WO1998001084A1 - Surgical appliance for the treatment of pulmonary emphysema - Google Patents
Surgical appliance for the treatment of pulmonary emphysema Download PDFInfo
- Publication number
- WO1998001084A1 WO1998001084A1 PCT/IT1997/000159 IT9700159W WO9801084A1 WO 1998001084 A1 WO1998001084 A1 WO 1998001084A1 IT 9700159 W IT9700159 W IT 9700159W WO 9801084 A1 WO9801084 A1 WO 9801084A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lung
- sheath
- surgical appliance
- pulmonary
- surgical
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/08—Accessories or related features not otherwise provided for
- A61B2090/0815—Implantable devices for insertion in between organs or other soft tissues
Landscapes
- Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Surgical appliance for the treatment of pulmonary emphysema consisting of a sheath (1) made up of a biocompatible elastic material provided with a hole (4) suitable for the passage of the bronchia and vessels of the lung onto which the sheath (1) is to be applied. Once applied onto the lungs of an emphysematous, the surgical appliance according to the present invention remarkably improves his breathing functionality without resorting to traumatic surgical operations, such as for instance the partial removal or the application of the pulmonary parenchyma.
Description
"SURGICAL APPLIANCE FOR THE TREATMENT OF PULMONARY EMPHYSEMA"
DESCRIPTION The present invention relates to a surgical appliance for the treatment of pulmonary emphysema, and in particular to a surgical appliance which, once applied onto the lungs of an emphysematous, remarkably improves his breathing functionality without resorting to traumatic surgical operations, such as for instance the partial removal or the plication of the pulmonary parenchyma .
It is acknowledged that pulmonary emphysema has always been considered a disease that mainly, if not exclusively, relates to internal medicine and pneumology. The medical therapy of pulmonary emphysema, based upon breathing rehabilitation and use of specific medicines, is effective both as a therapeutic approach and in the preparation for a possible surgical operation. Surgery of pulmonary emphysema, preferably based upon bullectomy and pulmonary transplant, has had so far an absolutely secondary role in the therapy of this disease.
Recently Cooper has instead proposed, with great success, a surgical operation that revolutionizes the treatment of pulmonary emphysema thereby resuming a
procedure developed by Brantigan in 1959 and forgotten for many years. This operation, known as lung volume reduction, consists of a reduction of the volume occupied by the emphysematous lung through surgically removing 20 to 25 % of the total mass of parenchyma, in particular its functionally hypoactive peripheral areas. While the lung volume reduction seems to be illogical for the treatment of patients affected by breathing insufficiency, this kind of operation is based upon precise physiopathological 'fundamentals which justify the execution and the good clinical results. Indeed, the lung with a reduced volume exerts a higher elastic retraction force against the thoracic cage, thereby improving both the volumetric balance of the lung/thoracic cage system and the efficiency of the inspiratory muscles. Such an improvement is due to the fact that the emphysematous lung, less elastic than a healthy lung, tends to expand more than the usual, especially in the apical areas, causing the expansion of the thoracic cage, which is no longer subject to the elastic retraction force of the lung.
The surgical operation for the lung reduction is carried out with the assistance of linear suturing devices which automatically section the pulmonary tissue and suture it by means of metal clamps. However,
the quality of such a suture, with respect to haemostasis and aerostasis, is frequently insufficient because of the fragility of the tissue altered by emphysema. Recent proposals recommend the interposition of stripes of bovine pericardium between the clamps and the pulmonary parenchyma in order to reduce the traumatic effect of the suture. The latter measure does not however eliminate the postoperatory complications such as hemorrhage and copious air losses from the sectioned and sutured pulmonary parenchyma,- which often confine the patient to extensive hospitalization periods .
To reduce the frequency and the gravity of said complications it has been proposed, as an alternative to said pulmonary parenchyma partial removal technique, the plication-suture technique by means of linear suturing devices with bladeless clamps. However, such a technique cannot be performed at all times and presently there is no sufficient information confirming its effective validity.
