WO1996032923A2 - Agents antisudoraux - Google Patents

Agents antisudoraux Download PDF

Info

Publication number
WO1996032923A2
WO1996032923A2 PCT/EP1996/001511 EP9601511W WO9632923A2 WO 1996032923 A2 WO1996032923 A2 WO 1996032923A2 EP 9601511 W EP9601511 W EP 9601511W WO 9632923 A2 WO9632923 A2 WO 9632923A2
Authority
WO
WIPO (PCT)
Prior art keywords
weight
water
oil component
oil
antiperspirant
Prior art date
Application number
PCT/EP1996/001511
Other languages
German (de)
English (en)
Other versions
WO1996032923A3 (fr
Inventor
Holger Tesmann
Heike Thomas
Armin Wadle
Thomas Förster
Marcus Claas
Bernhard Banowski
Claudia Weiler
Marion Zinken
Original Assignee
Henkel Kommanditgesellschaft Auf Aktien
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Henkel Kommanditgesellschaft Auf Aktien filed Critical Henkel Kommanditgesellschaft Auf Aktien
Priority to AU55001/96A priority Critical patent/AU5500196A/en
Publication of WO1996032923A2 publication Critical patent/WO1996032923A2/fr
Publication of WO1996032923A3 publication Critical patent/WO1996032923A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/062—Oil-in-water emulsions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/21—Emulsions characterized by droplet sizes below 1 micron
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm

