WO1996036316A1 - Self-emulsifying formulations of lipophilic drugs - Google Patents
Self-emulsifying formulations of lipophilic drugs Download PDFInfo
- Publication number
- WO1996036316A1 WO1996036316A1 PCT/US1996/007155 US9607155W WO9636316A1 WO 1996036316 A1 WO1996036316 A1 WO 1996036316A1 US 9607155 W US9607155 W US 9607155W WO 9636316 A1 WO9636316 A1 WO 9636316A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- self
- tpgs
- concentrate according
- emulsifying
- weight
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8535087A JPH11505257A (en) | 1995-05-19 | 1996-05-17 | Self-emulsifying formulations of lipophilic drugs |
EP96915876A EP0825849A1 (en) | 1995-05-19 | 1996-05-17 | Self-emulsifying formulations of lipophilic drugs |
MXPA/A/1997/008934A MXPA97008934A (en) | 1995-05-19 | 1997-11-19 | Self-emulsifying formulations of lipofili drugs |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44524295A | 1995-05-19 | 1995-05-19 | |
US08/445,242 | 1995-05-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996036316A1 true WO1996036316A1 (en) | 1996-11-21 |
Family
ID=23768134
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/007155 WO1996036316A1 (en) | 1995-05-19 | 1996-05-17 | Self-emulsifying formulations of lipophilic drugs |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0825849A1 (en) |
JP (1) | JPH11505257A (en) |
CA (1) | CA2221145A1 (en) |
WO (1) | WO1996036316A1 (en) |
Cited By (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997022358A1 (en) * | 1995-12-15 | 1997-06-26 | Bernard Charles Sherman | Microemulsion preconcentrates comprising cyclosporins |
EP0793966A1 (en) * | 1996-03-05 | 1997-09-10 | Hanmi Pharm. Co. Ltd | Cyclosporin-containing topical pharmaceutical composition |
WO1997035587A1 (en) * | 1996-03-22 | 1997-10-02 | Glaxo Group Limited | Compositions comprising an hiv protease inhibitor such as vx 478 and a water soluble vitamin e compound such as vitamin e-tpgs |
WO1998033512A1 (en) * | 1997-01-30 | 1998-08-06 | Novartis Ag | Oil-free pharmaceutical compositions containing cyclosporin a |
US5886030A (en) * | 1994-05-06 | 1999-03-23 | Alcon Laboratories, Inc. | Use of vitamin E tocopheryl derivatives in ophthalmic compositions |
WO1999026607A1 (en) * | 1997-11-21 | 1999-06-03 | Fuisz Technologies Ltd. | Drug delivery systems utilizing crystal structures |
GB2317562B (en) * | 1995-07-20 | 1999-08-18 | Danbiosyst Uk | Lipid vehicle drug delivery composition containing vitamin E |
WO2000033862A1 (en) | 1998-12-11 | 2000-06-15 | Pharmasolutions, Inc. | Self-emulsifying compositions for drugs poorly soluble in water |
EP1017366A1 (en) * | 1996-09-01 | 2000-07-12 | Pharmos Corporation | Solid coprecipitates for enhanced bioavailability of lipophilic substances |
AU724239B2 (en) * | 1996-03-22 | 2000-09-14 | Glaxo Group Limited | Compositions comprising an HIV protease inhibitor such as VX 478 and a water soluble vitamin E compound such as vitamin E-TPGS |
EP1039893A1 (en) * | 1997-12-10 | 2000-10-04 | Severson, Mary L. | Pharmaceutical compositions containing an omega-3 fatty acid oil |
WO2002051414A1 (en) * | 2000-12-22 | 2002-07-04 | Takeda Chemical Industries, Ltd. | Medicinal compositions for oral use |
US6432445B1 (en) | 1999-05-28 | 2002-08-13 | Novartis Ag | Pharmaceutical capsules comprising a cyclosporin |
