WO1998004127A3 - Transplant solutions containing pyruvate and methods for transplantation - Google Patents

Transplant solutions containing pyruvate and methods for transplantation Download PDF

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Publication number
WO1998004127A3
WO1998004127A3 PCT/US1997/013160 US9713160W WO9804127A3 WO 1998004127 A3 WO1998004127 A3 WO 1998004127A3 US 9713160 W US9713160 W US 9713160W WO 9804127 A3 WO9804127 A3 WO 9804127A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyruvate
transplantation
transplant
organ
present
Prior art date
Application number
PCT/US1997/013160
Other languages
French (fr)
Other versions
WO1998004127A2 (en
Inventor
Ronald T Stanko
Luca Cicalese
Original Assignee
Ronald T Stanko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ronald T Stanko filed Critical Ronald T Stanko
Publication of WO1998004127A2 publication Critical patent/WO1998004127A2/en
Publication of WO1998004127A3 publication Critical patent/WO1998004127A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid

Abstract

The present invention is based upon the discovery that the use of pyruvate in transplant solutions and the feeding of pyruvate and/or pyruvate derivatives to the organ recipients prior to and subsequent to transplantation, greatly enhances the survivability of the recipient and the viability of the transplanted organ. According to the present invention, providing pyruvate prior to the transplantation of an organ and/or subsequent to the transplantation of the organ, will significantly increase the likelihood of a successful transplantation. Further, the use of pyruvate-containing preservation, transplant, perfusion and pyruvate irrigation solutions will greatly enhance the maintenance of the organs prior to transplantation. The transplant and irrigation solutions of the present invention contain components that are known in the art and pyruvate at a concentration from 1 to 100 mM.
PCT/US1997/013160 1996-07-25 1997-07-25 Transplant solutions containing pyruvate and methods for transplantation WO1998004127A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68631396A 1996-07-25 1996-07-25
US08/686,313 1996-07-25

Publications (2)

Publication Number Publication Date
WO1998004127A2 WO1998004127A2 (en) 1998-02-05
WO1998004127A3 true WO1998004127A3 (en) 1998-03-05

Family

ID=24755810

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/013160 WO1998004127A2 (en) 1996-07-25 1997-07-25 Transplant solutions containing pyruvate and methods for transplantation

Country Status (1)

Country Link
WO (1) WO1998004127A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000030442A1 (en) * 1998-11-25 2000-06-02 Abbott Laboratories Organ preservation solution containing pyruvate
US6846842B2 (en) 1999-10-07 2005-01-25 Beth Israel Deconess Medical Center, Inc. Pyruvate ester composition and method of use for resuscitation after events of ischemia and reperfusion
GB0001172D0 (en) * 2000-01-20 2000-03-08 Res Del International Limited Physiological medium for perfusing, preserving and storing isolated cell tissue and organ samples

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0215138A1 (en) * 1985-09-06 1987-03-25 Societe Des Produits Nestle S.A. Preservation of living tissues
SU1632427A1 (en) * 1988-06-20 1991-03-07 Харьковский государственный университет им.А.М.Горького Medium for ischemic damage tissues prevention during organs transplantation
WO1991009520A1 (en) * 1989-12-21 1991-07-11 The Regents Of The University Of California Novel and improved technology for preservation of organs for transplantation
WO1992004826A1 (en) * 1990-09-21 1992-04-02 Regents Of The University Of Minnesota Pyruvate solutions to counteract acute renal failure
US5294641A (en) * 1991-11-27 1994-03-15 Montefiore - University Hospital Method for treating a medical patient for cardiac trauma
US5536751A (en) * 1994-05-09 1996-07-16 The United States Of America As Represented By The Secretary Of The Army Pharmaceutical alpha-keto carboxylic acid compositions method of making and use thereof
US5599659A (en) * 1993-03-11 1997-02-04 Breonics, Inc. Preservation solution for ex vivo, warm preservation of tissues, explants,organs and vascular endothelial cells comprising retinal-derived fibroblast growth factor, cyclodextrin and chondroitin sulfate

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0215138A1 (en) * 1985-09-06 1987-03-25 Societe Des Produits Nestle S.A. Preservation of living tissues
SU1632427A1 (en) * 1988-06-20 1991-03-07 Харьковский государственный университет им.А.М.Горького Medium for ischemic damage tissues prevention during organs transplantation
WO1991009520A1 (en) * 1989-12-21 1991-07-11 The Regents Of The University Of California Novel and improved technology for preservation of organs for transplantation
WO1992004826A1 (en) * 1990-09-21 1992-04-02 Regents Of The University Of Minnesota Pyruvate solutions to counteract acute renal failure
US5294641A (en) * 1991-11-27 1994-03-15 Montefiore - University Hospital Method for treating a medical patient for cardiac trauma
US5599659A (en) * 1993-03-11 1997-02-04 Breonics, Inc. Preservation solution for ex vivo, warm preservation of tissues, explants,organs and vascular endothelial cells comprising retinal-derived fibroblast growth factor, cyclodextrin and chondroitin sulfate
US5536751A (en) * 1994-05-09 1996-07-16 The United States Of America As Represented By The Secretary Of The Army Pharmaceutical alpha-keto carboxylic acid compositions method of making and use thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BIOLOGICAL ABSTRACTS, vol. 96, 1993, Philadelphia, PA, US; abstract no. 37299, S. KOJIMA ET AL.: "Simple 24-hour preservation of rabit hearts with hexanol and pyruvate cardioplegia." XP002049016 *
DATABASE WPI Section Ch Week 9205, Derwent World Patents Index; Class B05, AN 92-039875, XP002049017 *
J. MOL. CELL CARDIOL., vol. 25, no. 4, 1993, pages 453 - 458 *

Also Published As

Publication number Publication date
WO1998004127A2 (en) 1998-02-05

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