 2010-02-02 2017-11-01 Micell Technologies, Inc. Stent and stent delivery system with improved deliverability
WO2011105520A1 (en) 2010-02-26 2011-09-01 国立大学法人 長崎大学 Composite body for antigen or drug delivery
PE20130580A1 (en) 2010-03-02 2013-06-02 Abbvie Inc THERAPEUTIC BINDING PROTEINS TO DLL4
US8795762B2 (en) 2010-03-26 2014-08-05 Battelle Memorial Institute System and method for enhanced electrostatic deposition and surface coatings
CN103096874A (en) 2010-04-15 2013-05-08 华盛顿大学 Prodrug compositions, prodrug nanoparticles, and methods of use thereof
CA2797110C (en) 2010-04-22 2020-07-21 Micell Technologies, Inc. Stents and other devices having extracellular matrix coating
PE20130207A1 (en) 2010-05-06 2013-02-28 Novartis Ag ANTIBODIES ANTAGONISTS TO LRP6 (LOW DENSITY LIPOPROTEIN-RELATED PROTEIN 6) AND COMPOSITIONS
SG185415A1 (en) 2010-05-06 2012-12-28 Novartis Ag Compositions and methods of use for therapeutic low density lipoprotein - related protein 6 (lrp6) multivalent antibodies
KR20180099900A (en) 2010-05-26 2018-09-05 셀렉타 바이오사이언시즈, 인크. Dose selection of adjuvanted synthetic nanocarriers
US20110318421A1 (en) * 2010-06-24 2011-12-29 Edward E. Parsonage Surface functionalized ceramic nanoparticles
US20120009196A1 (en) 2010-07-08 2012-01-12 Abbott Laboratories Monoclonal antibodies against hepatitis c virus core protein
UY33492A (en) 2010-07-09 2012-01-31 Abbott Lab IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME
WO2012009684A2 (en) 2010-07-16 2012-01-19 Micell Technologies, Inc. Drug delivery medical device
US9120862B2 (en) 2010-07-26 2015-09-01 Abbott Laboratories Antibodies relating to PIVKA-II and uses thereof
MX339622B (en) 2010-08-02 2016-06-02 Macrogenics Inc Covalent diabodies and uses thereof.
AU2011285852B2 (en) 2010-08-03 2014-12-11 Abbvie Inc. Dual variable domain immunoglobulins and uses thereof
WO2012024187A1 (en) 2010-08-14 2012-02-23 Abbott Laboratories Amyloid-beta binding proteins
MY162825A (en) 2010-08-20 2017-07-31 Novartis Ag Antibodies for epidermal growth factor receptor 3 (her3)
KR20130139884A (en) 2010-08-26 2013-12-23 애브비 인코포레이티드 Dual variable domain immunoglobulins and uses thereof
US9572880B2 (en) 2010-08-27 2017-02-21 Sienna Biopharmaceuticals, Inc. Ultrasound delivery of nanoparticles
US20130245233A1 (en) 2010-11-24 2013-09-19 Ming Lei Multispecific Molecules
US8591876B2 (en) 2010-12-15 2013-11-26 Novan, Inc. Methods of decreasing sebum production in the skin
RU2627171C2 (en) 2010-12-21 2017-08-03 Эббви Инк. Il-1 alpha and beta bispecific immunoglobulins with double variable domains and their application
TW201307388A (en) 2010-12-21 2013-02-16 Abbott Lab IL-1 binding proteins
CA2823355C (en) * 2010-12-30 2017-08-22 Micell Technologies, Inc. Nanoparticle and surface-modified particulate coatings, coated balloons, and methods therefore
JP6082901B2 (en) * 2011-01-31 2017-02-22 オリンパス株式会社 Vaccine / adjuvant
WO2012118819A2 (en) 2011-02-28 2012-09-07 Novan, Inc. Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same
JP6072771B2 (en) 2011-04-20 2017-02-01 メディミューン，エルエルシー Antibodies and other molecules that bind to B7-H1 and PD-1
US9289476B2 (en) 2011-04-29 2016-03-22 Selecta Biosciences, Inc. Tolerogenic synthetic nanocarriers for allergy therapy
JP6145088B2 (en) 2011-05-21 2017-06-07 マクロジェニクス，インコーポレーテッド Deimmunized serum binding domain and its use to extend serum half-life
US10464100B2 (en) 2011-05-31 2019-11-05 Micell Technologies, Inc. System and process for formation of a time-released, drug-eluting transferable coating
WO2013009521A2 (en) 2011-07-13 2013-01-17 Abbvie Inc. Methods and compositions for treating asthma using anti-il-13 antibodies
CA2841360A1 (en) 2011-07-15 2013-01-24 Micell Technologies, Inc. Drug delivery medical device
US20130039954A1 (en) 2011-07-29 2013-02-14 Selecta Biosciences, Inc. Control of antibody responses to synthetic nanocarriers
WO2013025779A1 (en) 2011-08-15 2013-02-21 Amplimmune, Inc. Anti-b7-h4 antibodies and their uses
US9399678B2 (en) 2011-09-23 2016-07-26 Technophage, Investigacao E Desenvolvimento Em Biotecnologia, Sa Anti-tumor necrosis factor-alpha agents and uses thereof
US10188772B2 (en) 2011-10-18 2019-01-29 Micell Technologies, Inc. Drug delivery medical device
WO2013059509A1 (en) * 2011-10-18 2013-04-25 Micell Technologies, Inc. Drug delivery medical device
US8999331B2 (en) 2011-10-24 2015-04-07 Abbvie Inc. Immunobinders directed against sclerostin
AU2012349735B2 (en) 2011-12-05 2016-05-19 Novartis Ag Antibodies for epidermal growth factor receptor 3 (HER3)
BR112014013568A8 (en) 2011-12-05 2017-06-13 Novartis Ag epidermal growth factor 3 (her3) receptor antibodies directed to her3 domain ii
CN104144947B (en) 2011-12-14 2017-10-27 艾伯维德国有限责任两合公司 Composition and method for diagnosing and treating iron phase related disorders
CN104136462B (en) 2011-12-14 2017-06-09 艾伯维德国有限责任两合公司 Composition and method for diagnosing and treating iron phase related disorders
EP3539982A3 (en) 2011-12-23 2020-01-15 Pfizer Inc Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
TW201333035A (en) 2011-12-30 2013-08-16 Abbvie Inc Dual specific binding proteins directed against IL-13 and/or IL-17
SG10202006762PA (en) 2012-01-27 2020-08-28 Abbvie Deutschland Composition and method for diagnosis and treatment of diseases associated with neurite degeneration
US20130195752A1 (en) 2012-02-01 2013-08-01 Regents Of The University Of Minnesota Functionalized nanoparticles and methods of use thereof
WO2013137498A1 (en) * 2012-03-14 2013-09-19 인제대학교 산학협력단 Production method for tissue-regenerating chip comprising biodegradable synthetic polymer surface-modified with natural water-soluble polymer, and tissue-regenerating chip produced thereby
US9597385B2 (en) 2012-04-23 2017-03-21 Allertein Therapeutics, Llc Nanoparticles for treatment of allergy
US9140681B2 (en) 2012-05-15 2015-09-22 The Procter & Gamble Company Method for quantitatively determining eyelash clumping
KR20150027072A (en) 2012-06-04 2015-03-11 아이알엠 엘엘씨 Site-specific labeling methods and molecules produced thereby
CN104364264B (en) 2012-06-06 2018-07-24 硕腾服务有限责任公司 Dog source anti-ngf antibodies and its method
US20140148671A1 (en) * 2012-07-05 2014-05-29 Empire Technology Development Llc Compositions and methods for detecting anastomosis leakage
AR091755A1 (en) 2012-07-12 2015-02-25 Abbvie Inc PROTEINS OF UNION TO IL-1
CA2885193C (en) 2012-09-17 2021-04-27 Bind Therapeutics, Inc. Process for preparing therapeutic nanoparticles
KR20180008921A (en) 2012-11-01 2018-01-24 애브비 인코포레이티드 Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof
RU2015115956A (en) 2012-11-09 2017-01-10 Пфайзер Инк. ANTIBODIES SPECIFIC TO THE THROMBOCYTE B GROWTH FACTOR, AND THEIR COMPOSITION AND APPLICATION
AU2013361275B2 (en) 2012-12-19 2016-11-24 Amplimmune, Inc. Anti-human B7-H4 antibodies and their uses
EP2935332B1 (en) 2012-12-21 2021-11-10 MedImmune, LLC Anti-h7cr antibodies
WO2014124258A2 (en) 2013-02-08 2014-08-14 Irm Llc Specific sites for modifying antibodies to make immunoconjugates
KR102447350B1 (en) 2013-02-08 2022-09-23 노파르티스 아게 Specific sites for modifying antibodies to make immunoconjugates
WO2014165264A1 (en) 2013-03-12 2014-10-09 Micell Technologies, Inc. Bioabsorbable biomedical implants
US9498532B2 (en) 2013-03-13 2016-11-22 Novartis Ag Antibody drug conjugates
JP2016514130A (en) 2013-03-14 2016-05-19 ノバルティス アーゲー Antibody against Notch3
US9993427B2 (en) 2013-03-14 2018-06-12 Biorest Ltd. Liposome formulation and manufacture
US9790478B2 (en) 2013-03-14 2017-10-17 Abbott Laboratories HCV NS3 recombinant antigens and mutants thereof for improved antibody detection
CN105228649B (en) 2013-03-14 2019-01-18 雅培制药有限公司 HCV Ag-Ab combination measurement is with method and used in composition therein
CA2904448A1 (en) 2013-03-15 2014-09-18 Tariq Ghayur Dual specific binding proteins directed against il-1.beta. and/or il-17
US9469686B2 (en) 2013-03-15 2016-10-18 Abbott Laboratories Anti-GP73 monoclonal antibodies and methods of obtaining the same
