WO1998008490A1 - Solid coprecipitates for enhanced bioavailability of lipophilic substances - Google Patents
Solid coprecipitates for enhanced bioavailability of lipophilic substances Download PDFInfo
- Publication number
- WO1998008490A1 WO1998008490A1 PCT/US1997/015072 US9715072W WO9808490A1 WO 1998008490 A1 WO1998008490 A1 WO 1998008490A1 US 9715072 W US9715072 W US 9715072W WO 9808490 A1 WO9808490 A1 WO 9808490A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- tpgs
- coprecipitate
- solid
- lipophilic substance
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP51187998A JP2001523221A (en) | 1996-09-01 | 1997-08-27 | Solid co-precipitates for enhanced bioavailability of lipophilic substances |
EP97940639A EP1017366A4 (en) | 1996-09-01 | 1997-08-27 | Solid coprecipitates for enhanced bioavailability of lipophilic substances |
AU42373/97A AU730216B2 (en) | 1996-09-01 | 1997-08-27 | Solid coprecipitates for enhanced bioavailability of lipophilic substances |
CA002264718A CA2264718C (en) | 1996-09-01 | 1997-08-27 | Solid coprecipitates for enhanced bioavailability of lipophilic substances |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL11917696A IL119176A (en) | 1996-09-01 | 1996-09-01 | Soluble coprecipitates for enhanced oral bioavailability of lipophilic substances |
IL119176 | 1996-09-01 | ||
US08/833,076 US5891469A (en) | 1997-04-02 | 1997-04-02 | Solid Coprecipitates for enhanced bioavailability of lipophilic substances |
US08/833,076 | 1997-04-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998008490A1 true WO1998008490A1 (en) | 1998-03-05 |
Family
ID=26323300
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/015072 WO1998008490A1 (en) | 1996-09-01 | 1997-08-27 | Solid coprecipitates for enhanced bioavailability of lipophilic substances |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1017366A4 (en) |
JP (1) | JP2001523221A (en) |
AU (1) | AU730216B2 (en) |
CA (1) | CA2264718C (en) |
WO (1) | WO1998008490A1 (en) |
Cited By (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999026607A1 (en) * | 1997-11-21 | 1999-06-03 | Fuisz Technologies Ltd. | Drug delivery systems utilizing crystal structures |
WO1999047175A1 (en) * | 1998-03-13 | 1999-09-23 | Recordati S.A. Chemical And Pharmaceutical Company | Pharmaceutical compositions containing melatonin inclusion complexes |
WO2000061189A3 (en) * | 1999-04-02 | 2001-01-11 | Ca Nat Research Council | Water-soluble compositions of bioactive lipophilic compounds |
US6200550B1 (en) * | 1998-12-11 | 2001-03-13 | Q-Pharma, Inc. | Oral care compositions comprising coenzyme Q10 |
WO2001039836A1 (en) * | 1999-12-01 | 2001-06-07 | Natco Pharma Limited | A rapid acting freeze dired oral pharmaceutical composition for treating migraine |
WO2002024184A2 (en) * | 2000-09-19 | 2002-03-28 | Abbott Gmbh & Co. Kg | Mechanically stable dosage forms containing ubiquinones |
JP2002519318A (en) * | 1998-06-26 | 2002-07-02 | エルデイエス・テクノロジーズ・インコーポレーテツド | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
WO2002062392A2 (en) * | 2001-02-02 | 2002-08-15 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
WO2002089773A2 (en) * | 2001-05-09 | 2002-11-14 | Novartis Ag | Pharmaceutical compositions comprising cyclosporin |
JP2003520227A (en) * | 2000-01-20 | 2003-07-02 | スプラテック ファーマ インコーポレイテッド | Novel podophyllotoxin composition |
