WO1996023526A3 - Diagnostic imaging contrast agents with extended blood retention - Google Patents

Diagnostic imaging contrast agents with extended blood retention Download PDF

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Publication number
WO1996023526A3
WO1996023526A3 PCT/US1996/000164 US9600164W WO9623526A3 WO 1996023526 A3 WO1996023526 A3 WO 1996023526A3 US 9600164 W US9600164 W US 9600164W WO 9623526 A3 WO9623526 A3 WO 9623526A3
Authority
WO
WIPO (PCT)
Prior art keywords
diagnostic imaging
contrast agents
blood
moiety
compounds
Prior art date
Application number
PCT/US1996/000164
Other languages
French (fr)
Other versions
WO1996023526A2 (en
Inventor
Thomas J Mcmurry
Hironao Sajiki
Daniel M Scott
Randall B Lauffer
Original Assignee
Metasyn Inc
Thomas J Mcmurry
Hironao Sajiki
Daniel M Scott
Randall B Lauffer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP96902106A priority Critical patent/EP0806968B1/en
Priority to DK96902106T priority patent/DK0806968T3/en
Priority to BR9607136A priority patent/BR9607136A/en
Priority to DE69636635T priority patent/DE69636635T2/en
Priority to CA002211100A priority patent/CA2211100C/en
Priority to AU46543/96A priority patent/AU689700B2/en
Priority to NZ301181A priority patent/NZ301181A/en
Priority to JP52354396A priority patent/JP4064458B2/en
Application filed by Metasyn Inc, Thomas J Mcmurry, Hironao Sajiki, Daniel M Scott, Randall B Lauffer filed Critical Metasyn Inc
Priority to DE1996636635 priority patent/DE122006000061I1/en
Priority to SI9630747T priority patent/SI0806968T1/en
Publication of WO1996023526A2 publication Critical patent/WO1996023526A2/en
Publication of WO1996023526A3 publication Critical patent/WO1996023526A3/en
Priority to IS4523A priority patent/IS2505B/en
Priority to NO19973510A priority patent/NO326114B1/en
Priority to FI973183A priority patent/FI973183A/en
Priority to MXPA/A/1997/005823A priority patent/MXPA97005823A/en
Priority to HK98100980A priority patent/HK1002551A1/en
Priority to US10/034,522 priority patent/US6676929B2/en
Priority to US10/354,723 priority patent/US7011815B2/en
Priority to US10/755,506 priority patent/US7060250B2/en
Priority to US10/755,507 priority patent/US7229606B2/en
Priority to US11/472,842 priority patent/US8017105B2/en
Priority to US11/526,312 priority patent/US20070020185A1/en
Priority to US11/526,302 priority patent/US20070020184A1/en
Priority to DE200612000061 priority patent/DE122006000061I2/en
Priority to NL300253C priority patent/NL300253I2/en
Priority to NO20081355A priority patent/NO20081355L/en
Priority to US13/220,103 priority patent/US8394356B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
    • A61B6/50—Clinical applications
    • A61B6/507—Clinical applications involving determination of haemodynamic parameters, e.g. perfusion CT