NZ710929A (en) 2013-03-15 2018-02-23 Novartis Ag Antibody drug conjugates
CA2907915C (en) 2013-04-03 2023-03-07 Allertein Therapeutics, Llc Immunomodulatory nanoparticle compositions comprising a plurality of nanoparticles comprising biodegradable or biocompatible polymers and hydrophilic and hydrophobic cellular components
WO2014179772A2 (en) 2013-05-03 2014-11-06 Selecta Biosciences, Inc. Tolerogenic synthetic nanocarriers to reduce or prevent anaphylaxis in response to a non-allergenic antigen
EP2996629B1 (en) 2013-05-15 2021-09-22 Micell Technologies, Inc. Bioabsorbable biomedical implants
BR112015029395A2 (en) 2013-05-24 2017-09-19 Medimmune Llc ANTI-B7-H5 ANTIBODIES AND THEIR USES
ES2891755T3 (en) 2013-06-06 2022-01-31 Pf Medicament Anti-C10orf54 antibodies and uses thereof
EP3003372B1 (en) 2013-06-07 2019-10-09 Duke University Inhibitors of complement factor h
US11384149B2 (en) 2013-08-09 2022-07-12 Macrogenics, Inc. Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof
UA116479C2 (en) 2013-08-09 2018-03-26 Макродженікс, Інк. Bi-specific monovalent fc diabodies that are capable of binding cd32b and cd79b and uses thereof
EP2839842A1 (en) 2013-08-23 2015-02-25 MacroGenics, Inc. Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof
EP2840091A1 (en) 2013-08-23 2015-02-25 MacroGenics, Inc. Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof
SI3311845T1 (en) 2013-09-16 2020-06-30 Astrazeneca Ab Therapeutic polymeric nanoparticles and methods of making and using same
CN105793284A (en) 2013-09-17 2016-07-20 大学健康网络(Uhn):技术开发和商业化公司 Agents directed against cis RGMa/Neogenin interaction or lipid rafts and use of same in methods of treatment
WO2015058868A1 (en) 2013-10-25 2015-04-30 Pangaea Biotech, S.L. Compositions and methods for the treatment of cancer
US9683998B2 (en) 2013-11-13 2017-06-20 Pfizer Inc. Tumor necrosis factor-like ligand 1A specific antibodies and compositions and uses thereof
TW201536320A (en) 2013-12-02 2015-10-01 Abbvie Inc Compositions and methods for treating osteoarthritis
WO2015109212A1 (en) 2014-01-17 2015-07-23 Pfizer Inc. Anti-il-2 antibodies and compositions and uses thereof
SG11201606018UA (en) 2014-01-24 2016-08-30 Ngm Biopharmaceuticals Inc Binding proteins and methods of use thereof
EP3104880B1 (en) 2014-02-14 2020-03-25 MacroGenics, Inc. Improved methods for the treatment of vascularizing cancers
US10272117B2 (en) 2014-02-24 2019-04-30 Celgene Corporation Methods of using an activator of cereblon for neural cell expansion and the treatment of central nervous system disorders
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
US20150291689A1 (en) 2014-03-09 2015-10-15 Abbvie, Inc. Compositions and Methods for Treating Rheumatoid Arthritis
US20170021033A1 (en) 2014-03-12 2017-01-26 Novartis Ag Specific sites for modifying antibodies to make immunoconjugates
PL3116547T3 (en) 2014-03-14 2019-11-29 Pfizer Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same
KR20220123560A (en) 2014-03-21 2022-09-07 애브비 인코포레이티드 Anti-egfr antibodies and antibody drug conjugates
EP3888690A3 (en) 2014-05-16 2021-10-20 MedImmune, LLC Molecules with altered neonate fc receptor binding having enhanced therapeutic and diagnostic properties
US20170105407A1 (en) * 2014-05-21 2017-04-20 Albert Einstein College Of Medicine, Inc. Compositions and methods for enhancing red blood cell storage time and survivability using nitric oxide releasing hybrid hydrogel nanoparticles
RU2718692C2 (en) 2014-05-29 2020-04-13 Мэкроудженикс, Инк. Trispecific binding molecules, which specifically bind antigens of a variety of malignant tumors, and methods of using them
TWI693232B (en) 2014-06-26 2020-05-11 美商宏觀基因股份有限公司 Covalently bonded diabodies having immunoreactivity with pd-1 and lag-3, and methods of use thereof
CN107257691B (en) 2014-07-16 2021-09-21 达娜-法勃肿瘤研究所公司 HER3 inhibition in low-grade serous ovarian cancer
US10786578B2 (en) 2014-08-05 2020-09-29 Novartis Ag CKIT antibody drug conjugates
KR20170040249A (en) 2014-08-12 2017-04-12 노파르티스 아게 Anti-cdh6 antibody drug conjugates
WO2016037165A1 (en) 2014-09-07 2016-03-10 Selecta Biosciences, Inc. Methods and compositions for attenuating exon skipping anti-viral transfer vector immune responses
AU2015321546B2 (en) 2014-09-26 2020-09-03 Macrogenics, Inc. Bi-specific monovalent diabodies that are capable of binding CD19 and CD3, and uses thereof
SG11201703464UA (en) 2014-11-14 2017-05-30 Novartis Ag Antibody drug conjugates
US10093733B2 (en) 2014-12-11 2018-10-09 Abbvie Inc. LRP-8 binding dual variable domain immunoglobulin proteins
PT3800202T (en) 2014-12-11 2023-01-05 Pf Medicament Anti-c10orf54 antibodies and uses thereof
CN107278151A (en) 2014-12-15 2017-10-20 约翰霍普金斯大学 Sutent preparation and its application method in treatment glaucoma
US20160244520A1 (en) 2015-01-24 2016-08-25 Abbvie Inc. Compositions and methods for treating psoriatic arthritis
US10501552B2 (en) 2015-01-26 2019-12-10 Macrogenics, Inc. Multivalent molecules comprising DR5-binding domains
BR112017015880A2 (en) 2015-03-03 2018-07-31 Kymab Ltd antibodies, uses and methods
RS59935B1 (en) 2015-05-29 2020-03-31 Abbvie Inc Anti-cd40 antibodies and uses thereof
TWI773646B (en) 2015-06-08 2022-08-11 美商宏觀基因股份有限公司 Lag-3-binding molecules and methods of use thereof
JP6750153B2 (en) * 2015-06-10 2020-09-02 エボニック オペレーションズ ゲーエムベーハー Method for producing powder containing human coagulation factor protein and lactic acid polymer
TW201710286A (en) 2015-06-15 2017-03-16 艾伯維有限公司 Binding proteins against VEGF, PDGF, and/or their receptors
EP3310813A1 (en) 2015-06-17 2018-04-25 Novartis AG Antibody drug conjugates
WO2016205010A1 (en) * 2015-06-19 2016-12-22 The Regents Of The University Of California Treating vasculature related diseases or disorders using nanoparticles
CA3025896A1 (en) 2015-07-23 2017-01-26 The Regents Of The University Of California Antibodies to coagulation factor xia and uses thereof
SG10201906059VA (en) 2015-07-30 2019-08-27 Macrogenics Inc Pd-1-binding molecules and methods of use thereof
KR101709628B1 (en) * 2015-09-10 2017-02-24 한국과학기술연구원 A process for preparing modified biodegradable polylmer and a modified biodegradable polymer by the same method and biodegradable stent prepared therefrom
CN116059340A (en) 2015-09-11 2023-05-05 艾伯维公司 Methods for treating relapsing forms of multiple sclerosis
US9862760B2 (en) 2015-09-16 2018-01-09 Novartis Ag Polyomavirus neutralizing antibodies
CN108289953B (en) 2015-09-29 2022-03-11 细胞基因公司 PD-1 binding proteins and methods of use thereof
CA3039906A1 (en) 2015-10-21 2017-04-27 The Regents Of The University Of Michigan Detection and treatment of caries and microcavities with nanoparticles
TW201722989A (en) 2015-10-23 2017-07-01 輝瑞大藥廠 Anti-IL-2 antibodies and compositions and uses thereof
CA3004886A1 (en) * 2015-11-12 2017-05-18 Graybug Vision, Inc. Aggregating microparticles for medical therapy
WO2017096017A1 (en) 2015-12-02 2017-06-08 Stsciences, Inc. Antibodies specific to glycosylated btla (b- and t- lymphocyte attenuator)
ES2861449T3 (en) 2015-12-02 2021-10-06 Stcube & Co Inc Antibodies and Molecules that Immunospecifically Bind to BTN1A1 and Their Therapeutic Uses
EA201891178A1 (en) 2015-12-14 2019-01-31 Макродженикс, Инк. Bispecific molecules possessing immunoreactivity with respect to PD-1 and CTLA-4, and methods of their use
WO2017125897A1 (en) 2016-01-21 2017-07-27 Novartis Ag Multispecific molecules targeting cll-1
US11298678B2 (en) 2016-03-30 2022-04-12 Trustees Of Tufts College Fabrication of macroporous polymeric hydrogel microparticles
TW202304996A (en) 2016-06-08 2023-02-01 美商艾伯維有限公司 Anti-b7-h3 antibodies and antibody drug conjugates
BR112018075653A2 (en) 2016-06-08 2019-08-27 Abbvie Inc anti-b7-h3 antibodies and drug antibody conjugates
JP2019524651A (en) 2016-06-08 2019-09-05 アッヴィ・インコーポレイテッド Anti-CD98 antibodies and antibody drug conjugates
