WO1996028118A1 - Spinal fixation device - Google Patents
Spinal fixation device Download PDFInfo
- Publication number
- WO1996028118A1 WO1996028118A1 PCT/US1996/002629 US9602629W WO9628118A1 WO 1996028118 A1 WO1996028118 A1 WO 1996028118A1 US 9602629 W US9602629 W US 9602629W WO 9628118 A1 WO9628118 A1 WO 9628118A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- rod
- screws
- bone
- screw
- vertebrae
- Prior art date
Links
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 57
- 230000000087 stabilizing effect Effects 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims description 15
- 238000012937 correction Methods 0.000 claims description 6
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 230000004927 fusion Effects 0.000 claims description 3
- 208000010392 Bone Fractures Diseases 0.000 claims description 2
- 206010017076 Fracture Diseases 0.000 claims description 2
- 230000005856 abnormality Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000002271 resection Methods 0.000 claims 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 5
- 239000010936 titanium Substances 0.000 description 5
- 229910052719 titanium Inorganic materials 0.000 description 5
- 239000000919 ceramic Substances 0.000 description 4
- 210000000709 aorta Anatomy 0.000 description 3
- 238000005553 drilling Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
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- 208000032170 Congenital Abnormalities Diseases 0.000 description 2
- 206010061619 Deformity Diseases 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 230000036770 blood supply Effects 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 230000001009 osteoporotic effect Effects 0.000 description 2
- 206010039722 scoliosis Diseases 0.000 description 2
- 206010065687 Bone loss Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 201000009859 Osteochondrosis Diseases 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000008468 bone growth Effects 0.000 description 1
- 239000000316 bone substitute Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000001647 drug administration Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000007943 implant Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 238000010079 rubber tapping Methods 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 210000000626 ureter Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
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- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
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- A61B17/7074—Tools specially adapted for spinal fixation operations other than for bone removal or filler handling
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/0034—D-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0069—Three-dimensional shapes cylindrical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00179—Ceramics or ceramic-like structures
Definitions
- This invention relates to a device for fixing adjacent vertebrae to each other using a rod and unique hollow screws.
- Fixation (or fusion) of vertebral columns with bone material or rods and plates is a common, long practiced surgical method for treating a variety of conditions.
- Many of the existing procedures involve components that protrude outwardly that may contact and damage a body part, such as the aorta, the vena cava, the sympathetic nerves, the intestine and the ureter.
- many constructions involve components that may loosen and cause undesirable problems.
- a Dunn device was on the market until pulled by the U.S. Food & Drug Administration because of problems with delayed rupture of the aorta secondary to the device being so bulky as to contact the aorta, erode its surface and lead to fatal hemorrhage in several cases.
- U.S. Patent 5,152,303 issued to Allen on October 6, 1992 relates to an anterolateral spinal fixation system including a cannulated screw threaded into a vertebra and a rod attached to the screw. The process involves threading the cannulated screw into a pilot hole drilled into the vertebral body portion and fastening a rod at its lower and upper ends to the vertebral body by the cannulated screws.
- U.S. Patent 4,059, 115 issued to Jumashev et al. on November 22, 1977 relates to a surgical instrument for operation of anterior fenestrated spondylodesis in vertebral osteochondrosis.
- the instrument includes a hollow cylindrical cutter with a cutting edge, and a handle. By rotation of the handle accompanied with slight pressure the cutter is worked into the bodies of the adjacent vertebras (abstract, Col. 6, lines 56-58).
- U.S. Patent 5,015,247 issued to Michelson on May 14, 1991 relates to a method of performing internal stabilization of a spine.
- the method involves seating a drill sleeve into the two vertebrae and drilling the vertebrae with the drill installed through the drill sleeve. Bagby 4,501 ,269 is mentioned. (Col. 6, lines 27-30, Col. 7, line 68, Col. 9, lines 22-25, 39).
- Current devices have substantial deficiencies when osteoporotic bone is encountered.
- the soft, decalcified bone in such patients has poor pull-out strength for screws. Bone screws are known to have very little holding power in osteoporotic bone and loosen readily, severely limiting the holding power and fixation ability of current devices.
- the invention provides a method and device for fixing two or more vertebrae.