Definitions

  • the invention relates to antiperspirants based on a very finely divided, almost transparent oil-in-water emulsion of a cosmetic oil component and an inorganic, astringent deodorant active ingredient which is soluble in the aqueous phase.
  • the task was to improve the antiperspirants in their skin and mucous membrane compatibility by using an emulsion as a carrier for the astringent active ingredients, the oil components of which have a softening and anti-inflammatory effect on the skin. effect.
  • the problem mainly consisted in the fact that conventional oil-in-water emulsions are not sufficiently stable in the presence of the inorganic active substances.
  • the invention relates to an antiperspirant in the form of a finely divided oil-in-water emulsion with a droplet diameter of 100-300 nm and a content of 40-80% by weight of water and
  • Such antiperspirant formulations according to the invention are notable for the fact that the astringent active ingredients are well tolerated even when used regularly on the skin.
  • oil-in-water emulsions are known which were prepared with a combination of nonionic emulsifiers and coemulsifiers and were heated to phase inversion temperature during or after their preparation.
  • Such emulsions are characterized by high stability, fine particle size and particularly low viscosity.
  • DE 38 19 193 discloses an emulsifier system which enables the production of such emulsions even with polar oils which contain little or no hydrocarbon content.
  • PIT emulsions - The droplet diameter of such fine-particle emulsions - hereinafter referred to as PIT emulsions - is of the order of 100-300 nanometers (nm), i.e. they are not yet optically isotropic, single-phase systems such as are found in solubilizates and microemulsions, the particle diameter of which is far below 100 nm.
  • the PIT emulsions have a brown-red appearance when viewed through and bluish shimmering in reflected light, which is explained by the Tynda11 scattering on the emulsion droplets.
  • Particularly suitable as water-soluble, inorganic, astringent antiperspirant active ingredients (A) are salts of aluminum, Zi onium or zinc.
  • Such suitable antiperspirant active ingredients are, for example, aluminum chloride, aluminum chlorohydrate, aluminum dichlorohydrate, aluminum sesquichlorohydrate and their complex compounds with propylene glycol 1,2.
  • salts are understood to be water-soluble if they are at least 1% by weight soluble in water at 20 ° C.
  • All water-insoluble, skin-compatible oils and fatty substances and their mixtures with solid paraffins and waxes are suitable as cosmetic oil components.
  • the melting point of the mixtures with solid paraffins and waxes which may be used should be as far as possible below the phase inversion range of the emulsion and preferably below 40 ° C.
  • Suitable skin-compatible oil components (B) are preferably still liquid hydrocarbons at 20 ° C., for example paraffin oils and synthetic hydrocarbons such as 1,3-di- (2-ethylhexyl) cyclohexane (cetiol ( R ) s).
  • Another particularly suitable oil component are the di-n-alkyl ethers such as di-n-octyl ether, di- (2-ethylhexyl) ether, lauryl methyl ether or octyl butyl ether.
  • a particularly versatile group of cosmetic oil components is that of the fatty acid and Fettalkoholester, for example isopropyl myristate, n-butyl stearate, 2-ethylhexyl caprylate, cetyl oleate, glycerol trica- prylat, Kokosfettalkohol- (Ci2 _ CISS) -caprylat- / caprate and other .
  • Also suitable are naturally occurring ester oils such as jojoba oil or liquid vegetable triglyceride oils such as olive oil, sunflower oil, soybean oil, rapeseed oil, almond oil, the liquid portions of coconut oil or beef tallow and synthetic triglceride oils.
  • Suitable dicarboxylic acid esters (II) are, for example, di-n-butyl adipate, di-n-butyl sebacate, di- (2-ethylhexyl) adipate, di- (2-hexyldecyl) succinate and di-isotridecylfugate.
  • Suitable diol esters (III) are, for example, ethylene glycol dioleate, ethylene glycol di-isotridecanoate, propylene glycol di (2-ethylhexanoate), propylene glycol di-isostearate, propylene glycol di-pelargonate, butanediol di-isostearate and neopentyl glycol - di-caprylate.
  • the PIT emulsions contain a combination of a hydrophobic, nonionic emulsifier (C) with an HLB value of preferably 10-15 and a lipophilic coe ulgator (D).
  • C hydrophobic, nonionic emulsifier
  • D lipophilic coe ulgator
  • L is the weight percentage l (in%) of the lipophilic groups, e.g. is the fatty alkyl or fatty acyl groups in the emulsifier.
  • the hydrophilic emulsifiers (C) are preferably ethylene oxide adducts on fatty alcohols with 16-22 C atoms or on partial esters of polyols with 3-6 C atoms and fatty acids with 14-22 C atoms.
  • ethylene oxide addition products on fatty acids, on alkyl glucosides, on methyl glucoside fatty acid esters, on fatty acid alkanolamides, on fatty acid glucamides and other fatty substances with ethoxylatable substituents are also suitable.
  • alkyl polyglycosides of the formula R0 - (Z) x as hydrophilic emulsifiers, in which R is a C ⁇ -C22-alkyl or alkenyl radical, Z is a monosaccharide, in particular glucose, and x is sen degree of oligomerization represents a number from 1.1 to 5, in particular from 1.2 to 1.4.
  • the lipophilic co-emulsifiers (D) are preferably saturated fatty alcohols with 16-22 C atoms, partial esters of polyols with 3-6 C atoms with saturated fatty acids with 14-22 C atoms, free fatty acids with 16- 22 carbon atoms, to glycol ono fatty acid esters, to fatty acid alkanolamides from Ci2-Cl8 ⁇ ⁇ et-t'aur '-' t mono- or dialkanolamines with 2 - 4 carbon atoms in the alkanol group or to glycerol mono-fatty alcohol ether.
  • the antiperspirant preparations according to the invention preferably additionally comprise 1 to 20% by weight of a water-soluble polyol having 2 to 8 carbon atoms and 2 to 6 hydroxyl groups.
  • a water-soluble polyol having 2 to 8 carbon atoms and 2 to 6 hydroxyl groups.
  • suitable polyols are e.g. Ethylene glycol, 1,2-propylene glycol, glycerin, erythritol, trimethylolpropane, sorbitol or methyl glucoside.
  • polyethylene glycols or adducts of ethylene oxide with such polyols can also be used.
  • oil-soluble and water-soluble auxiliaries can be present in smaller amounts in the antiperspirants according to the invention.
  • oil soluble aids can e.g. his
  • water-soluble additives are e.g. Preservatives, water-soluble fragrances, pH adjusting agents, e.g. Buffer mixtures, water soluble thickeners, e.g. water-soluble natural or synthetic polymers such as e.g. Xanthan gum, hydroxyethyl cellulose, polyvinyl pyrrolidone or high molecular weight polyethylene oxides.
  • the mixture of oil component (B), emulsifier (C) and coemulsifier (D) is emulsified at a temperature above the melting point of this mixture with at least 1 part by weight of water (based on 1 part by weight of the oil component (B)), where the emulsion is heated during its production or thereafter to a temperature within or above the phase inversion temperature range and then cooled to a temperature below the phase inversion temperature range and optionally further diluted with water, and the deodorant active ingredient (D) , optionally in the form of an aqueous solution and optionally further water-soluble components.
  • the process according to the invention can be carried out by first determining the phase inversion temperature by heating a sample of the emulsion prepared in the customary manner using a conductivity meter and determining the temperature at which the Conductivity decreases sharply.
  • the decrease in the specific conductivity of the oil-in-water emulsion initially present usually takes place over a temperature range from 2 to 8 ° C. from initially over 1 millisiemens per cm (mS / cm) to values below 0.1 mS / cm from. This temperature range is referred to as the phase inversion temperature range. ⁇
  • the process according to the invention can either be carried out by subsequently heating the emulsion initially prepared in the customary manner to a temperature which is within or above the phase inversion temperature range, or in such a way that that a temperature which is within or above the phase inversion temperature range is already selected during the preparation of the emulsion.
  • Antiperspirant preparations of the following composition were produced:
  • Glycerol mono / di-stearate 2.25 2.0 3.7 1.9 0.7