WO2005058290A2 (en) * | 2003-12-18 | 2005-06-30 | Dsm Ip Assets B.V. | Vitamin e for facilitating the synchronization of circadian rhythm |
WO2006039268A2 (en) * | 2004-09-30 | 2006-04-13 | Eastman Chemical Company | Pharmaceutical formulations containing vitamin e tpgs molecules that solubilize lipophilic drugs without significant efflux inhibition, and use of such formulations |
WO2006047067A1 (en) * | 2004-10-22 | 2006-05-04 | Eastman Chemical Company | Tablets comprising a poorly compressible active agent and tocopherol polyethyleneglycol succinate (tpgs) |
WO2008007728A1 (en) * | 2006-07-13 | 2008-01-17 | Kaneka Corporation | Oral preparation in the form enclosed in lipid membrane structure, and fatigue-ameliorating agent comprising coenzyme a as active ingredient |
US7423004B2 (en) | 2003-01-31 | 2008-09-09 | Smithkline Beecham Corporation | Solid dispersion compositions |
WO2009117152A1 (en) * | 2008-03-20 | 2009-09-24 | Virun, Inc. | Emulsions including a peg-derivative of tocopherol |
US7947670B2 (en) | 2006-12-12 | 2011-05-24 | Infinity Pharmaceuticals Inc. | Ansamycin formulations and methods of use thereof |
US8012494B2 (en) | 1999-09-13 | 2011-09-06 | Hoffmann-La Roche Inc. | Pharmaceutical compositions containing lipase inhibitors |
ITMI20112042A1 (en) * | 2011-11-10 | 2013-05-11 | Eratech S R L | POWDER TO RECONSTITUTE BEFORE INCLUDING MELATONIN AND INJECTABLE PREPARATION OBTAINABLE FROM SUCH POWDER. |
CN103190631A (en) * | 2008-03-20 | 2013-07-10 | 维尔恩公司 | Compositions containing non-polar compounds and method for manufacturing phytosterol |
US8524696B2 (en) | 1999-04-02 | 2013-09-03 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
WO2014009926A1 (en) | 2012-07-12 | 2014-01-16 | Laboratori Guidotti S.P.A. | Pediatric oral liquid compositions containing nepadutant |
US8722094B2 (en) | 2008-03-11 | 2014-05-13 | Aska Pharmaceutical Co., Ltd. | Solid dispersion and pharmaceutical composition of the same, and production processes thereof |
WO2015071837A1 (en) * | 2013-11-12 | 2015-05-21 | Druggability Technologies Holdings Limited | Complexes of cyclosporine a and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
US9192577B2 (en) | 2002-11-29 | 2015-11-24 | Janssen Pharmaceutica Nv | Pharmaceutical compositions comprising a basic drug compound, a surfactant, and a physiologically tolerable water soluble acid |
WO2015193673A1 (en) * | 2014-06-18 | 2015-12-23 | Perioc Limited | Novel pharmaceutical formulations and their use in the treatment of periodontal disease |
US9320295B2 (en) | 2010-03-23 | 2016-04-26 | Virun, Inc. | Compositions containing non-polar compounds |
US9351517B2 (en) | 2013-03-15 | 2016-05-31 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and compositions containing same |
US9693574B2 (en) | 2013-08-08 | 2017-07-04 | Virun, Inc. | Compositions containing water-soluble derivatives of vitamin E mixtures and modified food starch |
US9765119B2 (en) | 2001-10-19 | 2017-09-19 | Aurinia Pharmaceuticals Inc. | Cyclosporine analogue mixtures and their use as immunomodulating agents |
US9861611B2 (en) | 2014-09-18 | 2018-01-09 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same |
CN108245683A (en) * | 2018-01-26 | 2018-07-06 | 华中科技大学 | A kind of anti-tumor predrug and preparation method with the inhibition of P- glycoprotein |