MX2019002867A (en) 2016-09-19 2019-11-12 Celgene Corp Methods of treating immune disorders using pd-1 binding proteins.
US10766958B2 (en) 2016-09-19 2020-09-08 Celgene Corporation Methods of treating vitiligo using PD-1 binding antibodies
AU2017343553A1 (en) * 2016-10-10 2019-05-02 Abraxis Bioscience, Llc Nanoparticle formulations and methods of making and using thereof
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
JP7274417B2 (en) 2016-11-23 2023-05-16 イミュノア・セラピューティクス・インコーポレイテッド 4-1BB binding protein and uses thereof
US11684583B2 (en) 2016-12-08 2023-06-27 Massachusetts Institute Of Technology Compositions and related methods for targeted drug delivery
JOP20190187A1 (en) 2017-02-03 2019-08-01 Novartis Ag Anti-ccr7 antibody drug conjugates
KR20190124295A (en) 2017-03-11 2019-11-04 셀렉타 바이오사이언시즈, 인크. Methods and compositions related to combination treatment with synthetic nanocarriers comprising anti-inflammatory agents and immunosuppressants
CA3056923A1 (en) 2017-03-23 2018-09-27 Graybug Vision, Inc. Drugs and compositions for the treatment of ocular disorders
WO2018185618A1 (en) 2017-04-03 2018-10-11 Novartis Ag Anti-cdh6 antibody drug conjugates and anti-gitr antibody combinations and methods of treatment
US10865238B1 (en) 2017-05-05 2020-12-15 Duke University Complement factor H antibodies
AU2018265415A1 (en) 2017-05-10 2019-10-31 Graybug Vision, Inc. Extended release microparticles and suspensions thereof for medical therapy
US20200131266A1 (en) 2017-05-31 2020-04-30 Stcube & Co., Inc. Methods of treating cancer using antibodies and molecules that immunospecifically bind to btn1a1
KR20200015602A (en) 2017-05-31 2020-02-12 주식회사 에스티큐브앤컴퍼니 Antibodies and molecules immunospecifically binding to BTN1A1 and therapeutic uses thereof
KR20200026209A (en) 2017-06-06 2020-03-10 주식회사 에스티큐브앤컴퍼니 How to treat cancer using antibodies and molecules that bind BTN1A1 or BTN1A1-ligand
EP3717510A2 (en) 2017-12-01 2020-10-07 Novartis AG Polyomavirus neutralizing antibodies
WO2019108639A1 (en) 2017-12-01 2019-06-06 Pfizer Inc. Anti-cxcr5 antibodies and compositions and uses thereof
US10982002B2 (en) 2018-03-12 2021-04-20 Zoetis Services Llc Anti-NGF antibodies and methods thereof
KR102088663B1 (en) * 2018-03-20 2020-03-13 한국세라믹기술원 Thermosponge nanoparticle platform for co-delivery of hydrophilic and hydrophobic drugs and its use
SG11202009539XA (en) 2018-03-29 2020-10-29 Pfizer Lfa3 variants and compositions and uses thereof
US10633458B2 (en) 2018-04-10 2020-04-28 Y-Biologics Inc. Cell engaging binding molecules
WO2019209883A1 (en) * 2018-04-23 2019-10-31 Graybug Vision, Inc. Improved continuous microparticle manufacture
EP3801766A1 (en) 2018-05-31 2021-04-14 Novartis AG Hepatitis b antibodies
US11492409B2 (en) 2018-06-01 2022-11-08 Novartis Ag Binding molecules against BCMA and uses thereof
MA53160A (en) 2018-07-20 2021-05-26 Pf Medicament RECEIVER FOR VISTA
TW202024131A (en) 2018-09-07 2020-07-01 美商輝瑞大藥廠 Anti-αvβ8 antibodies and compositions and uses thereof
WO2020053742A2 (en) 2018-09-10 2020-03-19 Novartis Ag Anti-hla-hbv peptide antibodies
WO2020128863A1 (en) 2018-12-19 2020-06-25 Novartis Ag Anti-tnf-alpha antibodies
JOP20210159A1 (en) 2018-12-21 2023-01-30 Novartis Ag Antibodies to pmel17 and conjugates thereof
CN113710192B (en) 2019-01-31 2024-03-15 细胞医药股份有限公司 Inorganic salt protein composite medical apparatus
EP3936501A4 (en) 2019-03-08 2022-11-09 ABTIS Co., Ltd. Site-specific antibody conjugation and antibody-drug conjugate as specific example thereof
TW202102526A (en) 2019-04-04 2021-01-16 美商銳進科斯生物股份有限公司 Recombinant adeno-associated viruses and uses thereof
CA3145112A1 (en) 2019-07-26 2021-02-04 Chunping Qiao Engineered nucleic acid regulatory element and methods of uses thereof
WO2021062323A1 (en) 2019-09-26 2021-04-01 Stcube & Co. Antibodies specific to glycosylated ctla-4 and methods of use thereof
WO2021072277A1 (en) 2019-10-09 2021-04-15 Stcube & Co. Antibodies specific to glycosylated lag3 and methods of use thereof
JP2021147329A (en) * 2020-03-16 2021-09-27 株式会社リコー Method for producing particles
US20230181756A1 (en) 2020-04-30 2023-06-15 Novartis Ag Ccr7 antibody drug conjugates for treating cancer
EP4143224A1 (en) 2020-05-01 2023-03-08 Novartis AG Immunoglobulin variants
EP4143236A1 (en) 2020-05-01 2023-03-08 Novartis AG Engineered immunoglobulins
CN114073791B (en) * 2020-08-21 2022-05-31 中国科学院化学研究所 Cartilage tissue engineering scaffold and preparation method and application thereof
WO2022072597A1 (en) * 2020-09-30 2022-04-07 Diomics Corporation Transdermal medicament delivery device
CA3193697A1 (en) 2020-10-07 2022-04-14 Joseph Bruder Adeno-associated viruses for ocular delivery of gene therapy
WO2022076750A2 (en) 2020-10-07 2022-04-14 Regenxbio Inc. Recombinant adeno-associated viruses for cns or muscle delivery
AU2021373366A1 (en) 2020-11-06 2023-06-01 Novartis Ag Cd19 binding molecules and uses thereof
CN116472288A (en) 2020-11-06 2023-07-21 诺华股份有限公司 Antibody Fc variants
EP4240494A1 (en) 2020-11-06 2023-09-13 Novartis AG Anti-cd19 agent and b cell targeting agent combination therapy for treating b cell malignancies
EP4271482A2 (en) 2020-12-31 2023-11-08 Alamar Biosciences, Inc. Binder molecules with high affinity and/ or specificity and methods of making and use thereof
AR124681A1 (en) 2021-01-20 2023-04-26 Abbvie Inc ANTI-EGFR ANTIBODY-DRUG CONJUGATES
EP4323526A1 (en) 2021-04-16 2024-02-21 Novartis AG Antibody drug conjugates and methods for making thereof
WO2023060272A2 (en) 2021-10-07 2023-04-13 Regenxbio Inc. Recombinant adeno-associated viruses for cns tropic delivery
WO2023060269A1 (en) 2021-10-07 2023-04-13 Regenxbio Inc. Recombinant adeno-associated viruses for targeted delivery
WO2023073599A1 (en) 2021-10-28 2023-05-04 Novartis Ag Engineered fc variants
WO2023077092A1 (en) 2021-10-28 2023-05-04 Regenxbio Inc. Engineered nucleic acid regulatory elements and methods and uses thereof
US20230227545A1 (en) 2022-01-07 2023-07-20 Johnson & Johnson Enterprise Innovation Inc. Materials and methods of il-1beta binding proteins
WO2023152633A1 (en) 2022-02-09 2023-08-17 Janssen Biotech, Inc. Methods and compositions comprising v beta 17 bispecific t cell engagers and bioengineered virus specific lymphocytes
TW202346590A (en) 2022-03-13 2023-12-01 美商銳進科斯生物股份有限公司 Modified muscle-specific promoters
WO2023201308A1 (en) 2022-04-14 2023-10-19 Regenxbio Inc. Gene therapy for treating an ocular disease
WO2023201277A1 (en) 2022-04-14 2023-10-19 Regenxbio Inc. Recombinant adeno-associated viruses for cns tropic delivery
WO2023205610A2 (en) 2022-04-18 2023-10-26 Regenxbio Inc. Hybrid aav capsids
US20230357381A1 (en) 2022-04-26 2023-11-09 Novartis Ag Multispecific antibodies targeting il-13 and il-18
WO2024013727A1 (en) 2022-07-15 2024-01-18 Janssen Biotech, Inc. Material and methods for improved bioengineered pairing of antigen-binding variable regions
CN115006605A (en) * 2022-07-20 2022-09-06 苏州中天医疗器械科技有限公司 Drug coating balloon and preparation method and application thereof
WO2024018426A1 (en) 2022-07-22 2024-01-25 Janssen Biotech, Inc. Enhanced transfer of genetic instructions to effector immune cells
WO2024028731A1 (en) 2022-08-05 2024-02-08 Janssen Biotech, Inc. Transferrin receptor binding proteins for treating brain tumors
WO2024028732A1 (en) 2022-08-05 2024-02-08 Janssen Biotech, Inc. Cd98 binding constructs for treating brain tumors
WO2024044725A2 (en) 2022-08-24 2024-02-29 Regenxbio Inc. Recombinant adeno-associated viruses and uses thereof
WO2024073492A1 (en) * 2022-09-28 2024-04-04 Championx Llc Extended release asphaltene inhibitor composition
CN116211732B (en) * 2023-01-03 2023-11-17 广州澳特朗生物技术有限公司 Fibronectin nano preparation with tissue repair, anti-wrinkle and soothing effects, and preparation method and application thereof
CN116874996B (en) * 2023-09-01 2023-12-05 山东龙兴塑膜科技股份有限公司 Preparation method of modified polyester and application of modified polyester in polyester film for coated iron

