WO1998005430A1 - Vorrichtung und verfahren zur abtrennung magnetischer materialien aus pharmazeutischen zubereitungen, deren ausgangs- oder zwischenprodukten sowie mit hilfe dieser vorrichtung hergestellte mittel - Google Patents
Vorrichtung und verfahren zur abtrennung magnetischer materialien aus pharmazeutischen zubereitungen, deren ausgangs- oder zwischenprodukten sowie mit hilfe dieser vorrichtung hergestellte mittel Download PDFInfo
- Publication number
- WO1998005430A1 WO1998005430A1 PCT/EP1997/004099 EP9704099W WO9805430A1 WO 1998005430 A1 WO1998005430 A1 WO 1998005430A1 EP 9704099 W EP9704099 W EP 9704099W WO 9805430 A1 WO9805430 A1 WO 9805430A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- separation space
- magnetic
- separation
- gradient field
- starting
- Prior art date
Links
- 239000013067 intermediate product Substances 0.000 title claims abstract description 12
- 238000000034 method Methods 0.000 title claims description 29
- 239000000696 magnetic material Substances 0.000 title claims description 17
- 239000008194 pharmaceutical composition Substances 0.000 title abstract description 3
- 238000000926 separation method Methods 0.000 claims abstract description 75
- 230000005291 magnetic effect Effects 0.000 claims abstract description 54
- 238000001802 infusion Methods 0.000 claims abstract description 12
- 238000002347 injection Methods 0.000 claims abstract description 11
- 239000007924 injection Substances 0.000 claims abstract description 11
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 29
- 239000002245 particle Substances 0.000 claims description 22
- 230000005298 paramagnetic effect Effects 0.000 claims description 14
- 238000007885 magnetic separation Methods 0.000 claims description 11
- 239000002872 contrast media Substances 0.000 claims description 10
- 150000001875 compounds Chemical class 0.000 claims description 6
- 239000004020 conductor Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- 238000002595 magnetic resonance imaging Methods 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 230000005293 ferrimagnetic effect Effects 0.000 claims description 4
- 229910001220 stainless steel Inorganic materials 0.000 claims description 4
- 239000010935 stainless steel Substances 0.000 claims description 4
- 238000002583 angiography Methods 0.000 claims description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 16
- 229910052742 iron Inorganic materials 0.000 description 8
- 239000000725 suspension Substances 0.000 description 8
- 229910000831 Steel Inorganic materials 0.000 description 7
- 238000001914 filtration Methods 0.000 description 7
- 239000010959 steel Substances 0.000 description 7
- 239000003814 drug Substances 0.000 description 6
- 239000006249 magnetic particle Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000012535 impurity Substances 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 230000005294 ferromagnetic effect Effects 0.000 description 4
- 230000002706 hydrostatic effect Effects 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000000356 contaminant Substances 0.000 description 3
- 230000005292 diamagnetic effect Effects 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 3
- 239000011241 protective layer Substances 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- MVZXTUSAYBWAAM-UHFFFAOYSA-N iron;sulfuric acid Chemical compound [Fe].OS(O)(=O)=O MVZXTUSAYBWAAM-UHFFFAOYSA-N 0.000 description 2
- 210000000865 mononuclear phagocyte system Anatomy 0.000 description 2
- 229940031182 nanoparticles iron oxide Drugs 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 210000002268 wool Anatomy 0.000 description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 230000003670 easy-to-clean Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- IZOOGPBRAOKZFK-UHFFFAOYSA-K gadopentetate Chemical compound [Gd+3].OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O IZOOGPBRAOKZFK-UHFFFAOYSA-K 0.000 description 1
