WO1996033666A1 - Gerät zur behandlung mit akustischen wellen - Google Patents
Gerät zur behandlung mit akustischen wellen Download PDFInfo
- Publication number
- WO1996033666A1 WO1996033666A1 PCT/DE1996/000672 DE9600672W WO9633666A1 WO 1996033666 A1 WO1996033666 A1 WO 1996033666A1 DE 9600672 W DE9600672 W DE 9600672W WO 9633666 A1 WO9633666 A1 WO 9633666A1
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- WIPO (PCT)
- Prior art keywords
- treated
- image
- therapy device
- relative
- source
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/225—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for extracorporeal shock wave lithotripsy [ESWL], e.g. by using ultrasonic waves
- A61B17/2255—Means for positioning patient, shock wave apparatus or locating means, e.g. mechanical aspects, patient beds, support arms, aiming means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/70—Manipulators specially adapted for use in surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
- A61B2034/2046—Tracking techniques
- A61B2034/2055—Optical tracking systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
- A61B34/20—Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
Definitions
- the invention relates to a device for treatment with acoustic waves, comprising a source of acoustic waves which are focused on a therapeutic effective area, means for shifting the therapeutic effective area and an object to be treated relative to one another, means for displaying an image of a the focused acoustic waves to be treated, the therapeutic effective area containing the area of the object to be treated, means for detecting the position of the effective area, and means for superimposing a mark indicating the position of the therapeutic effective area in the image, the data relating to the position of the therapeutic effective range are supplied.
- Such a device is for example from the EP
- the source together with the ultrasound transducer of the ultrasound locating device is first shifted relative to the body of the object to be treated until the body area to be treated is depicted in the ultrasound sectional image , and the brand coincides with the body area to be treated. Then the area to be treated is exposed to the focused ultrasound waves.
- the known device can only be used to a limited extent, and only in cases in which the area of the body to be treated differs sufficiently in terms of its acoustic properties from the structures surrounding it in order to enable a sufficiently clear representation in an ultrasound slice image .
- a magnetic resonance (MR) diagnostic device is provided in the case of a device known from EP 0 534 607 AI as a locating device.
- MR magnetic resonance
- due to the presence of magnets and high-frequency coils the patient is difficult to access for medical personnel.
- the invention is based on the object of designing a device of the type mentioned at the outset in such a way that, in a simple and cost-effective manner, safe location and treatment is also possible of those parts of the body which are not or only insufficiently clearly reproducible in ultrasound images without that a diagnostic device required for the location is required during the entire duration of the treatment, and the treatment can nevertheless take place using image information obtained during the location.
- this object is achieved according to a first solution principle by having a therapy device for treatment with acoustic waves
- a source of acoustic waves which are focused on a therapeutic effective range
- e means for displaying an image of an area of the object to be treated containing a body area to be treated with the focused acoustic waves, with respect to which the spatial position and orientation of the area to be treated can be determined relative to a third spatial coordinate system, and
- Means for displaying displayed image which means for fading in
- the fade-in of the mark indicating the position of the therapeutic active region into the image of the diagnostic device takes into account the spatial position of the therapeutic active region and the orientation of the source, the spatial position and orientation of the object to be treated and the spatial position and position direction of the body area to be treated during the production of the image, regardless of the fact that the therapy device itself does not contain or need to contain a location device in the sense of an imaging diagnostic device itself, safe location and treatment of the body area to be treated is possible.
- the means for relocating can include a hand-held, freely relocatable source.
- the treating doctor then aligns the source while observing the image displayed by means of the display means in such a way that the mark indicating the position of the therapeutic range of action is located in the image at the position associated with the acoustic waves is to be acted upon, and then activates the source for emitting the acoustic waves.
- the means for moving can also include a motorized adjustment unit for the source, preferably Control elements for manual operation of the adjustment unit are assigned.
- the source is then aligned by means of the motorized adjustment unit which is controlled manually by means of the operating elements in such a way that the mark indicating the position of the therapeutic effective area coincides with the body area to be treated in each case before the source is activated to emit the acoustic waves .
- means are provided for marking the area of the body to be treated, by means of which a marking, preferably surrounding the area of the body to be treated, is provided in the image displayed by means of the means for displaying can be faded in.
- An area can then be marked before the actual treatment begins, within which the focus zone is to be shifted during the treatment.
- the marking thus serves as a guideline for the doctor to be treated, i.e. he will only activate the source to emit acoustic waves if the mark indicating the position of the therapeutic effective area is within the marking.
