WO1997033552A1 - Water soluble paclitaxel prodrugs - Google Patents
Water soluble paclitaxel prodrugs Download PDFInfo
- Publication number
- WO1997033552A1 WO1997033552A1 PCT/US1997/003687 US9703687W WO9733552A1 WO 1997033552 A1 WO1997033552 A1 WO 1997033552A1 US 9703687 W US9703687 W US 9703687W WO 9733552 A1 WO9733552 A1 WO 9733552A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- paclitaxel
- composition
- acid
- poly
- water soluble
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/547—Chelates, e.g. Gd-DOTA or Zinc-amino acid chelates; Chelate-forming compounds, e.g. DOTA or ethylenediamine being covalently linked or complexed to the pharmacologically- or therapeutically-active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Vascular Medicine (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Epoxy Compounds (AREA)
- Saccharide Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
Claims
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL12617997A IL126179A (en) | 1996-03-12 | 1997-03-11 | Pharmaceutical compositions containing anti-tumor drug conjugates |
BR9710646-1A BR9710646A (en) | 1996-03-12 | 1997-03-11 | Water soluble prodrugs of paclitaxel. |
DE69735057T DE69735057T2 (en) | 1996-03-12 | 1997-03-11 | WATER-SOLUBLE PACLITAXEL PRODUCTS |
NZ332234A NZ332234A (en) | 1996-03-12 | 1997-03-11 | Water soluble paclitaxel prodrugs formed by conjugating paclitaxel or docetaxel with a polyglutamic acid polymer and use for treating cancer |
KR1019980711024A KR100561788B1 (en) | 1996-03-12 | 1997-03-11 | Compositions comprising water-soluble paclitaxel prodrugs and implantable medical devices comprising such compositions |
CA002250295A CA2250295C (en) | 1996-03-12 | 1997-03-11 | Water soluble paclitaxel prodrugs |
SI9730728T SI0932399T1 (en) | 1996-03-12 | 1997-03-11 | Water soluble paclitaxel prodrugs |
AU25806/97A AU735900B2 (en) | 1996-03-12 | 1997-03-11 | Water soluble paclitaxel prodrugs |
PL97328807A PL189698B1 (en) | 1996-03-12 | 1997-03-11 | Water-soluble promedicines of paklitaxel |
HU9903952A HU226646B1 (en) | 1996-03-12 | 1997-03-11 | Water soluble pharmaceutical compositions containing taxane derivatives |
EA199800817A EA002400B1 (en) | 1996-03-12 | 1997-03-11 | Water soluable prodrugs of anti-tumor action |
JP53273497A JP3737518B2 (en) | 1996-03-12 | 1997-03-11 | Water-soluble paclitaxel prodrug |
EP97917512A EP0932399B1 (en) | 1996-03-12 | 1997-03-11 | Water soluble paclitaxel prodrugs |
UA98105316A UA68330C2 (en) | 1996-03-12 | 1997-11-03 | Water soluble anticancer pharmaceutical composition (variants) and method for treatment (variants) |
NO19984210A NO324461B1 (en) | 1996-03-12 | 1998-09-11 | A composition comprising an anti-tumor drug conjugated to a water-soluble polymer, the use thereof and an implantable medical device comprising the composition |
NO20072562A NO332539B1 (en) | 1996-03-12 | 2007-05-21 | Use of a mixture of a water-soluble anti-tumor drug and a platinum drug for the manufacture of a drug preparation for the treatment of disease |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1318496P | 1996-03-12 | 1996-03-12 | |
US60/013,184 | 1996-03-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997033552A1 true WO1997033552A1 (en) | 1997-09-18 |
Family
ID=21758713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/003687 WO1997033552A1 (en) | 1996-03-12 | 1997-03-11 | Water soluble paclitaxel prodrugs |
Country Status (23)
Country | Link |
---|---|
US (2) | US5977163A (en) |
EP (2) | EP0932399B1 (en) |
JP (2) | JP3737518B2 (en) |
KR (1) | KR100561788B1 (en) |
CN (2) | CN1304058C (en) |
AT (1) | ATE314843T1 (en) |