Abstract

The present invention provides diagnostic imaging contrast agents which exhibit improved blood retention. The novel compounds comprise: a) an image-enhancing (or signal-generating) moiety (IEM); b) a plasma protein binding moiety (PPBM); and c) a blood half-life extending moiety (BHEM). This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for blood half-life extension and contrast enhancement of diagnostic imaging. These contrast agents exhibit reduced rates of both renal and hepatocellular uptake and no apparent uptake by the RE system. The agents may be targeted to the blood pool or any other biological component. Since the agent is lost less rapidly from the bloodstream, lower doses can be used at a higher margin of safety. The approach is general to both large and small molecules.
PCT/US1996/000164 1995-02-01 1996-01-16 Diagnostic imaging contrast agents with extended blood retention WO1996023526A2 (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
NZ301181A NZ301181A (en) 1995-02-01 1996-01-16 Diagnostic imaging contrast agents with extended blood retention
BR9607136A BR9607136A (en) 1995-02-01 1996-01-16 Imaging contrast agents for diagnosis with increased blood retention
DE69636635T DE69636635T2 (en) 1995-02-01 1996-01-16 CONTRASTING AGENT FOR DIAGNOSTIC IMAGING WITH EXTENDED DWELLING TIME IN THE BLOOD
CA002211100A CA2211100C (en) 1995-02-01 1996-01-16 Diagnostic imaging contrast agents with extended blood retention
AU46543/96A AU689700B2 (en) 1995-02-01 1996-01-16 Diagnostic imaging contrast agents with extended blood reention
EP96902106A EP0806968B1 (en) 1995-02-01 1996-01-16 Diagnostic imaging contrast agents with extended blood retention
JP52354396A JP4064458B2 (en) 1995-02-01 1996-01-16 Diagnostic imaging contrast agent with extended blood retention
DK96902106T DK0806968T3 (en) 1995-02-01 1996-01-16 Diagnostic imaging contrast agents with enhanced blood retention
DE1996636635 DE122006000061I1 (en) 1995-02-01 1996-01-16 Contrast media for diagnostic imaging with increased residence time in the blood
SI9630747T SI0806968T1 (en) 1995-02-01 1996-01-16 Diagnostic imaging contrast agents with extended blood retention
IS4523A IS2505B (en) 1995-02-01 1997-07-14 Reflective contrast agents, preferably long in the blood, for diagnostic purposes
NO19973510A NO326114B1 (en) 1995-02-01 1997-07-30 Diagnostic imaging contrast agents with prolonged blood retention
MXPA/A/1997/005823A MXPA97005823A (en) 1995-02-01 1997-07-31 Agents of contrast for formation of images for diagnosis that exhibit a greater retention in the san
FI973183A FI973183A (en) 1995-02-01 1997-07-31 Suitable contrast agents with prolonged retention in the blood for diagnostic imaging
HK98100980A HK1002551A1 (en) 1995-02-01 1998-02-09 Diagnostic imaging contrast agents with extended blood retention
US10/034,522 US6676929B2 (en) 1995-02-01 2001-12-20 Diagnostic imaging contrast agents with extended blood retention
US10/354,723 US7011815B2 (en) 1995-02-01 2003-01-30 Diagnostic imaging contrast agents with extended blood retention
US10/755,506 US7060250B2 (en) 1995-02-01 2004-01-12 Diagnostic imaging contrast agents with extended blood retention
US10/755,507 US7229606B2 (en) 1995-02-01 2004-01-12 Diagnostic imaging contrast agents with extended blood retention
US11/472,842 US8017105B2 (en) 1995-02-01 2006-06-22 Diagnostic imaging contrast agents with extended blood retention
US11/526,302 US20070020184A1 (en) 1995-02-01 2006-09-25 Diagnostic imaging contrast agents with extended blood retention
US11/526,312 US20070020185A1 (en) 1995-02-01 2006-09-25 Diagnostic imaging contrast agents with extended blood retention
DE200612000061 DE122006000061I2 (en) 1995-02-01 2006-11-10 Contrast agent for diagnostic imaging with prolonged retention time in the blood.
NL300253C NL300253I2 (en) 1995-02-01 2007-01-05 Contrast agent for diagnostic imaging with extended retention in blood.
NO20081355A NO20081355L (en) 1995-02-01 2008-03-14 Imaging agents
US13/220,103 US8394356B2 (en) 1995-02-01 2011-08-29 Diagnostic imaging contrast agents with extended blood retention

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38231795A 1995-02-01 1995-02-01
US08/382,317 1995-02-01

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US38231795A Continuation-In-Part 1995-02-01 1995-02-01

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US08875365 A-371-Of-International 1996-01-16
US10/034,522 Continuation US6676929B2 (en) 1995-02-01 2001-12-20 Diagnostic imaging contrast agents with extended blood retention

Publications (2)

Publication Number Publication Date
WO1996023526A2 WO1996023526A2 (en) 1996-08-08
WO1996023526A3 true WO1996023526A3 (en) 1996-10-17

Family

ID=23508434

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/000164 WO1996023526A2 (en) 1995-02-01 1996-01-16 Diagnostic imaging contrast agents with extended blood retention

Country Status (25)

