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Patentes

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Número de publicaciónWO1996031206 A3
Tipo de publicaciónSolicitud
Número de solicitudPCT/US1996/004028
Fecha de publicación12 Dic 1996
Fecha de presentación25 Mar 1996
Fecha de prioridad7 Abr 1995
También publicado comoWO1996031206A2
Número de publicaciónPCT/1996/4028, PCT/US/1996/004028, PCT/US/1996/04028, PCT/US/96/004028, PCT/US/96/04028, PCT/US1996/004028, PCT/US1996/04028, PCT/US1996004028, PCT/US199604028, PCT/US96/004028, PCT/US96/04028, PCT/US96004028, PCT/US9604028, WO 1996/031206 A3, WO 1996031206 A3, WO 1996031206A3, WO 9631206 A3, WO 9631206A3, WO-A3-1996031206, WO-A3-9631206, WO1996/031206A3, WO1996031206 A3, WO1996031206A3, WO9631206 A3, WO9631206A3
InventoresUday Saxena, Bharat Kalidas Trivedi
SolicitanteWarner Lambert Co
Exportar citaBiBTeX, EndNote, RefMan
Enlaces externos:  Patentscope, Espacenet
Flavones and coumarins as agents for the treatment of atherosclerosis
WO 1996031206 A3
Resumen
Flavones and coumarins or a pharmaceutically acceptable salt thereof are inhibitors of VCAM-1 and ICAM-1 and are thus useful in the treatment of atherosclerosis, restenosis, and immune disorders such as arthritis and transplant rejection.
Citas de patentes
Patente citada Fecha de presentación Fecha de publicación Solicitante Título
DE3601417A1 *20 Ene 198623 Jul 1987Nattermann A & Cie2'-Alkyl(alkenyl)-substituted quercetins
EP0347864A2 *20 Jun 198927 Dic 1989Andries Johannes Cornelus StrydomAnti-atherogenic agents
EP0564350A1 *30 Mar 19936 Oct 1993Adir Et Compagnie3',5'-ditertbutyl-4'-hydroxyflavones, method for their preparation and pharmaceutical compositions with an antioxidant and antivasoconstricting activity
EP0633022A2 *27 Jun 199411 Ene 1995Kureha Chemical Industry Co., Ltd.Chondroprotective flavones
FR2244493A1 * Título no disponible
GB1175808A * Título no disponible
US5242397 *2 Ene 19927 Sep 1993Cedars-Sinai Medical CenterCatheter device and method of use for intramural delivery of protein kinase C and tyrosine protein kinase inhibitors to prevent restenosis after balloon angioplasty
Otras citas
Referencia
1 *A. DE NEELING: "Coumarine bij atherosclerose", NED. TIJDSCHR. GENEESKD., vol. 119, no. 117, 26 April 1975 (1975-04-26), pages 673 - 677, XP000575659
2 *Conference on "Molecular and Clinical Implications for Allergy in the 21st Century" in Nantucket, Massachusetts September 25-29, 1994
3 *E. MIDDLETON ET AL.: "Quercetin inhibits lipopolysaccharide-induced expression of endothelial cell intracellular adhesion molecule-1", INT. ARCH. ALLERGY IMMUNOL., vol. 107, no. 1-3, 13 July 1995 (1995-07-13), pages 435 - 436, XP000576204
4 *E. SEMPINSKA ET AL.: "Effect of flavonoids on the platelet adhesivness in repeatedly bred rats", POL. J. PHARMACOL. PHARM., vol. 29, no. 1, 1977, pages 7 - 10, XP000575657
5 *H.K. NIEUWENHUIS ET AL.: "Agents interfering with the platelet-vessel wall interaction", PHARM. WEEKBL. SCI., vol. 6, no. 1, 24 February 1984 (1984-02-24), pages 27 - 31, XP000575665
6 *M.E. GERRITSEN ET AL.: "Flavonoids inhibit cytokine.induced endothelial cell adhesion protein gene expression", AM. J. PATHOLOGY, vol. 147, no. 2, 2 August 1995 (1995-08-02), pages 278 - 292, XP000575649
7 *S. TRANCHINA ET AL.: "Inhibition of human monocyte adhesion to endothelial cells by the coumarin derivative, chloricromene", BR. J. PHARMACOL., vol. 111, no. 2, 1994, pages 578 - 581, XP000575658
Citada por
Patente citante Fecha de presentación Fecha de publicación Solicitante Título
US888969823 Sep 201118 Nov 2014Resverlogix Corp.Compounds for the prevention and treatment of cardiovascular diseases
Clasificaciones
Clasificación internacionalA61K31/37, A61K31/352
Clasificación cooperativaA61K31/37, A61K31/352
Clasificación europeaA61K31/37, A61K31/352
Eventos legales
FechaCódigoEventoDescripción
10 Oct 1996ALDesignated countries for regional patents
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12 Dic 1996ALDesignated countries for regional patents
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12 Dic 1996DFPERequest for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
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19 Ago 1998122Ep: pct application non-entry in european phase
7 Oct 1998NENPNon-entry into the national phase in:
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