WO1998013493A3 - A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof - Google Patents

A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof Download PDF

Info

Publication number
WO1998013493A3
WO1998013493A3 PCT/US1997/017154 US9717154W WO9813493A3 WO 1998013493 A3 WO1998013493 A3 WO 1998013493A3 US 9717154 W US9717154 W US 9717154W WO 9813493 A3 WO9813493 A3 WO 9813493A3
Authority
WO
WIPO (PCT)
Prior art keywords
sarp
peptides
methods
family
genes encoding
Prior art date
Application number
PCT/US1997/017154
Other languages
French (fr)
Other versions
WO1998013493A2 (en
WO1998013493A9 (en
Inventor
Samuil Umansky
Hovsep Melkonyan
Original Assignee
Lxr Biotechnology Inc
Samuil Umansky
Hovsep Melkonyan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26701439&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1998013493(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lxr Biotechnology Inc, Samuil Umansky, Hovsep Melkonyan filed Critical Lxr Biotechnology Inc
Priority to CA2266325A priority Critical patent/CA2266325C/en
Priority to EP97945277A priority patent/EP0932678B2/en
Priority to JP51587798A priority patent/JP4299886B2/en
Priority to AU46513/97A priority patent/AU737323B2/en
Priority to DK97945277.8T priority patent/DK0932678T4/en
Priority to DE69735375T priority patent/DE69735375T3/en
Publication of WO1998013493A2 publication Critical patent/WO1998013493A2/en
Publication of WO1998013493A3 publication Critical patent/WO1998013493A3/en
Publication of WO1998013493A9 publication Critical patent/WO1998013493A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

An isolated polynucleotide at leat 60 % homologous to SEQ ID NO: 1, 3, 5 or 18 encoding a SARP polypeptide; vectors comprising a polynucleotide sequence encoding at least 11 consecutive amino acids of αSARP polypeptide; a host cell transformed with an isolated polynucleotide or vector; antibodies specific for SARP and use of such polynucleotides and antibodies in diagnostic and therapeutic method. Therapeutic uses of antibodies and polynucleotides of sarp. Methods for treating diseases related to the regulation of SARP expression in tissue and bodily fluid samples, including cancers.
PCT/US1997/017154 1996-09-24 1997-09-24 A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof WO1998013493A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2266325A CA2266325C (en) 1996-09-24 1997-09-24 A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof
EP97945277A EP0932678B2 (en) 1996-09-24 1997-09-24 A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof
JP51587798A JP4299886B2 (en) 1996-09-24 1997-09-24 Gene family encoding apoptosis-related peptides, peptides encoded thereby, and methods of use thereof
AU46513/97A AU737323B2 (en) 1996-09-24 1997-09-24 A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof
DK97945277.8T DK0932678T4 (en) 1996-09-24 1997-09-24 A family of genes encoding apoptosis-related peptides, peptides encoded therein, and methods for their use
DE69735375T DE69735375T3 (en) 1996-09-24 1997-09-24 GENE FAMILY OF APOPTOSIS-RELATED PEPTIDES, THEREFORE, ENCODED PEPTIDES AND METHOD FOR THE PRODUCTION THEREOF

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2660396P 1996-09-24 1996-09-24
US60/026,603 1996-09-24
US2836396P 1996-10-11 1996-10-11
US60/028,363 1996-10-11

Publications (3)

Publication Number Publication Date
WO1998013493A2 WO1998013493A2 (en) 1998-04-02
WO1998013493A3 true WO1998013493A3 (en) 1998-06-04
WO1998013493A9 WO1998013493A9 (en) 1998-07-09

Family

ID=26701439

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/017154 WO1998013493A2 (en) 1996-09-24 1997-09-24 A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof

Country Status (11)

