WO1996027330A1 - Bone marrow biopsy needle - Google Patents

Bone marrow biopsy needle Download PDF

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Publication number
WO1996027330A1
WO1996027330A1 PCT/US1996/003111 US9603111W WO9627330A1 WO 1996027330 A1 WO1996027330 A1 WO 1996027330A1 US 9603111 W US9603111 W US 9603111W WO 9627330 A1 WO9627330 A1 WO 9627330A1
Authority
WO
WIPO (PCT)
Prior art keywords
bone marrow
pincers
outer tube
biopsy
tube member
Prior art date
Application number
PCT/US1996/003111
Other languages
French (fr)
Inventor
Alan Rubinstein
Andrew M. Olah
Emery Olah
Original Assignee
Rubinstein, Daniel, B.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rubinstein, Daniel, B. filed Critical Rubinstein, Daniel, B.
Priority to AU55235/96A priority Critical patent/AU5523596A/en
Priority to JP8527040A priority patent/JPH11501544A/en
Priority to EP96912407A priority patent/EP0813388A4/en
Publication of WO1996027330A1 publication Critical patent/WO1996027330A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/025—Pointed or sharp biopsy instruments for taking bone, bone marrow or cartilage samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/0266—Pointed or sharp biopsy instruments means for severing sample
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A61B10/0233—Pointed or sharp biopsy instruments
    • A61B10/025—Pointed or sharp biopsy instruments for taking bone, bone marrow or cartilage samples
    • A61B2010/0258—Marrow samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/320016—Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes
    • A61B2017/32004—Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes having a laterally movable cutting member at its most distal end which remains within the contours of said end

