WO1996040768A3 - Anti-fungal and anti-bacterial histatin-based peptides - Google Patents

Anti-fungal and anti-bacterial histatin-based peptides Download PDF

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Publication number
WO1996040768A3
WO1996040768A3 PCT/US1996/009374 US9609374W WO9640768A3 WO 1996040768 A3 WO1996040768 A3 WO 1996040768A3 US 9609374 W US9609374 W US 9609374W WO 9640768 A3 WO9640768 A3 WO 9640768A3
Authority
WO
WIPO (PCT)
Prior art keywords
fungal
based peptides
histatin
bacterial
naturally occurring
Prior art date
Application number
PCT/US1996/009374
Other languages
French (fr)
Other versions
WO1996040768A2 (en
Inventor
Frank G Oppenheim
Tao Xu
F Donald Roberts
Peter Spacciapoli
Phillip M Friden
Original Assignee
Periodontix Inc
Univ Boston
Frank G Oppenheim
Tao Xu
F Donald Roberts
Peter Spacciapoli
Phillip M Friden
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Periodontix Inc, Univ Boston, Frank G Oppenheim, Tao Xu, F Donald Roberts, Peter Spacciapoli, Phillip M Friden filed Critical Periodontix Inc
Priority to DE69610424T priority Critical patent/DE69610424T2/en
Priority to CA002223505A priority patent/CA2223505C/en
Priority to AT96919182T priority patent/ATE196475T1/en
Priority to DK96919182T priority patent/DK0832119T3/en
Priority to US08/973,559 priority patent/US5912230A/en
Priority to JP9501707A priority patent/JPH11508238A/en
Priority to EP96919182A priority patent/EP0832119B1/en
Priority to AU61585/96A priority patent/AU709204B2/en
Publication of WO1996040768A2 publication Critical patent/WO1996040768A2/en
Publication of WO1996040768A3 publication Critical patent/WO1996040768A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Histatin-based peptides representing defined portions of the amino acid sequences of naturally occurring human histatins and methods for treatment of fungal or bacterial infection are described. These histatin-based peptides represent the active anti-fungal and anti-bacterial region of naturally occurring human histatins.
PCT/US1996/009374 1991-11-01 1996-06-07 Anti-fungal and anti-bacterial histatin-based peptides WO1996040768A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
DE69610424T DE69610424T2 (en) 1995-06-07 1996-06-07 HISTATINE-BASED PEPTIDES AGAINST MUSHROOMS AND BACTERIA
CA002223505A CA2223505C (en) 1995-06-07 1996-06-07 Anti-fungal and anti-bacterial histatin-based peptides
AT96919182T ATE196475T1 (en) 1995-06-07 1996-06-07 HISTATIN-BASED, ANTI-FUNGAL AND BACTERIAL PEPTIDES
DK96919182T DK0832119T3 (en) 1995-06-07 1996-06-07 Histatin-based peptides against fungi and bacteria
US08/973,559 US5912230A (en) 1991-11-01 1996-06-07 Anti-fungal and anti-bacterial histatin-based peptides
JP9501707A JPH11508238A (en) 1995-06-07 1996-06-07 Antifungal and antibacterial histatin peptides
EP96919182A EP0832119B1 (en) 1995-06-07 1996-06-07 Anti-fungal and anti-bacterial histatin-based peptides
AU61585/96A AU709204B2 (en) 1995-06-07 1996-06-07 Anti-fungal and anti-bacterial histatin-based peptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/481,888 US5631228A (en) 1991-11-01 1995-06-07 Anti-fungal and anti-bacterial histatin-based peptides
US08/481,888 1995-06-07

Publications (2)

Publication Number Publication Date
WO1996040768A2 WO1996040768A2 (en) 1996-12-19
WO1996040768A3 true WO1996040768A3 (en) 1997-03-06

Family

ID=23913789

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/009374 WO1996040768A2 (en) 1991-11-01 1996-06-07 Anti-fungal and anti-bacterial histatin-based peptides

Country Status (11)

Country Link
US (1) US5631228A (en)
EP (1) EP0832119B1 (en)
JP (1) JPH11508238A (en)
AT (1) ATE196475T1 (en)
AU (1) AU709204B2 (en)
CA (1) CA2223505C (en)
DE (1) DE69610424T2 (en)
DK (1) DK0832119T3 (en)
ES (1) ES2151172T3 (en)
IL (1) IL122386A0 (en)
WO (1) WO1996040768A2 (en)