- the source can only be activated to generate acoustic waves if the therapeutic effective area lies within the body area to be treated corresponding to the marking. This can easily be guaranteed by the control of the therapy device by allowing activation of the source only when the mark indicating the position of the therapeutic active area lies within the marking.
- the above-mentioned object is achieved according to a second solution principle by a therapy device for treatment with acoustic waves
- a source of acoustic waves which are focused on a therapeutic effective range
- e means for displaying an image of a region of the object to be treated containing a body region to be treated with the focused acoustic waves, with respect to which the spatial position and orientation of the region to be treated can be determined relative to a third spatial coordinate system
- a control unit which actuates the displacement means in such a way that the therapeutic active region lies in the body region to be treated, identified by means of the marking, and the
- g2) data relating to the spatial position and the orientation of the object to be treated relative to the second spatial coordinate system
- the data relating to the spatial position of the therapeutic effective area and the alignment of the source, the spatial position and alignment of the object to be treated and the spatial position and alignment of the body area to be treated do not become available during the production of the image Fading in of a mark indicating the position of the therapeutic range of action, but used to enable a control unit to actuate the means for relocating in such a way that the therapeutic range of action is identified by means of a marking which can be faded in by means of marking, body area to be treated.
- safe location and treatment of the relevant body area is possible, although the image on which the location and treatment is based was created before the treatment and with an imaging diagnostic device that is independent of the therapy device.
- means for fading in are provided according to a particularly preferred variant of the invention, which fade into the image a mark indicating the position of the therapeutic effective range.
- the image represented by means of the display means can be an image that contains the image information contains at least one sectional image.
- a perspective image which, for example, calculates from several sectional images, the data generated by means of a computer tomograph in the spiral scan mode or the data obtained by means of an MR diagnostic device or the images obtained by means of a conventional X-ray diagnostic device with defined different radiation directions becomes. It can be provided that the perspective image is partially shown in section.
- a variant of the invention provides that the means for fading into several images fade in a mark indicating the position of the therapeutic effective area and / or by means of the means for fading into several images a mark identifying the body region to be treated is.
- the means for detecting the spatial position of the therapeutic active area and the orientation of the source and / or the means for detecting the spatial position and the orientation of the object to be treated contain a commercially available 3D image.
- Navigation system Such a navigation system is preferably also used to record the spatial position and orientation of the area to be treated when the picture is taken.
- the means for displaying contain a commercially available surgical workstation, which can also fulfill the function of the means for fading in and the means for marking.
- a commercially available surgical workstation which can also fulfill the function of the means for fading in and the means for marking.
- the therapy device does contain imaging agents. However, these do not then serve to generate an image for locating purposes, but rather, by briefly activating the source and / or activating the source with reduced intensity, to bring about a temperature difference which is visible in an image obtained by means of the imaging means and which, in the event of possible To be able to make corrections of the position of the temperature difference from the position that the therapeutic effective area should have according to the relevant data.
- the image-generating means may be used to take a further image before activating the source in order to be able to determine the position of the temperature change caused by the activation of the source by comparing the two images.
- the two images are expediently compared by subtraction.
- the imaging means can be formed by an ultrasound diagnostic device.
- a magnetic resonance diagnostic device as the imaging means, which is operated with temperature-sensitive measuring sequences.
- a further variant of the invention provides that an image corresponding to the image displayed by means of the display is produced after treatment has been carried out at least partially or after treatment has been completed, and those areas in which tissue changes have been caused by the acoustic waves are produced by Comparison of the two images are determined, and that the means for displaying the position and shape of those areas in which tissue changes were caused by the acoustic waves, in one Show image.
- the two images can be compared by subtraction.
- FIG. 1 shows the essential parts of a therapy device according to the invention in a schematic perspective illustration
- FIG. 2 shows a patient to be treated during the production of an image of the body area to be treated that is required for the operation of the therapy device according to FIG. 1,
- Fig. 3 shows the source of acoustic waves of the device
- Fig. 1 in a partially sectioned view
- the therapy device has a treatment table, generally designated 1, on the support plate 2 of which a patient P is fixed in the supine position by means of several belts, one of which is designated 3.
- a therapy head 4 which contains a source of acoustic waves which emits focused ultrasound waves.
- the therapy head 4 is connected to a supply unit 6 via a cable 5.
- a motor adjustment unit 8 designed in the manner of a robot arm for the therapy head 4 attached to it is connected to this via a further cable, designated 7.
- the control and supply unit 6 has an operating panel 9 with the operating elements required for operating the therapy head 4 and the adjusting unit 8.
- the therapy head 4 shown in FIG. 3 contains a piezoelectric therapeutic ultrasound source 10 constructed in the manner of a phased array, the ultrasound transducer elements of which are mounted in a mosaic on a suitable support body 12 (backing).