US10016363B2 (en) | 2014-09-18 | 2018-07-10 | Virun, Inc. | Pre-spray emulsions and powders containing non-polar compounds |
US10335385B2 (en) | 2010-06-21 | 2019-07-02 | Virun, Inc. | Composition containing non-polar compounds |
WO2021123108A1 (en) * | 2019-12-20 | 2021-06-24 | Intervet International B.V. | A pyrazole pharmaceutical composition |
WO2021123949A1 (en) * | 2019-12-20 | 2021-06-24 | Idorsia Pharmaceuticals Ltd | Pharmaceutical compositions comprising n-[1-(5-cyano-pyridin-2-ylmethyl)-1h-pyrazol-3-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide |
US11246852B2 (en) | 2016-12-02 | 2022-02-15 | Receptor Holdings, Inc. | Fast-acting plant-based medicinal compounds and nutritional supplements |
US11331279B2 (en) | 2014-05-29 | 2022-05-17 | Radius Pharmaceuticals, Inc. | Stable cannabinoid formulations |
WO2023152672A1 (en) * | 2022-02-11 | 2023-08-17 | Pierpaoli Exelyas S.R.L. | Composition comprising melatonin with high bioavailability |
US11911361B2 (en) | 2014-05-29 | 2024-02-27 | Radius Pharmaceuticals, Inc. | Stable cannabinoid formulations |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2840614B1 (en) * | 2002-06-07 | 2004-08-27 | Flamel Tech Sa | POLYAMINOACIDS FUNCTIONALIZED BY ALPHA-TOCOPHEROL AND THEIR PARTICULARLY THERAPEUTIC APPLICATIONS |
JP2006517929A (en) * | 2003-02-19 | 2006-08-03 | ハー・ルンドベック・アクチエゼルスカベット | Method for producing agglomerates using melt agglomeration |
US20050096365A1 (en) * | 2003-11-03 | 2005-05-05 | David Fikstad | Pharmaceutical compositions with synchronized solubilizer release |
WO2006036614A2 (en) * | 2004-09-24 | 2006-04-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | A new class of surfactant-like materials comprising vitamin e tpgs and a water soluble polymer |
US7446096B2 (en) * | 2005-12-19 | 2008-11-04 | Industrial Technology Research Institute | Glutathione based delivery system |
US8067380B2 (en) | 2005-12-19 | 2011-11-29 | Industrial Technology Research Institute | Glutathione-based delivery system |
AR075180A1 (en) * | 2009-01-29 | 2011-03-16 | Novartis Ag | SOLID ORAL FORMULATIONS OF A PYRIDOID-PYRIMIDINONE |
WO2010092925A1 (en) * | 2009-02-12 | 2010-08-19 | あすか製薬株式会社 | Solid dispersion, pharmaceutical composition comprising the solid dispersion, and processes for producing the solid dispersion and the pharmaceutical composition |
US8252821B2 (en) * | 2009-04-14 | 2012-08-28 | Bristol-Myers Squibb Company | Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
FR2999081B1 (en) * | 2012-12-06 | 2015-02-27 | Hra Pharma Lab | SOLID DISPERSION OF A SELECTIVE PROGESTERONE RECEPTOR MODULATOR |
ES2938560T3 (en) * | 2015-05-28 | 2023-04-12 | Radius Pharmaceuticals Inc | Stable cannabinoid formulations |
KR20190103302A (en) | 2017-01-03 | 2019-09-04 | 리셉터 홀딩스, 인크. | Medicinal Compounds and Nutritional Supplements |
MX2019009642A (en) * | 2017-02-15 | 2019-11-11 | Molecular Infusions Llc | Formulations. |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3102078A (en) * | 1961-01-13 | 1963-08-27 | Eastman Kodak Co | Water-dispersible vitamin preparations |
US3673163A (en) * | 1970-06-16 | 1972-06-27 | Lilly Co Eli | Pharmacological preparation containing an acronycine-polyvinylprrolidone coprecipitate |
US4327080A (en) * | 1981-07-13 | 1982-04-27 | E. R. Squibb & Sons, Inc. | Novel Bendroflumethiazide formulations and method |
