WO1996024054A1 - A colorimetric device for indicating carbon dioxide - Google Patents
A colorimetric device for indicating carbon dioxide Download PDFInfo
- Publication number
- WO1996024054A1 WO1996024054A1 PCT/SE1995/001363 SE9501363W WO9624054A1 WO 1996024054 A1 WO1996024054 A1 WO 1996024054A1 SE 9501363 W SE9501363 W SE 9501363W WO 9624054 A1 WO9624054 A1 WO 9624054A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- colorimetric device
- group
- component
- carbon dioxide
- linear
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
- G01N31/221—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating pH value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
- G01N31/22—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
- G01N31/223—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating presence of specific gases or aerosols
- G01N31/224—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators for investigating presence of specific gases or aerosols for investigating presence of dangerous gases
Definitions
- the present invention relates to a colorimetric device for indicating carbon dioxide.
- German Patents Nos 919510 and 1 007 525 both discloses selec ⁇ tive absorption of CO2 on a substance which contains a pH- sensitive dye.
- the change in the pH-value caused by the C0 2 bound to the substance becomes apparent as a change in colour of the dye which is present in the substance. Accordingly the change in colour becomes a measure of the content of C0 7 in the gas flow under investigation.
- a reverible C0 2 indicator device is disclosed in US-A-
- This prior art device comprises a system consis- ting of a pH-sensitive indicator dye, a basic substance and a viscous hygroscopic liquid.
- the indicator is able both to absorb and desorb C0 2 with a time constant of a few seconds so that it can be used e.g. in hospitals for monitoring the breathing of a patient.
- exhalation which takes about 4 seconds
- the air contains 3-5 % by volume of CO-
- the CO-, content during inhalation which typically takes about 2 seconds, is about 0.05% by volume corresponding to the normal concentration of C0 7 in atmospheric air.
- the indicator hence changes colour to and fro with breathing about 10 times a minute.
- the present invention provides a colorimetric device for indicating carbon dioxide which device contains a) at least one pH-sensitive indicator dye, b) at least one basic substance selected from the group consisting of quaternary ammonium salts, phosphonium salts and sulphonium salts, and c) at least one member selected from the group consisting of water-insoluble, organic substances of low volatility, which are not susceptible to alkaline hydro-lysis and are liquid at a temperature preferably below 100°C.
- said device also contains d) an inert, porous gas permeable carrier for components a) to c) .
- This component d) can be any conventional carrier used in connection with the conventional colorimetric devices such a a paper sheet but is preferably a thin cellulose layer applied on a transparent thin plastics foil, in which latter case observation of the device from both sides is enabled.
- the pH-sensitive indicator dye to be used in the device according to the invention can be any dye which has been used in the prior art, reversible colori- metric devices discussed above such as thymol blue, m-cresol purple and cresol red.
- X represents N, P or S
- R l , R , WRr and R 4 which may be equal or different, each represents (C j - C 2 Q) alkyl; (C
- Y is an anion selected from the group consisting of hydroxide, fluoride, chloride, bromide, iodide, carbonate an tetrafluoroborate.
- Another example of substances which can be used as component b) in the colorimetric device according to the invention are pyridiniu compounds of the general formula (II) :
- R ⁇ is selected from the group consisting of (C j - C 2Q ) alkyl and benzyl and
- Y " is an anion selected from the group consisting of hydroxide, fluoride, chloride, bromide, iodide, carbonate and tetrafluoroborate.
- R 6 represents (C j - C 2Q ) alkyl
- R represents (C j - C 2Q ) alkyl, which is optionally substi- tuted with hydroxyl or amino groups, and o
- R° represents H or (C j - C ⁇ Q ) alkyl, which is linear or branched, saturated or unsaturated or contains ring struc ⁇ tures.
- Component c) of the colorimetric device according to the present invention is at least one member selected from the group consisting of water-insoluble, organic substances of low volatility, which are not susceptible to alkaline hydro ⁇ lysis and are liquid at room temperature or moderately elevated temperatures, preferably below 100°C.
