WO1997002829A3 - Use of indigestible oligosaccharides to prevent and treat diarrhea - Google Patents

Use of indigestible oligosaccharides to prevent and treat diarrhea Download PDF

Info

Publication number
WO1997002829A3
WO1997002829A3 PCT/US1996/011201 US9611201W WO9702829A3 WO 1997002829 A3 WO1997002829 A3 WO 1997002829A3 US 9611201 W US9611201 W US 9611201W WO 9702829 A3 WO9702829 A3 WO 9702829A3
Authority
WO
WIPO (PCT)
Prior art keywords
indigestible oligosaccharides
diarrhea
fos
grams
administered
Prior art date
Application number
PCT/US1996/011201
Other languages
French (fr)
Other versions
WO1997002829A2 (en
Inventor
Margaret Ione Halpin Dohnalek
Karin Margaret Ostrom
Milo Duane Hilty
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Priority to MX9800330A priority Critical patent/MX9800330A/en
Priority to AU63447/96A priority patent/AU723942B2/en
Priority to JP50586797A priority patent/JP2002502356A/en
Priority to NZ312019A priority patent/NZ312019A/en
Priority to CA002226422A priority patent/CA2226422C/en
Priority to IL12313196A priority patent/IL123131A/en
Priority to EP96922639A priority patent/EP0837685A2/en
Publication of WO1997002829A2 publication Critical patent/WO1997002829A2/en
Publication of WO1997002829A3 publication Critical patent/WO1997002829A3/en
Priority to NO19980083A priority patent/NO314242B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/13—Fermented milk preparations; Treatment using microorganisms or enzymes using additives
    • A23C9/1307—Milk products or derivatives; Fruit or vegetable juices; Sugars, sugar alcohols, sweeteners; Oligosaccharides; Organic acids or salts thereof or acidifying agents; Flavours, dyes or pigments; Inert or aerosol gases; Carbonation methods
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/346—Finished or semi-finished products in the form of powders, paste or liquids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/244—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from corms, tubers or roots, e.g. glucomannan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/733—Fructosans, e.g. inulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G2200/00—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents
    • A23G2200/06—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF containing organic compounds, e.g. synthetic flavouring agents containing beet sugar or cane sugar if specifically mentioned or containing other carbohydrates, e.g. starches, gums, alcohol sugar, polysaccharides, dextrin or containing high or low amount of carbohydrate

Abstract

A method is provided for reducing the duration of diarrhea and recurrent episodes of diarrhea in humans by enterally administering indigestible oligosaccharides prophylactically. More specifically, the present invention relates to a method using indigestible oligosaccharides or fructooligosaccharides (FOS) to reduce the duration and recurrence of diarrhea in a human wherein between 0.5 grams and 5 grams of at least one FOS selected from the group consisting of 1-kestose, nystose, and 1F-β-fructofuranosyl nystose is administered to said human per day. The indigestible oligosaccharides can be produced through enzymatic synthesis, chemical techniques or isolated from plant materials and are administered in the form of a nutritional product, candy, tablets, chewing gum, lozenges, milk, yogurts, fermented products and the like.
PCT/US1996/011201 1995-07-11 1996-07-02 Use of indigestible oligosaccharides to prevent and treat diarrhea WO1997002829A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
MX9800330A MX9800330A (en) 1995-07-11 1996-07-02 Use of indigestible oligosaccharides to prevent and treat diarrhea.
AU63447/96A AU723942B2 (en) 1995-07-11 1996-07-02 Use of indigestible oligosaccharides to prevent and treat diarrhea
JP50586797A JP2002502356A (en) 1995-07-11 1996-07-02 Use of non-digestible oligosaccharides for prevention and treatment of diarrhea
NZ312019A NZ312019A (en) 1995-07-11 1996-07-02 Indigestible oligosaccharides to treat diarrhea typically contained in infants milk beverages
CA002226422A CA2226422C (en) 1995-07-11 1996-07-02 Use of indigestible oligosaccharides to prevent and treat diarrhea
IL12313196A IL123131A (en) 1995-07-11 1996-07-02 Compositions containing indigestible oligosaccharides for reducing the duration of diarrhea
EP96922639A EP0837685A2 (en) 1995-07-11 1996-07-02 Use of indigestible oligosaccharides to prevent and treat diarrhea
NO19980083A NO314242B1 (en) 1995-07-11 1998-01-08 Use of indigestible oligosaccharides to prevent and treat diarrhea

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US103695P 1995-07-11 1995-07-11
US60/001,036 1996-06-11
US08/653,084 1996-06-11
US08/653,084 US5827526A (en) 1995-07-11 1996-06-12 Use of indigestible oligosaccharides to prevent gastrointestinal infections and reduce duration of diarrhea in humans

Publications (2)

Publication Number Publication Date
WO1997002829A2 WO1997002829A2 (en) 1997-01-30
WO1997002829A3 true WO1997002829A3 (en) 1997-03-27