Country Link
US (8) US6676929B2 (en)
EP (2) EP1716871A3 (en)
JP (4) JP4064458B2 (en)
KR (1) KR100403755B1 (en)
CN (3) CN1177806C (en)
AR (1) AR006510A1 (en)
AT (1) ATE342738T1 (en)
AU (1) AU689700B2 (en)
BR (1) BR9607136A (en)
CA (1) CA2211100C (en)
DE (3) DE69636635T2 (en)
DK (1) DK0806968T3 (en)
ES (1) ES2274523T3 (en)
FI (1) FI973183A (en)
HK (2) HK1002551A1 (en)
IL (1) IL116847A (en)
IS (1) IS2505B (en)
MY (1) MY128089A (en)
NL (1) NL300253I2 (en)
NO (2) NO326114B1 (en)
NZ (1) NZ301181A (en)
PT (1) PT806968E (en)
TW (1) TW319763B (en)
WO (1) WO1996023526A2 (en)
ZA (1) ZA96417B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9295737B2 (en) 2002-03-01 2016-03-29 Bracco Suisse Sa Targeting vector-phospholipid conjugates
US9408926B2 (en) 2002-03-01 2016-08-09 Bracco Suisse S.A. KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US9446155B2 (en) 2002-03-01 2016-09-20 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW319763B (en) * 1995-02-01 1997-11-11 Epix Medical Inc
US6770261B2 (en) 1995-06-02 2004-08-03 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
DE19543077C2 (en) * 1995-11-13 1997-10-16 Schering Ag Use of gas-containing metal complexes as ultrasound contrast agent
AU726914B2 (en) 1996-04-01 2000-11-23 Epix Pharmaceuticals, Inc. Bioactivated diagnostic imaging contrast agents
US5900228A (en) 1996-07-31 1999-05-04 California Institute Of Technology Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
US5919967A (en) * 1997-04-11 1999-07-06 Epix Medical, Inc. Process for synthesizing phosphodiesters
US6495118B1 (en) 1997-09-26 2002-12-17 Schering Aktiengesellschaft Lipophilic metal complexes for necrosis and infarction imaging
DE19744004C1 (en) * 1997-09-26 1999-07-22 Schering Ag Lipophilic metal complexes for necrosis and infarct imaging
AU742438C (en) * 1997-10-02 2003-05-22 Lantheus Medical Imaging, Inc. Contrast-enhanced diagnostic imaging method for monitoring interventional therapies
WO1999021592A1 (en) * 1997-10-27 1999-05-06 California Institute Of Technology Magnetic resonance imaging agents for the delivery of therapeutic agents
US6713046B1 (en) 1997-10-27 2004-03-30 Research Corporation Technologies Magnetic resonance imaging agents for the delivery of therapeutic agents
CA2309749A1 (en) * 1997-11-17 1999-05-27 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
GB9912356D0 (en) 1999-05-26 1999-07-28 Btg Int Ltd Generation of microfoam
JP3848493B2 (en) * 1999-06-30 2006-11-22 英三 盛 X-ray diagnostic system
JP2003505519A (en) 1999-07-29 2003-02-12 エピックス メディカル， インコーポレイテッド Targeting multimeric imaging agents through multidentate binding
DK1072604T3 (en) * 1999-09-09 2001-06-25 Schering Ag Calcium complex of 4R0-4-bis (carboxy-kappa.O) methyl-amino-kappa.N-6,9-bis (carboxy-kappa.O) methyl-1- (4,4-diphenylcyclohexyl) oxy-1 -hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-yl-acid-kappa.N6,. kappa.N9,. kappa.o11-1-oxidato (6 -) -, hexa .. ......
US6559330B1 (en) 1999-09-09 2003-05-06 Schering Aktiengesellschaft Calcium complex of [[(4r)-4-[bis{carboxy-.kappa.o)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.o)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.n6,.kappa.n9,.kappa.011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
DE19944893C2 (en) * 1999-09-09 2001-09-20 Schering Ag Calcium complex of [[(4R) -4- [bis [(carboxy-.kappa.O) methyl] amino-. kappa.N] -6,9-bis [(carboxy-.kappa.O) methyl] -1 - [(4,4-diphenylcyclohexyl) oxy] -1-hydroxy-2-oxa-6,9-diaza-1 -phosphaundecan-11-yl-acid-.kappa.N6, .kappa.N9, .kappa.O11] 1-oxidato (6 -)] -, hexahydrogen, its salts and pharmaceutical compositions containing these complexes
DE19964224B4 (en) * 1999-09-09 2005-09-01 Schering Ag Pharmaceutical compositions containing calcium complex of [[(4R) -4- [bis [(carboxy-.kappa.O) methyl] amino-.kappa.N] -6,9-bis [(carboxy-.kappa.O) methyl] -1 - [(4,4-diphenylcyclohexyl) oxy] -1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-yl-acid-.kappa.N6, .kappa.N9, .kappa.011] 1-oxidato (6 -)], tetrahydrogen (MS-325) and its salts, and process for their preparation
US20030203879A1 (en) * 1999-09-09 2003-10-30 Schering Ag Calcium complex of [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.O)methyl]-1-[(4,4-diphenylcyclohexy)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.N6,.Kappa.N9,.Kappa 011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
US6548044B1 (en) 1999-11-22 2003-04-15 Epix Medical, Inc. Imaging sexual response
US20030082106A1 (en) * 2000-01-22 2003-05-01 Aleksandr Nivorozhkin Magnetic resonance imaging using contrast agents bioactivated by enzymatic cleavage
US6673333B1 (en) 2000-05-04 2004-01-06 Research Corporation Technologies, Inc. Functional MRI agents for cancer imaging
WO2002006287A2 (en) 2000-07-17 2002-01-24 California Institute Of Technology Macrocyclic mri contrast agents
WO2002028441A2 (en) 2000-10-04 2002-04-11 California Institute Of Technology Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