US4412986A (en) * | 1977-06-07 | 1983-11-01 | Yamanouchi Pharmaceutical Co. Ltd. | Nifedipine-containing solid preparation composition |
US4758427A (en) * | 1985-08-08 | 1988-07-19 | Ciba-Geigy Corporation | Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone |
US5179122A (en) * | 1991-02-11 | 1993-01-12 | Eastman Kodak Company | Nutritional supplement containing vitamin e |
US5234696A (en) * | 1991-12-27 | 1993-08-10 | Abbott Laboratories | Method of producing tablets, tablets produced thereby, and method of treatment using same |
US5430021A (en) * | 1994-03-18 | 1995-07-04 | Pharmavene, Inc. | Hydrophobic drug delivery systems |
US5491154A (en) * | 1992-08-05 | 1996-02-13 | Bayer S.P.A. | Pharmaceutical preparation for the oral administration of dihydropyridines |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU215966B (en) * | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Oral multiple emulsion-preconcentrate containing cyclosporin |
CA2221145A1 (en) * | 1995-05-19 | 1996-11-21 | Abbott Laboratories | Self-emulsifying formulations of lipophilic drugs |
MY126358A (en) * | 1996-03-22 | 2006-09-29 | Glaxo Group Ltd | Compositions comprising vx478 and a water soluble tocopherol derivative such as vitamin e-tpgs |
-
1997
- 1997-08-27 EP EP97940639A patent/EP1017366A4/en not_active Withdrawn
- 1997-08-27 WO PCT/US1997/015072 patent/WO1998008490A1/en active Application Filing
- 1997-08-27 JP JP51187998A patent/JP2001523221A/en not_active Ceased
- 1997-08-27 CA CA002264718A patent/CA2264718C/en not_active Expired - Fee Related
- 1997-08-27 AU AU42373/97A patent/AU730216B2/en not_active Ceased
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3102078A (en) * | 1961-01-13 | 1963-08-27 | Eastman Kodak Co | Water-dispersible vitamin preparations |
US3673163A (en) * | 1970-06-16 | 1972-06-27 | Lilly Co Eli | Pharmacological preparation containing an acronycine-polyvinylprrolidone coprecipitate |
US4412986A (en) * | 1977-06-07 | 1983-11-01 | Yamanouchi Pharmaceutical Co. Ltd. | Nifedipine-containing solid preparation composition |
US4327080A (en) * | 1981-07-13 | 1982-04-27 | E. R. Squibb & Sons, Inc. | Novel Bendroflumethiazide formulations and method |
US4758427A (en) * | 1985-08-08 | 1988-07-19 | Ciba-Geigy Corporation | Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone |
US5179122A (en) * | 1991-02-11 | 1993-01-12 | Eastman Kodak Company | Nutritional supplement containing vitamin e |
US5234696A (en) * | 1991-12-27 | 1993-08-10 | Abbott Laboratories | Method of producing tablets, tablets produced thereby, and method of treatment using same |
US5491154A (en) * | 1992-08-05 | 1996-02-13 | Bayer S.P.A. | Pharmaceutical preparation for the oral administration of dihydropyridines |
US5430021A (en) * | 1994-03-18 | 1995-07-04 | Pharmavene, Inc. | Hydrophobic drug delivery systems |
Non-Patent Citations (4)
Title |
---|
M.W. ADAMS: "d-Alpha tocopheryl polyethylene glycol 1000 succinate (Eastman Vitamin E TPGS) as an emulsifier and bioenhancer for drugs and lipophilic compounds", INTERNATIONAL CONGRESS OF TECHNOLOGY AND PHARMACOLOGY., ASSOC. PHARM. GALENIQUE IND., CHATENAY MALABRY., FR, vol. 04., no. 4, 1 January 1992 (1992-01-01), FR, pages 254 - 262., XP002011712 * |
See also references of EP1017366A4 * |