- component c) should also preferably be non-irritating in the concentrations used in the colorimetric device according to the invention.
- Component c) is most preferably one or more substances which is liquid at room temperature (about 25°C) , or is semi-solid, e.g. of waxy structure, at room temperature but becomes liquid at moderately elevated temperatures, preferably below 100°C.
- com ⁇ ponent c) is at least one member of the group consisting of alcohols, phenols and alkoxylated derivatives of such sub ⁇ stances, advantageously at least one linear or branched polyether.
- component c) comprises at least one compound havin one of the following structures:
- R 9 and R 12 each represents H or a linear or branched hydrocarbon residue of 1 to 50 carbon atoms, optionally containing one or more double bonds, triple bonds and/or rin structures
- R'O, R 11 and R 13 each represents a linear or branched hydro- carbon residue of 1 to 10 carbon atoms.
- n and n are equal or different integers from 0 to 100
- p is an integer from 1 to 6
- q and r are equal or different integers from 0 to 4.
- Polyalkylene glycols such as polymethylene glycols, polyethylene glycols, polypropylene glycols, polybutylene glycols and copolymers of ethylene oxide, propylene oxid and/or butylene oxide.
- linear polyethers such as polytetrahydrofurans.
- Alkoxylated alcohols or phenols such as ethoxylated, propoxylated or butoxylated alcohols derived from fatty alcohols (straight or branched, saturated or unsaturated, etc) , alkyl phenols, dialkyl phenols, alkyl naphthalenes, bisphenol A, alkyne diols, lanolin, cholesterol, phytosterol, sitosterol, glucose ethers and silicones; and mixed ethoxy- lated/ propoxylated alcohols.
- Branched polyethers for instance products obtained by ethoxylating and/or propoxylating trimethylol propane or pentaerythritol.
- Alkoxylated amines such as ethoxylated and/or propoxylated primary or secondary amines or diamines.
- Alkoxylated (ethoxylated and/or propoxylated) thiols Alkoxylated (ethoxylated and/or propoxylated) thiols.
- Dialkyl ethers e.g. dioctyl ether.
- the colorimetric device according to the invention is pre ⁇ pared in a conventional way by mixing components a) , b) and c) in a volatile organic solvent, such as a lower aliphatic alcohol, e.g. ethanol, and applying the solution on a carrier, e.g. a paper sheet, whereafter the solvent is eva ⁇ porated.
- a volatile organic solvent such as a lower aliphatic alcohol, e.g. ethanol
- the enclosed drawing ( Figure 1) shows a comparison between a prior art colorimetric device (A) and a colorimetric device according to the invention (B) as to the shelf life in air a a constant relative humidity of 50% by volume.
- composition of the prior art colorimetric device (A) was tetraoctylammonium hydroxide as the base, thymol blue as the pH-sensitive dye and 70% by weight (calculated on the total weight of the mixture) of tributyl phosphate as a further component.
- the colorimetric device according to the invention (B) differed in composition from the one according to the prior art only in that the tributyl phosphate was replaced by the same amount of an alkyl aryl polyether alcohol having the formula
- Figure 1 shows the shelf life (in logarithmic scale) as a function of temperature for the two devices.
- the shelf life was defined as the time required for the indicator (without being in contact with C0 2 ) to become aged to such an extent that the "basic” colour is changed in the direction to the "acid” colour corresponding to an exposure to about 1% by volume of C0 7 .