US6549798B2 (en) 2001-02-07 2003-04-15 Epix Medical, Inc. Magnetic resonance angiography data
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
TWI284539B (en) 2001-07-30 2007-08-01 Epix Pharm Inc A method for making a magnetic resonance (MR) imaging agent, a MR imaging contrast agent, a method for altering stability of a peptide and a modified peptide
US8512680B2 (en) 2001-08-08 2013-08-20 Btg International Ltd. Injectables in foam, new pharmaceutical applications
EP1423136A4 (en) * 2001-08-10 2007-07-25 Epix Pharm Inc Polypeptide conjugates with extended circulating half-lives
WO2003029257A1 (en) * 2001-09-27 2003-04-10 Schering Aktiengesellschaft (ethylene)-(propene/butene)-phosphodiester triamine pentaacetic acid derivatives
ES2398393T3 (en) 2002-03-01 2013-03-15 Dyax Corp. KDR and VEGF / KDR binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
ES2396368T3 (en) 2003-03-03 2013-02-21 Dyax Corporation Peptides that specifically bind to the HGF receptor (CMET) and uses thereof
BRPI0410635A (en) 2003-05-23 2006-06-13 Epix Pharm Inc optically pure enriched isomers of chelating binders and contrast agents
US7251520B2 (en) * 2003-07-08 2007-07-31 General Electric Company Method and apparatus of slice selective magnetization preparation for moving table MRI
AR047692A1 (en) * 2003-07-10 2006-02-08 Epix Medical Inc IMAGES OF STATIONARY WHITE
US7731986B2 (en) 2003-11-17 2010-06-08 Btg International Ltd. Therapeutic foam
US8048439B2 (en) 2003-11-17 2011-11-01 Btg International Ltd. Therapeutic foam
US7189879B2 (en) 2004-05-25 2007-03-13 Schering Ag Process for the production of 1-hydroxymethyl-1,3,5-triazapentane, trihydrochloride
DE102004026102B4 (en) * 2004-05-25 2006-08-24 Schering Ag Process for the preparation of 1-hydroxymethyl-1,3,5-triazapentane, trihydrochloride
JP2008502726A (en) * 2004-06-09 2008-01-31 ケレオス インコーポレーティッド Lipophilic derivatives of chelating monoamides
DE102004062258B3 (en) * 2004-12-23 2006-01-05 Schering Ag New hydroxypyrimidone, hydroxypyridinone or dihydroxybenzene derivatives useful for preparing conjugates of biomolecules useful as magnetic resonance contrast agents
US8778299B2 (en) * 2005-01-26 2014-07-15 The Regents Of The University Of Colorado, A Body Corporate Methods for diagnosis and intervention of hepatic disorders
WO2006081521A2 (en) 2005-01-26 2006-08-03 The Regents Of The University Of Colorado Methods for diagnosis and intervention of hepatic disorders
MX2007009354A (en) * 2005-02-03 2008-01-14 Epix Pharm Inc Steady state perfusion methods.
JP2006248978A (en) 2005-03-10 2006-09-21 Mebiopharm Co Ltd New liposome preparation
GB0509824D0 (en) 2005-05-13 2005-06-22 Btg Int Ltd Therapeutic foam
US20100098640A1 (en) * 2005-06-20 2010-04-22 Cohen Seth M Multidentate Pyrone-Derived Chelators for Medicinal Imaging and Chelation
KR100762359B1 (en) * 2005-06-28 2007-10-05 원광대학교산학협력단 Vascular-specific contrast media for magnetic resonance imaging and process for preparing the same
KR100762357B1 (en) * 2005-06-28 2007-10-05 원광대학교산학협력단 Inflammation-specific contrast media for magnetic resonance imaging and process for preparing the same
WO2007009058A2 (en) * 2005-07-13 2007-01-18 Georgia State University Research Foundation, Inc. Contrast agents and methods for preparing contrast agents
JP5377965B2 (en) 2005-09-09 2013-12-25 ジョージア ステート ユニバーシティ リサーチ ファウンデーション、インコーポレイテッド Targeted contrast agents and methods for targeting contrast agents
WO2007073792A1 (en) * 2005-12-19 2007-07-05 Bayer Schering Pharma Aktiengesellschaft Process for preparing 4,4- diphenylcyclohexanol
WO2007084264A2 (en) 2005-12-29 2007-07-26 Epix Pharmaceuticals, Inc. Methods for myocardial imaging
DE102006025940B4 (en) * 2006-06-02 2009-11-05 Siemens Ag Dielectric element, method for generating magnetic resonance recordings of an examination object and use of the dielectric element
EP2054514A4 (en) * 2006-08-04 2009-11-04 Univ Georgia State Res Found Enzyme sensors, methods for preparing and using such sensors, and methods of detecting protease activity
CN101528124A (en) * 2006-08-17 2009-09-09 艾佩斯制药公司 Methods for lymph system imaging
EP2097507B1 (en) 2006-12-14 2015-05-06 Georgia State University Research Foundation, Inc. Analyte sensors and use thereof for detecting analyte activity
DE102007002726A1 (en) * 2007-01-18 2008-07-31 Bayer Schering Pharma Aktiengesellschaft New cascade polymer complexes, processes for their preparation and pharmaceutical compositions containing them
JPWO2008108163A1 (en) * 2007-03-06 2010-06-10 コニカミノルタホールディングス株式会社 Gadolinium compound and contrast medium for MRI
EP1982733A1 (en) * 2007-04-17 2008-10-22 Bayer Schering Pharma Aktiengesellschaft Use of a contrast agent for magnetic resonance imaging of endoleaks
WO2008144728A1 (en) * 2007-05-21 2008-11-27 Bracco Imaging S.P.A. Conjugates which bind a blood protein such as human serum albumin and methods of using the same in diagnostic and therapeutic applications