Definitions

  • the present invention relates to a bone marrow biopsy needle, and more particularly to a bone marrow biopsy needle having an improved mechanism for gripping and withdrawing a biopsy core from the body of the patient.
  • U.S. Serial No. 07/863,457 discloses in Figs. 5A-5E a bone marrow biopsy needle including an outer tube with an inwardly tapered distal end, and an inner tube with a pair of opposed blades hinged to the inner tube at its distal end.
  • the inner tube is slidable axially within the outer tube.
  • the taper at the distal end of the outer tube defines a dead space radially outward of the needle opening.
  • the blades have an open position in which they are contained within the dead space.
  • the outer tube is inserted into the bone being biopsied with the blades retracted into the dead space so as not to obstruct the entry of the biopsy into the space within the outer and inner tubes.
  • the outer tube is sharp, as is customary, so as to enter the bone easily.
  • the inner tube is pressed axially in the distal direction.
  • the blades engage the tapered end of the outer tube, which folds them radially inward on their hinges, simultaneously cutting off the biopsy core and retaining it in the needle.
  • a detent and blocking arrangement is provided for holding the inner and outer tubes in various relative positions.
  • the above-described needle is effective and greatly improves the ease and security of the bone marrow biopsy process, it would be desirable to make further improvements by reducing the number of moving parts and assembly steps required to manufacture the needle. More particularly, it would be desirable to simplify the hinge arrangement, as well as the detent and blocking arrangement.
  • a further advantage of the inventive needle is that it is more economical and simpler to manufacture than the prior needle.
  • a bone marrow biopsy needle may comprise an outer tube having a lumen extending therethrough, and a proximal end and a distal end with an opening at the distal end.
  • the lumen of the outer tube narrows at the opening at the distal end.
  • An inner tube is adapted to slide in the lumen of the outer tube.
  • the inner tube includes pincers at its distal end, which are used for receiving and grasping a biopsy core from bone marrow of a patient. As the pincers extend through the narrowed lumen at the distal end of the outer tube, the narrowed lumen causes the pincers to close and grasp, just forward of the distal end of the outer tube, a biopsy core of the bone marrow of a patient.
  • the pincers may have sharpened edges and/or the edges may be bent radially inwardly so as to enhance the cutting action of the pincers as they grasp a biopsy core from the bone marrow.
  • Fig. l is a plan view of an outer tube and a stylet which form part of the embodiment
  • Fig. 2 is a plan view, partly in cross-section, showing the stylet inserted into the outer tube;
  • Fig. 3 is a plan view of an inner tube which forms a further part of the embodiment
  • Fig. 4 is a side view of the inner tube
  • Fig. 5 is a plan view, partly in cross-section, showing the inner tube inserted into the outer tube;
  • Fig. 6 is a plan view of a push rod which forms a further part of the embodiment.
  • Fig. 7 is a plan view showing the push rod inserted into the inner tube.
  • Fig. l and 2 show an outer tube 10 and a stylet 20.
  • the outer tube 10 has a knurled control knob 12 at its proximal end and a taper 14 at its distal end.
  • the stylet 20 has a knurled control knob 22 with a locating pin 24 adapted for being inserted into a recess 16 in the control knob 12 to prevent relative movement during the stylet process.
  • the stylet 20 has a narrow portion 26 at its distal end with a bevelled chisel end 28 formed therein. As best seen in Fig. 2, when the stylet is fully inserted into outer tube, the narrow portion 26 is accommodated closely with a narrowed portion 18 of the lumen 17 of the outer tube, with the chisel end 28 slightly projecting out of the outer tube ID.
  • the stylet 20 also has a proximal end 29 which is sized for being closely accommodated within the proximal end of the outer tube. The close engagement of the stylet 20 and the outer tube 10 contributes to minimizing their relative movement during the stylet process.
  • the bevel angle of the chisel end 28 is advantageously similar to or the same as the taper angle of the taper 14 of the outer tube, in order to form a continuous or substantially continuous distal surface which is generally cone-shaped.
  • the cone-shaped distal surface enables the combination of the outer tube and the stylet to enter into the bone being biopsied with maximum smoothness and with the distal end being closed. If the surfaces of the taper 14 and the chisel end 28 did not substantially line up, the discontinuity between them would increase the difficulty of the needle entering the bone.
  • stylet 20 may be similar or identical to the stylet incorporated in the conventionally known Jamshidi Bone Marrow BX Needle.
  • the outer tube 10 and the stylet 20 are engaged as shown in Fig. 2 in order to be inserted into the bone.
  • the stylet 20 is withdrawn from outer tube 20, leaving the outer tube in the bone marrow.
  • the inner tube 30 is inserted into the outer tube 10 in order to take the bone marrow biopsy.
  • the inner tube 30 has a control knob 31 at a proximal end and a pair of pincers 32 at a distal end.
  • the pincers 32 shown in side view in Fig. 4, are substantially narrower than the rest of the inner tube 30, so as to be able to pass through the narrowed portion 18 of the outer tube 10.
  • the inner tube 30 has a hollow lumen 34 extending along its entire length, including through the control knob.
  • Fig. 5 shows the position of the inner tube 30 after being inserted into the outer tube 10.
  • the inner tube in this embodiment is long enough for the pincers to project out of the outer tube when the inner tube has been fully inserted into the outer tube.
  • the pincers 32 engage the narrowed portion 18 and are thereby urged radially inward and together, pinching off and grasping a sample of bone marrow just forward of the distal end of the outer tube.
  • the pincers 32 may have sharpened edges and/or their edges may be bent radially inwardly, so as to enhance the cutting action.
  • the pincers 32 may be two opposed blades which are tapered at their distal ends, i.e., tweezer- like in structure.
  • both the outer tube 10 and inner tube 30 may be rotated, i.e., 180° to 380°. This procedure, however, may not be necessary. Then the outer and inner tubes 10, 30 are withdrawn together from the bone, with the narrowed portion 18 continuing to hold the pincers 32 together in order to hold the sample during the process of withdrawal.
  • a push rod 40 shown in Fig. 6, may be employed as shown in Fig. 7 to expel the bone marrow sample distally out of the inner tube 30.
  • the push rod 40 is sized to closely fit the lumen of the inner tube 30, and may have a cone-like distal end to enhance displacement of a bone marrow sample from the inner tube 30.