- the process is elegantly simple and solves many of the problems attendant with previous devices.
- Each vertebra to be joined is prepared by forming a partial annular cut, as by a hole saw, preferably leaving the core plug of bone in place.
- a hollow screw is threaded into the annular ring recess thus formed.
- a channel is cut in the vertebral bone between each of the screws to accommodate a rod that is placed over each screw.
- a locking cap over each screw secures the rod to the screws and thereby fixes the spine as desired.
- the method and device provide many advantages.
- the hollow screws are exceptionally strong, having greater holding surface area than conventional solid screws.
- the rod is held in the screw between two widely spaced slots.
- the rod is also held firmly by a third point by a dimple on the locking cap.
- the rod is secured to the screws by at least three points of fixation over a much greater distance than traditional systems. This provides a linkage which is significantly greater in terms of mechanical stability over the prior art.
- the rod By varying the cross-section geometric structure and diameter of the rod, various degrees of stiffness may be imparted. Also, by varying the geometric cross-section structure of the rod, stiffness may be imparted selectively in the appropriate plane of motion. For instance, if increased flexion-extension stability is desired, the rod can be oriented in the flexion-extension plane and elongated such that it will provide greater stiffness in flexion-extension than in lateral bending. Such a feature will allow the surgeon to define the plane of stiffness necessary to match the pathology encountered.
- the rods within the cut channels avoid the cantilever effect of prior art devices where the load is carried far from the center of the spine. Thus, the rod acts more like an intramedullary rod in the vertebrae. This is far preferable in that a rod nearer the center of the axis of rotation does not have the cantilever effect of prior art systems. This also presents no protrusions that may abut against vital body components.
- the process is very simple, requiring only the drilling of a single hole saw cut in each vertebra, formation of channels therebetween and installation of the hollow screws, placement of the rod and securement with the locking caps.
- FIG. 1 is a perspective view of the device of the invention securing vertebrae together;
- FIG. 2 is an exploded view of the rod, screw, cap and prepared vertebrae;
- FIG. 3 is a cross-sectional view taken through line 3-3 of Fig. 1;
- FIG. 4 is a cross-sectional view taken through line 4-4 of Fig. 3;
- FIG. 5a is a cross-sectional view taken through line 5-5 of Fig. 4 showing the rod in cross-section;
- FIG. 5b is a cross-sectional view taken through line 5-5 of Fig. 4 showing an alternate rod in cross-section
- FIG. 5c is a cross-sectional view taken through line 5-5 of Fig. 4 showing an alternate rod in cross-section
- FIG. 5d is a cross-sectional view taken through line 5-5 of Fig. 4 showing an alternate rod in cross-section;
- FIG. 5e is a cross-sectional view taken through line 5-5 of Fig. 4 showing an alternate rod in cross-section;
- FIG. 6 is a cross-sectional view similar to Fig. 3 with an overcap design
- FIG. 7 is an end view of a corpectomy block partially cut away
- FIG. 8 is a tool for threading in the device into the annular ring recess in the ve ⁇ ebral body
- FIG. 9 is a perspective view of the corpectomy block of Fig. 7;
- FIG. 10 is a perspective view of a wedge placable between adjacent ve ⁇ ebrae
- FIG. 11 is a cross-sectional view of the wedge of FIG. 10 through line 11-11 ;
- FIG. 12 is a cross-sectional view of the wedge of FIG. 10 through line
- FIG. 13 is an alternative wedge in which a top is not planar:
- FIG. 14 shows a section of a spinal column in need of realignment;
- FIG. 15 shows the spinal column of FIG. 14 with a correcting wedge in place;
- FIG. 16 shows a spinal column in need of alignment, such as in scoliosis.
- FIG. 17 shows the spinal column of FIG. 16 in cross-section, realigned with a correcting wedge.
- an anterior spinal fixation system 10 may join adjacent ve ⁇ ebrae together.
- the system includes an elongated rod 12 and at least two hollow cylindrical screws 14.
- Each screw 14 includes external bone engaging threads 16, internal cap engaging threads 28, an upper rim 18 and a lower rim 20.
- the internal threads 28 need only be as deep as the locking cap.
- a smooth inner wall is preferred to avoid placing torque on the remaining bone core during inse ⁇ ion of the screw.