WO2009089022A1 (en) * 2008-01-08 2009-07-16 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
WO2009146099A2 (en) * 2008-04-02 2009-12-03 Georgia State University Research Foundation, Inc. Contrast agents, methods for preparing contrast agents, and methods of imaging
WO2010107832A1 (en) 2009-03-17 2010-09-23 Bracco Imaging Spa Lhrh-ii peptide analogs
WO2010121133A2 (en) 2009-04-17 2010-10-21 The General Hospital Corporation Multimodal imaging of fibrin
AR075900A1 (en) 2009-03-19 2011-05-04 Wyeth Llc METHODS FOR THE PREPARATION OF ACIDS (2- (8,9-DIOXO-2,6-DIAZABICICLIC (5.2.0) NON-1 (7) -EN-2-IL) ETIL) PHOSPHONIC AND ITS PRECURSORS.
CA2803520C (en) 2009-07-08 2019-10-22 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
US20110071403A1 (en) * 2009-09-21 2011-03-24 Board Of Regents Of The University Of Texas System Functional near-infrared fluorescence lymphatic mapping for diagnosing, accessing, monitoring and directing therapy of lymphatic disorders
WO2011041470A2 (en) 2009-09-30 2011-04-07 Mallinckrodt Inc. Sustained-release opiate and opiate derivative compositions
EP2489655A4 (en) * 2009-10-15 2014-03-12 Univ Tokushima Process for preparation of diethylenetriaminepentaacetic acid derivatives, and diethylenetriaminepentaacetic acid derivatives
EP2432191A1 (en) * 2010-09-15 2012-03-21 Alcatel Lucent Methods and systems for service delivery
ES2823349T3 (en) 2011-05-31 2021-05-06 Univ Colorado Regents Procedure for evaluation of liver function and portal blood flow
AU2013229631B2 (en) 2012-03-05 2017-09-14 Bracco Imaging Spa Dynamic Contrast Enhanced MRI method and agents for the assessment of the macromolecular transport within pathologic tissues
EP2917727B1 (en) 2012-11-12 2018-01-10 The Regents of the University of Colorado, A Body Corporate Disease severity index for assessment of chronic liver disease and method for diagnosis of three distinct subtypes of primary sclerosing cholangitis
TW201514188A (en) * 2013-03-13 2015-04-16 Lantheus Medical Imaging Inc Process for manufacture of gadofosveset trisodium monohydrate
WO2015038968A1 (en) 2013-09-13 2015-03-19 The General Hospital Corporation Activatable fibrin-binding probes
WO2015171543A1 (en) 2014-05-05 2015-11-12 California Institute Of Technology Mutant akt-specific capture agents, compositions, and methods of using and making
WO2015179258A2 (en) * 2014-05-17 2015-11-26 The Johns Hopkins University Mri-guided intraarterial catheter-based method for predicting territory of local blood brain barrier opening
WO2015196208A2 (en) 2014-06-20 2015-12-23 The General Hospital Corporation Collagen targeted imaging probes
CN107624115B (en) 2015-03-16 2021-10-26 加州理工学院 Botulinum neurotoxin specific capture agents, compositions, methods of use, and methods of manufacture
WO2017004211A1 (en) 2015-06-29 2017-01-05 Collagen Medical, LLC Collagen imaging compositions
US10598671B2 (en) 2015-07-15 2020-03-24 Indi Molecular, Inc. IL-17F-specific capture agents, compositions, and methods of using and making
CN114805196A (en) 2015-08-13 2022-07-29 通用医疗公司 Manganese-based chelate conjugates for MR molecular imaging
CN115109120A (en) 2016-04-04 2022-09-27 英蒂分子公司 CD 8-specific capture agents, compositions and methods of use and preparation
EP3519425B1 (en) 2016-09-29 2024-02-28 Indi Molecular, Inc. Compositions for detection, inhibition and imaging of indoleamine 2,3-dioxygenase 1 (ido1) and methods of making and using same
WO2018085375A1 (en) 2016-11-01 2018-05-11 Ohio State Innovation Foundation Methods for the iodination of biomolecules
US11719705B2 (en) 2017-06-15 2023-08-08 Indi Molecular, Inc. IL-17F and IL-17A-specific capture agents, compositions, and methods of using and making
EP3661563A4 (en) * 2017-07-31 2021-11-10 The Ohio State Innovation Foundation Biomimetic nanomaterials and uses thereof
US10933146B2 (en) 2017-12-12 2021-03-02 Massachusetts Institute Of Technology Cell-permeable imaging sensors and uses thereof
TWI667996B (en) * 2018-03-23 2019-08-11 中國醫藥大學附設醫院 Assisted detection model of breast tumor, and assisted detection system of breast tumor
US11919972B2 (en) 2018-11-02 2024-03-05 Regeneron Pharmaceuticals, Inc. Peptide libraries with non-canonical amino acids
WO2020097531A1 (en) 2018-11-08 2020-05-14 Indi Molecular, Inc. Theranostic capture agents, compositions, and methods of using and making
WO2020186091A1 (en) 2019-03-12 2020-09-17 Indi Molecular, Inc. Cross-linked epitopes and methods of use thereof
WO2020236969A1 (en) 2019-05-20 2020-11-26 Indi Molecular, Inc. Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (ido1)
US11414460B2 (en) 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
AU2021265205A1 (en) 2020-04-30 2023-01-05 Academisch Ziekenhuis Groningen Anti-CD103 antibodies
WO2022098743A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)
WO2022098745A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, delivery systems, and methods useful in tumor therapy