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0335972A1 (en) * 1986-11-21 1989-10-11 Terumo Kabushiki Kaisha Medical material and process for its production
EP0336964A1 (en) * 1986-12-03 1989-10-18 Terumo Kabushiki Kaisha Antithrombotic medical materials and process for their production
WO1990010034A1 (en) * 1989-02-28 1990-09-07 Basf Corporation Mixture of epoxy/diol copolymer and epoxy/diol copolymer//epoxy-capped polybutadiene block copolymer
FR2649321A1 (en) * 1989-07-07 1991-01-11 Inst Nat Sante Rech Med Compositions based on nucleotide derivatives, methods for preparing them and their uses, in particular as pharmaceutical compositions
EP0407580A1 (en) * 1988-03-28 1991-01-16 Terumo Kabushiki Kaisha Medical material and process for their production
WO1991015193A1 (en) * 1990-04-06 1991-10-17 Rhone-Poulenc Rorer S.A. Microspheres, a preparation method therefor and uses thereof
WO1992017167A1 (en) * 1991-04-02 1992-10-15 Biotech Australia Pty. Ltd. Oral delivery systems for microparticles
WO1993000076A1 (en) * 1991-06-24 1993-01-07 Minnesota Mining And Manufacturing Company Carrier systems for drugs
EP0529711A1 (en) * 1991-08-08 1993-03-03 Laboratorios Cusi, S.A. Process of continuous preparation of disperse colloidal systems in the form of nanocapsules or nanoparticles
WO1994018955A1 (en) * 1993-02-22 1994-09-01 Alza Corporation Compositions for oral delivery of active agents
WO1995022963A1 (en) * 1994-02-28 1995-08-31 Medinova Medical Consulting Gmbh Drug targeting system, method for preparing same and its use