Therefore, object of the present invention is to provide a surgical appliance for the treatment of pulmonary emphysema which reduces the volume of the emphysematous lungs without resorting to traumatic surgical operations, such as the partial removal or the
plication of the pulmonary parenchyma. Said object is achieved by means of a surgical appliance whose features are disclosed in claim 1.
Thanks to the surgical appliance according to the present invention, it is possible to restore elasticity in the pulmonary parenchyma, thereby opposing the emphysematous hyperexpansion as well as helping the recovery of the physiological partial retraction state of the thoracic cage. Moreover, the surgical operation for applying the surgical appliance according to the present invention has little traumatic effects and can be easily carried out even by means of a video-endoscopic technique, thereby without resorting to a sternotomic operation which, in this kind of patients, increases the postoperatory pain and extends the hospitalization.
Another advantage of the surgical appliance according to the present invention is due to the compression action exerted onto the pulmonary parenchyma which appears almost exclusively on the peripheral mantle and on the apical areas of the lung, that is to say, on those areas which are substantially inactive in the emphysematous with respect to the pulmonary ventilation. Further advantages and features of the surgical
appliance according to the present invention will become clearer to those skilled in the art through the following detailed description of an embodiment thereof with reference to the attached drawings wherein: - figure 1 shows a frontal view of the surgical appliance according to the present invention;
- figure 2 shows a right side view of the surgical appliance of fig. 1; and
- figure 3 shows a schematic frontal view of the open thoracic cage of a patient wherein the surgical appliance of fig. 1 has been applied onto his left lung.
Referring to fig. 1, it can be noticed that the surgical appliance according to the present invention essentially consists of a sheath 1 made up of an elastic and permeable material. Such a material may be for example a tissue knitted or processed in another way suitable for conferring to the resulting tissue a remarkable degree of both longitudinal and transversal elasticity. Such a tissue should be produced using biocompatible and hypoallergenic yarns having their own particular elasticity. They may not even be elastic when the structure of the tissue is sufficiently elastic in itself. As well, sheath 1 may be produced with an impermeable material even though this option is
to be avoided in order to keep the possibility of draining air, liquids or blood residuals, if any, collected between the lung and the sheath. As a matter of fact, it serves to contain the whole pulmonary parenchyma and to control its expansion, whereby its shape should preferably follow, obviously in a simplified manner, the shape of a lung, that is, it should have a substantially ovoid shape flat at the base 2 and on the side 3 corresponding to the mediastinal face of the lung.
Referring now to fig. 2, it can be observed that the side 3 of sheath 1 centrally has a circular or oval hole 4 that allows the passage of the bronchia and vessels intended for the ventilation and the perfusion of the pulmonary parenchyma. At rest, this hole should preferably be 9 to 12 cm high and 5 to 7 cm wide . These dimensions may obviously vary depending on the elasticity of sheath 1.
The portion of the sheath above hole 4 has a volume lower than the portion below hole 4. Furthermore, the ratio between the volumes of the portion below and the portion above the hole 4 is suitably greater than the ratio between the volumes of the corresponding basal and apical areas of the lung. Thanks to this arrangement it is possible to compress the apical
areas, which are functionally less active, more than the basal ones .