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991003200A1 (en) * 1989-08-28 1991-03-21 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic nmr imaging
WO1991018630A1 (en) * 1990-05-30 1991-12-12 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Polyether-substituted tumor agents
EP0535668A1 (en) * 1991-10-04 1993-04-07 Nihon Medi-Physics Co., Ltd. Imaging agent for diagnosis
US5385719A (en) * 1991-09-24 1995-01-31 Unger; Evan C. Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
EP0661279A1 (en) * 1993-12-30 1995-07-05 Guerbet S.A. Polyaminated ligands, metal complexes, process for their preparation and diagnostic and therapeutic applications

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US488008A (en) * 1892-12-13 Method of forming dental crowns
DE450742C (en) 1924-12-04 1927-10-15 Arthur Korn Dr Method for the wireless transmission of images
US3632637A (en) 1968-02-13 1972-01-04 Arthur E Martell Hydroxyaryl-containing aminocarboxylic chelating agents
US4088747A (en) 1975-02-19 1978-05-09 Australian Atomic Energy Commission Phenolic amino-carboxylic acid radiopharmaceuticals
FR2354993A1 (en) 1976-06-16 1978-01-13 Dabeer Soil-modifying hydroxyalkyl-alkylenediamine-acetic acid prepn. - by reacting the prod. of alkali salt of hydroxyethyl-alkylenediamine-acetic acid and formaldehyde with phenolic acid cpd.
US4150047A (en) 1978-03-06 1979-04-17 Air Products And Chemicals, Inc. Process for preparing halogenated metal chelates
IN152852B (en) * 1978-08-09 1984-04-21 Gen Electric Co Ltd
US4352751A (en) 1979-09-10 1982-10-05 Analytical Radiation Corporation Species-linked diamine triacetic acids and their chelates
US4308249A (en) 1979-12-13 1981-12-29 G. D. Searle & Co. Radiopharmaceutical complexes of N-(tri-substituted alkyl)-iminodiacetic acids
US4401647A (en) 1980-03-03 1983-08-30 The Regents Of The University Of Ca Radiolabeled neoglycopeptides
US4361544A (en) 1980-03-03 1982-11-30 Goldenberg Milton David Tumor localization and therapy with labeled antibodies specific to intracellular tumor-associated markers
US4331647A (en) 1980-03-03 1982-05-25 Goldenberg Milton David Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
US4308149A (en) 1980-07-14 1981-12-29 Nalco Chemical Company Branched/cross-linked cationic phenol-formaldehyde polymers useful in wastewater treatment
US4647447A (en) 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4957939A (en) 1981-07-24 1990-09-18 Schering Aktiengesellschaft Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging
DE3129906C3 (en) 1981-07-24 1996-12-19 Schering Ag Paramagnetic complex salts, their preparation and agents for use in NMR diagnostics
US4472509A (en) 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
NL194579C (en) 1983-01-21 2002-08-05 Schering Ag Diagnostic.
FR2550449B1 (en) 1983-08-12 1986-01-31 Commissariat Energie Atomique SPECIFIC ORGAN OR PATHOLOGY RELAXATION AGENTS FOR USE IN MODIFYING CONTRASTS IN MEDICAL IMAGING BY NUCLEAR MAGNETIC RESONANCE
US4615879A (en) 1983-11-14 1986-10-07 Vanderbilt University Particulate NMR contrast agents for gastrointestinal application
SE463651B (en) 1983-12-21 1991-01-07 Nycomed As DIAGNOSTIC AND CONTRACTOR
GB8413772D0 (en) 1984-05-30 1984-07-04 Nyegaard & Co As Chemical compounds
GB8413849D0 (en) 1984-05-31 1984-07-04 Amersham Int Plc Nmr contrast agents
CA1260827A (en) 1984-08-31 1989-09-26 Richard C. Siegel Antibody-metal ion complexes
US4687659A (en) 1984-11-13 1987-08-18 Salutar, Inc. Diamide-DTPA-paramagnetic contrast agents for MR imaging
US4687658A (en) 1984-10-04 1987-08-18 Salutar, Inc. Metal chelates of diethylenetriaminepentaacetic acid partial esters for NMR imaging
US4859451A (en) 1984-10-04 1989-08-22 Salutar, Inc. Paramagnetic contrast agents for MR imaging
US4639365A (en) 1984-10-18 1987-01-27 The Board Of Regents, The University Of Texas System Gadolinium chelates as NMR contrast agents
US4746507A (en) 1985-04-02 1988-05-24 Salutar, Inc. EDHPA based contrast agents for MR imaging, apparatus and methods
US4899755A (en) 1985-05-08 1990-02-13 The General Hospital Corporation Hepatobiliary NMR contrast agents
US5250285A (en) 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US4880008A (en) 1985-05-08 1989-11-14 The General Hospital Corporation Vivo enhancement of NMR relaxivity
US5525338A (en) 1992-08-21 1996-06-11 Immunomedics, Inc. Detection and therapy of lesions with biotin/avidin conjugates
US5512332A (en) 1985-10-04 1996-04-30 Immunivest Corporation Process of making resuspendable coated magnetic particles