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0335972A1 (en) * 1986-11-21 1989-10-11 Terumo Kabushiki Kaisha Medical material and process for its production
EP0336964A1 (en) * 1986-12-03 1989-10-18 Terumo Kabushiki Kaisha Antithrombotic medical materials and process for their production
EP0407580A1 (en) * 1988-03-28 1991-01-16 Terumo Kabushiki Kaisha Medical material and process for their production
WO1990010034A1 (en) * 1989-02-28 1990-09-07 Basf Corporation Mixture of epoxy/diol copolymer and epoxy/diol copolymer//epoxy-capped polybutadiene block copolymer
FR2649321A1 (en) * 1989-07-07 1991-01-11 Inst Nat Sante Rech Med Compositions based on nucleotide derivatives, methods for preparing them and their uses, in particular as pharmaceutical compositions
WO1991015193A1 (en) * 1990-04-06 1991-10-17 Rhone-Poulenc Rorer S.A. Microspheres, a preparation method therefor and uses thereof
WO1992017167A1 (en) * 1991-04-02 1992-10-15 Biotech Australia Pty. Ltd. Oral delivery systems for microparticles
WO1993000076A1 (en) * 1991-06-24 1993-01-07 Minnesota Mining And Manufacturing Company Carrier systems for drugs
EP0529711A1 (en) * 1991-08-08 1993-03-03 Laboratorios Cusi, S.A. Process of continuous preparation of disperse colloidal systems in the form of nanocapsules or nanoparticles
WO1994018955A1 (en) * 1993-02-22 1994-09-01 Alza Corporation Compositions for oral delivery of active agents
WO1995022963A1 (en) * 1994-02-28 1995-08-31 Medinova Medical Consulting Gmbh Drug targeting system, method for preparing same and its use