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US6025326A (en) * 1995-07-07 2000-02-15 Intrabiotics Pharmaceuticals, Inc. Compositions and methods for the prevention and treatment of oral mucositis
SK56598A3 (en) * 1995-11-03 1998-09-09 Unilever Nv Natural composition for combatting fungi
US6531573B1 (en) 1997-12-18 2003-03-11 Trustees Of Boston University Antifungal and antibacterial peptides
NL1008745C2 (en) * 1998-03-30 1999-10-01 Stichting Tech Wetenschapp New peptide conjugates useful for treating yeast, fungal and bacterial infections and tumors
US8283315B2 (en) 1998-08-28 2012-10-09 Lytix Biopharma As Inhibition of tumour growth
GB9818938D0 (en) 1998-08-28 1998-10-21 Alpharma As Bioactive peptides
US6528488B2 (en) * 1999-01-08 2003-03-04 Demegen, Inc. Method for treating cystic fibrosis
US6800291B1 (en) * 1999-03-24 2004-10-05 Zengen, Inc. Uro-genital condition treatment system
US6833435B2 (en) * 1999-08-23 2004-12-21 Matthew Glenn Compositions isolated from bovine tissues and methods for their use
US7632803B2 (en) 1999-10-01 2009-12-15 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US20030158111A1 (en) * 1999-10-01 2003-08-21 David Bar-Or Methods and products for oral care
US7592304B2 (en) 1999-10-01 2009-09-22 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
CA2285673C (en) 1999-10-21 2008-07-29 Gilles Andre Lajoie Cyclic analogs of histatins
US6858581B2 (en) 2000-06-16 2005-02-22 Arizona State University Chemically-modified peptides, compositions, and methods of production and use
US6726898B2 (en) 2000-11-17 2004-04-27 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US6576226B1 (en) * 2000-11-17 2003-06-10 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US7090497B1 (en) 2001-02-21 2006-08-15 Harris David M Method of periodontal laser treatment
US20040127892A1 (en) * 2002-01-31 2004-07-01 Harris David M. Periodontal laser and methods
US7033769B2 (en) 2002-05-23 2006-04-25 The United States Of America As Represented By The Secretary Of The Army Method for discovering one or more peptides adapted for specific binding to a microorganism of interest
US7087228B2 (en) * 2002-07-03 2006-08-08 University Of Southern California Preventing tooth decay and infective endocarditis using natural oligopeptides
AU2004227999B2 (en) 2003-04-01 2009-09-24 Proactive Oral Solutions, Inc. Caries risk test for predicting and assessing the risk of disease
US9127045B2 (en) * 2005-11-17 2015-09-08 University Of Southern California Method of inhibiting bacterial growth and biofilm formation with natural quorum sensing peptides
WO2009005798A2 (en) * 2007-07-03 2009-01-08 Pacgen Biopharmaceuticals Corporation Antifungal formulation and method of preparation
US9115180B2 (en) 2008-01-07 2015-08-25 Rapid Pathogen Screening, Inc. Use of peptides for promoting wound healing
MX2010007442A (en) 2008-01-07 2010-12-21 Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek En Patientenzorg Use of peptides for promoting wound healing.
US20100047734A1 (en) * 2008-08-20 2010-02-25 PathoLase, Inc. Periodontal laser treatment and laser applicator
EP2536379A2 (en) * 2010-02-19 2012-12-26 The University Of South Dakota Rechargeable long-term antifungal denture materials
US20130310327A1 (en) * 2012-05-18 2013-11-21 Rapid Pathogen Screening, Inc. Histatin for Corneal Wound Healing and Ocular Surface Disease
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US20170022256A1 (en) * 2015-07-23 2017-01-26 General Biologicals Corporation Anti-fungal and anti-bacterial peptide and therapeutic method using same
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
EP4294825A1 (en) * 2021-02-16 2023-12-27 The University of Hong Kong Antibacterial and mineralizing compositions and methods of use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994021672A1 (en) * 1993-03-19 1994-09-29 The Regents Of The University Of California Novel antimicrobial peptides from bovine neutrophils
US5486503A (en) * 1991-11-01 1996-01-23 The Trustees Of Boston University Anti-fungal histatin-based peptides

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
US4725576A (en) * 1983-12-29 1988-02-16 Research Foundation Of State University Of New York Fungicidal polypeptide compositions containing L-histidine and methods for use therefore
US5032574A (en) * 1988-05-26 1991-07-16 Invitron Corporation Novel antimicrobial peptide
US5221732A (en) * 1988-12-06 1993-06-22 The United States Of America As Represented By The Department Of Health And Human Services Antimicrobial magainin modified peptides
JP2818056B2 (en) * 1990-09-07 1998-10-30 森永乳業株式会社 Antimicrobial peptides and antimicrobial agents
US5225399A (en) * 1991-04-15 1993-07-06 The Children's Hospital Of Philadelphia Antimicrobial amphiphilic peptides
US5239059A (en) * 1991-05-10 1993-08-24 The Children's Hospital Of Philadelphia Ion-channel forming peptides
US5324716A (en) * 1991-06-14 1994-06-28 Regents Of The University Of California Broad spectrum antimicrobial compounds and methods of use
JPH06234653A (en) * 1993-02-10 1994-08-23 Sunstar Inc Periodontium regeneration accelerating agent and material therefor
JPH06287146A (en) * 1993-03-31 1994-10-11 Sunstar Inc External agent for skin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486503A (en) * 1991-11-01 1996-01-23 The Trustees Of Boston University Anti-fungal histatin-based peptides
WO1994021672A1 (en) * 1993-03-19 1994-09-29 The Regents Of The University Of California Novel antimicrobial peptides from bovine neutrophils

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
P.A. RAJ ET AL.: "Salivary Histatin 5: Dependence of Sequence, Chain Length, and Helical Conformation for Candidacidal Activity", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, no. 7, 5 March 1990 (1990-03-05), BALTIMORE, MD US, pages 3898 - 3905, XP002020121 *
R.F. TROXLER ET AL.: "Structural relationship between human salvary histatins", JOURNAL OF DENTAL RESEARCH, vol. 69, no. 1, January 1990 (1990-01-01), pages 2 - 6, XP000611621 *

Also Published As

Publication number Publication date
DE69610424T2 (en) 2001-01-25
US5631228A (en) 1997-05-20
DK0832119T3 (en) 2000-11-20
WO1996040768A2 (en) 1996-12-19
IL122386A0 (en) 1998-06-15
EP0832119A2 (en) 1998-04-01
DE69610424D1 (en) 2000-10-26
AU709204B2 (en) 1999-08-26
CA2223505C (en) 2003-10-14
AU6158596A (en) 1996-12-30
CA2223505A1 (en) 1996-12-19
ES2151172T3 (en) 2000-12-16
JPH11508238A (en) 1999-07-21
EP0832119B1 (en) 2000-09-20
ATE196475T1 (en) 2000-10-15

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