WO1997015288A3 - Zubereitungen und verfahren zur stabilisierung biologischer materialien mittels trocknungsverfahren ohne einfrieren - Google Patents
Zubereitungen und verfahren zur stabilisierung biologischer materialien mittels trocknungsverfahren ohne einfrieren Download PDFInfo
- Publication number
- WO1997015288A3 WO1997015288A3 PCT/EP1996/004627 EP9604627W WO9715288A3 WO 1997015288 A3 WO1997015288 A3 WO 1997015288A3 EP 9604627 W EP9604627 W EP 9604627W WO 9715288 A3 WO9715288 A3 WO 9715288A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- freezing
- preparations
- biological materials
- substance mixtures
- drying methods
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000008014 freezing Effects 0.000 title abstract 2
- 238000007710 freezing Methods 0.000 title abstract 2
- 239000012620 biological material Substances 0.000 title 1
- 238000001035 drying Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 230000000087 stabilizing effect Effects 0.000 title 1
- 239000000126 substance Substances 0.000 abstract 4
- 239000000203 mixture Substances 0.000 abstract 3
- 239000011149 active material Substances 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/443—Oxidoreductases (1) acting on CH-OH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Drying Of Solid Materials (AREA)
- Enzymes And Modification Thereof (AREA)
- Materials For Medical Uses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines Containing Plant Substances (AREA)
- Storage Of Fruits Or Vegetables (AREA)
Abstract
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP96934811A EP0857060B1 (de) | 1995-10-25 | 1996-10-24 | Zubereitungen und verfahren zur stabilisierung biologischer materialien mittels trocknungsverfahren ohne einfrieren |
US09/051,918 US7172999B2 (en) | 1995-10-25 | 1996-10-24 | Method and preparations for stabilizing biological materials by drying methods without freezing |
SI9630426T SI0857060T1 (en) | 1995-10-25 | 1996-10-24 | Method and preparations for stabilizing biological materials by drying methods without freezing |
HU9901314A HU222601B1 (hu) | 1995-10-25 | 1996-10-24 | Készítmények és eljárás biológiai anyagok stabilizálására fagyasztás nélküli szárítással |
AU72984/96A AU712489B2 (en) | 1995-10-25 | 1996-10-24 | Method and preparations for stabilizing biological materials by drying methods without freezing |
JP9516286A JPH11513700A (ja) | 1995-10-25 | 1996-10-24 | 凍結しない乾燥過程により生物材料を安定化するための調製物及び方法 |
NZ320276A NZ320276A (en) | 1995-10-25 | 1996-10-24 | Method and preparations for stabilizing biological materials by drying methods without freezing |
AT96934811T ATE212541T1 (de) | 1995-10-25 | 1996-10-24 | Zubereitungen und verfahren zur stabilisierung biologischer materialien mittels trocknungsverfahren ohne einfrieren |
PL96326358A PL190657B1 (pl) | 1995-10-25 | 1996-10-24 | Sposób wytwarzania suchych, częściowo amorficznych produktów, mieszanina substancji i zastosowanie kombinacji substancji |
DK96934811T DK0857060T3 (da) | 1995-10-25 | 1996-10-24 | Præparater og fremgangsmåder til stabilisering af biologiske materialer ved hjælp af tørringsprocesser uden nedfrysning |
BR9611265A BR9611265A (pt) | 1995-10-25 | 1996-10-24 | Preparações e processos para estabilização de materiais biológicos por meio de processos de secagem sem congelamento |
DE59608684T DE59608684D1 (de) | 1995-10-25 | 1996-10-24 | Zubereitungen und verfahren zur stabilisierung biologischer materialien mittels trocknungsverfahren ohne einfrieren |
KR10-1998-0703022A KR100466670B1 (ko) | 1995-10-25 | 1996-10-24 | 비동결건조법에의한생물질의안정화제제및안정화방법 |
CA002235243A CA2235243C (en) | 1995-10-25 | 1996-10-24 | Method and preparations for stabilizing biological materials by drying methods without freezing |
SK509-98A SK283664B6 (sk) | 1995-10-25 | 1996-10-24 | Spôsob prípravy suchých, čiastočne amorfných produktov, zmesi substancií získané týmto spôsobom, ich použitie a diagnostické prostriedky a terapeutické prípravky obsahujúce tieto zmesi |
IL12420496A IL124204A (en) | 1995-10-25 | 1996-10-24 | A process for creating dry, partly amorphous materials, without freezing |