Country Link
US (3) US6433155B1 (en)
EP (1) EP0932678B2 (en)
JP (2) JP4299886B2 (en)
AT (1) ATE318915T1 (en)
AU (1) AU737323B2 (en)
CA (1) CA2266325C (en)
DE (1) DE69735375T3 (en)
DK (1) DK0932678T4 (en)
ES (1) ES2263181T5 (en)
PT (1) PT932678E (en)
WO (1) WO1998013493A2 (en)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070299005A1 (en) * 1996-09-24 2007-12-27 Tanox, Inc. Family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof
WO1998035043A1 (en) 1997-02-06 1998-08-13 Genetics Institute, Inc. Human sdf-5 protein and compositions
CA2224473A1 (en) * 1997-05-21 1998-11-21 Smithkline Beecham Corporation A novel human gene similar to a secreted murine protein sdf5
EP0879885A1 (en) * 1997-05-23 1998-11-25 Smithkline Beecham Corporation A novel human gene similar to a secreted murine protein sFRP-1
WO1998054325A1 (en) * 1997-05-29 1998-12-03 The Government Of The United States Of America,Re Presented By The Secretary, Department Of Health And Human Services Human frp and fragments thereof including methods for using them
US20030203446A1 (en) * 1998-10-07 2003-10-30 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
KR20010087383A (en) * 1998-10-30 2001-09-15 추후제출 Trans-species transfer of apoptotic genes and transgenic plants developed thereby
GB9921009D0 (en) * 1999-09-07 1999-11-10 Neuropa Ltd Essential genes and assays relating thereto
US20080166356A9 (en) * 1999-09-13 2008-07-10 Peter Bodine Pharmaceutical compositions and methods of using secreted frizzled related protein
US6600018B1 (en) 2000-04-10 2003-07-29 The United States Of America As Represented By The Department Of Health And Human Services Secreted frizzled related protein, sFRP, fragments and methods of use thereof
KR100804885B1 (en) 2000-12-06 2008-02-20 라보라토리스 세로노 에스.에이. Use of sarp-1 for treatment and/or prevention of scleroderma
CA2434672C (en) 2001-01-10 2014-03-25 Jeffrey S. Rubin Sfrp and peptide motifs that interact with sfrp and methods of their use
EP1222933A1 (en) * 2001-01-15 2002-07-17 Academisch Ziekenhuis Leiden h.o.d.n., Leids Universitair Medisch Centrum Generation and/or reduction of new lung tissue in an affected lung, by modulation of the Wnt-pathway
US20030044409A1 (en) * 2001-05-01 2003-03-06 Carson Dennis A. Immunologic compositions and methods for studying and treating cancers expressing frizzled antigens
AU2002308557A1 (en) * 2001-05-01 2002-11-11 The Regents Of The University Of California Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
WO2004011618A2 (en) * 2002-07-29 2004-02-05 Hmgene, Inc. Methods of identifying adipocyte specific genes, the genes identified, and their uses
US20050054599A1 (en) * 2003-05-02 2005-03-10 Coles John G. Biosynthetic platform for cardioprotective stress response in human fetal heart tissue
CA2549796A1 (en) * 2003-12-16 2005-07-07 Aventis Pharmaceuticals Inc. Secreted neural apoptosis inhibiting proteins
CN114250299A (en) 2004-07-23 2022-03-29 太平洋边缘有限公司 Urine markers for detection of bladder cancer
ATE497389T1 (en) * 2005-08-19 2011-02-15 Univ Duke PARACCRINE FACTOR H12 OBTAINED FROM STEM CELLS FOR USE IN REDUCING CELL DEATH OR FOR REPAIR OF TISSUE
US7723477B2 (en) 2005-10-31 2010-05-25 Oncomed Pharmaceuticals, Inc. Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth
JP2009513708A (en) * 2005-10-31 2009-04-02 オンコメッド ファーマシューティカルズ インコーポレイテッド Compositions and methods for diagnosis and treatment of cancer
NZ545243A (en) * 2006-02-10 2009-07-31 Pacific Edge Biotechnology Ltd Urine gene expression ratios for detection of cancer
CA2662041A1 (en) * 2006-09-08 2008-03-13 Genentech, Inc. Wnt antagonists and their use in the diagnosis and treatment of wnt-mediated disorders
AU2009296246B2 (en) 2008-09-26 2015-07-30 Oncomed Pharmaceuticals, Inc. Frizzled-binding agents and uses thereof
TWI535445B (en) 2010-01-12 2016-06-01 安可美德藥物股份有限公司 Wnt antagonists and methods of treatment and screening
CN102971337B (en) 2010-04-01 2016-09-21 昂考梅德药品有限公司 FZ combines medicament and application thereof
EP3578205A1 (en) 2010-08-06 2019-12-11 ModernaTX, Inc. A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
US20120237975A1 (en) 2010-10-01 2012-09-20 Jason Schrum Engineered nucleic acids and methods of use thereof
EP2691101A2 (en) 2011-03-31 2014-02-05 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CA2850624A1 (en) 2011-10-03 2013-04-11 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
KR20140102759A (en) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 Modified nucleoside, nucleotide, and nucleic acid compositions
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
CA2868398A1 (en) 2012-04-02 2013-10-10 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
CA2887711A1 (en) 2012-10-23 2014-05-01 Oncomed Pharmaceuticals, Inc. Methods of treating neuroendocrine tumors using wnt pathway-binding agents
JP6144355B2 (en) 2012-11-26 2017-06-07 モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． Chemically modified mRNA
CN105073195A (en) 2013-02-04 2015-11-18 昂科梅德制药有限公司 Methods and monitoring of treatment with a Wnt pathway inhibitor
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
EP3052106A4 (en) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucleotides encoding immune modulating polypeptides
JP2016538829A (en) 2013-10-03 2016-12-15 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Polynucleotide encoding low density lipoprotein receptor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995013701A1 (en) * 1993-11-15 1995-05-26 Lxr Biotechnology Inc. Novel fas protein and methods of use thereof
WO1996005232A1 (en) * 1994-08-09 1996-02-22 Immunogen, Inc. Apoptosis related protein bcl-y, and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL154598B (en) 1970-11-10 1977-09-15 Organon Nv PROCEDURE FOR DETERMINING AND DETERMINING LOW MOLECULAR COMPOUNDS AND PROTEINS THAT CAN SPECIFICALLY BIND THESE COMPOUNDS AND TEST PACKAGING.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
AU2515992A (en) 1991-08-20 1993-03-16 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
US5639856A (en) * 1993-09-13 1997-06-17 The Regents Of The University Of California Semaphorin gene family
US5759548A (en) 1993-11-30 1998-06-02 Lxr Biotechnology Inc. Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995013701A1 (en) * 1993-11-15 1995-05-26 Lxr Biotechnology Inc. Novel fas protein and methods of use thereof
WO1996005232A1 (en) * 1994-08-09 1996-02-22 Immunogen, Inc. Apoptosis related protein bcl-y, and methods of use thereof

