WO1997026869A1 - Novel 'burst-free' sustained release poly-(lactide/glycolide) microspheres - Google Patents
Novel 'burst-free' sustained release poly-(lactide/glycolide) microspheres Download PDFInfo
- Publication number
- WO1997026869A1 WO1997026869A1 PCT/US1996/019440 US9619440W WO9726869A1 WO 1997026869 A1 WO1997026869 A1 WO 1997026869A1 US 9619440 W US9619440 W US 9619440W WO 9726869 A1 WO9726869 A1 WO 9726869A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- microcapsules
- release
- uncapped
- emulsion
- capped
- Prior art date
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- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 title claims abstract description 37
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- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims abstract description 36
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 23
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- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 2
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- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
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- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002216371A CA2216371C (en) | 1996-01-24 | 1996-11-18 | Novel "burst-free" sustained release poly-(lactide/glycolide) microspheres |
JP9526833A JPH11509862A (en) | 1996-01-24 | 1996-11-18 | New "burst-free" sustained release poly (lactide / glycolide) microspheres |
KR1019970706833A KR100511215B1 (en) | 1996-01-24 | 1996-11-18 | New non-temporal release sustained release poly (lactide / glycolide) microcapsules |
AU14104/97A AU722884B2 (en) | 1996-01-24 | 1996-11-18 | Novel "burst-free" sustained release poly-(lactide/glycolide) microspheres |
BRPI9607752-2A BR9607752B1 (en) | 1996-01-24 | 1996-11-18 | controlled release microcapsule pharmaceutical formulation. |
EP96944247A EP0817619A4 (en) | 1996-01-24 | 1996-11-18 | Novel "burst-free" sustained release poly-(lactide/glycolide) mi crospheres |
BRPI9607752A BRPI9607752B8 (en) | 1996-01-24 | 1996-11-18 | controlled release microcapsule pharmaceutical formulation. |
APAP/P/1997/001088A AP665A (en) | 1996-01-24 | 1996-11-18 | Novel "burst free" sustained release poly-(lactide/glycolide microspheres). |
NZ325561A NZ325561A (en) | 1996-01-24 | 1996-11-18 | Pharmaceutical composition containing an active ingredient and poly(lactide/glycolide) microcapsules which is a burst free controlled release formulation |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US59097396A | 1996-01-24 | 1996-01-24 | |
US08/590,973 | 1996-01-24 | ||
CNB961947683A CN100391445C (en) | 1996-01-24 | 1996-11-18 | Novel 'burst-free' sustained release poly-(lactide/glycolide) mi crospheres |
Publications (1)
Publication Number | Publication Date |
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WO1997026869A1 true WO1997026869A1 (en) | 1997-07-31 |
Family
ID=25744089
Family Applications (1)
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PCT/US1996/019440 WO1997026869A1 (en) | 1996-01-24 | 1996-11-18 | Novel 'burst-free' sustained release poly-(lactide/glycolide) microspheres |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0817619A4 (en) |
JP (1) | JPH11509862A (en) |
CN (1) | CN100391445C (en) |
AP (1) | AP665A (en) |
AU (1) | AU722884B2 (en) |
BR (1) | BR9607752B1 (en) |
NZ (1) | NZ325561A (en) |
WO (1) | WO1997026869A1 (en) |
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US7033608B1 (en) * | 1995-05-22 | 2006-04-25 | The United States Of America As Represented By The Secretary Of The Army | “Burst-free” sustained release poly-(lactide/glycolide) microspheres |
KR100816065B1 (en) | 2006-11-27 | 2008-03-24 | 동국제약 주식회사 | Preparation method of sustained-release microcapsules having good initial burst inhibiting property and the microcapsules thereby |
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1996
- 1996-11-18 JP JP9526833A patent/JPH11509862A/en active Pending
- 1996-11-18 EP EP96944247A patent/EP0817619A4/en not_active Ceased
- 1996-11-18 AP APAP/P/1997/001088A patent/AP665A/en active
- 1996-11-18 WO PCT/US1996/019440 patent/WO1997026869A1/en not_active Application Discontinuation
- 1996-11-18 AU AU14104/97A patent/AU722884B2/en not_active Ceased
- 1996-11-18 CN CNB961947683A patent/CN100391445C/en not_active Expired - Fee Related
- 1996-11-18 NZ NZ325561A patent/NZ325561A/en not_active IP Right Cessation
- 1996-11-18 BR BRPI9607752-2A patent/BR9607752B1/en not_active IP Right Cessation
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US7033608B1 (en) * | 1995-05-22 | 2006-04-25 | The United States Of America As Represented By The Secretary Of The Army | “Burst-free” sustained release poly-(lactide/glycolide) microspheres |
US6217893B1 (en) | 1997-04-18 | 2001-04-17 | Pharma Biotech | Sustained-release compositions and method for preparing same |
WO1998047489A1 (en) * | 1997-04-18 | 1998-10-29 | Pharma Biotech | Sustained-release compositions and method for preparing same |
CN1075945C (en) * | 1998-02-26 | 2001-12-12 | 中国科学院化学研究所 | High-polymer encapsulated insulin microsome and its preparation method and use |
CN1073412C (en) * | 1998-03-19 | 2001-10-24 | 中国科学院化学研究所 | Method for prepn. of macromolecule microcapsule |
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US10206934B2 (en) | 2000-07-05 | 2019-02-19 | Allergan, Inc. | Implants and methods for treating inflammation-mediated conditions of the eye |
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Also Published As
Publication number | Publication date |
---|---|
BR9607752B1 (en) | 2009-05-05 |
BR9607752A (en) | 1999-11-30 |
AU1410497A (en) | 1997-08-20 |
CN100391445C (en) | 2008-06-04 |
NZ325561A (en) | 1999-06-29 |
AP665A (en) | 1998-08-19 |
EP0817619A4 (en) | 1999-02-03 |
CN1188408A (en) | 1998-07-22 |
JPH11509862A (en) | 1999-08-31 |
EP0817619A1 (en) | 1998-01-14 |
AU722884B2 (en) | 2000-08-10 |
AP9701088A0 (en) | 1997-10-31 |
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