- 229960003460 gadopentetic acid Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 159000000014 iron salts Chemical class 0.000 description 1
- VCMGMSHEPQENPE-UHFFFAOYSA-N ketamine hydrochloride Chemical compound [Cl-].C=1C=CC=C(Cl)C=1C1([NH2+]C)CCCCC1=O VCMGMSHEPQENPE-UHFFFAOYSA-N 0.000 description 1
- 239000004922 lacquer Substances 0.000 description 1
- 230000005415 magnetization Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000011177 media preparation Methods 0.000 description 1
- 238000005374 membrane filtration Methods 0.000 description 1
- 238000010327 methods by industry Methods 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 239000002907 paramagnetic material Substances 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- 239000005426 pharmaceutical component Substances 0.000 description 1
- 239000006223 plastic coating Substances 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000011045 prefiltration Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229940069575 rompun Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000011146 sterile filtration Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- QYEFBJRXKKSABU-UHFFFAOYSA-N xylazine hydrochloride Chemical compound Cl.CC1=CC=CC(C)=C1NC1=NCCCS1 QYEFBJRXKKSABU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
- B01D35/06—Filters making use of electricity or magnetism
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/035—Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical applications
Abstract
Description
Claims
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0001608A HUP0001608A3 (en) | 1996-08-05 | 1997-07-29 | Process for producing contrasting agents for magnetic resonance tomography |
KR10-1999-7000966A KR100502881B1 (ko) | 1996-08-05 | 1997-07-29 | 자기 공명 단층촬영용 조영제의 제조 방법 |
AT97936669T ATE211950T1 (de) | 1996-08-05 | 1997-07-29 | Vorrichtung und verfahren zur abtrennung magnetischer materialien aus pharmazeutischen zubereitungen, deren ausgangs- oder zwischenprodukten sowie mit hilfe dieser vorrichtung hergestellte mittel |
CA002262685A CA2262685C (en) | 1996-08-05 | 1997-07-29 | Process and device for separating magnetic materials from pharmaceutical compositions, their starting or intermediate products and agents produced by means of this device |
EP97936669A EP0915738B1 (de) | 1996-08-05 | 1997-07-29 | Vorrichtung und verfahren zur abtrennung magnetischer materialien aus pharmazeutischen zubereitungen, deren ausgangs- oder zwischenprodukten sowie mit hilfe dieser vorrichtung hergestellte mittel |
JP10507563A JP2000516131A (ja) | 1996-08-05 | 1997-07-29 | 薬剤組成物、その出発材料又は中間生成物から磁気材料を分離するための方法及び装置及びこの装置を用いて製造された薬剤 |
DK97936669T DK0915738T3 (da) | 1996-08-05 | 1997-07-29 | Fremgangsmåde til fremstilling af kontrastmidler til magnetresonanstomografi |
AU39415/97A AU727764B2 (en) | 1996-08-05 | 1997-07-29 | Process for the production of contrast media for magnetic resonance tomography |
DE59706019T DE59706019D1 (de) | 1996-08-05 | 1997-07-29 | Vorrichtung und verfahren zur abtrennung magnetischer materialien aus pharmazeutischen zubereitungen, deren ausgangs- oder zwischenprodukten sowie mit hilfe dieser vorrichtung hergestellte mittel |
NZ333962A NZ333962A (en) | 1996-08-05 | 1997-07-29 | Process and device for the production of contrast media for magnetic resonance tomography |
IL12805797A IL128057A (en) | 1996-08-05 | 1997-07-29 | Process for the production of contrast media |
NO19990523A NO318377B1 (no) | 1996-08-05 | 1999-02-04 | Kontrastmidler for magnetresonanstomografi og fremgangsmate for fremstilling av disse |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19632416.5 | 1996-08-05 | ||
DE19632416 | 1996-08-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998005430A1 true WO1998005430A1 (de) | 1998-02-12 |