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
FINCH P. ET AL.: "Purification and molecular cloning of a secreted, frizzled-related antagonist of Wnt action", PNAS, U.S.A., vol. 94, no. 13, 24 June 1997 (1997-06-24), pages 6770 - 6775, XP002057809 *
HILLIER L. ET AL.: "The WashU-Merck EST project, AC H45312", EMBL DATABASE, 18 November 1995 (1995-11-18), HEIDELBERG, XP002057808 *
HILLIER L. ET AL.: "The WashU-Merck EST project, AC H87071", EMBL DATABASE, 22 November 1995 (1995-11-22), HEIDELBERG, XP002054775 *
MARRA M. ET AL.: "The WashU-HHMI mouse EST project, AC W58777", EMBL DATABASE, 9 June 1996 (1996-06-09), HEIDELBERG, XP002057807 *
MELKONYAN H. ET AL.: "SARPs: a family of secreted apoptosis-related proteins", PNAS, U.S.A., vol. 94, no. 25, 9 December 1997 (1997-12-09), pages 13636 - 13641, XP002057810 *
RATTNER A ET AL: "A FAMILY OF SECRETED PROTEINS CONTAINS HOMOLOGY TO THE CYSTEINE-RICH LIGAND-BINDING DOMAIN OF FRIZZLED RECEPTORS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 94, no. 7, 1 April 1997 (1997-04-01), pages 2859 - 2863, XP002054779 *
SHIROZU M ET AL: "CHARACTERIZATION OF NOVEL SECRETED AND MEMBRANE PROTEINS ISOLATED BY THE SIGNAL SEQUENCE TRAP METHOD", GENOMICS, vol. 37, no. 3, 1 November 1996 (1996-11-01), pages 273 - 280, XP002054773 *
WANG Y ET AL: "A LARGE FAMILY OF PUTATIVE TRANSMEMBRANE RECEPTORS HOMOLOGOUS TO THE PRODUCT OF THE DROSOPHILA TISSUE POLARITY GENE FRIZZLED", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 8, 23 February 1996 (1996-02-23), pages 4468 - 4476, XP002054778 *