Abstract

A bone marrow biopsy needle includes an outer tube (10) having a lumen extending therethrough which narrows (18) at the distal end of the outer tube (10). An inner tube (30) is slidable through the lumen of the outer tube (10) and includes a pair of pincers (32) at its distal end. As the inner tube (30) is slid through the lumen of the outer tube (10), the pincers (32) will encounter the narrowed portion (18) of the lumen, and as the pincers (32) extend beyond an opening at the distal end of the outer tube (10), the pincers (32) close upon themselves. In this manner, the pincers (32) can grasp a biopsy core from bone marrow of a patient. The pincers (32) may have sharpened edges and/or have their edges bent radially inwardly so as to enhance the cutting of the biopsy core from the bone marrow.

Description

BONE MARROW BIOPSY NEEDLE
BACKGROUND OF THE INVENTION
The present invention relates to a bone marrow biopsy needle, and more particularly to a bone marrow biopsy needle having an improved mechanism for gripping and withdrawing a biopsy core from the body of the patient.
U.S. Serial No. 07/863,457 discloses in Figs. 5A-5E a bone marrow biopsy needle including an outer tube with an inwardly tapered distal end, and an inner tube with a pair of opposed blades hinged to the inner tube at its distal end. The inner tube is slidable axially within the outer tube. The taper at the distal end of the outer tube defines a dead space radially outward of the needle opening. The blades have an open position in which they are contained within the dead space.
The outer tube is inserted into the bone being biopsied with the blades retracted into the dead space so as not to obstruct the entry of the biopsy into the space within the outer and inner tubes. The outer tube is sharp, as is customary, so as to enter the bone easily. Then, when the biopsy has entered the needle, the inner tube is pressed axially in the distal direction. The blades engage the tapered end of the outer tube, which folds them radially inward on their hinges, simultaneously cutting off the biopsy core and retaining it in the needle. A detent and blocking arrangement is provided for holding the inner and outer tubes in various relative positions.
Although the above-described needle is effective and greatly improves the ease and security of the bone marrow biopsy process, it would be desirable to make further improvements by reducing the number of moving parts and assembly steps required to manufacture the needle. More particularly, it would be desirable to simplify the hinge arrangement, as well as the detent and blocking arrangement.
SUMMARY OF THE INVENTION
It is accordingly an advantage of the present invention to provide a bone marrow biopsy needle which has fewer moving parts than the above-described prior needle.
A further advantage of the inventive needle is that it is more economical and simpler to manufacture than the prior needle.
According to a preferred embodiment of the invention, a bone marrow biopsy needle may comprise an outer tube having a lumen extending therethrough, and a proximal end and a distal end with an opening at the distal end. The lumen of the outer tube narrows at the opening at the distal end. An inner tube is adapted to slide in the lumen of the outer tube. The inner tube includes pincers at its distal end, which are used for receiving and grasping a biopsy core from bone marrow of a patient. As the pincers extend through the narrowed lumen at the distal end of the outer tube, the narrowed lumen causes the pincers to close and grasp, just forward of the distal end of the outer tube, a biopsy core of the bone marrow of a patient.
The pincers may have sharpened edges and/or the edges may be bent radially inwardly so as to enhance the cutting action of the pincers as they grasp a biopsy core from the bone marrow.
Other features and advantages of the present invention will become apparent from the following description of a preferred embodiment of the invention, with reference to the accompanying drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
Fig. l is a plan view of an outer tube and a stylet which form part of the embodiment;
Fig. 2 is a plan view, partly in cross-section, showing the stylet inserted into the outer tube;
Fig. 3 is a plan view of an inner tube which forms a further part of the embodiment;
Fig. 4 is a side view of the inner tube;
Fig. 5 is a plan view, partly in cross-section, showing the inner tube inserted into the outer tube;