US5017359A (en) 1985-11-01 1991-05-21 Centre National De La Recherche Scientifique Aerosol compositions for in vivo imaging and therapy
US5223242A (en) * 1985-11-05 1993-06-29 The General Hospital Corporation Negatively charged specific affinity reagents
FI72080C (en) 1986-01-17 1987-04-13 Erkki Tapio Tuhkanen UPPHAENGNINGSFAESTE AV FOERVARINGSROER FOER DOKUMENT.
MX174467B (en) 1986-01-23 1994-05-17 Squibb & Sons Inc 1,4,7-TRISCARBOXIMETHYL-1,4,7,10-TETRAAZACICLODO DECAN SUBSTITUTE IN 1 AND ANALOG COMPOUNDS
EP0232751B1 (en) 1986-01-23 1991-09-11 E.R. Squibb & Sons, Inc. 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US4885363A (en) 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
IT1213029B (en) 1986-01-30 1989-12-07 Bracco Ind Chimica Spa PARAMAGNETIC METAL ION CHELATES.
US4834964A (en) 1986-03-07 1989-05-30 M.R.I., Inc. Use of charged nitroxides as NMR image enhancing agents for CSF
EP0250358A3 (en) 1986-06-20 1988-10-05 Schering Aktiengesellschaft Novel complex compounds
US5314679A (en) 1986-07-03 1994-05-24 Advanced Magnetics Inc. Vascular magnetic resonance imaging agent comprising nanoparticles
AU608759B2 (en) 1986-08-04 1991-04-18 Amersham Health Salutar Inc NMR imaging with paramagnetic polyvalents metal salts of poly-(acid-alkylene-amido)-alkanes
JPS6390586A (en) * 1986-09-29 1988-04-21 リ−・フア−マス−テイカルズ・インコ−ポレイテツド Improved adhesive tab system
US5057302A (en) 1987-02-13 1991-10-15 Abbott Laboratories Bifunctional chelating agents
DE3710730A1 (en) 1987-03-31 1988-10-20 Schering Ag SUBSTITUTED COMPLEX ILLUMINATORS, COMPLEX AND COMPLEX SALTS, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
US5091169A (en) * 1987-05-08 1992-02-25 Salutar, Inc. Dipyridoxyl phosphate NMRI contrast agent compositions
AR246956A1 (en) 1987-05-08 1994-10-31 Salutar Inc Dipyridoxyl phosphate nuclear magnetic resonance imagery contrast agents
US5223243A (en) 1987-05-08 1993-06-29 Salutar, Inc. Dipyridoxyl phosphate chelating compound intermediates useful as NMRI contrast agents
US4935518A (en) 1987-05-08 1990-06-19 Salutar, Inc. Manganese(II), chelate contrast agents derived from N,N'-bis-(pyridoxal ethylene diamine-N,N')-diacetic acid and derivatives thereof
US4842845A (en) 1987-05-08 1989-06-27 Salutar, Inc. Radioactive metal chelates for dipyridoxyl phosphate
GB8719041D0 (en) 1987-08-12 1987-09-16 Parker D Conjugate compounds
GB8719042D0 (en) 1987-08-12 1987-09-16 Parker D Conjugate compounds
DE3728600A1 (en) 1987-08-27 1989-03-09 Hoechst Ag METHOD FOR MARKING SUBSTANCES WITH TECHNETIUM OR RHENIUM
US5635180A (en) 1988-02-17 1997-06-03 Neorx Corporation Alteration of pharmacokinetics of proteins by charge modification
DE3806795A1 (en) 1988-02-29 1989-09-07 Schering Ag POLYMER-TIED COMPLEX IMAGERS, THEIR COMPLEXES AND CONJUGATES, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THEM
US5513332A (en) 1988-05-31 1996-04-30 Extended Systems, Inc. Database management coprocessor for on-the-fly providing data from disk media to all without first storing data in memory therebetween
KR0130770B1 (en) 1988-06-24 1998-04-17 나가이 아쯔시 Tape cartridge
EP0420942A1 (en) 1988-06-24 1991-04-10 The Dow Chemical Company Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates
DE3825278A1 (en) * 1988-07-26 1990-02-01 Basf Lacke & Farben METHOD FOR PRODUCING MULTI-LAYER, PROTECTIVE AND / OR DECORATIVE COATINGS ON SUBSTRATE SURFACES
WO1990003804A1 (en) 1988-09-27 1990-04-19 Salutar, Inc. Chelate compositions
WO1990007342A1 (en) 1988-12-23 1990-07-12 The Dow Chemical Company Process for preparing isothiocyanato functionalized metal complexes
US5078986A (en) 1989-02-15 1992-01-07 Mallinckrodt Medical, Inc. Method for enhancing magnetic resonance imaging using an image altering agent containing an excess of chelating agent
FR2643370B1 (en) 1989-02-22 1991-08-23 Air Liquide POLYAZOTO DERIVATIVES AND THEIR METAL COMPLEXES FOR USE IN FIXING OXYGEN
US5695739A (en) * 1989-06-30 1997-12-09 Schering Aktiengesellschaft Derivatized DTPA complexes, pharmaceutical agents containing these compounds, their use, and processes for their production
DE3922005A1 (en) 1989-06-30 1991-01-10 Schering Ag DERIVATIVED DTPA COMPLEXES, PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS, THEIR USE AND METHOD FOR THE PRODUCTION THEREOF
US5094848A (en) 1989-06-30 1992-03-10 Neorx Corporation Cleavable diphosphate and amidated diphosphate linkers
EP0418419B1 (en) * 1989-09-22 1994-12-14 Deutsche ITT Industries GmbH Two-phase clock generator
IN172208B (en) 1990-04-02 1993-05-01 Sint Sa
GB9007431D0 (en) 1990-04-03 1990-05-30 Shell Int Research Diesel fuel additives