US6730679B1 (en) | 1996-03-22 | 2004-05-04 | Smithkline Beecham Corporation | Pharmaceutical formulations |
US6828301B2 (en) | 2002-02-07 | 2004-12-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for hepatitis C viral protease inhibitors |
EP1498122A1 (en) * | 2003-07-18 | 2005-01-19 | Aventis Pharma S.A. | Semi-solid systems containing azetidine derivatives |
US7070802B1 (en) | 1996-01-22 | 2006-07-04 | Pliva, Inc. | Pharmaceutical compositions for lipophilic drugs |
CZ297206B6 (en) * | 1997-07-29 | 2006-10-11 | Pharmacia & Upjohn Company | Pharmaceutical composition and self-emulsifying formulation for lipophilic compounds |
EP1810694A2 (en) * | 2001-02-02 | 2007-07-25 | National Research Council of Canada | Water-soluble compositions of bioactive lipophilic compounds |
JP2007332157A (en) * | 1997-01-07 | 2007-12-27 | Sonus Pharmaceuticals Inc | Emulsion vehicle for drug poor in solubility |
WO2008142090A1 (en) * | 2007-05-23 | 2008-11-27 | Boehringer Ingelheim International Gmbh | Self-emulsifying formulation of tipranavir for oral administration |
WO2009117152A1 (en) | 2008-03-20 | 2009-09-24 | Virun, Inc. | Emulsions including a peg-derivative of tocopherol |
WO2011005646A2 (en) | 2009-07-07 | 2011-01-13 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition for a hepatitis c viral protease inhibitor |
US8337931B2 (en) | 2008-06-23 | 2012-12-25 | Virun, Inc. | Compositions containing non-polar compounds |
US20130108674A1 (en) * | 2010-06-11 | 2013-05-02 | Medivis S.R.L. | Ophthalmic compositions for the administration of liposoluble active ingredients |
WO2013120025A1 (en) | 2012-02-10 | 2013-08-15 | Virun, Inc. | Beverage compositions containing non-polar compounds |
US8524696B2 (en) | 1999-04-02 | 2013-09-03 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
US8722093B2 (en) | 2009-02-23 | 2014-05-13 | NanoRx, Inc. | Policosanol nanoparticles |
US9034383B2 (en) | 2010-08-23 | 2015-05-19 | NanoRx, Inc. | Policosanol nanoparticles |
US9320295B2 (en) | 2010-03-23 | 2016-04-26 | Virun, Inc. | Compositions containing non-polar compounds |
US9351517B2 (en) | 2013-03-15 | 2016-05-31 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and compositions containing same |
US9693574B2 (en) | 2013-08-08 | 2017-07-04 | Virun, Inc. | Compositions containing water-soluble derivatives of vitamin E mixtures and modified food starch |
US9788564B2 (en) | 2008-03-20 | 2017-10-17 | Virun, Inc. | Compositions containing non-polar compounds |
US9861611B2 (en) | 2014-09-18 | 2018-01-09 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same |
US10016363B2 (en) | 2014-09-18 | 2018-07-10 | Virun, Inc. | Pre-spray emulsions and powders containing non-polar compounds |
US10335385B2 (en) | 2010-06-21 | 2019-07-02 | Virun, Inc. | Composition containing non-polar compounds |
WO2021050697A1 (en) * | 2019-09-11 | 2021-03-18 | Barlean's Organic Oils, Llc | Softgel fill materials |
US11813246B2 (en) | 2008-03-28 | 2023-11-14 | Astrazeneca Ab | Pharmaceutical composition |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005047851A (en) * | 2003-07-29 | 2005-02-24 | Nisshin Pharma Inc | Ubidecarenone-containing composition |