Fig. 6 is a plan view of a push rod which forms a further part of the embodiment; and
Fig. 7 is a plan view showing the push rod inserted into the inner tube.
DETAILED DESCRIPTION OF THE EMBODIMENT
Fig. l and 2 show an outer tube 10 and a stylet 20. The outer tube 10 has a knurled control knob 12 at its proximal end and a taper 14 at its distal end. The stylet 20 has a knurled control knob 22 with a locating pin 24 adapted for being inserted into a recess 16 in the control knob 12 to prevent relative movement during the stylet process.
The stylet 20 has a narrow portion 26 at its distal end with a bevelled chisel end 28 formed therein. As best seen in Fig. 2, when the stylet is fully inserted into outer tube, the narrow portion 26 is accommodated closely with a narrowed portion 18 of the lumen 17 of the outer tube, with the chisel end 28 slightly projecting out of the outer tube ID. The stylet 20 also has a proximal end 29 which is sized for being closely accommodated within the proximal end of the outer tube. The close engagement of the stylet 20 and the outer tube 10 contributes to minimizing their relative movement during the stylet process.
The bevel angle of the chisel end 28 is advantageously similar to or the same as the taper angle of the taper 14 of the outer tube, in order to form a continuous or substantially continuous distal surface which is generally cone-shaped. The cone-shaped distal surface enables the combination of the outer tube and the stylet to enter into the bone being biopsied with maximum smoothness and with the distal end being closed. If the surfaces of the taper 14 and the chisel end 28 did not substantially line up, the discontinuity between them would increase the difficulty of the needle entering the bone.
It would be obvious to the skilled practitioner that other types of stylet can be used in carrying out the present invention. In particular, stylet 20 may be similar or identical to the stylet incorporated in the conventionally known Jamshidi Bone Marrow BX Needle. In use, the outer tube 10 and the stylet 20 are engaged as shown in Fig. 2 in order to be inserted into the bone. After the outer tube 10 and stylet 20 have been inserted into the bone marrow, the stylet 20 is withdrawn from outer tube 20, leaving the outer tube in the bone marrow. Next, the inner tube 30 is inserted into the outer tube 10 in order to take the bone marrow biopsy.
As seen in Fig. 3, the inner tube 30 has a control knob 31 at a proximal end and a pair of pincers 32 at a distal end. The pincers 32, shown in side view in Fig. 4, are substantially narrower than the rest of the inner tube 30, so as to be able to pass through the narrowed portion 18 of the outer tube 10. The inner tube 30 has a hollow lumen 34 extending along its entire length, including through the control knob.
Fig. 5 shows the position of the inner tube 30 after being inserted into the outer tube 10. As shown here, the inner tube in this embodiment is long enough for the pincers to project out of the outer tube when the inner tube has been fully inserted into the outer tube. As they are being inserted, the pincers 32 engage the narrowed portion 18 and are thereby urged radially inward and together, pinching off and grasping a sample of bone marrow just forward of the distal end of the outer tube. The pincers 32 may have sharpened edges and/or their edges may be bent radially inwardly, so as to enhance the cutting action. The pincers 32 may be two opposed blades which are tapered at their distal ends, i.e., tweezer- like in structure. To ensure cut-off from surrounding bone marrow, both the outer tube 10 and inner tube 30 may be rotated, i.e., 180° to 380°. This procedure, however, may not be necessary. Then the outer and inner tubes 10, 30 are withdrawn together from the bone, with the narrowed portion 18 continuing to hold the pincers 32 together in order to hold the sample during the process of withdrawal.
After withdrawal, if desired, a push rod 40, shown in Fig. 6, may be employed as shown in Fig. 7 to expel the bone marrow sample distally out of the inner tube 30. The push rod 40 is sized to closely fit the lumen of the inner tube 30, and may have a cone-like distal end to enhance displacement of a bone marrow sample from the inner tube 30.
Although a preferred embodiment has been described herein, many other variations and modifications and other uses will become apparent to those skilled in the art within the fair spirit and scope of the invention. The present invention, therefore, is not limited by the specific disclosure herein.