Of course, the size of sheath 1 depends both on the elasticity of the material used for its manufacture and the size and elasticity of the emphysematous lung onto which the sheath is applied. The volume occupied by sheath 1 at rest should be such as to ensure that the emphysematous lung provided with such a sheath reaches the normal theoretical values of the pulmonary capacity of an individual on which a pressure of 10' to 15 cm of water is exerted. Said pressure values, even if remarkably lower than pressures exertable by the thoracic cage under forced or maximum expansion, are indeed enough to prevent, on one hand, the pathological tendency of the emphysematous lung to expand and, on the other hand, the total collapse of the lung itself. Whichever the case, the volume occupied by sheath 1 at rest should not be lower than 2.5 liters in order to ensure a vital minimal expansion of the lung itself. The surgical appliance according to the present invention can be applied by way of median sternotomy, thoracotomy as well as videothoracoscopy . The patient is intubated with a two-way tube to avoid the ventilation of the lung onto which the surgical appliance is to be applied. This is followed by the
complete lysis of pleural adhesions, if any, and the section of the pulmonary ligament up to the lower pulmonary vein. The latter two procedures serve to completely free the mediastinal, diaphragmatic and costal surfaces of the lung, as well as to allow the correct placement of sheath 1 which must be oriented with its upper portion around the apical area of the lung. Such a placement is carried out after the whole lung has passed through hole 4. This is made possible because the lung, excluded from the -ventilation, collapses and thereby occupies a volume slightly lower than a fist.
Once sheath 1 is applied around the lung, the latter is ventilated, thereby verifying its correct position within the sheath itself and the amount of its expansion. A lung provided with the surgical appliance according to the present invention is shown in fig. 3. The figure shows that the left lung, provided with the surgical appliance, occupies a notably reduced volume with respect to the right lung. The volume difference between the two lungs practically corresponds to the amount of pulmonary parenchyma that would have been eliminated by means of removal or plication.
Any change and/or addition can be made by those skilled in the art to the embodiment hereinabove
described and illustrated remaining within the scope of the invention. For instance, it is clear that the shape of the surgical appliance according to the present invention may change depending upon the particular shape of the lung onto which it is to be applied as well as on the specific emphysematous pathology of said lung.
Claims
1. Surgical appliance for the treatment of pulmonary emphysema characterized in that it comprises a sheath (1) made up of a biocompatible elastic material, provided with a hole (4) suitable for the passage of the bronchia and vessels of the lung onto which the sheath (1) is to be applied.
2. Surgical appliance according to the above claim, characterized in that the portion of the sheath (1) above the hole (4) occupies a volume lower than the portion below the hole (4) .
3. Surgical appliance according to one of the above claims, characterized in that the side (3) of the sheath (1) on which the hole (4) is made, is flat.