Family

ID=26668456

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/011201 WO1997002829A2 (en) 1995-07-11 1996-07-02 Use of indigestible oligosaccharides to prevent and treat diarrhea

Country Status (11)

Country Link
US (1) US5827526A (en)
EP (1) EP0837685A2 (en)
JP (1) JP2002502356A (en)
AR (1) AR003448A1 (en)
AU (1) AU723942B2 (en)
CA (1) CA2226422C (en)
IL (1) IL123131A (en)
MX (1) MX9800330A (en)
NO (1) NO314242B1 (en)
NZ (1) NZ312019A (en)
WO (1) WO1997002829A2 (en)

Cited By (3)

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US8486668B2 (en) 2009-02-24 2013-07-16 Ritter Pharmaceuticals, Inc. Prebiotic formulations and methods of use
US8492124B2 (en) 2009-02-24 2013-07-23 Ritter Pharmaceuticals, Inc. Prebiotic formulations and methods of use
US9226933B2 (en) 2004-07-22 2016-01-05 Ritter Pharmaceuticals, Inc. Methods and compositions for treating lactose intolerance

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US6929807B1 (en) * 1996-08-09 2005-08-16 Mannatech, Inc. Compositions of plant carbohydrates as dietary supplements
US6045854A (en) * 1997-03-31 2000-04-04 Abbott Laboraties Nutritional formulations containing oligosaccharides
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US7147883B1 (en) 1998-08-27 2006-12-12 Silver Barnard S Compositions containing at least one polyol and inulin characterized by reduced tendencies of the at least one polyol to induce acute diarrhea
US6399142B1 (en) 1998-08-27 2002-06-04 Barnard Stewart Silver Liquid food products
US6569488B2 (en) 1998-08-27 2003-05-27 Barnard Stewart Silver Processes for making novel inulin products
US6419978B1 (en) 1998-08-27 2002-07-16 Barnard Stewart Silver Inulin fractions
US7186431B1 (en) 1998-08-27 2007-03-06 Barnard Stewart Silver Sweetening compositions and foodstuffs comprised thereof
US7045166B2 (en) * 1998-08-27 2006-05-16 Silver Barnard S Sweetener compositions containing fractions of inulin
US6491540B1 (en) 1999-09-20 2002-12-10 Jack Barreca Center-filled supplement gum
US9387168B2 (en) 1999-09-20 2016-07-12 Jack Barreca Chewing gum with tomatidine
US9253991B2 (en) 1999-09-20 2016-02-09 Jack Barreca Chewing gum with B vitamins
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FI119429B (en) * 2002-09-17 2008-11-14 Danisco New uses and compositions of carbohydrates
CN1703149A (en) * 2002-10-11 2005-11-30 惠氏公司 Nutritional formulations containing synbiotic substances
US8602774B2 (en) * 2002-12-04 2013-12-10 Bryan Wasylucha Process of tooth whitening and apparatus therefor
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US8685943B2 (en) * 2003-03-12 2014-04-01 Hill's Pet Nutrition, Inc. Methods for reducing diarrhea in a companion animal
US20040191295A1 (en) * 2003-03-28 2004-09-30 Locniskar Mary Frances Composition and method for viral inhibition
US20050118299A1 (en) * 2003-12-01 2005-06-02 The Iams Company Companion animal compositions comprising short chain oligofructose
US20080161230A1 (en) * 2004-04-23 2008-07-03 Novexin Limited Methods and Kits for Stabilising, Protecting and Solubilising Proteins
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9226933B2 (en) 2004-07-22 2016-01-05 Ritter Pharmaceuticals, Inc. Methods and compositions for treating lactose intolerance
US8486668B2 (en) 2009-02-24 2013-07-16 Ritter Pharmaceuticals, Inc. Prebiotic formulations and methods of use
US8492124B2 (en) 2009-02-24 2013-07-23 Ritter Pharmaceuticals, Inc. Prebiotic formulations and methods of use
US8785160B2 (en) 2009-02-24 2014-07-22 Ritter Pharmaceuticals, Inc. Prebiotic formulations and methods of use
US9579340B2 (en) 2009-02-24 2017-02-28 Ritter Pharmaceuticals, Inc. Prebiotic formulations and methods of use
US9592248B2 (en) 2009-02-24 2017-03-14 Ritter Pharmaceuticals, Inc. Prebiotic formulations and methods of use

Also Published As

Publication number Publication date
WO1997002829A2 (en) 1997-01-30
IL123131A (en) 2005-08-31
CA2226422C (en) 2003-06-17
NZ312019A (en) 2000-06-23
NO980083L (en) 1998-03-10
CA2226422A1 (en) 1997-01-30
EP0837685A2 (en) 1998-04-29
NO980083D0 (en) 1998-01-08
NO314242B1 (en) 2003-02-24
AU6344796A (en) 1997-02-10
AU723942B2 (en) 2000-09-07
US5827526A (en) 1998-10-27
JP2002502356A (en) 2002-01-22
AR003448A1 (en) 1998-08-05
IL123131A0 (en) 1998-09-24
MX9800330A (en) 1998-07-31

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