FR2861992B1 (en) * | 2003-11-10 | 2007-07-20 | Sanofi Synthelabo | PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION OF A PYRAZOLE-3-CARBOXAMIDE DERIVATIVE. |
TW202402319A (en) * | 2022-03-28 | 2024-01-16 | 日商中外製藥股份有限公司 | Compound pharmaceutical preparation containing oil component comprising polyoxyethylene structure |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2636534A1 (en) * | 1988-09-16 | 1990-03-23 | Sandoz Sa | PHARMACEUTICAL COMPOSITIONS BASED ON CYCLOSPORINS |
-
1996
- 1996-05-17 CA CA 2221145 patent/CA2221145A1/en not_active Abandoned
- 1996-05-17 EP EP96915876A patent/EP0825849A1/en not_active Withdrawn
- 1996-05-17 JP JP8535087A patent/JPH11505257A/en active Pending
- 1996-05-17 WO PCT/US1996/007155 patent/WO1996036316A1/en not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2636534A1 (en) * | 1988-09-16 | 1990-03-23 | Sandoz Sa | PHARMACEUTICAL COMPOSITIONS BASED ON CYCLOSPORINS |
Non-Patent Citations (4)
Title |
---|
CHEMICAL ABSTRACTS, vol. 116, no. 10, 9 March 1992, Columbus, Ohio, US; abstract no. 91269, XP002013045 * |
CHEMICAL ABSTRACTS, vol. 120, no. 26, 27 June 1994, Columbus, Ohio, US; abstract no. 330990, XP002013044 * |
N. H. SHAH ET AL.: "SELF-EMULSIFYING DRUG DELIVERY SYSTEMS (SEDDS) WITH POLYGLYCOLYZED GLYCERIDES FOR IMPROVING IN VITRO DISSOLUTION AND ORAL ABSORPTION OF LIPOPHILIC DRUGS", INT. J. PHARM., vol. 106, no. 1, 1994, pages 15 - 23 * |
S. A. CHARMAN ET AL.: "SELF-EMULSIFYING DRUG DELIVERY SYSTEMS:FORMULATION AND BIOPHARMACEUTIC EVALUATION OF AN INVESTIGATIONAL LIPOPHILIC COMPOUND", PHARM. RES., vol. 9, no. 1, 1992, pages 87 - 93 * |
Cited By (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5886030A (en) * | 1994-05-06 | 1999-03-23 | Alcon Laboratories, Inc. | Use of vitamin E tocopheryl derivatives in ophthalmic compositions |
GB2317562B (en) * | 1995-07-20 | 1999-08-18 | Danbiosyst Uk | Lipid vehicle drug delivery composition containing vitamin E |
US5998365A (en) * | 1995-12-15 | 1999-12-07 | Bernard C. Sherman | Microemulsion preconcentrates comprising cyclosporins |
WO1997022358A1 (en) * | 1995-12-15 | 1997-06-26 | Bernard Charles Sherman | Microemulsion preconcentrates comprising cyclosporins |
US7070802B1 (en) | 1996-01-22 | 2006-07-04 | Pliva, Inc. | Pharmaceutical compositions for lipophilic drugs |
EP0793966A1 (en) * | 1996-03-05 | 1997-09-10 | Hanmi Pharm. Co. Ltd | Cyclosporin-containing topical pharmaceutical composition |
WO1997035587A1 (en) * | 1996-03-22 | 1997-10-02 | Glaxo Group Limited | Compositions comprising an hiv protease inhibitor such as vx 478 and a water soluble vitamin e compound such as vitamin e-tpgs |
US6730679B1 (en) | 1996-03-22 | 2004-05-04 | Smithkline Beecham Corporation | Pharmaceutical formulations |
EA001484B1 (en) * | 1996-03-22 | 2001-04-23 | Глаксо Груп Лимитед | Compositions comprising an hiv protease inhibitor such as vx 478 and a water soluable vitamin e compound such as vitamin e-tpgs |
AU724239B2 (en) * | 1996-03-22 | 2000-09-14 | Glaxo Group Limited | Compositions comprising an HIV protease inhibitor such as VX 478 and a water soluble vitamin E compound such as vitamin E-TPGS |
EP1017366A4 (en) * | 1996-09-01 | 2006-03-22 | Pharmos Corp | Solid coprecipitates for enhanced bioavailability of lipophilic substances |