4. Surgical appliance according to one of the above claims, characterized in that the base (2) of the sheath (1) is flat.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/214,157 US6123663A (en) | 1996-07-04 | 1997-04-07 | Surgical appliance for the treatment of pulmonary emphysema |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT96MI001375A IT1284108B1 (en) | 1996-07-04 | 1996-07-04 | SURGICAL PRESIDIUM FOR THE TREATMENT OF PULMONARY EMPHYSEMA |
ITMI96A001375 | 1996-07-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998001084A1 true WO1998001084A1 (en) | 1998-01-15 |
Family
ID=11374536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IT1997/000159 WO1998001084A1 (en) | 1996-07-04 | 1997-07-04 | Surgical appliance for the treatment of pulmonary emphysema |
Country Status (3)
Country | Link |
---|---|
US (1) | US6123663A (en) |
IT (1) | IT1284108B1 (en) |
WO (1) | WO1998001084A1 (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1078601A3 (en) * | 1999-08-24 | 2002-05-22 | Spiration, Inc. | Lung volume reduction apparatus |
US6514290B1 (en) | 2000-03-31 | 2003-02-04 | Broncus Technologies, Inc. | Lung elastic recoil restoring or tissue compressing device and method |
AU772080B2 (en) * | 2000-03-23 | 2004-04-08 | Spiration, Inc. | Lung constriction apparatus and method |
WO2009099165A1 (en) * | 2008-02-08 | 2009-08-13 | Kyoto University | Therapeutic device for chronic obstructive pulmonary disease |
US8142455B2 (en) | 2006-03-13 | 2012-03-27 | Pneumrx, Inc. | Delivery of minimally invasive lung volume reduction devices |
US8632605B2 (en) | 2008-09-12 | 2014-01-21 | Pneumrx, Inc. | Elongated lung volume reduction devices, methods, and systems |
US8721734B2 (en) | 2009-05-18 | 2014-05-13 | Pneumrx, Inc. | Cross-sectional modification during deployment of an elongate lung volume reduction device |
US8888800B2 (en) | 2006-03-13 | 2014-11-18 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US8926647B2 (en) | 2002-03-20 | 2015-01-06 | Spiration, Inc. | Removable anchored lung volume reduction devices and methods |
US8974484B2 (en) | 2001-09-11 | 2015-03-10 | Spiration, Inc. | Removable lung reduction devices, systems, and methods |
US8974527B2 (en) | 2003-08-08 | 2015-03-10 | Spiration, Inc. | Bronchoscopic repair of air leaks in a lung |
US8986336B2 (en) | 2001-10-25 | 2015-03-24 | Spiration, Inc. | Apparatus and method for deployment of a bronchial obstruction device |
US9198669B2 (en) | 2006-03-31 | 2015-12-01 | Spiration, Inc. | Articulable anchor |
US9326873B2 (en) | 2007-10-12 | 2016-05-03 | Spiration, Inc. | Valve loader method, system, and apparatus |
US9402633B2 (en) | 2006-03-13 | 2016-08-02 | Pneumrx, Inc. | Torque alleviating intra-airway lung volume reduction compressive implant structures |
US10390838B1 (en) | 2014-08-20 | 2019-08-27 | Pneumrx, Inc. | Tuned strength chronic obstructive pulmonary disease treatment |
US10537334B2 (en) | 2013-10-25 | 2020-01-21 | Pneumrx, Inc. | Genetically-associated chronic obstructive pulmonary disease treatment |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5954766A (en) * | 1997-09-16 | 1999-09-21 | Zadno-Azizi; Gholam-Reza | Body fluid flow control device |
US7654998B1 (en) | 1999-08-23 | 2010-02-02 | Aeris Therapeutics, Inc. | Tissue volume reduction |
US6610043B1 (en) | 1999-08-23 | 2003-08-26 | Bistech, Inc. | Tissue volume reduction |
US6416554B1 (en) | 1999-08-24 | 2002-07-09 | Spiration, Inc. | Lung reduction apparatus and method |
US6679264B1 (en) | 2000-03-04 | 2004-01-20 | Emphasys Medical, Inc. | Methods and devices for use in performing pulmonary procedures |
US8474460B2 (en) | 2000-03-04 | 2013-07-02 | Pulmonx Corporation | Implanted bronchial isolation devices and methods |
US20030070683A1 (en) | 2000-03-04 | 2003-04-17 | Deem Mark E. | Methods and devices for use in performing pulmonary procedures |