WU S H W, HOPKINGS W, WYATT D: "D-ALPHA TOCOPHERYL POLYETHYLENE GLYCOL 1000 SUCCINATE (TPGS) AS AN ABSORPTION ENHANCER", WORLD MEETING APV/APGI. MEETING ON PHARMACEUTICS,BIOPHARMACEUTICS, PHARMACEUTICAL TECHNOLOGY, XX, XX, 9 May 1995 (1995-05-09), XX, pages 24/25, XP008063660 * |
WU W-M, LEE Y-S, BODOR N: "PHARMACOKINETICS, METABOLISM AND EXCRETION OF DELTA1-CORTIENIC ACID ETABONATE AND DELTA1-CORTIENIC ACID, THE METABOLITES OF A SOFT CORTICOSTEROID, LOTEPREDNOL ETABONATE", PHARMACEUTICAL RESEARCH, SPRINGER NEW YORK LLC, US, vol. 11, no. 10, SUPPL., 1 January 1994 (1994-01-01), US, pages S364 + ABSTR. NO. 8127, XP009037847, ISSN: 0724-8741 * |
Cited By (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999026607A1 (en) * | 1997-11-21 | 1999-06-03 | Fuisz Technologies Ltd. | Drug delivery systems utilizing crystal structures |
WO1999047175A1 (en) * | 1998-03-13 | 1999-09-23 | Recordati S.A. Chemical And Pharmaceutical Company | Pharmaceutical compositions containing melatonin inclusion complexes |
JP2002519318A (en) * | 1998-06-26 | 2002-07-02 | エルデイエス・テクノロジーズ・インコーポレーテツド | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
JP4875239B2 (en) * | 1998-06-26 | 2012-02-15 | アテナ・ニユーロサイエンシズ・インコーポレーテツド | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
US6200550B1 (en) * | 1998-12-11 | 2001-03-13 | Q-Pharma, Inc. | Oral care compositions comprising coenzyme Q10 |
WO2000061189A3 (en) * | 1999-04-02 | 2001-01-11 | Ca Nat Research Council | Water-soluble compositions of bioactive lipophilic compounds |
US6191172B1 (en) | 1999-04-02 | 2001-02-20 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
US7645816B2 (en) | 1999-04-02 | 2010-01-12 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
US8524696B2 (en) | 1999-04-02 | 2013-09-03 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
US8012494B2 (en) | 1999-09-13 | 2011-09-06 | Hoffmann-La Roche Inc. | Pharmaceutical compositions containing lipase inhibitors |
WO2001039836A1 (en) * | 1999-12-01 | 2001-06-07 | Natco Pharma Limited | A rapid acting freeze dired oral pharmaceutical composition for treating migraine |
JP2003520227A (en) * | 2000-01-20 | 2003-07-02 | スプラテック ファーマ インコーポレイテッド | Novel podophyllotoxin composition |
US6632443B2 (en) | 2000-02-23 | 2003-10-14 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
WO2002024184A2 (en) * | 2000-09-19 | 2002-03-28 | Abbott Gmbh & Co. Kg | Mechanically stable dosage forms containing ubiquinones |
WO2002024184A3 (en) * | 2000-09-19 | 2002-07-18 | Knoll Gmbh | Mechanically stable dosage forms containing ubiquinones |
US7273624B2 (en) | 2000-09-19 | 2007-09-25 | Abbott Gmbh & Co. Kg | Stable dosage forms containing ubiquinones |
EP1810694A3 (en) * | 2001-02-02 | 2008-01-09 | National Research Council of Canada | Water-soluble compositions of bioactive lipophilic compounds |
WO2002062392A3 (en) * | 2001-02-02 | 2002-11-14 | Ca Nat Research Council | Water-soluble compositions of bioactive lipophilic compounds |
WO2002062392A2 (en) * | 2001-02-02 | 2002-08-15 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
EP1810694A2 (en) * | 2001-02-02 | 2007-07-25 | National Research Council of Canada | Water-soluble compositions of bioactive lipophilic compounds |
WO2002089773A2 (en) * | 2001-05-09 | 2002-11-14 | Novartis Ag | Pharmaceutical compositions comprising cyclosporin |
WO2002089773A3 (en) * | 2001-05-09 | 2003-02-06 | Novartis Ag | Pharmaceutical compositions comprising cyclosporin |