EP1017366A1 (en) * | 1996-09-01 | 2000-07-12 | Pharmos Corporation | Solid coprecipitates for enhanced bioavailability of lipophilic substances |
JP2007332157A (en) * | 1997-01-07 | 2007-12-27 | Sonus Pharmaceuticals Inc | Emulsion vehicle for drug poor in solubility |
GB2355195A (en) * | 1997-01-30 | 2001-04-18 | Novartis Ag | Oil-free pharmaceutical composition containing Cyclosporin A |
GB2335854A (en) * | 1997-01-30 | 1999-10-06 | Novartis Ag | Oil-free pharmaceutical compositions containing cyclosporin a |
GB2335854B (en) * | 1997-01-30 | 2001-04-25 | Novartis Ag | Oil-free pharmaceutical compositions containing cyclosporin A |
GB2355195B (en) * | 1997-01-30 | 2001-09-12 | Novartis Ag | Oil-free pharmaceutical compositions containing cyclosporin A |
EP1331002A2 (en) * | 1997-01-30 | 2003-07-30 | Novartis AG | Oil-free pharmaceutical compositions containing cyclosporin A |
WO1998033512A1 (en) * | 1997-01-30 | 1998-08-06 | Novartis Ag | Oil-free pharmaceutical compositions containing cyclosporin a |
EP1331002A3 (en) * | 1997-01-30 | 2004-01-14 | Novartis AG | Oil-free pharmaceutical compositions containing cyclosporin A |
CZ297206B6 (en) * | 1997-07-29 | 2006-10-11 | Pharmacia & Upjohn Company | Pharmaceutical composition and self-emulsifying formulation for lipophilic compounds |
WO1999026607A1 (en) * | 1997-11-21 | 1999-06-03 | Fuisz Technologies Ltd. | Drug delivery systems utilizing crystal structures |
EP1039893A1 (en) * | 1997-12-10 | 2000-10-04 | Severson, Mary L. | Pharmaceutical compositions containing an omega-3 fatty acid oil |
EP1039893A4 (en) * | 1997-12-10 | 2003-03-12 | Cyclosporine Therapeutics Ltd | Pharmaceutical compositions containing an omega-3 fatty acid oil |
EP1135150A1 (en) * | 1998-12-11 | 2001-09-26 | Pharmasolutions, Inc. | Self-emulsifying compositions for drugs poorly soluble in water |
EP1135150A4 (en) * | 1998-12-11 | 2006-05-17 | Pharmasolutions Inc | Self-emulsifying compositions for drugs poorly soluble in water |
WO2000033862A1 (en) | 1998-12-11 | 2000-06-15 | Pharmasolutions, Inc. | Self-emulsifying compositions for drugs poorly soluble in water |
US8524696B2 (en) | 1999-04-02 | 2013-09-03 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
US7645816B2 (en) | 1999-04-02 | 2010-01-12 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
US6767555B2 (en) | 1999-05-28 | 2004-07-27 | Novartis Ag | Pharmaceutical compositions |
US6432445B1 (en) | 1999-05-28 | 2002-08-13 | Novartis Ag | Pharmaceutical capsules comprising a cyclosporin |
WO2002051414A1 (en) * | 2000-12-22 | 2002-07-04 | Takeda Chemical Industries, Ltd. | Medicinal compositions for oral use |
EP1810694A2 (en) * | 2001-02-02 | 2007-07-25 | National Research Council of Canada | Water-soluble compositions of bioactive lipophilic compounds |
EP1810694A3 (en) * | 2001-02-02 | 2008-01-09 | National Research Council of Canada | Water-soluble compositions of bioactive lipophilic compounds |
US6828301B2 (en) | 2002-02-07 | 2004-12-07 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for hepatitis C viral protease inhibitors |
WO2005013973A1 (en) * | 2003-07-18 | 2005-02-17 | Aventis Pharma S.A. | Semi-solid systems containing azetidine derivatives |
AU2004262498B2 (en) * | 2003-07-18 | 2009-01-22 | Aventis Pharma S.A. | Semi-solid systems containing azetidine derivatives |