- a suitable support body 12 backing
- some of the ultrasonic transducer elements are visible and designated 11a to 11h.
- a higher efficiency of the ultrasound source is achieved if it has an "air backing", that is to say no supporting body, and the rear sides of the ultrasound transducer elements therefore border on air.
- This can be achieved by a self-supporting structure of the ultrasound source, or by using, if present, a matching layer provided for impedance matching between the ultrasound source and the acoustic propagation medium as a support body for the ultrasound transducer elements.
- the source 10 is accommodated in a housing 13, which is closed at the end of its application by means of a flexible coupling membrane 14 and is filled with a suitable liquid acoustic propagation medium, for example water.
- a suitable liquid acoustic propagation medium for example water.
- the source 10 As a result of the formation of the source 10 as a phased array, suitable control of the ultrasound transducer elements makes it possible to electronically shift the focus zone of the therapeutic ultrasound waves relative to the source 10 in a manner known per se, namely within a spatial area , which is indicated by dashed lines in Fig. 3.
- a spatial area which is indicated by dashed lines in Fig. 3.
- the center of each of the farthest from source 10 and the closest position of source 10 of the focus zone Focus zone marked by a cross and labeled F2 and F] _.
- the respectively desired position of the focus zone relative to the source 10 can be set using the control elements provided on the control and supply unit 6; the control and supply unit 6 then controls the ultrasound transducer elements 11a to 11h of the source 10 in the necessary manner with a phase shift.
- a diagnostic ultrasound applicator is located in a central opening of the source 10 for purposes to be explained
- control and supply unit 15 arranged, which interacts with electronics contained in the control and supply unit for generating an ultrasound image of a sector-shaped layer indicated in dashed lines in FIG. 3, which if necessary on a screen assigned to the control and supply unit 6
- the therapy device has a commercially available surgical workstation 17 (e.g. "The Living Wing®” from ISG Technologies, Toronto, Ontario, Canada), which is connected to the control and supply unit 6 via a cable 18.
- a commercially available surgical workstation 17 e.g. "The Living Wing®” from ISG Technologies, Toronto, Ontario, Canada
- the workstation 17 can be supplied with image data via a further cable 19 or a floppy disk inserted into a floppy disk drive 20 of the workstation 17, said data being displayed on a screen 21 of the workstation 17.
- the usual image manipulations can be carried out by means of the workstation 17.
- the workstation 17 is expanded compared to a commercially available workstation in that video cameras 22 and 23 attached to the workstation 17 in two corners of the treatment room in the area of the corner are connected via corresponding cables 24 and 25.
- the video cameras 22, 23 are used in conjunction with three laser diodes 26a to 26c fixedly attached to the housing of the therapy head 4 at defined locations, the spatial position and orientation of the therapy head 4 and thus the source 10 and the spatial orientation of the central axis M to determine the source 10 with respect to a first spatial coordinate system xi, y-j_ / z ⁇ entered in FIG. 1.
- the workstation 17 evaluates the images from the video cameras 22 and 23 with respect to the coordinates of the images of the laser diodes 26a to 26c and from these coordinates the spatial position and the alignment of the therapy head 4 or the source 10 and the alignment the center axis of the source 10 with respect to the first coordinate system. As the workstation 17 via line 18 also data regarding the set position of the
- the workstation 17 is also able to determine the spatial position of the focus zone in the first coordinate system.
- the workstation 17 evaluates the images of the video cameras with respect to the coordinates of the images of the laser diodes 27a to 27j and calculates the spatial position and orientation of the support plate 2 from these coordinates. Since the patient P is fixed on the support plate 2, the spatial position and orientation of the patient P are known at the same time.
- FIG. 2 shows, for example, an MR diagnostic device 28 with the associated operating and display unit 29, which serves to obtain an image, specifically a sectional image, of the body region of the patient 8 to be treated .
- the procedure is such that the patient P fixed in a posture and position on the support plate 2 suitable for the treatment - the position during the admission is maintained unchanged during the treatment - together with the support plate 2 onto the patient support device 30 of the patient MR diagnostic device 28 is placed.
- MR diagnostic device 28 Also in the room in which the MR diagnostic device 28 is located are video cameras 31 and 32 which are connected to an image processing unit 35 via cables 33 and 34.
- the video cameras 31 and 32 and the image processing unit 35 serve to position the sectional plane of the sectional image of the patient P's body area to be treated by means of the MR diagnostic device and thus the body area to be treated itself in a third spatial coordinate system X3, to determine y3, Z3.