US7011094B2 (en) | 2001-03-02 | 2006-03-14 | Emphasys Medical, Inc. | Bronchial flow control devices and methods of use |
US7798147B2 (en) | 2001-03-02 | 2010-09-21 | Pulmonx Corporation | Bronchial flow control devices with membrane seal |
US20040074491A1 (en) * | 2001-03-02 | 2004-04-22 | Michael Hendricksen | Delivery methods and devices for implantable bronchial isolation devices |
EP1434615B1 (en) | 2001-10-11 | 2007-07-11 | Emphasys Medical, Inc. | Bronchial flow control device |
US6929637B2 (en) | 2002-02-21 | 2005-08-16 | Spiration, Inc. | Device and method for intra-bronchial provision of a therapeutic agent |
AU2003220124A1 (en) * | 2002-03-08 | 2003-09-22 | Emphasys Medical, Inc. | Methods and devices for inducing collapse in lung regions fed by collateral pathways |
US20030216769A1 (en) | 2002-05-17 | 2003-11-20 | Dillard David H. | Removable anchored lung volume reduction devices and methods |
US7819908B2 (en) * | 2002-06-17 | 2010-10-26 | Aeris Therapeutics, Inc. | Compositions and methods for reducing lung volume |
CA2530042C (en) * | 2002-06-17 | 2012-04-03 | Aeris Therapeutics, Inc. | Compositions and methods for reducing lung volume |
WO2004010845A2 (en) | 2002-07-26 | 2004-02-05 | Emphasys Medical, Inc. | Bronchial flow control devices with membrane seal |
US7814912B2 (en) | 2002-11-27 | 2010-10-19 | Pulmonx Corporation | Delivery methods and devices for implantable bronchial isolation devices |
ATE444722T1 (en) * | 2002-11-27 | 2009-10-15 | Pulmonx Corp | INTRODUCTION SET FOR IMPLANTABLE BRONCHIAL ISOLATION DEVICES |
US7100616B2 (en) | 2003-04-08 | 2006-09-05 | Spiration, Inc. | Bronchoscopic lung volume reduction method |
US8206684B2 (en) | 2004-02-27 | 2012-06-26 | Pulmonx Corporation | Methods and devices for blocking flow through collateral pathways in the lung |
US7771472B2 (en) | 2004-11-19 | 2010-08-10 | Pulmonx Corporation | Bronchial flow control devices and methods of use |
US8876791B2 (en) | 2005-02-25 | 2014-11-04 | Pulmonx Corporation | Collateral pathway treatment using agent entrained by aspiration flow current |
US8043301B2 (en) | 2007-10-12 | 2011-10-25 | Spiration, Inc. | Valve loader method, system, and apparatus |
US8795241B2 (en) | 2011-05-13 | 2014-08-05 | Spiration, Inc. | Deployment catheter |
EP2758010B1 (en) | 2011-09-23 | 2017-02-08 | Pulmonx, Inc | Implant loading system |
US10046126B2 (en) * | 2016-04-27 | 2018-08-14 | Suspended Animation, Inc. | Apparatus and method for delivering fluids and/or gases to the lungs |
RU2766521C1 (en) * | 2021-06-07 | 2022-03-15 | Олег Эммануилович Луцевич | Method of treating purulent-destructive pulmonary diseases |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4633873A (en) * | 1984-04-26 | 1987-01-06 | American Cyanamid Company | Surgical repair mesh |
EP0349505A2 (en) * | 1988-06-27 | 1990-01-03 | Astra Aktiebolag | A novel surgical material |
US5011493A (en) * | 1983-04-14 | 1991-04-30 | Belykh Sergei I | Material for connecting members for inner soft tissues and organs |
EP0719527A1 (en) * | 1994-12-30 | 1996-07-03 | Jean-Claude Sgro | Prosthetic element for the treatment of inguinal hernias, especially for celioscopic surgery |
-
1996
- 1996-07-04 IT IT96MI001375A patent/IT1284108B1/en active IP Right Grant
-
1997
- 1997-04-07 US US09/214,157 patent/US6123663A/en not_active Expired - Fee Related
- 1997-07-04 WO PCT/IT1997/000159 patent/WO1998001084A1/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5011493A (en) * | 1983-04-14 | 1991-04-30 | Belykh Sergei I | Material for connecting members for inner soft tissues and organs |
US4633873A (en) * | 1984-04-26 | 1987-01-06 | American Cyanamid Company | Surgical repair mesh |