Family
ID=7802388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1997/004099 WO1998005430A1 (de) | 1996-08-05 | 1997-07-29 | Vorrichtung und verfahren zur abtrennung magnetischer materialien aus pharmazeutischen zubereitungen, deren ausgangs- oder zwischenprodukten sowie mit hilfe dieser vorrichtung hergestellte mittel |
Country Status (19)
Country | Link |
---|---|
US (2) | US6517813B1 (de) |
EP (1) | EP0915738B1 (de) |
JP (1) | JP2000516131A (de) |
KR (1) | KR100502881B1 (de) |
CN (1) | CN1151846C (de) |
AR (1) | AR008817A1 (de) |
AT (1) | ATE211950T1 (de) |
AU (1) | AU727764B2 (de) |
CA (1) | CA2262685C (de) |
DE (2) | DE29713847U1 (de) |
DK (1) | DK0915738T3 (de) |
ES (1) | ES2171985T3 (de) |
HU (1) | HUP0001608A3 (de) |
IL (1) | IL128057A (de) |
NO (1) | NO318377B1 (de) |
NZ (1) | NZ333962A (de) |
PT (1) | PT915738E (de) |
WO (1) | WO1998005430A1 (de) |
ZA (1) | ZA976967B (de) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002022011A1 (de) | 2000-09-15 | 2002-03-21 | Institut für Diagnostikforschung GmbH an der Freien Universität Berlin | Verfahren zur bildlichen darstellung und diagnose von thromben mittels kernspintomographie unter verwendung partikulärer kontrastmittel |
US6517813B1 (en) | 1996-08-05 | 2003-02-11 | Schering Ag | Device and process for separating magnetic materials from pharmaceutical preparations, their starting or intermediate products, as well as agents that are produced with the aid of said device |
WO2003011459A1 (de) * | 2001-07-26 | 2003-02-13 | Institut für Diagnostikforschung GmbH an der Freien Universität Berlin | Verfahren zur hestellung pharmazeutischer zubereitungen |
FR2918868A1 (fr) | 2006-06-06 | 2009-01-23 | Guerbet Sa | Methode d'imagerie de diagnostic utilisant en combinaison avec l'imagerie de diffusion de l'eau, des agents de contraste |
US7601550B2 (en) | 2000-03-03 | 2009-10-13 | Osram Gmbh | Methods for producing a light emitting semiconductor body with a luminescence converter element |
CN103006589A (zh) * | 2011-09-27 | 2013-04-03 | 闫亚梅 | 阿莫西林分散片及其生产方法 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19938372A1 (de) * | 1999-08-09 | 2001-03-08 | Diagnostikforschung Inst | Verfahren und Vorrichtung zur Trennung magnetischer Teilchen |
WO2005079995A1 (en) | 2004-02-17 | 2005-09-01 | E.I. Dupont De Nemours And Company | Magnetic field and field gradient enhanced centrifugation solid-liquid separations |
CN101022931A (zh) * | 2004-09-09 | 2007-08-22 | 格伦达·费伊·贝尔 | 食品和药品中的塑料以及弹性体的分离 |
US8066877B2 (en) | 2005-02-17 | 2011-11-29 | E. I. Du Pont De Nemours And Company | Apparatus for magnetic field and magnetic gradient enhanced filtration |
US8075771B2 (en) * | 2005-02-17 | 2011-12-13 | E. I. Du Pont De Nemours And Company | Apparatus for magnetic field gradient enhanced centrifugation |
EP1738774A1 (de) * | 2005-06-29 | 2007-01-03 | Schering AG | Magnetische Eisenoxidpartikel enthaltende Zusammensetzungen und deren Verwendung in bildgebenden Verfahren |
EP1738773A1 (de) * | 2005-06-29 | 2007-01-03 | Schering AG | Magnetische Eisenoxidpartikel enthaltende Zusammensetzung und deren Vervendung in bildgebenden Verfahren |
CN102178986A (zh) * | 2011-04-13 | 2011-09-14 | 李明 | 一种血液体外循环磁性杀菌装置 |
CN106975567B (zh) * | 2017-05-17 | 2018-10-09 | 谢齐容 | 药材中铁质杂质去除装置及其方法 |
CN108287236B (zh) * | 2017-11-24 | 2020-03-13 | 中国农业大学 | 一种基于高梯度磁分离和量子点的荧光生物传感器及其应用 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3817389A (en) * | 1973-01-15 | 1974-06-18 | Sherwood Medical Ind Inc | Filter device in tubular fitting for medical injection equipment and the like |
JPS60241914A (ja) * | 1984-05-16 | 1985-11-30 | Hitachi Plant Eng & Constr Co Ltd | 電磁フイルタ用耐食性濾過材 |
JPS6211519A (ja) * | 1985-07-05 | 1987-01-20 | Agency Of Ind Science & Technol | 磁選機用選別素子 |