USRE48226E1 (en) | 2001-10-19 | 2020-09-29 | Aurinia Pharmaceuticals Inc. | Cyclosporine analogue mixtures and their use as immunomodulating agents |
US10472394B2 (en) | 2001-10-19 | 2019-11-12 | Aurinia Pharmaceuticals Inc. | Cyclosporine analogue mixtures and their use as immunomodulating agents |
US9765119B2 (en) | 2001-10-19 | 2017-09-19 | Aurinia Pharmaceuticals Inc. | Cyclosporine analogue mixtures and their use as immunomodulating agents |
US9192577B2 (en) | 2002-11-29 | 2015-11-24 | Janssen Pharmaceutica Nv | Pharmaceutical compositions comprising a basic drug compound, a surfactant, and a physiologically tolerable water soluble acid |
US7423004B2 (en) | 2003-01-31 | 2008-09-09 | Smithkline Beecham Corporation | Solid dispersion compositions |
WO2005058290A3 (en) * | 2003-12-18 | 2007-05-10 | Dsm Ip Assets Bv | Vitamin e for facilitating the synchronization of circadian rhythm |
WO2005058290A2 (en) * | 2003-12-18 | 2005-06-30 | Dsm Ip Assets B.V. | Vitamin e for facilitating the synchronization of circadian rhythm |
WO2006039268A3 (en) * | 2004-09-30 | 2006-07-27 | Eastman Chem Co | Pharmaceutical formulations containing vitamin e tpgs molecules that solubilize lipophilic drugs without significant efflux inhibition, and use of such formulations |
WO2006039268A2 (en) * | 2004-09-30 | 2006-04-13 | Eastman Chemical Company | Pharmaceutical formulations containing vitamin e tpgs molecules that solubilize lipophilic drugs without significant efflux inhibition, and use of such formulations |
WO2006047067A1 (en) * | 2004-10-22 | 2006-05-04 | Eastman Chemical Company | Tablets comprising a poorly compressible active agent and tocopherol polyethyleneglycol succinate (tpgs) |
WO2008007728A1 (en) * | 2006-07-13 | 2008-01-17 | Kaneka Corporation | Oral preparation in the form enclosed in lipid membrane structure, and fatigue-ameliorating agent comprising coenzyme a as active ingredient |
US8283343B2 (en) | 2006-12-12 | 2012-10-09 | Infinity Pharmaceuticals Inc. | Ansamycin formulations and methods of use thereof |
US7947670B2 (en) | 2006-12-12 | 2011-05-24 | Infinity Pharmaceuticals Inc. | Ansamycin formulations and methods of use thereof |
US8357676B2 (en) | 2006-12-12 | 2013-01-22 | Infinity Discovery, Inc. | Ansamycin formulations and methods of use thereof |
US8722094B2 (en) | 2008-03-11 | 2014-05-13 | Aska Pharmaceutical Co., Ltd. | Solid dispersion and pharmaceutical composition of the same, and production processes thereof |
US8282977B2 (en) | 2008-03-20 | 2012-10-09 | Virun, Inc. | Compositions containing non-polar compounds |
US9788564B2 (en) | 2008-03-20 | 2017-10-17 | Virun, Inc. | Compositions containing non-polar compounds |
WO2009117152A1 (en) * | 2008-03-20 | 2009-09-24 | Virun, Inc. | Emulsions including a peg-derivative of tocopherol |
CN103190631A (en) * | 2008-03-20 | 2013-07-10 | 维尔恩公司 | Compositions containing non-polar compounds and method for manufacturing phytosterol |
US10668029B2 (en) | 2008-03-20 | 2020-06-02 | Virun, Inc. | Compositions containing non-polar compounds |
EP2548456A1 (en) * | 2008-03-20 | 2013-01-23 | Virun, Inc. | Emulsions including a PEG-derivative of tocopherol |
US10220007B2 (en) | 2008-03-20 | 2019-03-05 | Virun, Inc. | Compositions containing non-polar compounds |