Abstract

Des agents antisudoraux renfermant des substances actives antisudorales astringentes inorganiques, solubles dans l'eau, par exemple du chlorhydrate d'aluminium, peuvent être préparés, sous la forme d'émulsions stables, finement réparties, du type huile dans l'eau, d'un diamètre de gouttelettes de 100-300 nm, et d'une teneur en eau de 40 à 80 % en poids, en émulsionnant le composant huileux, suivant le processus par inversion de phase, avec utilisation de 0,1 à 0,3 partie en poids d'un émulsionnant non ionique d'indice HLB 10 à 15, et de 0,1 à 0,3 partie en poids d'un co-émulsionnant du type alcool gras saturé ou ester partiel de polyols d'acides gras, les proportions de chacun de ces produits se rapportant à une partie en poids du composant huileux. Les agents antisudoraux selon l'invention peuvent en outre contenir 1 à 20 % en poids d'un polyol, soluble dans l'eau, de 2 à 8 atomes de carbone et de 2 à 6 groupes hydroxyle, et sont de préférence exempts d'alcools inférieurs de 2 à 3 atomes de carbone.
PCT/EP1996/001511 1995-04-15 1996-04-09 Agents antisudoraux WO1996032923A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU55001/96A AU5500196A (en) 1995-04-15 1996-04-09 Anti-transpirants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19514269.1 1995-04-15
DE1995114269 DE19514269A1 (de) 1995-04-15 1995-04-15 Antitranspirantien

Publications (2)

Publication Number Publication Date
WO1996032923A2 true WO1996032923A2 (fr) 1996-10-24
WO1996032923A3 WO1996032923A3 (fr) 1997-01-16

Family

ID=7759802

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/001511 WO1996032923A2 (fr) 1995-04-15 1996-04-09 Agents antisudoraux

Country Status (3)

Country Link
AU (1) AU5500196A (fr)
DE (1) DE19514269A1 (fr)
WO (1) WO1996032923A2 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0797983A2 (fr) * 1996-03-25 1997-10-01 Henkel Kommanditgesellschaft auf Aktien Utilisation des ethers méthyliques dans les compositions cosmétiques et/ou pharmaceutiques
EP1287813A1 (fr) * 2001-08-28 2003-03-05 Coty Inc. Emulsion déodorante contre la transpiration
EP2204410A1 (fr) 2008-12-31 2010-07-07 Borealis AG Article recouvert d'une composition comportant un polyéthylène préparé avec un seul catalyseur de site

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9709853A (pt) * 1996-06-20 1999-08-10 Unilever Nv Composição cosmética anti-perspirante ou desodorante
DE10005556A1 (de) 2000-02-09 2001-08-23 Cognis Deutschland Gmbh Hochviskose Mikroemulsionen
DE10058224A1 (de) * 2000-11-23 2002-05-29 Henkel Kgaa Treibgasfreie Sprayzubereitungen
DE10140637A1 (de) * 2001-08-18 2003-03-06 Beiersdorf Ag Emulsionen mit hohen Gehalten an Antitranspirantien
WO2005065630A1 (fr) * 2004-01-06 2005-07-21 Shiseido Co., Ltd. Composition de microemulsion monophase, formulation externe d'emulsion ultrafine huile dans l'eau et procede de production associe
GB0416252D0 (en) * 2004-07-20 2004-08-25 Unilever Plc Cosmetic method and composition
DE102009028156A1 (de) 2009-07-31 2011-02-03 Evonik Stockhausen Gmbh Schäumbare O/W-Emulsion