EP0349505A2 (en) * | 1988-06-27 | 1990-01-03 | Astra Aktiebolag | A novel surgical material |
EP0719527A1 (en) * | 1994-12-30 | 1996-07-03 | Jean-Claude Sgro | Prosthetic element for the treatment of inguinal hernias, especially for celioscopic surgery |
Cited By (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1078601A3 (en) * | 1999-08-24 | 2002-05-22 | Spiration, Inc. | Lung volume reduction apparatus |
AU772080B2 (en) * | 2000-03-23 | 2004-04-08 | Spiration, Inc. | Lung constriction apparatus and method |
USRE45921E1 (en) | 2000-03-23 | 2016-03-15 | Spiration, Inc. | Tissue resection device, system, and method |
US6514290B1 (en) | 2000-03-31 | 2003-02-04 | Broncus Technologies, Inc. | Lung elastic recoil restoring or tissue compressing device and method |
US8974484B2 (en) | 2001-09-11 | 2015-03-10 | Spiration, Inc. | Removable lung reduction devices, systems, and methods |
US8986336B2 (en) | 2001-10-25 | 2015-03-24 | Spiration, Inc. | Apparatus and method for deployment of a bronchial obstruction device |
US8926647B2 (en) | 2002-03-20 | 2015-01-06 | Spiration, Inc. | Removable anchored lung volume reduction devices and methods |
US9622752B2 (en) | 2003-08-08 | 2017-04-18 | Spiration, Inc. | Bronchoscopic repair of air leaks in a lung |
US8974527B2 (en) | 2003-08-08 | 2015-03-10 | Spiration, Inc. | Bronchoscopic repair of air leaks in a lung |
US9402971B2 (en) | 2006-03-13 | 2016-08-02 | Pneumrx, Inc. | Minimally invasive lung volume reduction devices, methods, and systems |
US9402632B2 (en) | 2006-03-13 | 2016-08-02 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US8888800B2 (en) | 2006-03-13 | 2014-11-18 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US8668707B2 (en) | 2006-03-13 | 2014-03-11 | Pneumrx, Inc. | Minimally invasive lung volume reduction devices, methods, and systems |
US8932310B2 (en) | 2006-03-13 | 2015-01-13 | Pneumrx, Inc. | Minimally invasive lung volume reduction devices, methods, and systems |
US10226257B2 (en) | 2006-03-13 | 2019-03-12 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US8282660B2 (en) | 2006-03-13 | 2012-10-09 | Pneumrx, Inc. | Minimally invasive lung volume reduction devices, methods, and systems |
US8157837B2 (en) | 2006-03-13 | 2012-04-17 | Pneumrx, Inc. | Minimally invasive lung volume reduction device and method |
US10188398B2 (en) | 2006-03-13 | 2019-01-29 | Pneumrx, Inc. | Cross-sectional modification during deployment of an elongate lung volume reduction device |
US10188397B2 (en) | 2006-03-13 | 2019-01-29 | Pneumrx, Inc. | Torque alleviating intra-airway lung volume reduction compressive implant structures |
US9782558B2 (en) | 2006-03-13 | 2017-10-10 | Pneumrx, Inc. | Minimally invasive lung volume reduction devices, methods, and systems |
US8157823B2 (en) | 2006-03-13 | 2012-04-17 | Pneumrx, Inc. | Lung volume reduction devices, methods, and systems |
US9474533B2 (en) | 2006-03-13 | 2016-10-25 | Pneumrx, Inc. | Cross-sectional modification during deployment of an elongate lung volume reduction device |
US8142455B2 (en) | 2006-03-13 | 2012-03-27 | Pneumrx, Inc. | Delivery of minimally invasive lung volume reduction devices |
US9402633B2 (en) | 2006-03-13 | 2016-08-02 | Pneumrx, Inc. | Torque alleviating intra-airway lung volume reduction compressive implant structures |
US9198669B2 (en) | 2006-03-31 | 2015-12-01 | Spiration, Inc. | Articulable anchor |
US9326873B2 (en) | 2007-10-12 | 2016-05-03 | Spiration, Inc. | Valve loader method, system, and apparatus |
WO2009099165A1 (en) * | 2008-02-08 | 2009-08-13 | Kyoto University | Therapeutic device for chronic obstructive pulmonary disease |