WO1990007380A2 (en) * | 1988-12-28 | 1990-07-12 | Stefan Miltenyi | Methods and materials for high gradient magnetic separation of biological materials |
DE4309333A1 (de) * | 1993-03-17 | 1994-09-22 | Silica Gel Gmbh | Superparamagnetische Teilchen, Verfahren zu ihrer Herstellung und Verwendung derselben |
EP0670185A2 (de) * | 1994-01-24 | 1995-09-06 | LANSDORP, Peter, M. | Einrichtung zur Trennung von magnetisch markierten Zellen |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5913521B2 (ja) * | 1975-06-19 | 1984-03-30 | メイトウサンギヨウ カブシキガイシヤ | 磁性酸化鉄・デキストラン複合体の製造法 |
GB8408127D0 (en) * | 1984-03-29 | 1984-05-10 | Nyegaard & Co As | Contrast agents |
US4641517A (en) | 1984-12-20 | 1987-02-10 | United Technologies Corporation | Control system actuator position synthesis for failure detection |
US5160726A (en) * | 1990-02-15 | 1992-11-03 | Advanced Magnetics Inc. | Filter sterilization for production of colloidal, superparamagnetic MR contrast agents |
US5055288A (en) | 1987-06-26 | 1991-10-08 | Advanced Magnetics, Inc. | Vascular magnetic imaging method and agent comprising biodegradeable superparamagnetic metal oxides |
NO159162C (no) | 1986-07-29 | 1988-12-07 | Fjeldsend As Olaf | Apparat for magnetisk paavirkning av stroemmende vaeske. |
US5045304A (en) * | 1988-08-31 | 1991-09-03 | Wayne State University | Contras agent having an imaging agent coupled to viable granulocytes for use in magnetic resonance imaging of abscess and a method of preparing and using same |
US5268165A (en) * | 1990-10-16 | 1993-12-07 | Biomedical Frontiers, Inc. | Polymer-deferoxamine-ferric iron adducts for use in magnetic resonance imaging |
ATE179894T1 (de) | 1991-01-19 | 1999-05-15 | Meito Sangyo Kk | Ultrafeine magnetische metalloxideteilchen enthaltende zusammensetzung |
DK0543020T3 (da) | 1991-06-11 | 1998-08-31 | Oxideret sammensætning indeholdende vandopløseligtcarboxypolysaccharid og magnetisk jernoxid | |
US5225282A (en) * | 1991-12-13 | 1993-07-06 | Molecular Bioquest, Inc. | Biodegradable magnetic microcluster comprising non-magnetic metal or metal oxide particles coated with a functionalized polymer |
WO1994003501A1 (en) | 1992-08-05 | 1994-02-17 | Meito Sangyo Kabushiki Kaisha | Small-diameter composite composed of water-soluble carboxypolysaccharide and magnetic iron oxide |
DE59403734D1 (de) * | 1993-03-17 | 1997-09-18 | Silica Gel Gmbh | Superparamagnetische teilchen, verfahren zu ihrer herstellung und verwendung derselben |
US5411730A (en) * | 1993-07-20 | 1995-05-02 | Research Corporation Technologies, Inc. | Magnetic microparticles |
DE4428851C2 (de) | 1994-08-04 | 2000-05-04 | Diagnostikforschung Inst | Eisen enthaltende Nanopartikel, ihre Herstellung und Anwendung in der Diagnostik und Therapie |
ES2139097T3 (es) * | 1994-09-27 | 2000-02-01 | Nycomed Imaging As | Agente de contraste. |
US5804162A (en) * | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
US5855868A (en) | 1996-04-01 | 1999-01-05 | Nycomed Imaging As | Method of T1 -weighted resonance imaging of RES organs |
IL128057A (en) | 1996-08-05 | 2001-08-26 | Schering Ag | Process for the production of contrast media |
-
1997
- 1997-07-29 IL IL12805797A patent/IL128057A/xx not_active IP Right Cessation
- 1997-07-29 WO PCT/EP1997/004099 patent/WO1998005430A1/de active IP Right Grant
- 1997-07-29 HU HU0001608A patent/HUP0001608A3/hu unknown
- 1997-07-29 CA CA002262685A patent/CA2262685C/en not_active Expired - Fee Related
- 1997-07-29 DK DK97936669T patent/DK0915738T3/da active
- 1997-07-29 PT PT97936669T patent/PT915738E/pt unknown
- 1997-07-29 DE DE29713847U patent/DE29713847U1/de not_active Expired - Lifetime
- 1997-07-29 NZ NZ333962A patent/NZ333962A/xx unknown
- 1997-07-29 EP EP97936669A patent/EP0915738B1/de not_active Expired - Lifetime
- 1997-07-29 AT AT97936669T patent/ATE211950T1/de not_active IP Right Cessation