- the third coordinate system is related to the mounting plate 2, wherein the axes X3 and Z3 correspond to a transverse or a longitudinal edge of the mounting plate 2 and the axis y3 is perpendicular to these.
- the position of the section plane set on the MR diagnostic device 28 in a fourth spatial coordinate system, for example the coordinate system X4, y ⁇ , Z4 with coordinate origin in the upper right corner of the room, is known.
- the position of the third coordinate system and thus the position of the patient P in the fourth coordinate system can be determined from the coordinates of the laser diodes 27a to 27j attached to the support plate 2 in the fourth coordinate system.
- the image processing unit 35 inputs data corresponding to the coordinates of the laser diodes 27a to 27j
- the data mentioned can then be transmitted via a cable 18 to the control and supply unit 6 of the therapy device according to the invention.
- the workstation 17 now calculates the position of the cutting plane of the image in the third coordinate system.
- the workstation 17 is now able to move into the screen 21 displayed image made by means of the MR diagnostic device 28 fade in a mark corresponding to the position of the focus zone.
- FIG. 4 shows a sectional image of an internal organ afflicted with a tumor T, namely the liver L, of the patient P, which was produced by means of the MR diagnostic device and now on the screen 21 of the workstation tion 17 is displayed.
- the center of the focus zone of the ultrasound waves lies within the tumor T, which shows the position of the mark F ', which represents the center of the focus zone of the ultrasound waves. Treatment with focused ultrasound waves is therefore possible without risk.
- the procedure according to a first operating mode of the therapy device according to the invention is such that the treating doctor uses the control elements provided on the control panel 9 of the control and supply unit 6 to insert the therapy head 4 into a by means of the adjustment unit 8 brings such position that the coupling membrane 14 fits snugly against the body surface of the patient P.
- the attending physician then actuates the adjusting unit 8 by means of the operating elements provided on the control panel 9 such that the mark F 1 is located inside the tumor T in the sectional image displayed on the screen 21 of the workstation 17.
- the attending physician now actuates a foot switch 38 connected to the control and supply unit 6, which causes the source 10 to emit an ultrasound pulse, the energy content of which is sufficient to bring the tumor tissue in the focus zone to a temperature, depending on the type of treatment between 42 and 45 ° C (so-called hyperthermia, through which the metabolism of the tumor cells is to be disrupted) or a temperature beyond 45 ° C (so-called thermotherapy, through which tumor tissue is to be necrotized).
- the doctor moves the focus zone electronically slightly by operating the control elements of the control panel 9 while observing the mark F 1 and actuates the foot switch 38 again. This is repeated until the entire area of the tumor T shown in the slice image is treated . If the electronic adjustment range of the focus zone is not sufficient to treat the entire area of the tumor shown in the sectional image, it is necessary It is necessary to additionally adjust the therapy head 4 by means of the adjustment unit 8 in relation to the body of the patient P in the necessary manner.
- the source 10 is only activated by the control and supply unit 6 to emit ultrasound waves if the mark F 'within the MK marking is located.
- the workstation 17 sends a signal to the control and supply unit 6, which indicates whether the mark F 'lies inside or outside the mark MK.
- the variant described is of particular importance if the attending physician, in a modification of the operating mode described first, separates the therapy head from the adjustment unit 8 in the manner indicated by the broken line in FIG. 1 in order to hold it hand-held while observing the sectional image displayed on the screen 21 to be aligned so that the mark F 'and thus the focal zone of the ultrasound is located at the point to be treated.
- the focus zone of the ultrasound and, if necessary, of the therapy head 4 are shifted automatically, in such a way that, if necessary, step by step, that within a by means of
- Light pen 39 set marker MK area of the tumor T is treated. There is either the option in addition to the marking MK, the marking F 'indicating the position of the focus zone is also superimposed on the sectional image, as is also shown in FIG. 4.
- the workstation 17 passes the data required for automatic control to the control and supply unit 6.
- the body area to be treated is generally not in its entirety in a single body layer that can be displayed by means of the MR diagnostic device 28, it is expedient before the treatment to take pictures of a plurality of adjacent body layers containing the body area to be treated and determine the position of the cutting plane with respect to these images. These images are then displayed simultaneously on the screen 21 of the workstation 17, as is the case in FIG. 5 for ten sectional images labeled I to X. It is then possible, in the manner not shown in FIG. 5, to mark MK in the individual sectional images analogously to the previously described procedure by means of light pen 39 and then gradually to manually mark the body area located within markings MK to treat the first operating mode or automatically according to the second operating mode with focused ultrasound.