AU (1) | AU735900B2 (en) |
BR (1) | BR9710646A (en) |
CA (1) | CA2250295C (en) |
CZ (1) | CZ297979B6 (en) |
DE (1) | DE69735057T2 (en) |
DK (1) | DK0932399T3 (en) |
EA (1) | EA002400B1 (en) |
ES (2) | ES2448467T3 (en) |
HU (1) | HU226646B1 (en) |
IL (1) | IL126179A (en) |
NO (2) | NO324461B1 (en) |
NZ (1) | NZ332234A (en) |
PL (1) | PL189698B1 (en) |
PT (1) | PT932399E (en) |
SI (1) | SI0932399T1 (en) |
UA (1) | UA68330C2 (en) |
WO (1) | WO1997033552A1 (en) |
Cited By (116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997040854A2 (en) * | 1996-05-01 | 1997-11-06 | Antivirals Inc. | Polypeptide conjugates for transporting substances across cell membranes |
EP0895784A1 (en) * | 1996-04-15 | 1999-02-10 | Asahi Kasei Kogyo Kabushiki Kaisha | Medicament composite |
WO1999016416A2 (en) * | 1997-09-29 | 1999-04-08 | Schering Ag | Coated medical implants, method for producing them, and use of the same for preventing restenosis |
WO1999033473A1 (en) * | 1997-12-25 | 1999-07-08 | Toray Industries, Inc. | Remedies for intramedullary diseases |
WO1999039694A2 (en) * | 1998-02-05 | 1999-08-12 | Novartis Ag | Compositions containing organic compounds |
US5977163A (en) * | 1996-03-12 | 1999-11-02 | Pg-Txl Company, L. P. | Water soluble paclitaxel prodrugs |
WO2000000238A1 (en) * | 1998-06-26 | 2000-01-06 | Quanam Medical Corporation | Topoisomerase inhibitors for prevention of restenosis |
WO2000001682A1 (en) * | 1998-07-01 | 2000-01-13 | Bcm Developpement Inc. | Water-soluble derivatives of paclitaxel, method for producing same and uses thereof |
WO2000003677A2 (en) * | 1998-07-14 | 2000-01-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Use of bisphosphonates in the treatment of vascular restenosis |
US6030941A (en) * | 1996-05-01 | 2000-02-29 | Avi Biopharma, Inc. | Polymer composition for delivering substances in living organisms |
WO2000010622A1 (en) * | 1998-08-20 | 2000-03-02 | Cook Incorporated | Coated implantable medical device |
WO2000018439A2 (en) * | 1998-09-29 | 2000-04-06 | Schering Aktiengesellschaft | Use of neoangiogenesis markers for diagnosing and treating tumours by therapy |
WO2000044443A2 (en) * | 1999-01-29 | 2000-08-03 | Angiotech Pharmaceuticals Inc. | Intra-pericardial delivery of anti-microtubule agents |
EP1028756A1 (en) * | 1998-03-30 | 2000-08-23 | PG-TXL Company, L.P. | Water soluble paclitaxel derivatives |
WO2000050016A2 (en) * | 1999-02-23 | 2000-08-31 | Angiotech Pharmaceuticals, Inc. | Compositions and methods for improving integrity of compromised body passageways and cavities |
US6179817B1 (en) | 1995-02-22 | 2001-01-30 | Boston Scientific Corporation | Hybrid coating for medical devices |
WO2001010342A1 (en) * | 1999-08-10 | 2001-02-15 | Scimed Life Systems, Inc. | Thrombosis filter having a surface treatment |
WO2001019406A2 (en) * | 1999-09-13 | 2001-03-22 | Nobex Corporation | Amphiphilic prodrugs |
WO2001026693A2 (en) * | 1999-10-12 | 2001-04-19 | Cell Therapeutics, Inc. | Manufacture of polyglutamate-therapeutic agent conjugates |
WO2001070275A2 (en) * | 2000-03-17 | 2001-09-27 | Cell Therapeutics, Inc. | Polyglutamic acid-camptothecin conjugates and methods of preparation |
US6306993B1 (en) | 1997-05-21 | 2001-10-23 | The Board Of Trustees Of The Leland Stanford, Jr. University | Method and composition for enhancing transport across biological membranes |
JP2001526224A (en) * | 1997-12-22 | 2001-12-18 | シェーリング コーポレイション | Combinations of benzocycloheptapyridine compounds and antitumor agents for treating proliferative diseases |
JP2002511845A (en) * | 1997-04-24 | 2002-04-16 | ニユコメド・イメージング・アクシエセルカペト | Contrast agent |