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
J. KREUTER: "POSSIBILITIES OF USING NANOPARTICLES AS CARRIERS FOR DRUGS AND VACCINES", JOURNAL OF MICROENCAPSULATION, vol. 5, no. 2, 1988, LONDON (GB), pages 115 - 127, XP002013572 *
P.D. SCHOLES ET AL: "THE PREPARATION OF SUB-200NM POLY(LACTIDE-CO-GLYCOLIDE) MICROSPHERES FOR SITE-SPECIFIC DRUG DELIVERY", JOURNAL OF CONTROLLED RELEASE, vol. 25, no. 1/02, 27 May 1993 (1993-05-27), AMSTERDAM (NL), pages 145 - 153, XP000361376 *
R. GREF ET AL.: "BIODEGRADABLE LONG-CIRCULATING POLYMERIC NANOSPHERES", SCIENCE, vol. 263, 18 March 1994 (1994-03-18), WASHINGTON (US), pages 1600 - 1603, XP002013571 *
S. J. DOUGLAS ET AL.: "poly(butyl 2-cyanoacrylate) nanoparticles with differing surface charges", JOURNAL OF CONTROLLED RELEASE, vol. 3, no. 1, January 1986 (1986-01-01), AMSTERDAM (NL), pages 15 - 23, XP002033952 *
T. NIWA ET AL.: "PREPARATIONS OF BIODEGRADABLE NANOSPHERES OF WATER-SOLUBLE AND INSOLUBLE DRUGS WITH D.L.-LACTIDE/GLYCOLIDE COPOLYMER BY A NOVEL SPONTANEOUS EMULSIFICATION SOLVENT DIFFUSION METHOD, AND THE DRUG RELEASE BEHAVIOR", JOURNAL OF CONTROLLED RELEASE, vol. 25, no. 1/02, 27 May 1993 (1993-05-27), AMSTERDAM (NL), pages 89 - 98, XP000361370 *