US9320295B2 (en) | 2010-03-23 | 2016-04-26 | Virun, Inc. | Compositions containing non-polar compounds |
US10335385B2 (en) | 2010-06-21 | 2019-07-02 | Virun, Inc. | Composition containing non-polar compounds |
ITMI20112042A1 (en) * | 2011-11-10 | 2013-05-11 | Eratech S R L | POWDER TO RECONSTITUTE BEFORE INCLUDING MELATONIN AND INJECTABLE PREPARATION OBTAINABLE FROM SUCH POWDER. |
WO2014009926A1 (en) | 2012-07-12 | 2014-01-16 | Laboratori Guidotti S.P.A. | Pediatric oral liquid compositions containing nepadutant |
US9351517B2 (en) | 2013-03-15 | 2016-05-31 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and compositions containing same |
US9693574B2 (en) | 2013-08-08 | 2017-07-04 | Virun, Inc. | Compositions containing water-soluble derivatives of vitamin E mixtures and modified food starch |
WO2015071837A1 (en) * | 2013-11-12 | 2015-05-21 | Druggability Technologies Holdings Limited | Complexes of cyclosporine a and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
US11331279B2 (en) | 2014-05-29 | 2022-05-17 | Radius Pharmaceuticals, Inc. | Stable cannabinoid formulations |
US11911361B2 (en) | 2014-05-29 | 2024-02-27 | Radius Pharmaceuticals, Inc. | Stable cannabinoid formulations |
WO2015193673A1 (en) * | 2014-06-18 | 2015-12-23 | Perioc Limited | Novel pharmaceutical formulations and their use in the treatment of periodontal disease |
US10016363B2 (en) | 2014-09-18 | 2018-07-10 | Virun, Inc. | Pre-spray emulsions and powders containing non-polar compounds |
US10285971B2 (en) | 2014-09-18 | 2019-05-14 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same |
US9861611B2 (en) | 2014-09-18 | 2018-01-09 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same |
US11246852B2 (en) | 2016-12-02 | 2022-02-15 | Receptor Holdings, Inc. | Fast-acting plant-based medicinal compounds and nutritional supplements |
CN108245683A (en) * | 2018-01-26 | 2018-07-06 | 华中科技大学 | A kind of anti-tumor predrug and preparation method with the inhibition of P- glycoprotein |
CN108245683B (en) * | 2018-01-26 | 2020-02-14 | 华中科技大学 | Anti-tumor prodrug with P-glycoprotein inhibition function and preparation method thereof |
WO2021123108A1 (en) * | 2019-12-20 | 2021-06-24 | Intervet International B.V. | A pyrazole pharmaceutical composition |
CN114845702A (en) * | 2019-12-20 | 2022-08-02 | 英特维特国际股份有限公司 | Pyrazole pharmaceutical composition |
CN115103668A (en) * | 2019-12-20 | 2022-09-23 | 爱杜西亚药品有限公司 | Pharmaceutical composition comprising N- [1- (5-cyano-pyridin-2-ylmethyl) -1H-pyrazol-3-yl ] -2- [4- (1-trifluoromethyl-cyclopropyl) -phenyl ] -acetamide |
WO2021123949A1 (en) * | 2019-12-20 | 2021-06-24 | Idorsia Pharmaceuticals Ltd | Pharmaceutical compositions comprising n-[1-(5-cyano-pyridin-2-ylmethyl)-1h-pyrazol-3-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide |
EP4282475A3 (en) * | 2019-12-20 | 2024-02-28 | Intervet International B.V. | A pyrazole pharmaceutical composition |
CN114845702B (en) * | 2019-12-20 | 2024-03-15 | 英特维特国际股份有限公司 | Pyrazole pharmaceutical composition |
WO2023152672A1 (en) * | 2022-02-11 | 2023-08-17 | Pierpaoli Exelyas S.R.L. | Composition comprising melatonin with high bioavailability |
Also Published As
Publication number | Publication date |
---|---|
JP2001523221A (en) | 2001-11-20 |
AU4237397A (en) | 1998-03-19 |
CA2264718A1 (en) | 1998-03-05 |
EP1017366A4 (en) | 2006-03-22 |
