WO1997049736A3 - Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications - Google Patents

Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications Download PDF

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Publication number
WO1997049736A3
WO1997049736A3 PCT/US1997/011610 US9711610W WO9749736A3 WO 1997049736 A3 WO1997049736 A3 WO 1997049736A3 US 9711610 W US9711610 W US 9711610W WO 9749736 A3 WO9749736 A3 WO 9749736A3
Authority
WO
WIPO (PCT)
Prior art keywords
domain
particles
cross
interior core
pharmaceutical
Prior art date
Application number
PCT/US1997/011610
Other languages
French (fr)
Other versions
WO1997049736A2 (en
Inventor
Denis Forster
Gary S Jacob
James M Warner
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Priority to JP10503615A priority Critical patent/JP2000514791A/en
Priority to EP97933272A priority patent/EP0907666A1/en
Priority to AU36496/97A priority patent/AU3649697A/en
Priority to CA002258744A priority patent/CA2258744A1/en
Publication of WO1997049736A2 publication Critical patent/WO1997049736A2/en
Publication of WO1997049736A3 publication Critical patent/WO1997049736A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C08J3/246—Intercrosslinking of at least two polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer

Abstract

Provided are methods of inhibiting bile acid uptake from the gastrointestinal system and reducing blood serum cholesterol by administering to a mammal, such as a human, an effective amount of particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain.
PCT/US1997/011610 1996-06-27 1997-06-27 Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications WO1997049736A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP10503615A JP2000514791A (en) 1996-06-27 1997-06-27 Particles consisting of an amphiphilic copolymer having a crosslinked outer shell region and inner core region, useful for pharmaceutical and other applications
EP97933272A EP0907666A1 (en) 1996-06-27 1997-06-27 Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications
AU36496/97A AU3649697A (en) 1996-06-27 1997-06-27 Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications
CA002258744A CA2258744A1 (en) 1996-06-27 1997-06-27 Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2069396P 1996-06-27 1996-06-27
US60/020,693 1996-06-27

Publications (2)

Publication Number Publication Date
WO1997049736A2 WO1997049736A2 (en) 1997-12-31
WO1997049736A3 true WO1997049736A3 (en) 1998-02-05

Family

ID=21800036

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US1997/011345 WO1997049387A1 (en) 1996-06-27 1997-06-27 Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications
PCT/US1997/011610 WO1997049736A2 (en) 1996-06-27 1997-06-27 Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US1997/011345 WO1997049387A1 (en) 1996-06-27 1997-06-27 Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications

Country Status (6)

Country Link
US (2) US6383500B1 (en)
EP (2) EP0910351A1 (en)
JP (2) JP2001508762A (en)
AU (2) AU3649697A (en)
CA (2) CA2258744A1 (en)
WO (2) WO1997049387A1 (en)

Families Citing this family (224)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
JP2001508762A (en) * 1996-06-27 2001-07-03 ジー．ディー．サール アンド カンパニー Particles consisting of an amphiphilic copolymer having a cross-linked outer shell region and inner core region, useful for pharmaceutical and other applications
AUPO888097A0 (en) * 1997-08-29 1997-09-25 Biotech Australia Pty Limited Cross-linked particles
US6479145B1 (en) 1999-09-09 2002-11-12 Regents Of The University Of Minnesota Biopolymers and biopolymer blends, and method for producing same
US6916488B1 (en) * 1999-11-05 2005-07-12 Biocure, Inc. Amphiphilic polymeric vesicles
WO2001037803A2 (en) 1999-11-15 2001-05-31 Biocure, Inc. Responsive polymeric hollow particles
WO2001064164A2 (en) * 2000-02-28 2001-09-07 Genesegues, Inc. Nanocapsule encapsulation system and method
AUPQ679400A0 (en) * 2000-04-07 2000-05-11 Commonwealth Scientific And Industrial Research Organisation Microgel synthesis
US7064151B1 (en) 2000-04-07 2006-06-20 E. I. Du Pont De Nemours And Company Process of microgel synthesis and products produced therefrom
US20040091451A1 (en) * 2000-05-29 2004-05-13 Marie-Therese Charreyre Biocompatible polymer for fixing biological ligands
US7897404B2 (en) * 2000-09-29 2011-03-01 Roche Diagnostics Operations, Inc. Conjugates of defined stoichiometry
WO2002030466A2 (en) * 2000-10-11 2002-04-18 Purdue Research Foundation Pharmaceutical applications of hydrotropic agents, polymers thereof, and hydrogels thereof
US20050158271A1 (en) * 2000-10-11 2005-07-21 Lee Sang C. Pharmaceutical applications of hydrotropic polymer micelles
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
FR2824563B1 (en) * 2001-05-10 2004-12-03 Bio Merieux COMPOSITE PARTICLES, DERIVATIVES, PREPARATION METHOD AND APPLICATIONS
US6780428B2 (en) * 2001-06-08 2004-08-24 Labopharm, Inc. Unimolecular polymeric micelles with an ionizable inner core
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US7094810B2 (en) * 2001-06-08 2006-08-22 Labopharm, Inc. pH-sensitive block copolymers for pharmaceutical compositions
KR100566911B1 (en) * 2001-06-25 2006-04-03 주식회사 삼양사 Negatively charged amphiphilic block copolymer as drug carrier and complex thereof with positively charged drug
US8815793B2 (en) 2001-07-20 2014-08-26 Northwestern University Polymeric compositions and related methods of use
US7858679B2 (en) 2001-07-20 2010-12-28 Northwestern University Polymeric compositions and related methods of use
US7618937B2 (en) 2001-07-20 2009-11-17 Northwestern University Peptidomimetic polymers for antifouling surfaces
US6916536B1 (en) * 2001-09-20 2005-07-12 Christopher R. Hammen Composites incorporating covalently bonded interstitial polymer resins
US6956084B2 (en) 2001-10-04 2005-10-18 Bridgestone Corporation Nano-particle preparation and applications
JP4094277B2 (en) * 2001-11-09 2008-06-04 独立行政法人科学技術振興機構 Preparation of metal nanoparticles using shell-crosslinked micelles as templates
JP2005514438A (en) * 2001-12-21 2005-05-19 ソーン， デイビッド エス． Use of oligomers and polymers for solubilization, stabilization and delivery of drugs
CN1200030C (en) 2002-02-05 2005-05-04 复旦大学 One-step process for preparing nano micelles of polymer with stable core-shell structure and high concentration
US20040010060A1 (en) * 2002-03-20 2004-01-15 Mathieu Joanicot Vesicles comprising an amphiphilic di-block copolymer and a hydrophobic compound
US20040038303A1 (en) * 2002-04-08 2004-02-26 Unger Gretchen M. Biologic modulations with nanoparticles
AU2003226428A1 (en) * 2002-04-18 2003-11-03 Northwestern University Encapsulation of nanotubes via self-assembled nanostructures
WO2003104307A1 (en) * 2002-06-10 2003-12-18 Rhodia Inc Phase-separated composition comprising two miscible solvents, and use thereof in a process for making capsules
DE60307371T2 (en) * 2002-06-14 2007-08-02 Canon K.K. Particle composition, recording method and recording apparatus using the particle composition
JP3890266B2 (en) * 2002-07-03 2007-03-07 キヤノン株式会社 Block polymer compound, ink composition, dispersible composition, image forming method, and image forming apparatus
US20080226723A1 (en) * 2002-07-05 2008-09-18 Celonova Biosciences, Inc. Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same
US7160551B2 (en) * 2002-07-09 2007-01-09 The Board Of Trustees Of The University Of Illinois Injectable system for controlled drug delivery
US8911831B2 (en) 2002-07-19 2014-12-16 Northwestern University Surface independent, surface-modifying, multifunctional coatings and applications thereof
US20040016702A1 (en) * 2002-07-26 2004-01-29 Applera Corporation Device and method for purification of nucleic acids
US7465463B2 (en) * 2002-09-04 2008-12-16 Polyheal, Ltd. Compositions comprising microspheres with anti-inflammatory properties for healing of ocular tissues
AU2003266508A1 (en) * 2002-09-19 2004-04-08 Nisshinbo Industries, Inc. Flaky particles and process for production thereof
US7045069B2 (en) * 2002-11-14 2006-05-16 Gennady Ozeryansky Microfabrication method based on metal matrix composite technology
FR2848452B1 (en) * 2002-12-12 2007-04-06 Aventis Pharma Sa APPLICATION OF INTESTINAL BILIARY ACID RECAPTURE INHIBITORS FOR THE PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE
DE10258007B4 (en) 2002-12-12 2006-02-09 Sanofi-Aventis Deutschland Gmbh Aromatic fluoroglycoside derivatives, medicaments containing these compounds and methods for the preparation of these medicaments
US7576155B2 (en) * 2002-12-18 2009-08-18 Bridgestone Corporation Method for clay exfoliation, compositions therefore, and modified rubber containing same
US6858301B2 (en) * 2003-01-02 2005-02-22 Hewlett-Packard Development Company, L.P. Specific core-shell polymer additive for ink-jet inks to improve durability
EP1617808A4 (en) * 2003-04-25 2011-11-02 Penn State Res Found Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds
US7332527B2 (en) 2003-05-16 2008-02-19 Board Of Regents Of The University Of Nebraska Cross-linked ionic core micelles
US7317521B2 (en) * 2003-09-18 2008-01-08 Micron Technology, Inc. Particle detection method
US7311901B2 (en) * 2003-10-10 2007-12-25 Samyang Corporation Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
US7214825B2 (en) * 2003-10-17 2007-05-08 Honeywell International Inc. O-(3-chloropropenyl) hydroxylamine free base
US7335795B2 (en) 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7767768B2 (en) 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7608674B2 (en) 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US8309112B2 (en) * 2003-12-24 2012-11-13 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices comprising hydrophilic substances and methods for fabricating the same
US7205370B2 (en) * 2004-01-12 2007-04-17 Bridgestone Corporation Polymeric nano-particles of flower-like structure and applications
EP1559790A1 (en) * 2004-02-02 2005-08-03 International University Bremen Gmbh Vesicles for the removal of substances from liquids
US20050181000A1 (en) * 2004-02-17 2005-08-18 Lundquist Eric G. Polymeric nanoparticles in consumer products
US7718737B2 (en) 2004-03-02 2010-05-18 Bridgestone Corporation Rubber composition containing functionalized polymer nanoparticles
US8063142B2 (en) * 2004-03-02 2011-11-22 Bridgestone Corporation Method of making nano-particles of selected size distribution
EP1730516A1 (en) * 2004-03-30 2006-12-13 Pfizer Products Incorporated Method and device for evaluation of pharmaceutical compositions
US7556799B2 (en) 2004-03-30 2009-07-07 Relypsa, Inc. Ion binding polymers and uses thereof
CA2558029C (en) * 2004-03-30 2013-05-07 Ilypsa, Inc. Ion binding polymers and uses thereof
US8282960B2 (en) 2004-03-30 2012-10-09 Relypsa, Inc. Ion binding compositions
US8192758B2 (en) 2004-03-30 2012-06-05 Relypsa, Inc. Ion binding compositions
KR20130086262A (en) * 2004-03-30 2013-07-31 리립사, 인크. Ion binding polymers and uses thereof
US7429394B2 (en) 2004-03-30 2008-09-30 Relypsa, Inc. Ion binding compositions
US7854924B2 (en) 2004-03-30 2010-12-21 Relypsa, Inc. Methods and compositions for treatment of ion imbalances
US20050228074A1 (en) * 2004-04-05 2005-10-13 Bridgestone Corporation Amphiphilic polymer micelles and use thereof
US20050226932A1 (en) * 2004-04-09 2005-10-13 Samyang Corporation Pharmaceutical formulations for itraconazole
US7507439B2 (en) * 2004-05-06 2009-03-24 Hewlett-Packard Development Company, L.P. Use and preparation of crosslinked polymer particles for inkjet recording materials
US20050282956A1 (en) * 2004-06-21 2005-12-22 Xiaorong Wang Reversible polymer/metal nano-composites and method for manufacturing same
US20060194145A1 (en) * 2004-06-30 2006-08-31 Darrell Irvine Photogenerated polyelectrolyte bilayers from an aqueous-processible photoresist
US7998554B2 (en) * 2004-07-06 2011-08-16 Bridgestone Corporation Hydrophobic surfaces with nanoparticles
US20060078623A1 (en) * 2004-08-13 2006-04-13 Emisphere Technologies, Inc. Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent
TR200701423T1 (en) * 2004-09-09 2007-05-21 Bayer Animal Health Gmbh Pharmaceutical composition.
US9011831B2 (en) * 2004-09-30 2015-04-21 Advanced Cardiovascular Systems, Inc. Methacrylate copolymers for medical devices
US10675326B2 (en) 2004-10-07 2020-06-09 The Board Of Trustees Of The University Of Illinois Compositions comprising cupredoxins for treating cancer
EP1812864A2 (en) * 2004-10-07 2007-08-01 Emory University Multifunctional nanoparticles conjugates and their use
US8354093B2 (en) 2004-10-15 2013-01-15 Washington University Cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids (“PNAs”) with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
BRPI0518383A2 (en) * 2004-10-25 2008-11-18 Polyzenix Gmbh Chargeable polymeric particles for therapeutical and / or diagnostic applications and methods for preparing and using them
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US20060091228A1 (en) * 2004-11-02 2006-05-04 Keh-Ying Hsu Moisture-absorbing polymer particle, method for forming the same and application thereof
US20080032238A1 (en) * 2004-11-23 2008-02-07 Lu Jennifer Q System and method for controlling the size and/or distribution of catalyst nanoparticles for nanostructure growth
US7364672B2 (en) 2004-12-06 2008-04-29 Arlon, Inc. Low loss prepregs, compositions useful for the preparation thereof and uses therefor
WO2006073061A1 (en) * 2004-12-17 2006-07-13 Mitsubishi Chemical Corporation Novel core-shell structure
US7572855B2 (en) * 2005-01-28 2009-08-11 Bridgestone Corporation Nano-composite and compositions manufactured thereof
US7579398B2 (en) * 2005-02-02 2009-08-25 Bridgestone Corporation Nano-composite and compositions therefrom
US7659342B2 (en) 2005-02-03 2010-02-09 Bridgestone Corporation Polymer nano-particle with polar core and method for manufacturing same
GB0505569D0 (en) * 2005-03-18 2005-04-27 Syngenta Ltd Formulations
US20060224095A1 (en) * 2005-04-05 2006-10-05 University Of New Hampshire Biocompatible polymeric vesicles self assembled from triblock copolymers
BRPI0612914A2 (en) * 2005-05-06 2010-12-07 Unilever Nv method for hair treatment and use of a composition
KR101259853B1 (en) * 2005-08-01 2013-05-02 주식회사 동진쎄미켐 Photosensitive Polymer and photoresist composition including the same
JP2009505727A (en) * 2005-08-25 2009-02-12 メドトロニック ヴァスキュラー インコーポレイテッド Nitric oxide releasing biodegradable polymers useful as medical devices and their coatings
WO2007035296A2 (en) * 2005-09-15 2007-03-29 University Of Utah Research Foundation Polymeric compositions and methods of making and using thereof
WO2007041569A1 (en) 2005-09-30 2007-04-12 Ilypsa, Inc. Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal
AU2006294455B2 (en) 2005-09-30 2013-06-20 Relypsa, Inc. Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom
US9061900B2 (en) * 2005-12-16 2015-06-23 Bridgestone Corporation Combined use of liquid polymer and polymeric nanoparticles for rubber applications
US7538159B2 (en) * 2005-12-16 2009-05-26 Bridgestone Corporation Nanoparticles with controlled architecture and method thereof
US8288473B2 (en) 2005-12-19 2012-10-16 Bridgestone Corporation Disk-like nanoparticles
US7884160B2 (en) 2005-12-19 2011-02-08 Bridgestone Corporation Non-spherical nanoparticles made from living triblock polymer chains
US8697775B2 (en) * 2005-12-20 2014-04-15 Bridgestone Corporation Vulcanizable nanoparticles having a core with a high glass transition temperature
US8877250B2 (en) 2005-12-20 2014-11-04 Bridgestone Corporation Hollow nano-particles and method thereof
US7601772B2 (en) * 2005-12-20 2009-10-13 Bridgestone Corporation Nano-composite and method thereof
US7732539B2 (en) * 2006-02-16 2010-06-08 National Science Foundation Modified acrylic block copolymers for hydrogels and pressure sensitive wet adhesives
US7863381B2 (en) * 2006-03-08 2011-01-04 3M Innovative Properties Company Polymer composites
US7829140B1 (en) 2006-03-29 2010-11-09 The Research Foundation Of The State University Of New York Method of forming iron oxide core metal shell nanoparticles
EP2012803A4 (en) * 2006-04-20 2012-08-01 Univ Utah Res Found Polymeric compositions and methods of making and using thereof
US8703167B2 (en) * 2006-06-05 2014-04-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug
US20080009211A1 (en) * 2006-07-07 2008-01-10 Matthew Raymond Himes Assemblies useful for the preparation of electronic components and methods for making same
WO2008014464A2 (en) 2006-07-28 2008-01-31 Bridgestone Corporation Polymeric core-shell nanoparticles with interphase region
US7622533B2 (en) 2006-08-04 2009-11-24 Nerites Corporation Biomimetic compounds and synthetic methods therefor
WO2008091386A2 (en) 2006-08-04 2008-07-31 Northwestern University Biomimetic modular adhesive complex: material, methods and applications therefore
US8124598B2 (en) 2006-09-14 2012-02-28 Sharon Sageman 7-keto DHEA for psychiatric use
BRPI0716890A2 (en) * 2006-09-22 2013-10-22 Labopharm Inc COMPOSITION, AND METHOD OF PRODUCTION OF A COMPOSITION, ADMINISTRATION OF A PHARMACEUTICALLY ACTIVE WATER INSOLUBLE AGENT TO A MAMMER, AND CANCER TREATMENT IN A MAMMER
US20100062073A1 (en) * 2006-11-29 2010-03-11 Ronald Arthur Beyerinck Pharmaceutical compositions comprising nanoparticles comprising enteric polymers casein
AU2007329375A1 (en) 2006-12-04 2008-06-12 The Board Of Trustees Of The University Of Illinois Compositions and methods to treat cancer with cupredoxins and CpG rich DNA
US7597959B2 (en) 2006-12-19 2009-10-06 Bridgestone Corporation Core-shell fluorescent nanoparticles
US7649049B2 (en) 2006-12-20 2010-01-19 Bridgestone Corporation Rubber composition containing a polymer nanoparticle
US20080261045A1 (en) * 2007-01-22 2008-10-23 Glass James R Composite and layered particles for efficient delivery of polyelectrolytes
AU2008212788A1 (en) 2007-02-08 2008-08-14 The Board Of Trustees Of The University Of Illinois Compositions and methods to prevent cancer with cupredoxins
US8383092B2 (en) * 2007-02-16 2013-02-26 Knc Ner Acquisition Sub, Inc. Bioadhesive constructs
US8673286B2 (en) 2007-04-09 2014-03-18 Northwestern University DOPA-functionalized, branched, poly(aklylene oxide) adhesives
US8343627B2 (en) 2007-02-20 2013-01-01 Research Foundation Of State University Of New York Core-shell nanoparticles with multiple cores and a method for fabricating them
US20100119612A1 (en) * 2007-04-17 2010-05-13 Bend Research, Inc Nanoparticles comprising non-crystalline drug
US20100080852A1 (en) * 2007-05-03 2010-04-01 Ronald Arthur Beyerinck Phamaceutical composition comprising nanoparticles and casein
US8309129B2 (en) * 2007-05-03 2012-11-13 Bend Research, Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
US8703204B2 (en) * 2007-05-03 2014-04-22 Bend Research, Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
US9545384B2 (en) 2007-06-04 2017-01-17 Bend Research, Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate
WO2008149192A2 (en) * 2007-06-04 2008-12-11 Pfizer Products Inc. Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
US7829624B2 (en) 2007-06-29 2010-11-09 Bridgestone Corporation One-pot synthesis of nanoparticles and liquid polymer for rubber applications
WO2009010842A2 (en) * 2007-07-13 2009-01-22 Pfizer Products Inc. Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers
CN101801180A (en) * 2007-07-16 2010-08-11 艾尔维奥血管公司 antimicrobial constructs
US20100160274A1 (en) * 2007-09-07 2010-06-24 Sharon Sageman 7-KETO DHEA for Psychiatric Use
EP2042538A1 (en) * 2007-09-18 2009-04-01 Nirvana's Tree House Amphiphilic copolymers and compositions containing such polymers
WO2009049083A1 (en) 2007-10-09 2009-04-16 Washington University In St. Louis Particles for imaging
EP2197953A4 (en) * 2007-10-09 2011-06-22 Kraton Polymers Us Llc End use applications prepared from certain block copolymers
WO2009049089A1 (en) * 2007-10-09 2009-04-16 Washington University In St. Louis Ligand directed toroidal nanoparticles for therapy and diagnostic imaging
US20090111763A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090110738A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same
US20090110731A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same
US20100311903A1 (en) * 2007-11-07 2010-12-09 Raghavan Rajagopalan Photonic Shell-Core Cross Linked and Functionalized Nanostructures for Biological Applications
US9233078B2 (en) * 2007-12-06 2016-01-12 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer
US9724362B2 (en) * 2007-12-06 2017-08-08 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
KR101462536B1 (en) * 2007-12-17 2014-11-19 삼성디스플레이 주식회사 Pigment distribution system and encapsulation method for pigment
BRPI0910759A2 (en) * 2008-04-23 2018-03-20 Basf Se system and method for dispensing a hydrophobic benefit agent to a keratinous substrate, and, body rinse composition
JP5317031B2 (en) * 2008-05-07 2013-10-16 公立大学法人大阪府立大学 Hollow nano-particles of head-tail copolymer
AU2009246329B8 (en) * 2008-05-13 2013-12-05 Phaserx, Inc. Micellic assemblies
US20090291310A1 (en) * 2008-05-22 2009-11-26 Fields Ii Kenneth A Opal latex
WO2010022380A2 (en) 2008-08-22 2010-02-25 Relypsa, Inc. Linear polyol stabilized polyfluoroacrylate compositions
EP2348834B1 (en) 2008-09-25 2018-04-18 Vive Crop Protection Inc. Methods to produce polymer nanoparticles and formulations of active ingredients
AU2016200413B2 (en) * 2008-09-25 2017-09-14 Vive Nano, Inc. Methods to produce polymer nanoparticles and formulations of active ingredients