EP1498122A1 (en) * | 2003-07-18 | 2005-01-19 | Aventis Pharma S.A. | Semi-solid systems containing azetidine derivatives |
WO2008142090A1 (en) * | 2007-05-23 | 2008-11-27 | Boehringer Ingelheim International Gmbh | Self-emulsifying formulation of tipranavir for oral administration |
WO2009117152A1 (en) | 2008-03-20 | 2009-09-24 | Virun, Inc. | Emulsions including a peg-derivative of tocopherol |
US8282977B2 (en) | 2008-03-20 | 2012-10-09 | Virun, Inc. | Compositions containing non-polar compounds |
US9788564B2 (en) | 2008-03-20 | 2017-10-17 | Virun, Inc. | Compositions containing non-polar compounds |
EP2548456A1 (en) * | 2008-03-20 | 2013-01-23 | Virun, Inc. | Emulsions including a PEG-derivative of tocopherol |
US10668029B2 (en) | 2008-03-20 | 2020-06-02 | Virun, Inc. | Compositions containing non-polar compounds |
US10220007B2 (en) | 2008-03-20 | 2019-03-05 | Virun, Inc. | Compositions containing non-polar compounds |
AU2009226019B2 (en) * | 2008-03-20 | 2013-08-29 | Virun, Inc. | Emulsions including a PEG-derivative of tocopherol |
AU2009226019C1 (en) * | 2008-03-20 | 2014-02-20 | Virun, Inc. | Emulsions including a PEG-derivative of tocopherol |
US11813246B2 (en) | 2008-03-28 | 2023-11-14 | Astrazeneca Ab | Pharmaceutical composition |
US8337931B2 (en) | 2008-06-23 | 2012-12-25 | Virun, Inc. | Compositions containing non-polar compounds |
US8722093B2 (en) | 2009-02-23 | 2014-05-13 | NanoRx, Inc. | Policosanol nanoparticles |
WO2011005646A2 (en) | 2009-07-07 | 2011-01-13 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition for a hepatitis c viral protease inhibitor |
US9320295B2 (en) | 2010-03-23 | 2016-04-26 | Virun, Inc. | Compositions containing non-polar compounds |
US20130108674A1 (en) * | 2010-06-11 | 2013-05-02 | Medivis S.R.L. | Ophthalmic compositions for the administration of liposoluble active ingredients |
US10335385B2 (en) | 2010-06-21 | 2019-07-02 | Virun, Inc. | Composition containing non-polar compounds |
US9034383B2 (en) | 2010-08-23 | 2015-05-19 | NanoRx, Inc. | Policosanol nanoparticles |
US10874122B2 (en) | 2012-02-10 | 2020-12-29 | Virun, Inc. | Beverage compositions containing non-polar compounds |
WO2013120025A1 (en) | 2012-02-10 | 2013-08-15 | Virun, Inc. | Beverage compositions containing non-polar compounds |
US9351517B2 (en) | 2013-03-15 | 2016-05-31 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and compositions containing same |
US9693574B2 (en) | 2013-08-08 | 2017-07-04 | Virun, Inc. | Compositions containing water-soluble derivatives of vitamin E mixtures and modified food starch |
US10285971B2 (en) | 2014-09-18 | 2019-05-14 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same |
US10016363B2 (en) | 2014-09-18 | 2018-07-10 | Virun, Inc. | Pre-spray emulsions and powders containing non-polar compounds |
US9861611B2 (en) | 2014-09-18 | 2018-01-09 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same |
WO2021050697A1 (en) * | 2019-09-11 | 2021-03-18 | Barlean's Organic Oils, Llc | Softgel fill materials |
Also Published As
Publication number | Publication date |
---|---|
CA2221145A1 (en) | 1996-11-21 |
JPH11505257A (en) | 1999-05-18 |
MX9708934A (en) | 1998-03-31 |
EP0825849A1 (en) | 1998-03-04 |
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