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4010393A1 (de) * 1990-03-30 1991-10-02 Henkel Kgaa Verfahren zur herstellung von oel-in-wasser-cremes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3360341B2 (ja) * 1993-03-11 2002-12-24 三菱化学株式会社 油性成分の透明な可溶化組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4010393A1 (de) * 1990-03-30 1991-10-02 Henkel Kgaa Verfahren zur herstellung von oel-in-wasser-cremes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI 42 Derwent Publications Ltd., London, GB; AN 94337523 XP002019370 & JP,A,06 262 060 (MITSUBISHI) , 20.September 1994 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0797983A2 (fr) * 1996-03-25 1997-10-01 Henkel Kommanditgesellschaft auf Aktien Utilisation des ethers méthyliques dans les compositions cosmétiques et/ou pharmaceutiques
EP0797983A3 (fr) * 1996-03-25 2000-03-29 Cognis Deutschland GmbH Utilisation des ethers méthyliques dans les compositions cosmétiques et/ou pharmaceutiques
EP1287813A1 (fr) * 2001-08-28 2003-03-05 Coty Inc. Emulsion déodorante contre la transpiration
EP2204410A1 (fr) 2008-12-31 2010-07-07 Borealis AG Article recouvert d'une composition comportant un polyéthylène préparé avec un seul catalyseur de site
US9353283B2 (en) 2008-12-31 2016-05-31 Borealis Ag Article coated with a composition comprising polyethylene prepared with a single site catalyst

Also Published As

Publication number Publication date
AU5500196A (en) 1996-11-07
DE19514269A1 (de) 1996-10-17
WO1996032923A3 (fr) 1997-01-16

Similar Documents

Publication Publication Date Title
DE69627866T3 (de) Klare kosmetische gelzusammensetzung
EP0845978B1 (fr) Anti-transpirants/deodorants translucides
DE102005017032B4 (de) Kosmetische Formulierung enthaltend Mandelsäure
EP0973484B1 (fr) Emulsions huile dans l'eau pour la restitution de la lamellarite de la structure lipidique de la peau endommagee
DE3222471A1 (de) Emulgiermittel und emulgierte kosmetika
DE19548013A1 (de) Verfahren zur Herstellung von O/W- oder O/W/O-Emulsionen sowie nach solchen Verfahren erhältliche O/W- und O/W/O-Emulsionen
EP2099529A2 (fr) Stick antitranspirant sans traces
DE4411557A1 (de) Verfahren zur Herstellung von Mikroemulsionen
EP1092415A2 (fr) Formulations cosmétiques et dermatologiques de protection solaire en forme de macro-émulsions H/E ou micro-émulsions H/E contenant de dihydroxyacétone
EP0725619A1 (fr) Procede de realisation d'emulsions huile dans eau
WO1996032923A2 (fr) Agents antisudoraux
EP1178775A1 (fr) Baton antitranspiration
EP1043017A2 (fr) Composition cosmétique pour la peau contenant des céramides
EP1076551B1 (fr) Preparations cosmetiques sous forme de stick
WO2010072705A2 (fr) Gels transparents anti-transpirants
EP2288330B1 (fr) Gels anti-transpirants transparents
DE19832425A1 (de) Kosmetische Stiftpräparate
EP1594453A1 (fr) Composition emulsifiante et microemulsions transparentes ou translucides qui la contiennent
DE19548014A1 (de) Kosmetische und dermatologische Lichtschutzformulierungen in Form von Emulsionen, insbesondere O/W-Makroemulsionen, O/W-Mikroemulsionen oder O/W/O-Emulsionen, mit einem Gehalt an in fester, dispergierter Form vorliegenden, in Ölkomponenten schwerlöslichen oder unlöslichen UV-Filtersubstanzen
DE19537836A1 (de) Aerosolemulsionen
DE2646435B2 (de) Verfahren zur Herstellung einer stabilen Öl-in-Wasser-Emulsion
DE10058224A1 (de) Treibgasfreie Sprayzubereitungen
EP0876138A1 (fr) Preparation de gel de savon contenant de l'huile
DE102016210037A1 (de) "Hoch wirksame Antitranspirantien mit verbesserter Hautverträglichkeit"
DE102017214797A1 (de) Emulgatorsystem für Mikroemulsionen mit hoher Hautverträglichkeit

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AU JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase