WO1998000118A3 - Drug delivery devices and process of manufacture - Google Patents

Drug delivery devices and process of manufacture Download PDF

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Publication number
WO1998000118A3
WO1998000118A3 PCT/US1997/012545 US9712545W WO9800118A3 WO 1998000118 A3 WO1998000118 A3 WO 1998000118A3 US 9712545 W US9712545 W US 9712545W WO 9800118 A3 WO9800118 A3 WO 9800118A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery devices
drug delivery
manufacture
drug
devices
Prior art date
Application number
PCT/US1997/012545
Other languages
French (fr)
Other versions
WO1998000118A2 (en
Inventor
David J Enscore
Patricia S Campbell
Diane E Nedberge
Richard D Frame
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Priority to AU36035/97A priority Critical patent/AU721267B2/en
Priority to DE69716737T priority patent/DE69716737T2/en
Priority to AT97932630T priority patent/ATE226816T1/en
Priority to JP10504525A priority patent/JP2000514065A/en
Priority to BR9710128A priority patent/BR9710128A/en
Priority to DK97932630T priority patent/DK0909167T3/en
Priority to EP97932630A priority patent/EP0909167B1/en
Priority to CA002259407A priority patent/CA2259407C/en
Publication of WO1998000118A2 publication Critical patent/WO1998000118A2/en
Publication of WO1998000118A3 publication Critical patent/WO1998000118A3/en
Priority to HK99104694A priority patent/HK1020525A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

An improved process for manufacturing transdermal drug delivery devices and devices made therefrom. The invention provides a heat equilibration process for the manufacture of drug delivery devices which eliminates the need to preload the body contacting layer with a drug. The method has particular application in the manufacture of transdermal drug delivery devices including a drug reservoir comprising drug in excess of saturation.
PCT/US1997/012545 1996-07-03 1997-07-03 Drug delivery devices and process of manufacture WO1998000118A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU36035/97A AU721267B2 (en) 1996-07-03 1997-07-03 Drug delivery devices and process of manufacture
DE69716737T DE69716737T2 (en) 1996-07-03 1997-07-03 DEVICES FOR DRUG DELIVERY AND MANUFACTURING METHOD
AT97932630T ATE226816T1 (en) 1996-07-03 1997-07-03 DEVICES FOR DRUG DELIVERY AND PRODUCTION METHOD
JP10504525A JP2000514065A (en) 1997-07-03 1997-07-03 Drug delivery device and its manufacturing method
BR9710128A BR9710128A (en) 1996-07-03 1997-07-03 Device for drug supply and manufacturing process
DK97932630T DK0909167T3 (en) 1996-07-03 1997-07-03 Drug delivery devices and methods of manufacture
EP97932630A EP0909167B1 (en) 1996-07-03 1997-07-03 Drug delivery devices and process of manufacture
CA002259407A CA2259407C (en) 1996-07-03 1997-07-03 Drug delivery devices and process of manufacture
HK99104694A HK1020525A1 (en) 1996-07-03 1999-10-21 Drug delivery devices and process of manufacture

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60/012,124 1996-02-23
US2112496P 1996-07-03 1996-07-03

Publications (2)

Publication Number Publication Date
WO1998000118A2 WO1998000118A2 (en) 1998-01-08
WO1998000118A3 true WO1998000118A3 (en) 1998-03-05

Family

ID=21802466

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/012545 WO1998000118A2 (en) 1996-07-03 1997-07-03 Drug delivery devices and process of manufacture

Country Status (10)

Country Link
EP (1) EP0909167B1 (en)
AT (1) ATE226816T1 (en)
AU (1) AU721267B2 (en)
BR (1) BR9710128A (en)
CA (1) CA2259407C (en)
DE (1) DE69716737T2 (en)
ES (1) ES2183203T3 (en)
HK (1) HK1020525A1 (en)
PT (1) PT909167E (en)
WO (1) WO1998000118A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9186334B2 (en) 2009-05-04 2015-11-17 Nuvo Research Inc. Heat assisted lidocaine and tetracaine for transdermal analgesia
US9186273B2 (en) 2009-05-04 2015-11-17 Nuvo Research Inc. Methods of treating pains associated with neuroma, nerve entrapment, and other conditions

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2226394T3 (en) * 1998-05-22 2005-03-16 Novosis Ag TRANSDERMAL SYSTEMS CONTAINING ACTIVE SUBSTANCE THAT IS RELEASED CONTROLLED IN TIME.
EP1117357B1 (en) * 1998-09-29 2013-06-26 Nuvo Research Inc. Apparatus for improved administration of pharmaceutically active compounds
FR2793689B1 (en) * 1999-05-19 2001-08-24 Pf Medicament TRANSDERMAL DEVICE FOR THE ADMINISTRATION OF TESTOSTERONE OR A DERIVATIVE THEREOF
NZ537991A (en) 2002-08-30 2007-08-31 Alza Corp Embossable and writable multilaminate backing construction
US20060127463A1 (en) * 2004-12-15 2006-06-15 Nugara Peter N Composite structure including a low vinyl acetate layer
NZ582565A (en) * 2007-07-10 2012-07-27 Agile Therapeutics Inc Dermal delivery device with in situ seal