Also Published As

Publication number Publication date
AU4651397A (en) 1998-04-17
DE69735375T2 (en) 2006-11-30
DE69735375T3 (en) 2010-09-02
ES2263181T3 (en) 2006-12-01
PT932678E (en) 2006-07-31
WO1998013493A2 (en) 1998-04-02
AU737323B2 (en) 2001-08-16
US7045604B2 (en) 2006-05-16
DK0932678T3 (en) 2006-05-22
ATE318915T1 (en) 2006-03-15
US6433155B1 (en) 2002-08-13
JP2009050257A (en) 2009-03-12
CA2266325C (en) 2012-07-17
US7045596B2 (en) 2006-05-16
JP2002516564A (en) 2002-06-04
US20040039184A1 (en) 2004-02-26
US20030023061A1 (en) 2003-01-30
EP0932678B2 (en) 2010-03-10
DK0932678T4 (en) 2010-07-12
ES2263181T5 (en) 2011-04-07
CA2266325A1 (en) 1998-04-02
DE69735375D1 (en) 2006-04-27
JP4299886B2 (en) 2009-07-22
EP0932678A2 (en) 1999-08-04
EP0932678B1 (en) 2006-03-01

Similar Documents

Publication Publication Date Title
WO1998013493A3 (en) A family of genes encoding apoptosis-related peptides, peptides encoded thereby and methods of use thereof
Ouellette et al. Purification and primary structure of murine cryptdin‐1, a Paneth cell defensin
EP0233838A3 (en) Neurite-promoting factor and process for the manufacture thereof
WO1998039446A3 (en) 70 human secreted proteins
WO1998039448A3 (en) 186 human secreted proteins
WO1998040483A3 (en) 28 human secreted proteins
CA2200371A1 (en) Human npik gene
WO1998031800A3 (en) Human proteins
WO1999006554A3 (en) 5' ESTs FOR SECRETED PROTEINS EXPRESSED IN MUSCLE AND OTHER MESODERMAL TISSUES
NZ279963A (en) Human tissue inhibitor of metalloproteinase-4 (timp-4) and dna (rna) encoding polypeptide which may be derived from atcc 75946
WO1998045712A3 (en) 20 human secreted proteins
AU9291198A (en) Apoptosis-related compounds and their use
NZ333215A (en) a nucleic acid sequence encoding a lactoferrin variant or portion thereof which has modified iron binding capacity
WO2000017222A8 (en) 31 human secreted proteins
CA2230111A1 (en) Antisecretory factor peptides regulating pathological permeability changes
WO2000073323A3 (en) Adam polynucleotides and polypeptides
EP1042342A4 (en) 53 human secreted proteins
WO2002094859A3 (en) Mage-a1 peptides for treating or preventing cancer
WO2000040723A3 (en) Methods and products for delivering nucleic acids
WO2000058339A3 (en) 50 human secreted proteins
WO1998029438A3 (en) Cortistatin polypeptides
AU5327198A (en) Nucleotide sequence coding for a flavin-containing monooxygenase, corresponding protein and their applications in the fields of diagnosis and therapy
WO2000043495A3 (en) 33 human secreted proteins
WO2000061624A8 (en) 48 human secreted proteins
WO2001098355A3 (en) Cgi-69 compositions and methods of use

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CZ DE DK EE ES FI GB GE HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

COP Corrected version of pamphlet

Free format text: PAGES 1/16-16/16, DRAWINGS, REPLACED BY NEW PAGES 1/16-16/16; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE

121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2266325

Country of ref document: CA

Ref country code: CA

Ref document number: 2266325

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1997945277

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1997945277

Country of ref document: EP

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWG Wipo information: grant in national office

Ref document number: 1997945277

Country of ref document: EP