Cited By (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8986686B2 (en) 2002-06-14 2015-03-24 Medimmune, Llc Stabilized liquid anti-RSV antibody formulations
US9272032B2 (en) 2002-06-14 2016-03-01 Medimmune, Llc Stabilized liquid anti-RSV antibody formulations
US9176150B2 (en) 2003-01-31 2015-11-03 AbbVie Deutschland GmbH & Co. KG Amyloid beta(1-42) oligomers, derivatives thereof and antibodies thereto, methods of preparation thereof and use thereof
US8992992B2 (en) 2003-12-19 2015-03-31 The University Of North Carolina At Chapel Hill Methods for fabricating isolated micro- or nano-structures using soft or imprint lithography
US8691224B2 (en) 2005-11-30 2014-04-08 Abbvie Inc. Anti-Aβ globulomer 5F7 antibodies
US9540432B2 (en) 2005-11-30 2017-01-10 AbbVie Deutschland GmbH & Co. KG Anti-Aβ globulomer 7C6 antibodies
US9415142B2 (en) 2006-04-26 2016-08-16 Micell Technologies, Inc. Coatings containing multiple drugs
US8852625B2 (en) 2006-04-26 2014-10-07 Micell Technologies, Inc. Coatings containing multiple drugs
US9592293B2 (en) 2006-09-08 2017-03-14 Abbvie Inc. Interleukin-13 binding proteins
US9364503B2 (en) 2006-10-17 2016-06-14 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8911789B2 (en) 2006-10-17 2014-12-16 Carnegie Mellon University Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US9539593B2 (en) 2006-10-23 2017-01-10 Micell Technologies, Inc. Holder for electrically charging a substrate during coating
US9359430B2 (en) 2006-11-30 2016-06-07 Abbvie Inc. Abeta conformer selective anti-Abeta globulomer monoclonal antibodies
US9394360B2 (en) 2006-11-30 2016-07-19 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8877190B2 (en) 2006-11-30 2014-11-04 Abbvie Inc. Aβ conformer selective anti-Aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
US9433516B2 (en) 2007-04-17 2016-09-06 Micell Technologies, Inc. Stents having controlled elution
US8900651B2 (en) 2007-05-25 2014-12-02 Micell Technologies, Inc. Polymer films for medical device coating
US8962803B2 (en) 2008-02-29 2015-02-24 AbbVie Deutschland GmbH & Co. KG Antibodies against the RGM A protein and uses thereof
US9510856B2 (en) 2008-07-17 2016-12-06 Micell Technologies, Inc. Drug delivery medical device
US9486431B2 (en) 2008-07-17 2016-11-08 Micell Technologies, Inc. Drug delivery medical device
US8834913B2 (en) 2008-12-26 2014-09-16 Battelle Memorial Institute Medical implants and methods of making medical implants
US9481736B2 (en) 2009-03-05 2016-11-01 Abbvie, Inc. IL-17 binding proteins
US8835610B2 (en) 2009-03-05 2014-09-16 Abbvie Inc. IL-17 binding proteins
US9481735B2 (en) 2009-03-05 2016-11-01 Abbvie Inc. IL-17 binding proteins
US9283274B2 (en) 2009-10-06 2016-03-15 Medimmune Limited RSV specific binding molecule
US9216145B2 (en) 2009-10-27 2015-12-22 The Procter & Gamble Company Semi-permanent cosmetic concealer
US8987419B2 (en) 2010-04-15 2015-03-24 AbbVie Deutschland GmbH & Co. KG Amyloid-beta binding proteins
US9004791B2 (en) 2010-04-30 2015-04-14 The Procter & Gamble Company Package for multiple personal care compositions
US9447183B2 (en) 2010-05-14 2016-09-20 Abbvie Inc. IL-1 binding proteins
US9409986B2 (en) 2010-05-14 2016-08-09 Abbvie Inc. IL-1 binding proteins
US8841417B2 (en) 2010-05-14 2014-09-23 Abbvie Inc. IL-1 binding proteins
US9303085B2 (en) 2010-05-14 2016-04-05 Abbvie Inc. IL-1 binding proteins
US9447184B2 (en) 2010-05-14 2016-09-20 Abbvie Inc. IL-1 binding proteins
US9441038B2 (en) 2010-05-14 2016-09-13 Abbvie Inc. IL-1 binding proteins
US9505829B2 (en) 2010-08-19 2016-11-29 Zoetis Belgium S.A. Anti-NGF antibodies and their use
US9439964B2 (en) 2010-08-27 2016-09-13 Sienna Biopharmaceuticals, Inc. Thermal treatment of the skin surface with coated metal nanoparticles
US9446126B2 (en) 2010-08-27 2016-09-20 Sienna Biopharmaceuticals, Inc. Thermal treatment of acne with coated metal nanoparticles
US9439965B2 (en) 2010-08-27 2016-09-13 Sienna Biopharmaceuticals, Inc. Thermal treatment of the skin surface with metal nanoparticles in surfactant containing solutions
US9433677B2 (en) 2010-08-27 2016-09-06 Sienna Biopharmaceuticals, Inc. Thermal treatment of a pilosebaceous unit with metal nanoparticles in surfactant containing solutions
US9433676B2 (en) 2010-08-27 2016-09-06 Sienna Biopharmaceuticals, Inc. Hair removal with nanoparticles with coatings that facilitate selective removal from the skin surface
US9421261B2 (en) 2010-08-27 2016-08-23 Sienna Biopharmaceuticals, Inc. Thermal treatment of the skin surface with nanoparticles with coatings that facilitate selective removal from the skin surface
US9421259B2 (en) 2010-08-27 2016-08-23 Sienna Biopharmaceuticals, Inc. Hair removal with coated metal nanoparticles
US9421260B2 (en) 2010-08-27 2016-08-23 Sienna Biopharmaceuticals, Inc. Thermal treatment of acne with nanoparticles with coatings that facilitate selective removal from the skin surface
US9173824B2 (en) 2011-05-17 2015-11-03 The Procter & Gamble Company Mascara and applicator
US9526745B2 (en) 2012-10-11 2016-12-27 Nanocomposix, Inc. Silver nanoplate compositions and methods
US9249334B2 (en) 2012-10-11 2016-02-02 Nanocomposix, Inc. Silver nanoplate compositions and methods
US9212294B2 (en) 2012-10-11 2015-12-15 Nanocomposix, Inc. Silver nanoplate compositions and methods
US9371374B2 (en) 2013-03-14 2016-06-21 Abbott Laboratories HCV core lipid binding domain monoclonal antibodies

