WO1997039107A3 - Methods for increasing the maturation of cells - Google Patents

Methods for increasing the maturation of cells Download PDF

Info

Publication number
WO1997039107A3
WO1997039107A3 PCT/CA1997/000231 CA9700231W WO9739107A3 WO 1997039107 A3 WO1997039107 A3 WO 1997039107A3 CA 9700231 W CA9700231 W CA 9700231W WO 9739107 A3 WO9739107 A3 WO 9739107A3
Authority
WO
WIPO (PCT)
Prior art keywords
increasing
maturation
cells
methods
provides
Prior art date
Application number
PCT/CA1997/000231
Other languages
French (fr)
Other versions
WO1997039107A2 (en
Inventor
Gregory Korbutt
Ray Rajotte
Original Assignee
Univ Alberta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Alberta filed Critical Univ Alberta
Priority to AU22834/97A priority Critical patent/AU2283497A/en
Priority to EP97915222A priority patent/EP0894127A2/en
Publication of WO1997039107A2 publication Critical patent/WO1997039107A2/en
Publication of WO1997039107A3 publication Critical patent/WO1997039107A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • A61K2035/128—Immunoprotecting barriers, e.g. jackets, diffusion chambers capsules, e.g. microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/24—Genital tract cells, non-germinal cells from gonads
    • C12N2502/246—Cells of the male genital tract, non-germinal testis cells

Abstract

The present invention provides a method of increasing the maturation rate or proliferation rate of a cell utilizing microencapsulation techniques. The invention also provides a method of treatment of a subject having diabetes utilizing cells produced by the culture method described herein.
PCT/CA1997/000231 1996-04-12 1997-04-11 Methods for increasing the maturation of cells WO1997039107A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU22834/97A AU2283497A (en) 1996-04-12 1997-04-11 Methods for increasing the maturation of cells
EP97915222A EP0894127A2 (en) 1996-04-12 1997-04-11 Methods for increasing the maturation of cells

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US1531096P 1996-04-12 1996-04-12
US60/015,310 1996-04-12
US1973796P 1996-06-14 1996-06-14
US60/019,737 1996-06-14

Publications (2)

Publication Number Publication Date
WO1997039107A2 WO1997039107A2 (en) 1997-10-23
WO1997039107A3 true WO1997039107A3 (en) 1997-12-11

Family

ID=26687221

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1997/000231 WO1997039107A2 (en) 1996-04-12 1997-04-11 Methods for increasing the maturation of cells

Country Status (4)

Country Link
EP (1) EP0894127A2 (en)
AU (1) AU2283497A (en)
CA (1) CA2179341A1 (en)
WO (1) WO1997039107A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6231881B1 (en) 1992-02-24 2001-05-15 Anton-Lewis Usala Medium and matrix for long-term proliferation of cells
US6352707B1 (en) 1992-02-24 2002-03-05 Anton-Lewis Usala Transplant encapsulation in a hydrogel matrix to obscure immune recognition
EP1289537B1 (en) 2000-05-31 2005-11-30 Encelle, Inc. Method of treating chronic ulcers
ATE553766T1 (en) * 2000-10-17 2012-05-15 Diabcell Pty Ltd PREPARATION AND XENOTRANSPLANTATION OF ISLANDS OF LANGERHANS FROM PIGS
WO2003027270A1 (en) * 2001-09-28 2003-04-03 Diabcell Pty Limited Growing xenotransplant material in culture
EP2761297A4 (en) * 2011-09-28 2015-03-25 Islet Sciences Inc Ex vivo maturation of islet cells
KR101914837B1 (en) * 2016-12-08 2018-11-02 서울대학교산학협력단 Method for Isolating Pancreatic Islet of Neonatal Piglets
CN115197890A (en) * 2022-06-02 2022-10-18 成都中科奥格生物科技有限公司 Islet cell culture medium and preparation method and application thereof

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127989A2 (en) * 1983-06-01 1984-12-12 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4673566A (en) * 1983-06-01 1987-06-16 Connaught Laboratories Limited Microencapsulation of living tissue and cells
EP0363125A2 (en) * 1988-10-03 1990-04-11 Hana Biologics Inc. Proliferated pancreatic endocrine cell product and process
US5227298A (en) * 1990-08-17 1993-07-13 The Trustees Of Columbia University In The City Of New York Method for microencapuslation of cells or tissue
WO1994026915A1 (en) * 1993-05-10 1994-11-24 The Regents Of The University Of Michigan Gene transfer into pancreatic and biliary epithelial cells
WO1995019743A1 (en) * 1994-01-24 1995-07-27 The Regents Of The University Of California Multiple layer alginate coatings of biological tissue for transplantation
WO1996040178A1 (en) * 1995-06-07 1996-12-19 Research Corporation Technologies, Inc. Use of co-localized islets and sertoli cells in xenograft cellular transplants
WO1997016536A1 (en) * 1995-10-30 1997-05-09 Vivorx, Inc. Method for ex vivo proliferation and differentiation of adult pancreatic islet cells, media useful therefor and uses thereof

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0127989A2 (en) * 1983-06-01 1984-12-12 Connaught Laboratories Limited Microencapsulation of living tissue and cells
US4673566A (en) * 1983-06-01 1987-06-16 Connaught Laboratories Limited Microencapsulation of living tissue and cells
EP0363125A2 (en) * 1988-10-03 1990-04-11 Hana Biologics Inc. Proliferated pancreatic endocrine cell product and process
US5227298A (en) * 1990-08-17 1993-07-13 The Trustees Of Columbia University In The City Of New York Method for microencapuslation of cells or tissue
WO1994026915A1 (en) * 1993-05-10 1994-11-24 The Regents Of The University Of Michigan Gene transfer into pancreatic and biliary epithelial cells
WO1995019743A1 (en) * 1994-01-24 1995-07-27 The Regents Of The University Of California Multiple layer alginate coatings of biological tissue for transplantation
WO1996040178A1 (en) * 1995-06-07 1996-12-19 Research Corporation Technologies, Inc. Use of co-localized islets and sertoli cells in xenograft cellular transplants
WO1997016536A1 (en) * 1995-10-30 1997-05-09 Vivorx, Inc. Method for ex vivo proliferation and differentiation of adult pancreatic islet cells, media useful therefor and uses thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KORBUTT G.S. ET AL.: "Large scale isolation, growth and function of porcine neonatal islet cells", JOURNAL OF CLINICAL INVESTIGATION, vol. 97, no. 9, 1 May 1996 (1996-05-01), NEW YORK, US, pages 2119 - 2129, XP002040062 *
SELAWRY H.P. ET AL.: "Sertoli cell-induced effects on functional and structural characteristics of isolated neonatal porcine islets", CELL TRANSPLANTATION, vol. 5, no. 5, 1996, NEW YORK, pages 517 - 524, XP002040065 *

Also Published As

Publication number Publication date
AU2283497A (en) 1997-11-07
WO1997039107A2 (en) 1997-10-23
CA2179341A1 (en) 1997-10-13
EP0894127A2 (en) 1999-02-03

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