WO1998009600A3 - Novel silicon amphiphilic compounds and the use thereof - Google Patents

Novel silicon amphiphilic compounds and the use thereof Download PDF

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Publication number
WO1998009600A3
WO1998009600A3 PCT/US1997/015033 US9715033W WO9809600A3 WO 1998009600 A3 WO1998009600 A3 WO 1998009600A3 US 9715033 W US9715033 W US 9715033W WO 9809600 A3 WO9809600 A3 WO 9809600A3
Authority
WO
WIPO (PCT)
Prior art keywords
amphiphilic compounds
silicon
novel silicon
compositions
novel
Prior art date
Application number
PCT/US1997/015033
Other languages
French (fr)
Other versions
WO1998009600A2 (en
Inventor
Evan C Unger
Dekang Shen
Guanli Wu
Original Assignee
Imarx Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imarx Pharmaceutical Corp filed Critical Imarx Pharmaceutical Corp
Priority to AU40922/97A priority Critical patent/AU4092297A/en
Publication of WO1998009600A2 publication Critical patent/WO1998009600A2/en
Publication of WO1998009600A3 publication Critical patent/WO1998009600A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A61K51/1227—Micelles, e.g. phospholipidic or polymeric micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0834—Compounds having one or more O-Si linkage
    • C07F7/0838—Compounds with one or more Si-O-Si sequences

Abstract

Novel silicon amphiphilic compounds which comprise a silicon residue. The silicon amphiphilic compounds are particularly suitable for use in compositions for diagnostic imaging, such as ultrasound. Compositions of the silicon amphiphilic compounds comprise a gas or gaseous precursor, and may take the form of vesicle compositions, such as micelles or liposomes.
PCT/US1997/015033 1996-09-03 1997-08-26 Novel silicon amphiphilic compounds and the use thereof WO1998009600A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU40922/97A AU4092297A (en) 1996-09-03 1997-08-26 Novel silicon amphiphilic compounds and the use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/706,824 1996-09-03
US08/706,824 US6414139B1 (en) 1996-09-03 1996-09-03 Silicon amphiphilic compounds and the use thereof

Publications (2)

Publication Number Publication Date
WO1998009600A2 WO1998009600A2 (en) 1998-03-12
WO1998009600A3 true WO1998009600A3 (en) 1998-04-16

Family

ID=24839210

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/015033 WO1998009600A2 (en) 1996-09-03 1997-08-26 Novel silicon amphiphilic compounds and the use thereof

Country Status (3)

Country Link
US (1) US6414139B1 (en)
AU (1) AU4092297A (en)
WO (1) WO1998009600A2 (en)

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KR20180133527A (en) 2016-05-04 2018-12-14 랜티우스 메디컬 이메징, 인크. Method and apparatus for producing ultrasound contrast agent
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