- 1997-07-29 DE DE59706019T patent/DE59706019D1/de not_active Expired - Fee Related
- 1997-07-29 CN CNB971970351A patent/CN1151846C/zh not_active Expired - Fee Related
- 1997-07-29 AU AU39415/97A patent/AU727764B2/en not_active Ceased
- 1997-07-29 ES ES97936669T patent/ES2171985T3/es not_active Expired - Lifetime
- 1997-07-29 KR KR10-1999-7000966A patent/KR100502881B1/ko not_active IP Right Cessation
- 1997-07-29 JP JP10507563A patent/JP2000516131A/ja not_active Ceased
- 1997-08-01 US US08/904,765 patent/US6517813B1/en not_active Expired - Fee Related
- 1997-08-04 AR ARP970103534A patent/AR008817A1/es active IP Right Grant
- 1997-08-05 ZA ZA9706967A patent/ZA976967B/xx unknown
-
1999
- 1999-02-04 NO NO19990523A patent/NO318377B1/no not_active IP Right Cessation
-
2002
- 2002-12-19 US US10/322,475 patent/US20030108613A1/en not_active Abandoned
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3817389A (en) * | 1973-01-15 | 1974-06-18 | Sherwood Medical Ind Inc | Filter device in tubular fitting for medical injection equipment and the like |
JPS60241914A (ja) * | 1984-05-16 | 1985-11-30 | Hitachi Plant Eng & Constr Co Ltd | 電磁フイルタ用耐食性濾過材 |
JPS6211519A (ja) * | 1985-07-05 | 1987-01-20 | Agency Of Ind Science & Technol | 磁選機用選別素子 |
WO1990007380A2 (en) * | 1988-12-28 | 1990-07-12 | Stefan Miltenyi | Methods and materials for high gradient magnetic separation of biological materials |
DE4309333A1 (de) * | 1993-03-17 | 1994-09-22 | Silica Gel Gmbh | Superparamagnetische Teilchen, Verfahren zu ihrer Herstellung und Verwendung derselben |
EP0670185A2 (de) * | 1994-01-24 | 1995-09-06 | LANSDORP, Peter, M. | Einrichtung zur Trennung von magnetisch markierten Zellen |
Non-Patent Citations (2)
Title |
---|
PATENT ABSTRACTS OF JAPAN vol. 010, no. 112 (C - 342) 25 April 1986 (1986-04-25) * |
PATENT ABSTRACTS OF JAPAN vol. 011, no. 185 (C - 428) 13 June 1987 (1987-06-13) * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6517813B1 (en) | 1996-08-05 | 2003-02-11 | Schering Ag | Device and process for separating magnetic materials from pharmaceutical preparations, their starting or intermediate products, as well as agents that are produced with the aid of said device |
US7601550B2 (en) | 2000-03-03 | 2009-10-13 | Osram Gmbh | Methods for producing a light emitting semiconductor body with a luminescence converter element |
WO2002022011A1 (de) | 2000-09-15 | 2002-03-21 | Institut für Diagnostikforschung GmbH an der Freien Universität Berlin | Verfahren zur bildlichen darstellung und diagnose von thromben mittels kernspintomographie unter verwendung partikulärer kontrastmittel |
WO2003011459A1 (de) * | 2001-07-26 | 2003-02-13 | Institut für Diagnostikforschung GmbH an der Freien Universität Berlin | Verfahren zur hestellung pharmazeutischer zubereitungen |
FR2918868A1 (fr) | 2006-06-06 | 2009-01-23 | Guerbet Sa | Methode d'imagerie de diagnostic utilisant en combinaison avec l'imagerie de diffusion de l'eau, des agents de contraste |
CN103006589A (zh) * | 2011-09-27 | 2013-04-03 | 闫亚梅 | 阿莫西林分散片及其生产方法 |
Also Published As
Publication number | Publication date |
---|---|
US6517813B1 (en) | 2003-02-11 |
AR008817A1 (es) | 2000-02-23 |
NO990523L (no) | 1999-03-30 |
NO990523D0 (no) | 1999-02-04 |
ES2171985T3 (es) | 2002-09-16 |
EP0915738B1 (de) | 2002-01-16 |
US20030108613A1 (en) | 2003-06-12 |
CN1151846C (zh) | 2004-06-02 |
IL128057A (en) | 2001-08-26 |
KR100502881B1 (ko) | 2005-07-25 |
ZA976967B (en) | 1998-02-19 |
CN1230136A (zh) | 1999-09-29 |
CA2262685A1 (en) | 1998-02-12 |
HUP0001608A1 (hu) | 2000-09-28 |
ATE211950T1 (de) | 2002-02-15 |
DE29713847U1 (de) | 1997-12-18 |
KR20000029821A (ko) | 2000-05-25 |
DK0915738T3 (da) | 2002-05-06 |
AU3941597A (en) | 1998-02-25 |
IL128057A0 (en) | 1999-11-30 |
HUP0001608A3 (en) | 2001-01-29 |
EP0915738A1 (de) | 1999-05-19 |
JP2000516131A (ja) | 2000-12-05 |
PT915738E (pt) | 2002-07-31 |