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Dispersion Chemistry (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP95942328A EP0807250A1 (en) | 1995-02-03 | 1995-11-16 | A colorimetric device for indicating carbon dioxide |
AU43579/96A AU695069B2 (en) | 1995-02-03 | 1995-11-16 | A colorimetric device for indicating carbon dioxide |
JP8523451A JPH10513264A (en) | 1995-02-03 | 1995-11-16 | Colorimetric device for indicating carbon dioxide |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9500400A SE504069C2 (en) | 1995-02-03 | 1995-02-03 | Colorimetric device for indicating carbon dioxide |
SE9500400-8 | 1995-02-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996024054A1 true WO1996024054A1 (en) | 1996-08-08 |
Family
ID=20397083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE1995/001363 WO1996024054A1 (en) | 1995-02-03 | 1995-11-16 | A colorimetric device for indicating carbon dioxide |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0807250A1 (en) |
JP (1) | JPH10513264A (en) |
AU (1) | AU695069B2 (en) |
SE (1) | SE504069C2 (en) |
WO (1) | WO1996024054A1 (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999009406A1 (en) * | 1997-08-18 | 1999-02-25 | Novartis Ag | Optical carbon dioxide sensors |
WO2000002844A1 (en) * | 1998-07-11 | 2000-01-20 | Sensormetrix International Limited | Quaternary ammonium salts, polymeric film containing them and colorimetric device |
WO2000002845A1 (en) * | 1998-07-11 | 2000-01-20 | Sensormetrix International Limited | Quaternary ammonium salts, polymeric film containing them and colorimetric device |
FR2782646A1 (en) | 1998-09-02 | 2000-03-03 | Smiths Industries Plc | BREATHING APPARATUS HAVING AN INDICATOR ASSEMBLY |
WO2001004624A1 (en) * | 1999-07-10 | 2001-01-18 | Sensormetrix International Limited | Carbon dioxide sensor |
US6436347B1 (en) * | 1999-01-21 | 2002-08-20 | Mincor Ab | Indicator device |
WO2008003928A1 (en) | 2006-07-04 | 2008-01-10 | Smiths Group Plc | Respiratory assembly including a carbon dioxide detector |
DE10031555B4 (en) * | 2000-06-28 | 2010-04-15 | Robert Bosch Gmbh | Optical sensor |
US7863459B2 (en) | 2005-12-16 | 2011-01-04 | Sun Chemical Corporation | Process for preparing onium salts |
US7992561B2 (en) | 2006-09-25 | 2011-08-09 | Nellcor Puritan Bennett Llc | Carbon dioxide-sensing airway products and technique for using the same |
US8396524B2 (en) | 2006-09-27 | 2013-03-12 | Covidien Lp | Medical sensor and technique for using the same |
US8420405B2 (en) | 2006-09-25 | 2013-04-16 | Covidien Lp | Carbon dioxide detector having borosilicate substrate |
US8431087B2 (en) | 2006-09-25 | 2013-04-30 | Covidien Lp | Carbon dioxide detector having borosilicate substrate |
US8431088B2 (en) | 2006-09-25 | 2013-04-30 | Covidien Lp | Carbon dioxide detector having borosilicate substrate |
US8449834B2 (en) | 2006-09-25 | 2013-05-28 | Covidien Lp | Carbon dioxide detector having borosilicate substrate |
EP2977755A1 (en) * | 2014-07-21 | 2016-01-27 | Samsung Electronics Co., Ltd. | Gas sensor and method of manufacturing the gas sensor |
US10175254B2 (en) | 2013-07-16 | 2019-01-08 | Palo Alto Health Sciences, Inc. | Methods and systems for quantitative colorimetric capnometry |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5124129A (en) * | 1988-07-29 | 1992-06-23 | Mallinckrodt Medical, Inc. | Carbon dioxide indicator |
US5279289A (en) * | 1991-10-15 | 1994-01-18 | Kirk Gilbert M | Resuscitator regulator with carbon dioxide detector |
-
1995
- 1995-02-03 SE SE9500400A patent/SE504069C2/en not_active IP Right Cessation
- 1995-11-16 JP JP8523451A patent/JPH10513264A/en active Pending
- 1995-11-16 WO PCT/SE1995/001363 patent/WO1996024054A1/en not_active Application Discontinuation