- the mark F ' which characterizes the position of the focal zone of the ultrasound is of course only superimposed on the image of the body layer in which therapy is currently taking place. In the case of Fig. 5, this is the body layer shown in Figure IV.
- the surgical workstation 17 is able to calculate a spatial image of the body region of interest and to display this in perspective.
- a spatial image of the body region of interest There is, for example, the possibility of an organ or one located in it
- Perspective pictures can not only give the doctor a good overview of the anatomical situation. They can also be used to position the focal zone of the ultrasound in the required manner, which is illustrated in FIG. 6 in that the mark F 'indicating the position of the focal zone lies in the region of the area SF2 Area of the tumor T is entered.
- a correction function can be activated both in the first and in the second operating mode. This is based on the fact that, before an ultrasound pulse used for the treatment is emitted, an ultrasound pulse is emitted either with a reduced intensity or with a reduced duration that tissue damage is not to be expected. Nevertheless, heating then occurs in the area of the focus zone. This is detected by means of the ultrasound diagnostic device in accordance with a method described in DE 42 29 817 A1, in that a first ultrasound image is made before the emission of the ultrasound pulse with reduced intensity or duration, and a second after its emission and the two ultrasound images are compared with one another by subtraction.
- this is done by supplying the ultrasound images produced before and after the ultrasound pulse of reduced intensity or duration to workstation 17, which subtracts the two ultrasound images from one another, the resulting image to the intensity reduced after the transmission of the ultrasound pulse overlaid and superimposed in the image thus obtained the mark F 'indicating the position of the focus zone and displaying this image on the screen 21 (see FIG. 7).
- the attending physician can thus easily recognize whether there are any noticeable deviations between the theoretical position indicated by the mark F 'and the actual position of the focus zone corresponding to the position of the heating E, and can make appropriate corrections.
- the workstation 17 uses known methods of image processing to determine the deviation between the theoretical and the actual focus position and sends a corresponding signal to the control and supply unit, which controls the ultrasound transducer elements of the source 10 before sending out the treatment serving ultrasound pulse so corrected that the actual position of the focus zone corresponds to the position indicated by the mark F '.
- the MR diagnostic device 28 In order to be able to check, at the end of part of the treatment or the entire treatment, at which points tissue changes have been brought about by the ultrasound treatment, it is possible to again use the MR diagnostic device 28 in the case of patients 2 who are still fixed on the support plate 2 to produce exactly the same body layers with respect to which sectional images were made before the treatment.
- the corresponding data are additionally fed to the workstation 17 via the cable 19 or via diskette, which then compares corresponding images taken before and after the treatment, preferably by subtraction. On the basis of the subtraction images obtained in this way, the workstation 17 then displays on its screen 21 those areas in which tissue changes were caused by the focused ultrasound.
- the workstation 17 calculates a partially cut perspective image on the basis of the images taken before and after the treatment, from which the areas in which the focused ultrasound has caused tissue changes can be seen .
- FIG. 8 Such an image is shown in FIG. 8.
- This image is an enlarged detail of the image according to FIG. 6, in which, in the manner described above, those areas in which tissue changes were brought about are emphasized.
- Those areas of the tumor in which tissue changes were brought about by the focused ultrasound are provided with cross hatching and with TT.
- Areas of "healthy" tissue are designated with oblique hatching and puncturing, in which tissue changes were caused by the focused ultrasound. These areas are also designated TG.
- a hatched area from left to right indicates an area of the tumor T in which no tissue changes would be caused. This area is called UT.
- the remaining areas are untreated healthy tissue.
- the video cameras 22 and 23, and the laser diodes 26a to 26c and 27a to 27j, on the one hand, and the video cameras 31 and 32, the image processing unit 35 and the laser diodes 27a to 27j, on the other hand, are part of commercially available three-dimensional dimensional (3D) navigation systems, as the name "Flashpoint ®” from Pixsys Inc. Boulder, Colorado, USA, for example, are available un ⁇ ter.
- 3D three-dimensional dimensional
- 3D navigation systems for example using already mentioned stereotactic devices, can be used instead of the systems provided in the exemplary embodiment described.
- the focus zone of the ultrasound used for treatment is referred to above, this should be understood to mean the spatial area surrounding the location of maximum sound pressure, in that the intensity of the ultrasound is sufficient to achieve the desired therapeutic effect.