CA2262685C (en) | 2008-09-23 |
AU727764B2 (en) | 2000-12-21 |
DE59706019D1 (de) | 2002-02-21 |
NO318377B1 (no) | 2005-03-14 |
NZ333962A (en) | 2000-07-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP0915738B1 (de) | Vorrichtung und verfahren zur abtrennung magnetischer materialien aus pharmazeutischen zubereitungen, deren ausgangs- oder zwischenprodukten sowie mit hilfe dieser vorrichtung hergestellte mittel | |
Farrell et al. | Neuropathologic findings in cortical resections (including hemispherectomies) performed for the treatment of intractable childhood epilepsy | |
EP1304542B1 (de) | Verfahren zur Ermittlung der räumlichen Verteilung magnetischer Partikel | |
US6616623B1 (en) | System for correction of a biological fluid | |
EP0773796A1 (de) | Eisen enthaltende nanopartikel mit doppeltem coating und anwendung in der diagnostik und therapie | |
DE10038737A1 (de) | Katheter für magnetresonanztomographische Untersuchungen | |
WO2005006356A1 (de) | Magnetische nanopartikel mit verbesserten magneteigenschaften | |
EP1738774A1 (de) | Magnetische Eisenoxidpartikel enthaltende Zusammensetzungen und deren Verwendung in bildgebenden Verfahren | |
EP1281085A1 (de) | Dynamische superparamagnetische marker | |
WO2007023025A1 (de) | Endoskopiesystem | |
EP0659056A1 (de) | Störungsfreies kontrastmittel | |
EP1554734B1 (de) | Stabilisierte superparamagnetische teilchen | |
DE102010042723A1 (de) | Vorrichtung und Verfahren zur Separation von Neél- und Brown-magnetischen Partikeln | |
WO2009094990A2 (de) | Beschichtete instrumente für die invasivmedizin | |
EP2322142B1 (de) | Biokompatible, magnetische Nanopartikel zur Behandlung von Glioblastomen | |
MXPA99001229A (en) | Process and device for separating magnetic materials from pharmaceutical compositions, their starting or intermediate products and agents produced by means of this device | |
WO2001010558A1 (de) | Verfahren und vorrichtung zur trennung magnetischer teilchen | |
DE19600744A1 (de) | Magnetische Substanz zur lokalen hyperthermischen Behandlung vorwiegend kleiner Tumore | |
DE3443810A1 (de) | Verfahren zur entkeimung eines mediums | |
WO2008049537A1 (de) | Verwendung von magnetischen cs -kapseln und/oder mikrokapseln für die behandlung von aneurysmen | |
DE602006000867T2 (de) | Vorrichtung zur Freisetzung von Medikamenten | |
EP2944686B1 (de) | Verfahren und vorrichtung zur abreicherung von zirkulierenden tumorzellen aus einer zellsuspension | |
DE3703444C1 (de) | ||
WO2002087493A2 (de) | Kapsel für die magnetfeldtherapie | |
Kolecka et al. | Magnetresonanztomographische und klinische Befunde von drei Hunden nach Kohlenmonoxidvergiftung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 97197035.1 Country of ref document: CN |
|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AL AM AU AZ BB BG BR BY CA CN CZ EE GE HU IL IS JP KE KG KP KR KZ LK LR LS LT LV MD MG MK MN MW MX NO NZ PL RO RU SD SG SI SK TJ TM TR TT UA UG US UZ VN |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 1997936669 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 333962 Country of ref document: NZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/1999/001229 Country of ref document: MX |
|
ENP | Entry into the national phase |
Ref document number: 2262685 Country of ref document: CA Ref document number: 2262685 Country of ref document: CA Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1019997000966 Country of ref document: KR |
|
WWP | Wipo information: published in national office |
Ref document number: 1997936669 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1019997000966 Country of ref document: KR |
|
WWG | Wipo information: grant in national office |
Ref document number: 1997936669 Country of ref document: EP |
|
WWG | Wipo information: grant in national office |
Ref document number: 1019997000966 Country of ref document: KR |