AU2014201945B2 (en) * 2008-09-25 2015-10-29 Vive Nano, Inc. Methods to produce polymer nanoparticles and formulations of active ingredients
WO2010047765A2 (en) * 2008-10-20 2010-04-29 Massachussetts Institute Of Technology Nanostructures for drug delivery
US8445601B2 (en) * 2008-11-14 2013-05-21 3M Innovative Properties Company Polymeric compositions and method of making and articles thereof
US8846819B2 (en) 2008-12-31 2014-09-30 Bridgestone Corporation Core-first nanoparticle formation process, nanoparticle, and composition
CN102300890B (en) * 2009-01-30 2014-03-26 惠普开发有限公司 Block copolymers and block copolymer nanoparticle compositions
US20100203150A1 (en) * 2009-02-06 2010-08-12 National Tsing Hua University Novel amphiphilic copolymers and fabrication method thereof
US20120020106A1 (en) * 2009-03-23 2012-01-26 Cabot Corporation particle containing a hydrophobic region and a hydrophilic region and methods to make same
US9062144B2 (en) 2009-04-03 2015-06-23 Bridgestone Corporation Hairy polymeric nanoparticles with first and second shell block polymer arms
WO2011059994A2 (en) * 2009-11-11 2011-05-19 3M Innovative Properties Company Polymeric compositions and method of making and articles thereof
US9808500B2 (en) 2009-12-17 2017-11-07 Washington University Antithrombotic nanoparticle
US9764043B2 (en) 2009-12-17 2017-09-19 Washington University Antithrombotic nanoparticle
US20110172364A1 (en) * 2009-12-29 2011-07-14 Chen Yaohong Charged Nanoparticles And Method Of Controlling Charge
US9115222B2 (en) 2009-12-29 2015-08-25 Bridgestone Corporation Well defined, highly crosslinked nanoparticles and method for making same
US8288001B1 (en) 2010-02-16 2012-10-16 Sandia Corporation Method of making monodisperse nanoparticles
DE112011100657T5 (en) 2010-02-24 2013-02-28 Relypsa, Inc. AMIN POLYMERS FOR USE AS GALLENIC SEQUENCER
US8765098B2 (en) 2010-03-30 2014-07-01 International Business Machines Corporation Star polymers, methods of preparation thereof, and uses thereof
US9498439B2 (en) 2010-04-15 2016-11-22 Washington University Prodrug compositions, prodrug nanoparticles, and methods of use thereof
JP5848332B2 (en) 2010-05-14 2016-01-27 マリンクロッド エルエルシー Functional cross-linked nanostructures for optical contrast and therapy tandems
WO2011143540A1 (en) * 2010-05-14 2011-11-17 Mallinckrodt Llc UNIFORM, FUNCTIONALIZED, CROSS-LINKED NANOSTRUCTURES FOR MONITORING pH
EP2637707A4 (en) 2010-11-09 2014-10-01 Kensey Nash Corp Adhesive compounds and methods use for hernia repair
WO2012068476A2 (en) * 2010-11-18 2012-05-24 University Of South Florida Poly(vinyl benzoate) nanoparticles for molecular delivery
JP2014500266A (en) * 2010-12-07 2014-01-09 ザ・ユニヴァーシティ・オヴ・ウェスタン・オーストラリア Multifunctional nanoparticles
WO2012138730A1 (en) 2011-04-04 2012-10-11 Board Of Regents Of The University Of Nebraska Drug delivery compositions and methods
EP2524690A1 (en) * 2011-05-17 2012-11-21 ETH Zurich Method for making customised nanoparticles, nanoparticles and use thereof
US8487017B2 (en) 2011-06-27 2013-07-16 Covidien Lp Biodegradable materials for orthopedic devices based on polymer stereocomplexes
US9890351B2 (en) * 2011-08-10 2018-02-13 The Procter & Gamble Company Encapsulates
AU2012311247B2 (en) 2011-08-23 2016-10-13 Vive Crop Protection Inc. Pyrethroid formulations
US20130071482A1 (en) * 2011-09-20 2013-03-21 The University Of Kentucky Research Foundation Block copolymer cross-linked nanoassemblies as modular delivery vehicles
JP5257804B1 (en) * 2011-12-09 2013-08-07 Ｄｉｃ株式会社 Film-forming aid, aqueous resin composition containing the same, and steel sheet surface treatment agent
CN104080333B (en) 2011-12-22 2017-06-23 维弗作物保护公司 Strobilurins preparation
KR101430697B1 (en) * 2011-12-26 2014-08-18 코오롱인더스트리 주식회사 Electrophoresis particle, preparation method of electrophoresis particle, and electrophoresis display device
US9428604B1 (en) 2011-12-30 2016-08-30 Bridgestone Corporation Nanoparticle fillers and methods of mixing into elastomers
US9382387B2 (en) 2012-03-13 2016-07-05 California Institute Of Technology Rapid self-assembly of block copolymers to photonic crystals
US9045579B2 (en) 2012-03-13 2015-06-02 California Institute Of Technology Periodic nanostructures from self assembled wedge-type block-copolymers
US9127113B2 (en) * 2012-05-16 2015-09-08 Rohm And Haas Electronic Materials Llc Polystyrene-polyacrylate block copolymers, methods of manufacture thereof and articles comprising the same
US9961900B2 (en) 2012-06-11 2018-05-08 Vive Crop Protection Inc. Herbicide formulations