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6393714A (en) * 1986-10-09 1988-04-25 Sekisui Chem Co Ltd Plaster for transcutaneous absorption
EP0304227A2 (en) * 1987-08-13 1989-02-22 Alza Corporation A method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a nonaqueous matrix
US4863970A (en) * 1986-11-14 1989-09-05 Theratech, Inc. Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
WO1992007590A1 (en) * 1990-10-29 1992-05-14 Alza Corporation Transdermal contraceptive formulations, methods and devices
WO1992020377A1 (en) * 1991-05-20 1992-11-26 Alza Corporation Skin permeation enhancer compositions using glycerol monolinoleate
WO1994006383A1 (en) * 1992-09-14 1994-03-31 Rutgers, The State University Of New Jersey Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes
WO1995009006A1 (en) * 1993-09-29 1995-04-06 Alza Corporation Monoglyceride/lactate ester permeation enhancer
WO1996019205A1 (en) * 1994-12-21 1996-06-27 Theratech, Inc. Transdermal delivery system with adhesive overlay and peel seal disc
WO1996035427A1 (en) * 1995-05-10 1996-11-14 Hexal Ag Transdermal therapeutic system for administering testosterone
WO1997010812A2 (en) * 1995-09-08 1997-03-27 Cygnus, Inc. Supersaturated transdermal drug delivery systems, and methods for manufacturing the same
WO1997020550A2 (en) * 1995-12-01 1997-06-12 Alza Corporation Improved method for preventing crystal formation in a dispersion of a liquid in a matrix
WO1997024148A1 (en) * 1995-12-29 1997-07-10 Cygnus, Inc. Systems and methods for the transdermal administration of androgenic agents

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6393714A (en) * 1986-10-09 1988-04-25 Sekisui Chem Co Ltd Plaster for transcutaneous absorption
US4863970A (en) * 1986-11-14 1989-09-05 Theratech, Inc. Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
EP0304227A2 (en) * 1987-08-13 1989-02-22 Alza Corporation A method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a nonaqueous matrix
WO1992007590A1 (en) * 1990-10-29 1992-05-14 Alza Corporation Transdermal contraceptive formulations, methods and devices
WO1992020377A1 (en) * 1991-05-20 1992-11-26 Alza Corporation Skin permeation enhancer compositions using glycerol monolinoleate
WO1994006383A1 (en) * 1992-09-14 1994-03-31 Rutgers, The State University Of New Jersey Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes
WO1995009006A1 (en) * 1993-09-29 1995-04-06 Alza Corporation Monoglyceride/lactate ester permeation enhancer
WO1996019205A1 (en) * 1994-12-21 1996-06-27 Theratech, Inc. Transdermal delivery system with adhesive overlay and peel seal disc
WO1996035427A1 (en) * 1995-05-10 1996-11-14 Hexal Ag Transdermal therapeutic system for administering testosterone
WO1997010812A2 (en) * 1995-09-08 1997-03-27 Cygnus, Inc. Supersaturated transdermal drug delivery systems, and methods for manufacturing the same
WO1997020550A2 (en) * 1995-12-01 1997-06-12 Alza Corporation Improved method for preventing crystal formation in a dispersion of a liquid in a matrix
WO1997024148A1 (en) * 1995-12-29 1997-07-10 Cygnus, Inc. Systems and methods for the transdermal administration of androgenic agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 8822, Derwent World Patents Index; Class A96, AN 88-152039 *
PATENT ABSTRACTS OF JAPAN vol. 012, no. 333 (C - 526) 8 September 1988 (1988-09-08) *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9186334B2 (en) 2009-05-04 2015-11-17 Nuvo Research Inc. Heat assisted lidocaine and tetracaine for transdermal analgesia
US9186273B2 (en) 2009-05-04 2015-11-17 Nuvo Research Inc. Methods of treating pains associated with neuroma, nerve entrapment, and other conditions

Also Published As

Publication number Publication date
CA2259407C (en) 2006-04-04
AU721267B2 (en) 2000-06-29
EP0909167A2 (en) 1999-04-21
WO1998000118A2 (en) 1998-01-08
ES2183203T3 (en) 2003-03-16
HK1020525A1 (en) 2000-05-12
BR9710128A (en) 1999-08-10
DE69716737D1 (en) 2002-12-05
ATE226816T1 (en) 2002-11-15
AU3603597A (en) 1998-01-21
DE69716737T2 (en) 2003-03-20
EP0909167B1 (en) 2002-10-30
PT909167E (en) 2003-03-31
CA2259407A1 (en) 1998-01-08

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