NO19981868A NO324728B1 (no) | 1995-10-25 | 1998-04-24 | Fremgangsmate for fremstilling av torre, delvis amorfe produkter, stoffblanding, diagnostisk middel og preparat som omfatter stofflandingen, anvendelse av stoffblandingen til fremstilling av diagnostika og terapeutiske midler og fremgangsmate for stabilisering av biologisk eller terapeutisk aktive materialer |
US11/449,781 US20070020289A1 (en) | 1995-10-25 | 2006-06-09 | Preparations and processes for stabilizing biological materials by means of drying processes without freezing |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19539574A DE19539574A1 (de) | 1995-10-25 | 1995-10-25 | Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren |
DE19539574.3 | 1995-10-25 |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US09/051,918 A-371-Of-International US7172999B2 (en) | 1995-10-25 | 1996-10-24 | Method and preparations for stabilizing biological materials by drying methods without freezing |
US10/141,960 Division US20030059468A1 (en) | 1995-10-25 | 2002-05-10 | Preparations and processes for stabilizing biological materials by means of drying processes without freezing |
US11/449,781 Continuation US20070020289A1 (en) | 1995-10-25 | 2006-06-09 | Preparations and processes for stabilizing biological materials by means of drying processes without freezing |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1997015288A2 WO1997015288A2 (de) | 1997-05-01 |
WO1997015288A3 true WO1997015288A3 (de) | 1997-05-29 |
Family
ID=7775640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1996/004627 WO1997015288A2 (de) | 1995-10-25 | 1996-10-24 | Zubereitungen und verfahren zur stabilisierung biologischer materialien mittels trocknungsverfahren ohne einfrieren |
Country Status (25)
Country | Link |
---|---|
US (3) | US7172999B2 (de) |
EP (1) | EP0857060B1 (de) |
JP (2) | JPH11513700A (de) |
KR (1) | KR100466670B1 (de) |
CN (1) | CN1130196C (de) |
AT (1) | ATE212541T1 (de) |
AU (1) | AU712489B2 (de) |
BR (1) | BR9611265A (de) |
CA (1) | CA2235243C (de) |
CZ (1) | CZ293456B6 (de) |
DE (2) | DE19539574A1 (de) |
DK (1) | DK0857060T3 (de) |
ES (1) | ES2170274T3 (de) |
HU (1) | HU222601B1 (de) |
IL (1) | IL124204A (de) |
MX (1) | MX9803264A (de) |
NO (1) | NO324728B1 (de) |
NZ (1) | NZ320276A (de) |
PL (1) | PL190657B1 (de) |
PT (1) | PT857060E (de) |
RU (1) | RU2191003C2 (de) |
SK (1) | SK283664B6 (de) |
TR (1) | TR199800715T2 (de) |
WO (1) | WO1997015288A2 (de) |
ZA (1) | ZA968930B (de) |
Families Citing this family (49)
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US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
DE19539574A1 (de) * | 1995-10-25 | 1997-04-30 | Boehringer Mannheim Gmbh | Zubereitungen und Verfahren zur Stabilisierung biologischer Materialien mittels Trocknungsverfahren ohne Einfrieren |
EP0852951A1 (de) * | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
EP0913177A1 (de) * | 1997-11-03 | 1999-05-06 | Roche Diagnostics GmbH | Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialien mittels Konvektionstrocknung, insbesondere Sprühtrocknung |
EP0913178A1 (de) * | 1997-11-03 | 1999-05-06 | Boehringer Mannheim Gmbh | Verfahren zur Herstellung trockener, amorpher Produkte enthaltend biologisch aktive Materialen mittels Konvektionstrocknung und die erhaltenen Produkte |
BR9905867A (pt) * | 1998-11-06 | 2001-01-23 | Bio Sidus S A | Linhagem celular produtora de eritropoietina humana recombinante e a eritropoietina humana recombinante produzida por esta célula |
PL203797B1 (pl) * | 1999-04-09 | 2009-11-30 | Ortho Mcneil Pharm Inc | Kompozycje farmaceutyczne erytropoetyny |
DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
EP1290390A1 (de) * | 2000-06-07 | 2003-03-12 | Universal Preservation Technologies, Inc. | Barrieretechnologie in industriellem umfang für konservierung von empfindlichen biologischen materialien |
GB0017999D0 (en) * | 2000-07-21 | 2000-09-13 | Smithkline Beecham Biolog | Novel device |
EP1854454B1 (de) * | 2002-01-16 | 2013-11-06 | Boehringer Ingelheim Pharma GmbH & Co. KG | Verfahren zur Herstellung von amorphen Telmisartan |
KR100556503B1 (ko) * | 2002-11-26 | 2006-03-03 | 엘지전자 주식회사 | 건조기의 건조 시간제어 방법 |
US8377952B2 (en) * | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