US9453943B2 (en) 2012-06-28 2016-09-27 California Institute Of Technology Photonic structures from self assembly of brush block copolymers and polymer blends
KR101422918B1 (en) * 2012-09-05 2014-07-23 삼성전기주식회사 Super hydrophobic membrane and manufacturing method thereof
JP6475624B2 (en) 2012-10-08 2019-02-27 レリプサ， インコーポレイテッド Potassium binding agents for the treatment of hypertension and hyperkalemia
EP2909230B1 (en) 2012-10-19 2019-05-22 Danisco US Inc. Stabilization of biomimetic membranes
US9392786B2 (en) 2013-02-05 2016-07-19 Vive Crop Protection, Inc. Mectin and milbemycin polyelectrolyte nanoparticle formulations
BR112015023621A8 (en) 2013-03-15 2018-01-23 Kala Pharmaceuticals Inc meropenem derivatives and their uses
WO2014171945A1 (en) * 2013-04-18 2014-10-23 Empire Technology Development, Llc Thermostatic packaging materials
US10202479B2 (en) 2013-06-07 2019-02-12 Regents Of The University Of Minnesota Poly(cyclohexylethylene)-polyacrylate block copolymers, methods of manufacture thereof and articles comprising the same
US9283281B2 (en) * 2013-07-12 2016-03-15 University Of South Carolina Preparation of triple responsive nanogel system and its application
PL3140269T3 (en) 2014-05-09 2024-03-11 Yale University Hyperbranched polyglycerol-coated particles and methods of making and using thereof
US11918695B2 (en) * 2014-05-09 2024-03-05 Yale University Topical formulation of hyperbranched polymer-coated particles
WO2015200054A2 (en) * 2014-06-24 2015-12-30 The Trustees Of Princeton University Process for encapsulating soluble biologics, therapeutics, and imaging agents
US9782727B2 (en) 2014-07-14 2017-10-10 International Business Machines Corporation Filtration membranes with functionalized star polymers
JP2016052613A (en) * 2014-09-02 2016-04-14 国立大学法人 千葉大学 Core-shell particle
CN107072963B (en) 2014-09-03 2020-07-07 吉倪塞思公司 Therapeutic nanoparticles and related compositions, methods and systems
WO2016061095A1 (en) * 2014-10-14 2016-04-21 President And Fellows Of Harvard College Microcapsules and uses thereof
US9533051B2 (en) * 2014-12-03 2017-01-03 University Of South Florida Menthol-based nanoparticles for drug delivery
US9931598B2 (en) * 2015-02-16 2018-04-03 International Business Machines Corporation Anti-fouling coatings with star polymers for filtration membranes
US10005042B2 (en) 2015-02-16 2018-06-26 International Business Machines Corporation Thin film composite forward osmosis membranes with performance enhancing layers
US10608280B2 (en) 2015-03-09 2020-03-31 California Institute Of Technology Brush block copolymer electrolytes and electrocatalyst compositions
JP6516388B2 (en) * 2015-05-11 2019-05-22 国立大学法人名古屋大学 Non-covalent soft elastomer and method for producing the same
DE102015212611A1 (en) * 2015-07-06 2017-01-12 Henkel Ag & Co. Kgaa Star block comb polymers as bioactive carrier matrices for the drug-eluting semi-permanent coating of surfaces
US11103461B2 (en) 2015-12-22 2021-08-31 The Trustees Of Princeton University Process for encapsulating soluble biologics, therapeutics, and imaging agents
US11034786B2 (en) 2016-06-16 2021-06-15 Lg Chem, Ltd. Amphiphilic triblock polymer
JP6887713B2 (en) 2016-06-16 2021-06-16 エルジー・ケム・リミテッド Amphiphilic polymer
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists
AT519180B1 (en) * 2016-10-14 2018-12-15 Feuerer Josef Painting and drawing board
US11053356B2 (en) 2017-03-07 2021-07-06 California Institute Of Technology Control of polymer architectures by living ring-opening metathesis copolymerization
WO2019038642A1 (en) 2017-08-25 2019-02-28 Vive Crop Protection Inc. Multi-component, soil-applied, pesticidal compositions
WO2019055539A1 (en) 2017-09-12 2019-03-21 Prudhomme Robert K Cellulosic polymer nanoparticles and methods of forming them
AU2019284481B2 (en) 2018-06-13 2022-07-14 Abbott Diabetes Care Inc. Temperature-insensitive membrane materials and analyte sensors containing the same
US11731099B2 (en) 2018-07-20 2023-08-22 The Trustees Of Princeton University Method for controlling encapsulation efficiency and burst release of water soluble molecules from nanoparticles and microparticles produced by inverse flash nanoprecipitation
WO2021163024A1 (en) * 2020-02-11 2021-08-19 University Of Florida Research Foundation Compositions including dichotomous composite particles, article including the composition, and structures having superhydrophobic, superoleophobic, or omniphobic surfaces
CN112656763B (en) * 2020-12-29 2022-07-15 吉林大学 Preparation method of drug-loaded nano-micelle based on shear force response
CN113502690B (en) * 2021-06-25 2022-08-19 浙江纳美新材料股份有限公司 Water-based color paste for dyeing food packaging paper