- 1995-11-16 AU AU43579/96A patent/AU695069B2/en not_active Ceased
- 1995-11-16 EP EP95942328A patent/EP0807250A1/en not_active Withdrawn
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5124129A (en) * | 1988-07-29 | 1992-06-23 | Mallinckrodt Medical, Inc. | Carbon dioxide indicator |
US5279289A (en) * | 1991-10-15 | 1994-01-18 | Kirk Gilbert M | Resuscitator regulator with carbon dioxide detector |
Cited By (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999009406A1 (en) * | 1997-08-18 | 1999-02-25 | Novartis Ag | Optical carbon dioxide sensors |
US6338822B1 (en) | 1997-08-18 | 2002-01-15 | Novartis Ag | Optical carbon dioxide sensors |
WO2000002844A1 (en) * | 1998-07-11 | 2000-01-20 | Sensormetrix International Limited | Quaternary ammonium salts, polymeric film containing them and colorimetric device |
WO2000002845A1 (en) * | 1998-07-11 | 2000-01-20 | Sensormetrix International Limited | Quaternary ammonium salts, polymeric film containing them and colorimetric device |
FR2782646A1 (en) | 1998-09-02 | 2000-03-03 | Smiths Industries Plc | BREATHING APPARATUS HAVING AN INDICATOR ASSEMBLY |
US6436347B1 (en) * | 1999-01-21 | 2002-08-20 | Mincor Ab | Indicator device |
WO2001004624A1 (en) * | 1999-07-10 | 2001-01-18 | Sensormetrix International Limited | Carbon dioxide sensor |
DE10031555B4 (en) * | 2000-06-28 | 2010-04-15 | Robert Bosch Gmbh | Optical sensor |
US7863459B2 (en) | 2005-12-16 | 2011-01-04 | Sun Chemical Corporation | Process for preparing onium salts |
WO2008003928A1 (en) | 2006-07-04 | 2008-01-10 | Smiths Group Plc | Respiratory assembly including a carbon dioxide detector |
US7992561B2 (en) | 2006-09-25 | 2011-08-09 | Nellcor Puritan Bennett Llc | Carbon dioxide-sensing airway products and technique for using the same |
US8109272B2 (en) | 2006-09-25 | 2012-02-07 | Nellcor Puritan Bennett Llc | Carbon dioxide-sensing airway products and technique for using the same |
US8128574B2 (en) | 2006-09-25 | 2012-03-06 | Nellcor Puritan Bennett Llc | Carbon dioxide-sensing airway products and technique for using the same |
US8420405B2 (en) | 2006-09-25 | 2013-04-16 | Covidien Lp | Carbon dioxide detector having borosilicate substrate |
US8431087B2 (en) | 2006-09-25 | 2013-04-30 | Covidien Lp | Carbon dioxide detector having borosilicate substrate |
US8431088B2 (en) | 2006-09-25 | 2013-04-30 | Covidien Lp | Carbon dioxide detector having borosilicate substrate |
US8449834B2 (en) | 2006-09-25 | 2013-05-28 | Covidien Lp | Carbon dioxide detector having borosilicate substrate |
US8454526B2 (en) | 2006-09-25 | 2013-06-04 | Covidien Lp | Carbon dioxide-sensing airway products and technique for using the same |
US8396524B2 (en) | 2006-09-27 | 2013-03-12 | Covidien Lp | Medical sensor and technique for using the same |
US10175254B2 (en) | 2013-07-16 | 2019-01-08 | Palo Alto Health Sciences, Inc. | Methods and systems for quantitative colorimetric capnometry |
US11538569B2 (en) | 2013-07-16 | 2022-12-27 | Freespira. Inc. | Methods and systems for quantitative colorimetric capnometry |
EP2977755A1 (en) * | 2014-07-21 | 2016-01-27 | Samsung Electronics Co., Ltd. | Gas sensor and method of manufacturing the gas sensor |
US9989474B2 (en) | 2014-07-21 | 2018-06-05 | Samsung Electronics Co., Ltd. | Gas sensor, refrigerator having the same, and method for manufacturing the gas sensor |
Also Published As
Publication number | Publication date |
---|---|
SE504069C2 (en) | 1996-10-28 |
AU695069B2 (en) | 1998-08-06 |
EP0807250A1 (en) | 1997-11-19 |
SE9500400L (en) | 1996-08-04 |
SE9500400D0 (en) | 1995-02-03 |
JPH10513264A (en) | 1998-12-15 |
AU4357996A (en) | 1996-08-21 |
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