Also Published As

Publication number Publication date
AU4755696A (en) 1996-07-24
EP0805678B1 (en) 2003-10-29
EP0805678A1 (en) 1997-11-12
DE69630514D1 (en) 2003-12-04
CA2207961A1 (en) 1996-07-11
WO1996020698A2 (en) 1996-07-11
JPH10511957A (en) 1998-11-17
ATE252894T1 (en) 2003-11-15

Similar Documents

Publication Publication Date Title
WO1996020698A3 (en) Surface-modified nanoparticles and method of making and using same
US6541116B2 (en) Superoxide dismutase or superoxide dismutase mimic coating for an intracorporeal medical device
JP5106415B2 (en) Nanoparticle emitting medical device
EP1009451B1 (en) Compositions and their use to prevent formation of adhesions in biological tissues
Vendra et al. Polymer thin films for biomedical applications
US9284409B2 (en) Endoprosthesis having a non-fouling surface
EP2658527B1 (en) Nanoparticle and surface-modified particulate coatings, coated balloons, and methods therefore
EP1051208B1 (en) Hydrophilic coating for an intracorporeal medical device
EP2588157B1 (en) Lipid coating for medical devices delivering bioactive agent
US5571166A (en) Method of making an intraluminal stent
US7052711B2 (en) Nitric oxide-producing hydrogel materials
CN101972492B (en) Medical product for curing body channel narrow and preventing dangerous restenosis
US20080095847A1 (en) Stimulus-release carrier, methods of manufacture and methods of treatment
WO2007058190A1 (en) Controlled drug release composition and drug releasing medical device
WO1992022332A3 (en) Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology
CN110935070A (en) Drug delivery medical device
JP2007514518A (en) Capsule of multilayer neutral polymer film bonded by hydrogen bonding
WO2001082947A1 (en) Method and apparatus for vascular neuromuscular blockade
EP2434994B1 (en) Re-establishment of blood flow in blocked human arteries by transferring nano-encapsulated drug through medical devices, designed for the same and releasing the nano- encapsulated drug in human artery with body ph
CA2798459C (en) Glycerol ester active agent delivery systems and methods
EP1726318A1 (en) Medicine/gene leaching type stent
CN109528648A (en) The amphipathy macromolecule prodrug micelle and its preparation method and application of the slightly sour environmental response of tumor stroma
JP3631777B2 (en) Drug administration catheter
Srinivasan Macromolecules: New Frontiers: Proceedings of the IUPAC International Symposium on Advances in Polymer Science and Technology, MACRO-98, January 5-9, 1998
Cholkar et al. Therapeutic Applications of Polymeric Materials

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN AZ BY KZ RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

ENP Entry into the national phase

Ref document number: 2207961

Country of ref document: CA

Ref country code: CA

Ref document number: 2207961

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1996903476

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1996903476

Country of ref document: EP

AK Designated states

Kind code of ref document: A3

Designated state(s): AL AM AT AU AZ BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IS JP KE KG KP KR KZ LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN AZ BY KZ RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): KE LS MW SD SZ UG AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN

WWG Wipo information: grant in national office

Ref document number: 1996903476

Country of ref document: EP