- upper rim 18 is broken by two opposing rod fixation slots 22, 24 that are sized such that rod 12 may pass into the slots 22, 24 as shown.
- the screws 14 include a plurality of bone ingrowth openings 36 through the side walls which allow bone to grow therethrough.
- locking cap 26 may be disc-shaped, having threads 30 about the circular periphery.
- Top 32 of the cap 26 may have a pair of spaced holes 34 to which a tool (not shown) may connect to inse ⁇ said cap 26 into a hollow, threaded screw 14.
- Cap 26 may be threaded into said screw 14 such that no pan of said cap projects beyond the screw 14.
- the cap may be porous and may have holes to allow bone ingrowth and increase the blood supply to the interior.
- the cap may be designed as an overcap 72 which engages with threads 74 on the outer surface of the bone screw 14.
- overcap 72 includes a cap projection 42 which abuts against rod 12.
- some bone may be removed to accommodate the overcap as shown.
- Rod 12 is preferably made of a biocompatible, malleable metal such as titanium.
- a rod of titanium has an advantage of having a modulus of elasticity similar to natural bone. In any case, the rod is bent by the surgeon to attain the correct configuration desired for the patient.
- the rod 12 may have a plurality of spaced dimples 40 which may be round or elongated. The dimples 40 interface with a mating projection 42. In the case of a round dimple 40, the projection 42 engagement serves to prevent slippage of the rod relative to the screw 14. An elongated dimple 40 allows limited slippage which is sometimes desirable.
- Figures 5a-e show that the cross-section of rod 12 may be nearly any shape other than round. Although a round cross-section rod would work, any non-
- S B round rod provides better torsion control.
- the size of the rod may be selected depending on the individual patient's size. As stated previously, the cross-sectional shape of the rod may be altered to provide stability in the proper axis of motion for a particular patient.
- Installation of the device is straight forward.
- the surgeon exposes the vertebra 46 anteriorly and drills a cylindrical opening 50 in the vertebral bone as shown in Figure 2.
- a hole saw is used to form the opening 50, since a hole saw will leave the core 52 in place.
- Figure 2 does not show a bone core 52, although the bone core 52 is shown in Figs. 3 and 4. If a bone core 52 is not left in place, the opening may be packed with bone or bone substitute.
- the bone opening 50 may be threaded if the drill used is self-tapping or it may be tapped by an additional tool used after drilling.
- the implant screws 14 are slightly larger in external diameter than the external diameter of the hole saw cut, thus providing a high friction secure linkage to the vertebral body.
- This also provides a screw with an internal diameter slightly larger than the outer diameter of the bone core, thus reducing the possibility of torquing the core during placement of the screw. Torquing the core in the process of insertion may destroy the blood supply to the core at its posterior surface. This would be undesirable since it may lead to delayed incorporation of the bone locking ability through the holes in the screw.
- a bone screw 14 of the device may also be possible to use a bone screw 14 of the device to cut its own opening 50. In such a case, the screw 14 is then left in place after fully inserted. Each of the vertebra adjacent another bone opening 50 is then cut, as by a chisel or router tool, to form a channel 54 of a depth to hold at least half the diameter of the rod 12.
- a chisel or router tool to form a channel 54 of a depth to hold at least half the diameter of the rod 12.
- the bone screws 14 are then screwed into the bone openings 50 with threads 28, 16 on the interior and exterior of the bone screws 14 engaging vertebral bone.
- the screws are positioned such that the rod fixation slots 22, 24 line up with the bone channels 54.
- a tool 58 as shown in Fig. 8 may be used to screw the bone screws 14 into bone openings 50.
- tool 58 includes a shaft 60 with a handle 62 on one end a screw engaging head 64 on the other end. The screw engaging head
- SUBSTTTUTE SHEET RULE 26 64 includes a pair of tabs 66, 68 that engage with slots 22, 24.
- the head 64 closely fits into the interior of the screw 14. No part of tool 58 projects beyond the outer circumference of the bone screws 14.
- a rod 12 of the required length is then bent to the required shape and inserted into each screw via the rod fixation slots 22, 24 and into the formed bone channels 54.