US6380405B1 (en) | 1999-09-13 | 2002-04-30 | Nobex Corporation | Taxane prodrugs |
WO2002058688A1 (en) * | 2001-01-24 | 2002-08-01 | Mestex Ag | Use of neurotoxic substances in producing a medicament for treating joint pains |
US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
JP2002534461A (en) * | 1999-01-12 | 2002-10-15 | クアナム メディカル コーポレイション | Compositions and methods for administration of water-insoluble paclitaxel derivatives |
EP1251739A2 (en) * | 1999-04-13 | 2002-10-30 | Fannin Bioscience, Inc. | Poly(dipeptide) as a drug carrier |
US6541508B2 (en) | 1999-09-13 | 2003-04-01 | Nobex Corporation | Taxane prodrugs |
EP1301500A1 (en) * | 2000-06-22 | 2003-04-16 | Nitromed, Inc. | Nitrosated and nitrosylated taxanes, compositions and methods of use |
WO2003037385A1 (en) * | 2001-10-30 | 2003-05-08 | Nektar Therapeutics Al, Corporation | Water-soluble polymer conjugates of retinoic acid |
US6593292B1 (en) | 1999-08-24 | 2003-07-15 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
US6638906B1 (en) | 1999-12-13 | 2003-10-28 | Nobex Corporation | Amphiphilic polymers and polypeptide conjugates comprising same |
US6669951B2 (en) | 1999-08-24 | 2003-12-30 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into epithelial tissues |
US6683100B2 (en) | 1999-01-19 | 2004-01-27 | Novartis Ag | Organic compounds |
WO2004035629A2 (en) * | 2002-10-18 | 2004-04-29 | Fidia Farmaceutici S.P.A. | Taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives |
US6730293B1 (en) | 1999-08-24 | 2004-05-04 | Cellgate, Inc. | Compositions and methods for treating inflammatory diseases of the skin |
EP1475105A1 (en) * | 2003-05-09 | 2004-11-10 | Schering AG | Bone localising radiopharmaceutical and tubulin-interacting compound combinatorial radiotherapy |
EP1478406A1 (en) * | 2002-02-27 | 2004-11-24 | Pharmain, Ltd. | Compositions for delivery of therapeutics and other materials, and methods of making and using the same |
EP1561436A1 (en) * | 2004-02-05 | 2005-08-10 | SORIN BIOMEDICA CARDIO S.r.l. | A stent for endoluminal delivery of active principles or agents |
WO2005094897A2 (en) * | 2004-04-01 | 2005-10-13 | Cardiome Pharma Corp. | Pegylated ion channel modulating compounds |
US6984400B2 (en) | 1998-07-14 | 2006-01-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of treating restenosis using bisphosphonate nanoparticles |
US7008645B2 (en) | 1998-07-14 | 2006-03-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method of inhibiting restenosis using bisphosphonates |
US7030155B2 (en) | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US7067111B1 (en) | 1999-10-25 | 2006-06-27 | Board Of Regents, University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
US7153864B2 (en) | 2000-03-17 | 2006-12-26 | Cell Therapeutics Inc. | Polyglutamic acid-camptothecin conjugates and methods of preparation |
WO2007027941A3 (en) * | 2005-08-31 | 2007-04-26 | Abraxis Bioscience Inc | Compositions and methods for preparation of poorly water soluble drugs with increased stability |
US7229961B2 (en) | 1999-08-24 | 2007-06-12 | Cellgate, Inc. | Compositions and methods for enhancing drug delivery across and into ocular tissues |
JP2007153905A (en) * | 1999-12-16 | 2007-06-21 | F Hoffmann La Roche Ag | Substituted bisindolylmaleimide for inhibition of cell proliferation |
EP1800702A2 (en) * | 1998-10-14 | 2007-06-27 | Boston Scientific Limited | Loading and release of water-insoluble drugs |
EP1800664A1 (en) * | 1998-02-05 | 2007-06-27 | Novartis AG | Pharmaceutical formulations for parenteral administration comprising epothilone |
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