EP1017366A1 (en) | 2000-07-12 |
CA2264718C (en) | 2006-05-30 |
AU730216B2 (en) | 2001-03-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU730216B2 (en) | Solid coprecipitates for enhanced bioavailability of lipophilic substances | |
US5891469A (en) | Solid Coprecipitates for enhanced bioavailability of lipophilic substances | |
AU722217B2 (en) | Solid lipid compositions of lipophilic compounds for enhanced oral bioavailability | |
AU2002226374B2 (en) | Amphiphilic lipid nanoparticles for peptide and/or protein incorporation | |
JPH08509475A (en) | Pharmaceutically acceptable improved composition containing alcohol and hydrophobic drug | |
US20220280479A1 (en) | Self-emulsifying formulations of dim-related indoles | |
JP2001505928A (en) | Solid pharmaceutical composition comprising cyclosporin and an anionic surfactant | |
JP2010090132A (en) | Method for producing nanoparticle by fluidized bed spray drying | |
CA2353809A1 (en) | Nanoparticulate core-shell systems and use thereof in pharmaceutical and cosmetic preparations | |
WO2009092291A1 (en) | A drug delivery system, its preparation process and use | |
JP4721640B2 (en) | Fenofibrate nanoparticle formulation | |
WO2003017986A1 (en) | Compositions containing itraconazole and their preparation methods | |
JP2003500454A (en) | Substantially oil-free cyclosporin composition | |
JP2005509596A6 (en) | Fenofibrate nanoparticle formulation | |
JP2005526119A (en) | Methods and formulations for improving hydrophobic drug absorption and gastrointestinal bioavailability | |
JPH07121858B2 (en) | Emulsion composition dehydrated by heat | |
IL119176A (en) | Soluble coprecipitates for enhanced oral bioavailability of lipophilic substances | |
JP2006509785A (en) | Oral microemulsion composition of biphenyldimethyldicarboxylic acid | |
CA2251194C (en) | Solid lipid compositions of lipophilic compounds for enhanced oral bioavailability | |
KR100455216B1 (en) | Composition for oral administration of poorly soluble antifungal agent and process for the preparation thereof | |
KR101279568B1 (en) | Oral Pharmaceutical Composition Containing Megestrol Acetate | |
KR100352089B1 (en) | Oral micro-emulsion composition comprising fenofibrate | |
IL126384A (en) | Solid lipid compositions of lipophilic compounds for enhanced oral bioavailability | |
EP3714879A1 (en) | Structured encapsulated silicon-containing particles | |
SI26054A (en) | Super-saturable oil-free self-nanoemulsifying drug delivery system SNEDDS for poorly water-soluble pharmaceutical composition and procedure of preparation thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AL AM AU AZ BA BB BG BR BY CA CN CU CZ EE GE GH HU IL IS JP KG KP KR KZ LC LK LR LT LV MD MG MK MN MX NO NZ PL RO RU SG SI SK SL TJ TM TR TT UA US UZ VN YU AM AZ BY KG KZ MD RU TJ TM |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
ENP | Entry into the national phase |
Ref document number: 2264718 Country of ref document: CA Ref country code: CA Ref document number: 2264718 Kind code of ref document: A Format of ref document f/p: F Ref country code: JP Ref document number: 1998 511879 Kind code of ref document: A Format of ref document f/p: F |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1997940639 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 1997940639 Country of ref document: EP |