Claims

WHAT IS CLAIMED IS:
1. A bone marrow biopsy needle for removing bone marrow from a patient, comprising in combination: an outer tube member having a lumen therein, a proximal end and a distal end and an opening at said distal end, said lumen narrows at the opening; and an inner tube member adapted to be slidable in said lumen of said outer tube member, said inner tube member having pincers at a distal end thereof, which pincers being capable of being slidable in said outer tube member, said pincers capable of closing as it engages the narrowed lumen at said opening of said outer tube member, and thereby said pincers being adaptable to grasp a biopsy core when said needle being inserted into the bone marrow of a patient.
2. A bone marrow biopsy needle as in Claim 1, wherein said pincers include two opposed blades being tapered at their distal ends.
3. A bone marrow biopsy needle as in Claim 1, wherein said pincers being tweezer-like in structure.
4. A bone marrow biopsy needle as in Claim 1, wherein said pincers has sharp edges, and thereby being capable of enhancing the cutting of a biopsy core from the bone marrow of a patient.
5. A bone marrow biopsy need as in Claim 1, wherein said pincers have edges being bent radially inwardly, and thereby capable of enhancing the cutting of a biopsy core from the bone marrow of a patient.
6. A bone marrow biopsy needle as in Claim 1, wherein the distal end of said outer tube member being tapered.
7. A bone marrow biopsy need as in Claim 1, wherein said inner tube member and said pincers being unitary in structure.
8. A bone marrow biopsy needle as in Claim 1, wherein along an axis of the inner tube member, said pincers being narrower than the remaining portion of said inner tube member so as to be able to pass through the narrowed position of said lumen of said outer tube member.
9. A bone marrow biopsy needle as in Claim 1, wherein said inner tube member having a lumen therethrough.
10. A method of removing a biopsy core of a patient using said bone marrow biopsy needle of Claim 1, comprising the steps of: inserting said outer tube and said inner tube into a patient; grasping with said pincers of said inner tube a biopsy core of bone marrow; closing said pincers about said biopsy core of bone marrow by sliding said pincers through the narrowed lumen of said outer tube; and cutting off said biopsy core of bone marrow.
11. A method of removing a biopsy core of bone marrow as in Claim 10, further comprising the steps of: rotating said outer tube and said inner tube to ensure the cutting off of said biopsy core of bone marrow.
12. A bone marrow biopsy needle as in Claim 1, wherein said pincers are capable of closing as it extends from said opening of the outer tube member, and said pincers are capable of grasping a biopsy core forward of said distal end of said outer tube member.
PCT/US1996/003111 1995-03-08 1996-03-05 Bone marrow biopsy needle WO1996027330A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU55235/96A AU5523596A (en) 1995-03-08 1996-03-05 Bone marrow biopsy needle
JP8527040A JPH11501544A (en) 1995-03-08 1996-03-05 Bone marrow biopsy needle
EP96912407A EP0813388A4 (en) 1995-03-08 1996-03-05 Bone marrow biopsy needle

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/400,857 US5595186A (en) 1992-04-06 1995-03-08 Bone marrow biopsy needle
US08/400,857 1995-03-08

Publications (1)

Publication Number Publication Date
WO1996027330A1 true WO1996027330A1 (en) 1996-09-12

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/003111 WO1996027330A1 (en) 1995-03-08 1996-03-05 Bone marrow biopsy needle

Country Status (6)

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US (1) US5595186A (en)
EP (1) EP0813388A4 (en)
JP (1) JPH11501544A (en)
AU (1) AU5523596A (en)
CA (1) CA2214825A1 (en)
WO (1) WO1996027330A1 (en)

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EP0813388A4 (en) 1998-09-02
AU5523596A (en) 1996-09-23
JPH11501544A (en) 1999-02-09
US5595186A (en) 1997-01-21
CA2214825A1 (en) 1996-09-12
EP0813388A1 (en) 1997-12-29

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