- the focus zone is the area lying within the -6 db isobar, that is to say the area in which the sound pressure is at least equal to half the maximum sound pressure.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8532083A JPH11503943A (ja) | 1995-04-28 | 1996-04-17 | 音波による処置のための装置 |
EP96909966A EP0822784A1 (de) | 1995-04-28 | 1996-04-17 | Gerät zur behandlung mit akustischen wellen |
US08/930,174 US5944663A (en) | 1995-04-28 | 1996-04-17 | Apparatus for treatment with acoustic waves |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19515748.6 | 1995-04-28 | ||
DE19515748A DE19515748A1 (de) | 1995-04-28 | 1995-04-28 | Gerät zur Behandlung mit akustischen Wellen |
Publications (1)
Publication Number | Publication Date |
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WO1996033666A1 true WO1996033666A1 (de) | 1996-10-31 |
Family
ID=7760658
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/DE1996/000672 WO1996033666A1 (de) | 1995-04-28 | 1996-04-17 | Gerät zur behandlung mit akustischen wellen |
Country Status (5)
Country | Link |
---|---|
US (1) | US5944663A (de) |
EP (1) | EP0822784A1 (de) |
JP (1) | JPH11503943A (de) |
DE (1) | DE19515748A1 (de) |
WO (1) | WO1996033666A1 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6128522A (en) * | 1997-05-23 | 2000-10-03 | Transurgical, Inc. | MRI-guided therapeutic unit and methods |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11267133A (ja) | 1998-03-25 | 1999-10-05 | Olympus Optical Co Ltd | 治療装置 |
DE19841951C2 (de) * | 1998-09-14 | 2002-08-29 | Storz Medical Ag Kreuzlingen | Verfahren zur Visualisierung der Ausrichtung von therapeutischen Schallwellen auf einen zu behandelnden bzw. zu bearbeitenden Bereich |
US6684097B1 (en) * | 1999-04-22 | 2004-01-27 | University Of Miami | Intraoperative monitoring of temperature-induced tissue changes with a high-resolution digital x-ray system during thermotherapy |
JP2001061861A (ja) * | 1999-06-28 | 2001-03-13 | Siemens Ag | 画像撮影手段を備えたシステムおよび医用ワークステーション |
US6235038B1 (en) | 1999-10-28 | 2001-05-22 | Medtronic Surgical Navigation Technologies | System for translation of electromagnetic and optical localization systems |
US8256430B2 (en) | 2001-06-15 | 2012-09-04 | Monteris Medical, Inc. | Hyperthermia treatment and probe therefor |
US7347855B2 (en) * | 2001-10-29 | 2008-03-25 | Ultrashape Ltd. | Non-invasive ultrasonic body contouring |
AU2002217412B2 (en) * | 2001-01-03 | 2006-09-14 | Ultrashape Ltd. | Non-invasive ultrasonic body contouring |
US7846096B2 (en) | 2001-05-29 | 2010-12-07 | Ethicon Endo-Surgery, Inc. | Method for monitoring of medical treatment using pulse-echo ultrasound |
US20030032898A1 (en) | 2001-05-29 | 2003-02-13 | Inder Raj. S. Makin | Method for aiming ultrasound for medical treatment |
US7211044B2 (en) * | 2001-05-29 | 2007-05-01 | Ethicon Endo-Surgery, Inc. | Method for mapping temperature rise using pulse-echo ultrasound |
DE10202091B4 (de) * | 2002-01-21 | 2005-09-08 | Siemens Ag | Vorrichtung zur Ermittlung einer Koordinatentransformation |
DE10206193C1 (de) * | 2002-02-14 | 2003-07-03 | Siemens Ag | Vorrichtung und Verfahren zur Ausrichtung eines Röntgengerätes und eines Therapiegerätes relativ zueinander |
US7128711B2 (en) * | 2002-03-25 | 2006-10-31 | Insightec, Ltd. | Positioning systems and methods for guided ultrasound therapy systems |
BR0215785A (pt) * | 2002-06-25 | 2006-06-06 | Ultrashape Inc | dispositivos e metodologias uteis para esteticas do corpo |
DE10231071A1 (de) * | 2002-07-10 | 2004-01-22 | Philips Intellectual Property & Standards Gmbh | Therapiekombination |
US20080116179A1 (en) * | 2003-04-11 | 2008-05-22 | Hypertherm, Inc. | Method and apparatus for alignment of components of a plasma arc torch |
US6946617B2 (en) * | 2003-04-11 | 2005-09-20 | Hypertherm, Inc. | Method and apparatus for alignment of components of a plasma arc torch |
US7209538B2 (en) * | 2003-08-07 | 2007-04-24 | Xoran Technologies, Inc. | Intraoperative stereo imaging system |