JP4896006B2 (ja) | 2004-04-08 | 2012-03-14 | バイオマトリカ, インコーポレイテッド | ライフサイエンスのためのサンプル保存とサンプル管理との統合 |
US20080176209A1 (en) * | 2004-04-08 | 2008-07-24 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
US20060099567A1 (en) * | 2004-04-08 | 2006-05-11 | Biomatrica, Inc. | Integration of sample storage and sample management for life science |
GB0517688D0 (en) * | 2005-08-31 | 2005-10-05 | Cambridge Biostability Ltd | Improvements in the stabilisation of biological materials |
GB2430880A (en) * | 2005-10-04 | 2007-04-11 | Cambridge Biostability Ltd | Pharmaceutical compositions stabilized in glassy particles |
GB0523638D0 (en) * | 2005-11-21 | 2005-12-28 | Cambridge Biostability Ltd | Pharmaceutical device for the administration of substances to patients |
US8968721B2 (en) | 2005-12-28 | 2015-03-03 | Advanced Bionutrition Corporation | Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same |
JP5214464B2 (ja) | 2005-12-28 | 2013-06-19 | アドバンスド バイオニュートリション コーポレーション | 多糖類、糖類およびポリオール類の乾燥マトリックスを含む、ガラス形態の、プロバイオティクス細菌用送達媒体およびその製造方法 |
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US8466187B2 (en) * | 2007-09-18 | 2013-06-18 | Thermolife International, Llc | Amino acid compositions |
EP2410996B1 (de) | 2009-03-27 | 2017-08-02 | Advanced Bionutrition Corp. | Impfstoffe in mikropartikelform zur oralen oder nasalen impfung und stärkung von tieren einschliesslich fischen |
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WO2014100755A2 (en) | 2012-12-20 | 2014-06-26 | Biomatrica, Inc. | Formulations and methods for stabilizing pcr reagents |
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WO1990012029A1 (en) * | 1989-04-11 | 1990-10-18 | Immunobiology Research Institute, Inc. | Lyophilized peptide formulations |
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DE4242863A1 (de) * | 1992-12-18 | 1994-06-23 | Boehringer Mannheim Gmbh | Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF |
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1996
- 1996-10-24 PT PT96934811T patent/PT857060E/pt unknown
- 1996-10-24 JP JP9516286A patent/JPH11513700A/ja active Pending
- 1996-10-24 KR KR10-1998-0703022A patent/KR100466670B1/ko not_active IP Right Cessation
- 1996-10-24 DE DE59608684T patent/DE59608684D1/de not_active Revoked
- 1996-10-24 DK DK96934811T patent/DK0857060T3/da active
- 1996-10-24 AU AU72984/96A patent/AU712489B2/en not_active Ceased
- 1996-10-24 SK SK509-98A patent/SK283664B6/sk not_active IP Right Cessation
- 1996-10-24 PL PL96326358A patent/PL190657B1/pl not_active IP Right Cessation
- 1996-10-24 US US09/051,918 patent/US7172999B2/en not_active Expired - Fee Related
- 1996-10-24 HU HU9901314A patent/HU222601B1/hu not_active IP Right Cessation
- 1996-10-24 RU RU98109886/14A patent/RU2191003C2/ru not_active IP Right Cessation
- 1996-10-24 WO PCT/EP1996/004627 patent/WO1997015288A2/de not_active Application Discontinuation
- 1996-10-24 ES ES96934811T patent/ES2170274T3/es not_active Expired - Lifetime
- 1996-10-24 BR BR9611265A patent/BR9611265A/pt not_active IP Right Cessation
- 1996-10-24 TR TR1998/00715T patent/TR199800715T2/xx unknown
- 1996-10-24 AT AT96934811T patent/ATE212541T1/de active
- 1996-10-24 CN CN96199329A patent/CN1130196C/zh not_active Expired - Fee Related
- 1996-10-24 EP EP96934811A patent/EP0857060B1/de not_active Revoked
- 1996-10-24 IL IL12420496A patent/IL124204A/en not_active IP Right Cessation
- 1996-10-24 CZ CZ19981179A patent/CZ293456B6/cs not_active IP Right Cessation
- 1996-10-24 NZ NZ320276A patent/NZ320276A/xx not_active IP Right Cessation
- 1996-10-24 CA CA002235243A patent/CA2235243C/en not_active Expired - Fee Related
- 1996-10-24 ZA ZA9608930A patent/ZA968930B/xx unknown
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1998
- 1998-04-24 NO NO19981868A patent/NO324728B1/no not_active IP Right Cessation
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2002
- 2002-05-10 US US10/141,960 patent/US20030059468A1/en not_active Abandoned
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2006
- 2006-06-09 US US11/449,781 patent/US20070020289A1/en not_active Abandoned
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2007
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