DE4011684A1 (en) 1990-04-06 1991-10-10 Schering Ag DTPA MONOAMIDES, PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS, THEIR USE AND METHOD FOR THE PRODUCTION THEREOF
NZ237868A (en) 1990-04-18 1994-04-27 Celltech Ltd Paramagnetic metal complexes of 1,4,7,10-tetracyclododecane derivatives and their use as nmr imaging agents
CA2039399C (en) 1990-04-25 2000-09-05 C. Allen Chang Dual functioning excipient for metal chelate contrast agents
US5487390A (en) 1990-10-05 1996-01-30 Massachusetts Institute Of Technology Gas-filled polymeric microbubbles for ultrasound imaging
DE4035760A1 (en) 1990-11-08 1992-05-14 Schering Ag MONO-N-SUBSTITUTED 1,4,7,10-TETRAAZACYCLODODECAN DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM
TW213864B (en) 1991-08-01 1993-10-01 Squibb & Sons Inc
EP0598837A4 (en) 1991-08-09 1994-07-13 Univ California Amino acid, ester and/or catechol contrast agents for mri.
US5407659A (en) 1991-10-22 1995-04-18 Mallinckrodt Medical, Inc. Treated calcium/oxyanion-containing particles for medical diagnostic imaging
US5464696A (en) 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
US5362478A (en) 1993-03-26 1994-11-08 Vivorx Pharmaceuticals, Inc. Magnetic resonance imaging with fluorocarbons encapsulated in a cross-linked polymeric shell
US5318769A (en) 1993-03-31 1994-06-07 Sterling Winthrop Inc. Compositions of iodophenyl esters for X-ray visualization of the gastrointestinal tract
US5365180A (en) * 1993-04-16 1994-11-15 National Semiconductor Corporation Method for measuring contact resistance
ATE195432T1 (en) 1993-06-02 2000-09-15 Bracco Spa IODINATED PARAMAGNETIC CHELATES AND THEIR USE AS CONTRAST AGENTS
US5358704A (en) 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
DE4341724A1 (en) 1993-12-03 1995-06-08 Schering Ag Pharmaceutical compositions containing haloaryl-substituted metal complexes, their use in diagnostics, and methods for producing the complexes and compositions
NO940115D0 (en) 1994-01-13 1994-01-13 Nycomed Imaging As Contrast agents for X-ray and magnetic tomographic imaging
JP3878208B2 (en) 1994-04-08 2007-02-07 ブラッコ インターナショナル ベスローテン フェンノートシャップ Aromatic amide compounds and their chelates
GB9407435D0 (en) 1994-04-14 1994-06-08 Nycomed Salutar Inc Compounds
IT1269839B (en) 1994-05-26 1997-04-15 Bracco Spa CONJUGATES OF BILIARY ACIDS, THEIR DERIVATIVES WITH METALLIC COMPLEXES AND RELATED USES
TW319763B (en) * 1995-02-01 1997-11-11 Epix Medical Inc
IT1283650B1 (en) 1996-08-02 1998-04-23 Bracco Spa HIGH RELAXATION PARAMAGNETIC CHELATES IN SERUM
US6342598B1 (en) 1998-11-26 2002-01-29 Bracco International B.V. Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents
IT1304501B1 (en) 1998-12-23 2001-03-19 Bracco Spa USE OF BILIARY ACID DERIVATIVES CONJUGATED WITH METALLIC COMPLEXES LIKE "BLOOD POOL AGENTS" FOR THE DIAGNOSTIC INVESTIGATION THROUGH RESONANCE
JP2003505519A (en) 1999-07-29 2003-02-12 エピックス メディカル， インコーポレイテッド Targeting multimeric imaging agents through multidentate binding
IT1313617B1 (en) 1999-08-31 2002-09-09 Bracco Spa PROCESS FOR THE PREPARATION OF BILIARY ACID DERIVATIVES.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991003200A1 (en) * 1989-08-28 1991-03-21 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic nmr imaging
WO1991018630A1 (en) * 1990-05-30 1991-12-12 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Polyether-substituted tumor agents
US5385719A (en) * 1991-09-24 1995-01-31 Unger; Evan C. Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
EP0535668A1 (en) * 1991-10-04 1993-04-07 Nihon Medi-Physics Co., Ltd. Imaging agent for diagnosis
EP0661279A1 (en) * 1993-12-30 1995-07-05 Guerbet S.A. Polyaminated ligands, metal complexes, process for their preparation and diagnostic and therapeutic applications

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DE SMIDT PC ET AL: "Association of antisense oligonucleotides with lipoproteins prolongs the plasma half-life and modifies the tissue distribution.", NUCLEIC ACIDS RES, 11-9-1991, VOL. 19, NO. 17, PAGE(S) 4695-700, XP002011087 *
M. ROWLAND & T.N. TOZER: "Clinical Pharmacokinetics: Concepts and Applications", 1980, LEA & FEBIGER, PHILADELPHIA, US, XP002011088 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9295737B2 (en) 2002-03-01 2016-03-29 Bracco Suisse Sa Targeting vector-phospholipid conjugates
US9381258B2 (en) 2002-03-01 2016-07-05 Bracco Suisse S.A. Targeting vector-phospholipid conjugates
US9408926B2 (en) 2002-03-01 2016-08-09 Bracco Suisse S.A. KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US9446155B2 (en) 2002-03-01 2016-09-20 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy

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