US10058331B2 (en) | 2008-09-12 | 2018-08-28 | Pneumrx, Inc. | Enhanced efficacy lung volume reduction devices, methods, and systems |
US9192403B2 (en) | 2008-09-12 | 2015-11-24 | Pneumrx, Inc. | Elongated lung volume reduction devices, methods, and systems |
US9173669B2 (en) | 2008-09-12 | 2015-11-03 | Pneumrx, Inc. | Enhanced efficacy lung volume reduction devices, methods, and systems |
US8632605B2 (en) | 2008-09-12 | 2014-01-21 | Pneumrx, Inc. | Elongated lung volume reduction devices, methods, and systems |
US10285707B2 (en) | 2008-09-12 | 2019-05-14 | Pneumrx, Inc. | Enhanced efficacy lung volume reduction devices, methods, and systems |
US8721734B2 (en) | 2009-05-18 | 2014-05-13 | Pneumrx, Inc. | Cross-sectional modification during deployment of an elongate lung volume reduction device |
US10537334B2 (en) | 2013-10-25 | 2020-01-21 | Pneumrx, Inc. | Genetically-associated chronic obstructive pulmonary disease treatment |
US10390838B1 (en) | 2014-08-20 | 2019-08-27 | Pneumrx, Inc. | Tuned strength chronic obstructive pulmonary disease treatment |
Also Published As
Publication number | Publication date |
---|---|
ITMI961375A1 (en) | 1998-01-04 |
ITMI961375A0 (en) | 1996-07-04 |
US6123663A (en) | 2000-09-26 |
IT1284108B1 (en) | 1998-05-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6123663A (en) | Surgical appliance for the treatment of pulmonary emphysema | |
US4610248A (en) | Surgical finger assembly | |
JP3616101B2 (en) | Dilator for outer structure of human anatomy | |
EP0313577B1 (en) | A method and an apparatus for measuring blood pressure | |
JPH11513578A (en) | Cardiac function maintenance device with elastic filling chamber | |
JPS63143074A (en) | Improved body liquid drain apparatus | |
Brooks | Open thoracotomy in the management of spontaneous pneumothorax. | |
US4646739A (en) | Layman's nasal hemostat | |
Davies et al. | The significance of deep S waves in leads II and III | |
Heller et al. | Scoliosis in Duchenne muscular dystrophy: aspects of orthotic treatment | |
US11571555B2 (en) | Automatic pleural-peritonal pump | |
Sethia et al. | Disc embolisation after minor strut fracture in a Björk-Shiley mitral valve prosthesis. | |
CN211723385U (en) | Steel plate screw system for calcaneal osteotomy | |
CN208659431U (en) | A kind of centrum nail dilator | |
Sugimoto et al. | The diagnostic problem associated with blunt traumatic azygous vein injury: delayed appearance of right haemothorax after blunt chest trauma | |
TWI627934B (en) | Self-adjustable repair system of pectus excavatum | |
JP2013514098A (en) | Dorsal forearm plate | |
CN209048238U (en) | A kind of pressurizing abdominal belt postoperative for renal puncture | |
JPH0342936Y2 (en) | ||
Van Raaij et al. | Massive haemothorax following thoracic vertebral fracture | |
CN217525337U (en) | Vertebral universal restorer for orthopedic spinal surgery | |
US11679197B2 (en) | Device and methods for reducing pressure in muscle compartments | |
Knottenbelt et al. | Tension pneumopericardium following stab wounds to the chest: report of two cases | |
CN217472051U (en) | Anatomical form shoulder blade coaptation board | |
KR20120040542A (en) | Epithesis set for analgesic immobilistion of thorax surgical site |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): CA JP KR US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 09214157 Country of ref document: US |
|
NENP | Non-entry into the national phase |
Ref country code: JP Ref document number: 98505013 Format of ref document f/p: F |
|
NENP | Non-entry into the national phase |
Ref country code: CA |
|
122 | Ep: pct application non-entry in european phase |