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4593073A (en) * 1985-04-23 1986-06-03 The Royal Institution For The Advancement Of Learing (Mcgill Univ.) Polymer resins with amino acid containing pendants for sorption of bile pigments and bile acids
US5114709A (en) * 1991-05-17 1992-05-19 Lowchol Scientific Inc. Ferric ion coordinated polyamine resins for the lowering of blood cholesterol
US5428112A (en) * 1992-07-22 1995-06-27 Hoechst Aktiengesellschaft Crosslinked, nitrogen-containing vinyl copolymers, processes for their preparation and the use of these compounds
US5430110A (en) * 1992-07-22 1995-07-04 Hoechst Aktiengesellschaft Polyvinylamine derivatives having hydrophilic centers, processes for their preparation and the use of the compounds as a medicament, active compound carrier and foodstuff auxiliary

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU425620B2 (en) 1967-01-23 1972-06-29 Ici Australia Limited Core-sheel graft copolymers with ion exchange resin shell
AU422536B2 (en) 1968-01-24 1972-03-21 Imperial Chemical Industries Of Australia And New Zealand Limited Ion exchange resins
CH594444A5 (en) 1972-12-04 1978-01-13 Gerd Birrenbach
DE2732929A1 (en) 1977-07-21 1979-02-01 Bayer Ag POLYAETHER, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A LIPID ABSORPTION INHIBITOR
US4329332A (en) 1978-07-19 1982-05-11 Patrick Couvreur Biodegradable submicroscopic particles containing a biologically active substance and compositions containing them
DE2850058A1 (en) 1978-11-18 1980-05-29 Bayer Ag POLYAETHER DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
US4252793A (en) 1979-06-18 1981-02-24 American Lecithin Company Injectable lecithin preparation
US4359478A (en) 1981-07-15 1982-11-16 Basf Wyandotte Corporation Hypocholesterolaemic agents
IT1174495B (en) 1984-02-17 1987-07-01 Nuovo Consoricio Sanitario Nat COMPOUNDS WITH LUBRICATING ACTIVITY
JPS60195455A (en) * 1984-03-19 1985-10-03 Toray Ind Inc Polymer useful as blood treating agent and molding thereof
US4600578A (en) 1984-05-11 1986-07-15 Bristol-Myers Company Method of inhibiting diarrhea
US4604430A (en) 1984-05-11 1986-08-05 Bristol-Myers Company Novel bile sequestrant resin
US4649048A (en) 1984-05-11 1987-03-10 Bristol-Myers Company Novel bile sequestrant resin
US5597810A (en) 1984-12-27 1997-01-28 Hoffman; Allan S. Method for reducing absorption of undesired lipids in the gastrointestinal tract
US4681915A (en) 1985-12-20 1987-07-21 General Electric Company Impact modified polyphenylene ether-polyamide compositions
US5250294A (en) 1986-05-15 1993-10-05 Emory University Improved perfusion medium for transplantation of organs
FR2604903B1 (en) 1986-10-08 1989-01-13 Sopar Sa Nv THERAPEUTIC AGENTS IN THE FORM OF SUBMICROSCOPIC PARTICLES AGAINST PARASITOSIS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
DE3743142A1 (en) 1987-12-18 1989-06-29 Wacker Chemie Gmbh METHOD FOR EMULSION POLYMERIZATION OF GRAFT FCOPOLYMERS
US4851318A (en) * 1988-06-24 1989-07-25 Xerox Corporation Process for encapsulated toner compositions with oligomeric surfactant emulsifiers
JPH0277266A (en) * 1988-09-14 1990-03-16 Kuraray Co Ltd Adsorbent
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
US5260272A (en) 1991-03-29 1993-11-09 University Of South Alabama Polyanionic polyamino acid inhibitors of mineral deposition and their synthesis
JPH05178916A (en) 1991-12-30 1993-07-20 Kao Corp Production of self-crosslinkable polymer emulsion
CA2087125A1 (en) 1992-01-23 1993-07-24 Mridula Nair Chemically fixed micelles
US5384333A (en) 1992-03-17 1995-01-24 University Of Miami Biodegradable injectable drug delivery polymer
AU4114493A (en) 1992-04-24 1993-11-29 Polymer Technology Group, Inc., The Method of culturing viable cells and method of regulating the level of a compound in a body fluid
CA2153343A1 (en) * 1993-01-11 1994-07-21 Valery Alexandrovich Dyatlov Small diameter nanocapsules, process for their preparation and applications thereof
EP0683667A1 (en) * 1993-02-15 1995-11-29 Shield Research Limited Polyalkylcyanoacrylate nanocapsules
DE69433723T3 (en) * 1993-02-22 2008-10-30 Abraxis Bioscience, Inc., Los Angeles PROCESS FOR IN VIVO ADMINISTRATION OF BIOLOGICAL SUBSTANCES AND COMPOSITIONS USED THEREFROM
WO1994021308A1 (en) 1993-03-18 1994-09-29 Cedars-Sinai Medical Center Drug incorporating and releasing polymeric coating for bioprosthesis
US5414068A (en) * 1994-01-24 1995-05-09 Rohm And Haas Company Crosslinked anion exchange particles and method for producing the particles
US5585108A (en) 1994-12-30 1996-12-17 Nanosystems L.L.C. Formulations of oral gastrointestinal therapeutic agents in combination with pharmaceutically acceptable clays
US5712346A (en) 1995-02-14 1998-01-27 Avery Dennison Corporation Acrylic emulsion coatings
DE59609259D1 (en) * 1995-11-29 2002-07-04 Vantico Ag Core / Shell particles and curable epoxy resin compositions containing them
JP2001508762A (en) * 1996-06-27 2001-07-03 ジー．ディー．サール アンド カンパニー Particles consisting of an amphiphilic copolymer having a cross-linked outer shell region and inner core region, useful for pharmaceutical and other applications

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4593073A (en) * 1985-04-23 1986-06-03 The Royal Institution For The Advancement Of Learing (Mcgill Univ.) Polymer resins with amino acid containing pendants for sorption of bile pigments and bile acids
US5114709A (en) * 1991-05-17 1992-05-19 Lowchol Scientific Inc. Ferric ion coordinated polyamine resins for the lowering of blood cholesterol
US5428112A (en) * 1992-07-22 1995-06-27 Hoechst Aktiengesellschaft Crosslinked, nitrogen-containing vinyl copolymers, processes for their preparation and the use of these compounds
US5430110A (en) * 1992-07-22 1995-07-04 Hoechst Aktiengesellschaft Polyvinylamine derivatives having hydrophilic centers, processes for their preparation and the use of the compounds as a medicament, active compound carrier and foodstuff auxiliary

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Derwent World Patents Index; *

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