DE102004006021A1 (de) * | 2004-02-06 | 2005-09-01 | Dornier Medtech Systems Gmbh | Verfahren und Vorrichtung zum Positionieren des Fokuspunkts einer Wellenquelle zu einem Zielobjekt außerhalb des Isozentrums |
US7883468B2 (en) | 2004-05-18 | 2011-02-08 | Ethicon Endo-Surgery, Inc. | Medical system having an ultrasound source and an acoustic coupling medium |
US7951095B2 (en) | 2004-05-20 | 2011-05-31 | Ethicon Endo-Surgery, Inc. | Ultrasound medical system |
US7806839B2 (en) | 2004-06-14 | 2010-10-05 | Ethicon Endo-Surgery, Inc. | System and method for ultrasound therapy using grating lobes |
US7833221B2 (en) | 2004-10-22 | 2010-11-16 | Ethicon Endo-Surgery, Inc. | System and method for treatment of tissue using the tissue as a fiducial |
JP2008529580A (ja) * | 2005-02-06 | 2008-08-07 | ウルトラシェイプ エルティーディー. | 非熱式音波組織改質 |
US7840040B2 (en) | 2005-09-30 | 2010-11-23 | Siemens Medical Solutions Usa, Inc. | Method and apparatus for controlling ultrasound imaging systems having positionable transducers |
US20070225595A1 (en) * | 2006-01-17 | 2007-09-27 | Don Malackowski | Hybrid navigation system for tracking the position of body tissue |
US8287471B2 (en) * | 2007-02-20 | 2012-10-16 | National Health Research Institutes | Medical treatment using an ultrasound phased array |
DE102007004334A1 (de) * | 2007-03-12 | 2008-09-18 | Lite-Med Inc., Ta-An | Nierensteinzertrümmerer mit Steinverfolgung und Positionsverriegelung |
DE102007030066A1 (de) * | 2007-06-29 | 2008-05-15 | Siemens Ag | Anlage für und Verfahren zur Vorbereitung einer extrakorporalen Stoßwellentherapie an Körpergewebe eines Patienten |
US20090088625A1 (en) * | 2007-10-01 | 2009-04-02 | Kenneth Oosting | Photonic Based Non-Invasive Surgery System That Includes Automated Cell Control and Eradication Via Pre-Calculated Feed-Forward Control Plus Image Feedback Control For Targeted Energy Delivery |
US8655430B2 (en) * | 2007-12-26 | 2014-02-18 | National Health Research Institutes | Positioning system for thermal therapy |
US7956613B2 (en) * | 2008-05-02 | 2011-06-07 | The General Hospital Corporation | Method for imaging acoustically induced rotary saturation with a magnetic resonance imaging system |
FR2954903B1 (fr) * | 2010-01-05 | 2012-03-02 | Edap Tms France | Procede et appareil de localisation et de visualisation d'une cible par rapport a un point focal d'un systeme de traitement |
EP2524289B1 (de) * | 2010-01-14 | 2016-12-07 | Brainlab AG | Steuerung und/oder bedienung einer medizinischen vorrichtung mit einem lichtzeiger |
US20120330284A1 (en) * | 2011-06-23 | 2012-12-27 | Elwha LLC, a limited liability corporation of the State of Delaware | Systems, devices, and methods to induce programmed cell death in adipose tissue |
US9211082B2 (en) | 2011-06-30 | 2015-12-15 | The General Hospital Corporation | Method for magnetic resonance imaging using saturation harmonic induced rotary saturation |
JP6138162B2 (ja) * | 2012-02-06 | 2017-05-31 | インサイテック・リミテッド | 非侵襲的療法中の参照ベースの動き追跡 |
WO2014003855A1 (en) | 2012-06-27 | 2014-01-03 | Monteris Medical Corporation | Image-guided therapy of a tissue |
US9492121B2 (en) | 2014-03-18 | 2016-11-15 | Monteris Medical Corporation | Image-guided therapy of a tissue |
US10675113B2 (en) | 2014-03-18 | 2020-06-09 | Monteris Medical Corporation | Automated therapy of a three-dimensional tissue region |
WO2015143026A1 (en) | 2014-03-18 | 2015-09-24 | Monteris Medical Corporation | Image-guided therapy of a tissue |
US10327830B2 (en) | 2015-04-01 | 2019-06-25 | Monteris Medical Corporation | Cryotherapy, thermal therapy, temperature modulation therapy, and probe apparatus therefor |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0269801A1 (de) * | 1986-11-14 | 1988-06-08 | Dornier Medizintechnik Gmbh | Rechnerkontrollierte Patientenpositionierung |
US4764944A (en) * | 1986-06-18 | 1988-08-16 | University Of Florida | Methods for positioning an internal portion of a body relative to an extracorporeal referent |