- the rod 12 may be removed to adjust the curvature of the spine that will be defined by the installed system as needed. Once the degree of correction has been achieved, the rod is captively held in place by securing a locking cap 26 over each screw 14 thereby trapping the rod 12 in place.
- the bone screws 14 are preferably placed into the vertebral bone quite deep, leaving a safety zone of about 3mm. Depending on the size of the vertebrae, the screw diameters may range from 1.5 to 3.5cm. Preferably, the diameter of the screws 14 is sufficient to cut into the harder, outer bone of the vertebra.
- the screws 14 may have a relatively thin cylindrical wall and still provide great strength and holding power.
- the installed system of the invention provides a spinal correction with many important advantages. Since the cylindrical screws have far greater surface area than a conventional solid screw, the holding power is much higher. The installed system is entirely contained within the confines of the vertebral bone. None projects outwardly that may contact adjacent body structures. The rod 12 is much closer to the center of the vertebra meaning that undesirable cantilever effects as in the prior art devices is greatly reduced.
- the system of the invention may be used to stabilize many or only two vertebrae. It may be used to provide corrections due to tumor, fracture, degenerative disease, deformity or infection.
- the non-round rod used in most cases provides longitudinal rotational control. The normal healing process of the body will cause bone growth around the screws, rods and caps to lock the system even more securely to the vertebra.
- the screws 14 may include perforations throughout the length of the cylinder to allow bone ingrowth which may increase holding power.
- Figures 1 , 7 and 9 show that the invention may be used between two or more adjacent vertebrae and may be used in conjunction with a corpectomy block 80 which functions as a spacer for a removed vertebral body.
- a corpectomy block 80 is used when a large portion of the vertebral body has been removed, such as to remove tumor, fractured bone or in cases of massive bone loss. Most of the vertebra is removed anteriorly forming a gap between the remaining vertebrae.
- the usual prior art solution is to provide a number of fill plates with rods or a large ceramic block anchored with plates and conventional screws.
- U.S. Patent 5,192,327 shows a suitable corpectomy block which merely needs to be designed with a slot through which the rod 12 may pass.
- corpectomy block 80 is shown in which the block is substantially hollow and is formed from a body compatible material such as titanium or ceramic.
- the block may be porous or at least roughened at the ends to allow bone ingrowth.
- a fill port 82 may be built into the block 80 to allow addition of bone graft.
- the block 80 includes a lengthwise slot 84 through which rod 12 may pass.
- a block 80 of the appropriate size is fitted between the remaining vertebrae after re-section and is filled with bone graft.
- the rod 12 is placed through the slot 84 and is tightened at each bone screw 14 by end caps 26 or 72. This firmly holds the corpectomy block 80 in place to allow bone fusion to the adjacent vertebrae as shown in Figure 1.
- the block should allow for vascular ingrowth by having at least porous end plates 86, 88.
- the block 80 may be porous titanium or a ceramic with roughened end plates.
- Figure 1 shows that the invention will function even if one or more vertebra are resected and replaced with a corpectomy block.
- the hollow screws 14 provide greater holding power and allow for an intramedullary rod that eliminates the cantilevered structures found in prior art pedicle screw systems such as in U.S. Patent 5,324,290 that issued June 28, 1994.
- the present invention directs the forces from nearer the center of the vertebrae and therefor the axis of forces and motion.
- the spinal column is in need of realigning, front to back, side to side, or both.
- Figures 10 through 17 show means of correcting alignment while using the spinal fixation device 10 of the invention.
- wedges are shown which may be inserted between the vertebrae in place of a removed disc.
- the wedge 90 of Figs. 10-12 may be a solid block of ceramic, may be a titanium wedge or any other body implantable material that could replace a disc.
- the anterior side 92 of wedge 90 is higher than the posterior edge 94.
- a slot 96 is formed to allow the rod 12 to pass thereby.
- the wedge 100 of FIG. 12 includes a similarly formed body, includes a slot 96 but no directional wedge. Rather, a surface 102 of wedge 100 is rounded or otherwise non-planar. In this manner, wedge 100 with surface 102 against a vertebra may allow rotational or angular correction of deformity. Wedges 100 may be inserted to replace the disc, forming a clamshell appearance in which both adjacent vertebrae would rest against a rounded surface 102.
- FIGS. 14 through 17 show how a wedge of the invention may be used to correct a defect of the spinal alignment.
- a spinal column consisting of vertebra 104, 106 is out of alignment with the spine pitched forwardly.
- each vertebra includes a screw 14, rod 12 and a wedge 90 which, oy virtue of its greater anterior height, corrects the alignment.
- This procedure may be used instead of bending rod 12 to obtain similar results, or in conjunction with a bent rod.
- FIGS. 16 and 17 show a typical scoliosis of the spine in which a corrective wedge 90 is slipped in from the side such that the thickest portion of the wedge 90 is to a side, thereby correcting the curvature.
- the wedge is inserted into position, the vertebrae are allowed to contact the wedge and the locking caps 26 are screwed into engage with the rod 12 and keep the entire structure as desired.
- the invention may be used anteriorly, anterior-laterally and laterally depending on the needs of the patient.
- the drawings show the anterior use of the bone screws as one possible position.
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU9801325A HU219422B (en) | 1995-03-15 | 1996-02-27 | Spinal fixation device |
AU49972/96A AU689713C (en) | 1995-03-15 | 1996-02-27 | Spinal fixation device |
JP52763796A JP3303976B2 (en) | 1995-03-15 | 1996-02-27 | Spinal fixation device |
DE69625339T DE69625339T2 (en) | 1995-03-15 | 1996-02-27 | SPINE-FIXATION DEVICE |
EP96906647A EP0814732B1 (en) | 1995-03-15 | 1996-02-27 | Spinal fixation device |
AT96906647T ATE229309T1 (en) | 1995-03-15 | 1996-02-27 | SPINAL FIXATION DEVICE |
CA002214509A CA2214509C (en) | 1995-03-15 | 1996-02-27 | Spinal fixation device |
NZ303609A NZ303609A (en) | 1995-03-15 | 1996-02-27 | Surgically implantable system comprising a pair of externally threaded cylindrical members with slots for a rod, and a locking cap |
MXPA/A/1997/007030A MXPA97007030A (en) | 1995-03-15 | 1997-09-12 | Espi fixing device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/404,236 US5591235A (en) | 1995-03-15 | 1995-03-15 | Spinal fixation device |
US08/404,236 | 1995-03-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996028118A1 true WO1996028118A1 (en) | 1996-09-19 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/002629 WO1996028118A1 (en) | 1995-03-15 | 1996-02-27 | Spinal fixation device |
Country Status (11)
Country | Link |
---|---|
US (2) | US5591235A (en) |
EP (1) | EP0814732B1 (en) |
JP (1) | JP3303976B2 (en) |
KR (1) | KR100230605B1 (en) |
AT (1) | ATE229309T1 (en) |
CA (1) | CA2214509C (en) |
DE (1) | DE69625339T2 (en) |
ES (1) | ES2191089T3 (en) |
HU (1) | HU219422B (en) |
NZ (1) | NZ303609A (en) |
WO (1) | WO1996028118A1 (en) |
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Also Published As
Publication number | Publication date |
---|---|
EP0814732A1 (en) | 1998-01-07 |
DE69625339T2 (en) | 2003-10-16 |
KR100230605B1 (en) | 1999-11-15 |
ATE229309T1 (en) | 2002-12-15 |
HUP9801325A3 (en) | 2000-03-28 |
JP3303976B2 (en) | 2002-07-22 |
DE69625339D1 (en) | 2003-01-23 |
KR19980703020A (en) | 1998-09-05 |
ES2191089T3 (en) | 2003-09-01 |
AU4997296A (en) | 1996-10-02 |
CA2214509A1 (en) | 1996-09-19 |
EP0814732B1 (en) | 2002-12-11 |
JPH11502437A (en) | 1999-03-02 |
CA2214509C (en) | 2001-07-24 |
MX9707030A (en) | 1997-11-29 |
HUP9801325A2 (en) | 1998-09-28 |
NZ303609A (en) | 1998-09-24 |
AU689713B2 (en) | 1998-04-02 |
US5591235A (en) | 1997-01-07 |
EP0814732A4 (en) | 1998-09-16 |
HU219422B (en) | 2001-04-28 |
USRE37479E1 (en) | 2001-12-18 |
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