WO1991004711A1 (fr) * | 1989-10-05 | 1991-04-18 | Diadix S.A. | Systeme interactif d'intervention locale a l'interieur d'une structure non homogene |
US5389101A (en) * | 1992-04-21 | 1995-02-14 | University Of Utah | Apparatus and method for photogrammetric surgical localization |
WO1995007055A1 (fr) * | 1993-09-07 | 1995-03-16 | Deemed International S.A. | Installation pour operation de microchirurgie assistee par ordinateur et procedes mis en ×uvre par ladite installation |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2556582B1 (fr) * | 1983-12-14 | 1986-12-19 | Dory Jacques | Appareil a impulsions ultrasonores destine a la destruction des calculs |
US5107839A (en) * | 1990-05-04 | 1992-04-28 | Pavel V. Houdek | Computer controlled stereotaxic radiotherapy system and method |
US5291890A (en) * | 1991-08-29 | 1994-03-08 | General Electric Company | Magnetic resonance surgery using heat waves produced with focussed ultrasound |
JP3325300B2 (ja) * | 1992-02-28 | 2002-09-17 | 株式会社東芝 | 超音波治療装置 |
DE4207632C2 (de) * | 1992-03-11 | 1995-07-20 | Bodenseewerk Geraetetech | Vorrichtung und Verfahren zur Positionierung eines Körperteils für Behandlungszwecke |
DE4229817C2 (de) * | 1992-09-07 | 1996-09-12 | Siemens Ag | Verfahren zur zerstörungsfreien und/oder nichtinvasiven Messung einer Temperaturänderung im Inneren eines insbesondere lebenden Objektes |
DE4229819A1 (de) * | 1992-09-07 | 1994-03-10 | Helmut Kothe | Herausnehmbarer Kocher für Wohnmobile und -Anhänger |
US5275165A (en) * | 1992-11-06 | 1994-01-04 | General Electric Company | Magnetic resonance guided ultrasound therapy system with inclined track to move transducers in a small vertical space |
JP3860227B2 (ja) * | 1993-03-10 | 2006-12-20 | 株式会社東芝 | Mriガイド下で用いる超音波治療装置 |
US5443068A (en) * | 1994-09-26 | 1995-08-22 | General Electric Company | Mechanical positioner for magnetic resonance guided ultrasound therapy |
US5772594A (en) * | 1995-10-17 | 1998-06-30 | Barrick; Earl F. | Fluoroscopic image guided orthopaedic surgery system with intraoperative registration |
-
1995
- 1995-04-28 DE DE19515748A patent/DE19515748A1/de not_active Withdrawn
-
1996
- 1996-04-17 US US08/930,174 patent/US5944663A/en not_active Expired - Fee Related
- 1996-04-17 EP EP96909966A patent/EP0822784A1/de not_active Withdrawn
- 1996-04-17 JP JP8532083A patent/JPH11503943A/ja active Pending
- 1996-04-17 WO PCT/DE1996/000672 patent/WO1996033666A1/de not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4764944A (en) * | 1986-06-18 | 1988-08-16 | University Of Florida | Methods for positioning an internal portion of a body relative to an extracorporeal referent |
EP0269801A1 (de) * | 1986-11-14 | 1988-06-08 | Dornier Medizintechnik Gmbh | Rechnerkontrollierte Patientenpositionierung |
WO1991004711A1 (fr) * | 1989-10-05 | 1991-04-18 | Diadix S.A. | Systeme interactif d'intervention locale a l'interieur d'une structure non homogene |
US5389101A (en) * | 1992-04-21 | 1995-02-14 | University Of Utah | Apparatus and method for photogrammetric surgical localization |
WO1995007055A1 (fr) * | 1993-09-07 | 1995-03-16 | Deemed International S.A. | Installation pour operation de microchirurgie assistee par ordinateur et procedes mis en ×uvre par ladite installation |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6128522A (en) * | 1997-05-23 | 2000-10-03 | Transurgical, Inc. | MRI-guided therapeutic unit and methods |
US6374132B1 (en) | 1997-05-23 | 2002-04-16 | Transurgical, Inc. | MRI-guided therapeutic unit and methods |
US6516211B1 (en) | 1997-05-23 | 2003-02-04 | Transurgical, Inc. | MRI-guided therapeutic unit and methods |
Also Published As
Publication number | Publication date |
---|---|
US5944663A (en) | 1999-08-31 |
DE19515748A1 (de) | 1996-10-31 |
JPH11503943A (ja) | 1999-04-06 |
EP0822784A1 (de) | 1998-02-11 |
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