WO1998020162A3 - Electrodes linked via conductive oligomers to nucleic acids - Google Patents

Electrodes linked via conductive oligomers to nucleic acids Download PDF

Info

Publication number
WO1998020162A3
WO1998020162A3 PCT/US1997/020014 US9720014W WO9820162A3 WO 1998020162 A3 WO1998020162 A3 WO 1998020162A3 US 9720014 W US9720014 W US 9720014W WO 9820162 A3 WO9820162 A3 WO 9820162A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
via conductive
conductive oligomers
linked via
electrodes
Prior art date
Application number
PCT/US1997/020014
Other languages
French (fr)
Other versions
WO1998020162A2 (en
Inventor
Jon F Kayyem
Stephen D O'connor
Michael Gozin
Changjun Yu
Original Assignee
Clinical Micro Sensors Inc
Jon F Kayyem
Connor Stephen D O
Michael Gozin
Changjun Yu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/743,798 external-priority patent/US6096273A/en
Priority claimed from US08/873,978 external-priority patent/US7014992B1/en
Priority claimed from US08/873,597 external-priority patent/US7381525B1/en
Application filed by Clinical Micro Sensors Inc, Jon F Kayyem, Connor Stephen D O, Michael Gozin, Changjun Yu filed Critical Clinical Micro Sensors Inc
Priority to CA002270633A priority Critical patent/CA2270633A1/en
Priority to EP97946876A priority patent/EP0939762A2/en
Priority to JP52166898A priority patent/JP4072206B2/en
Priority to AU51967/98A priority patent/AU739375B2/en
Publication of WO1998020162A2 publication Critical patent/WO1998020162A2/en
Publication of WO1998020162A3 publication Critical patent/WO1998020162A3/en
Priority to US09/452,277 priority patent/US7160678B1/en
Priority to US11/208,384 priority patent/US7393645B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.
PCT/US1997/020014 1996-11-05 1997-11-05 Electrodes linked via conductive oligomers to nucleic acids WO1998020162A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA002270633A CA2270633A1 (en) 1996-11-05 1997-11-05 Electrodes linked via conductive oligomers to nucleic acids
EP97946876A EP0939762A2 (en) 1996-11-05 1997-11-05 Electrodes linked via conductive oligomers to nucleic acids
JP52166898A JP4072206B2 (en) 1996-11-05 1997-11-05 Electrode linked to nucleic acid via conductive oligomer
AU51967/98A AU739375B2 (en) 1996-11-05 1997-11-05 Electrodes linked via conductive oligomers to nucleic acids
US09/452,277 US7160678B1 (en) 1996-11-05 1999-11-30 Compositions for the electronic detection of analytes utilizing monolayers
US11/208,384 US7393645B2 (en) 1996-11-05 2005-08-19 Compositions for the electronic detection of analytes utilizing monolayers

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US08/743,798 US6096273A (en) 1996-11-05 1996-11-05 Electrodes linked via conductive oligomers to nucleic acids
US4015597P 1997-03-07 1997-03-07
US08/873,978 US7014992B1 (en) 1996-11-05 1997-06-12 Conductive oligomers attached to electrodes and nucleoside analogs
US08/873,597 US7381525B1 (en) 1997-03-07 1997-06-12 AC/DC voltage apparatus for detection of nucleic acids
US08/899,510 US6221583B1 (en) 1996-11-05 1997-07-24 Methods of detecting nucleic acids using electrodes
US60/040,155 1997-08-14
US08/911,085 US6090933A (en) 1996-11-05 1997-08-14 Methods of attaching conductive oligomers to electrodes
US08/873,978 1997-08-14
US08/743,798 1997-08-14
US08/873,597 1997-08-14
US08/911,589 1997-08-14
US08/911,085 1997-08-14
US08/911,589 US6232062B1 (en) 1997-03-07 1997-08-14 AC methods for the detection of nucleic acids
US08/899,510 1997-08-14

Publications (2)

Publication Number Publication Date
WO1998020162A2 WO1998020162A2 (en) 1998-05-14
WO1998020162A3 true WO1998020162A3 (en) 1998-11-12

Family

ID=27567906

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/020014 WO1998020162A2 (en) 1996-11-05 1997-11-05 Electrodes linked via conductive oligomers to nucleic acids

Country Status (5)

Country Link
EP (1) EP0939762A2 (en)
JP (1) JP4072206B2 (en)
AU (1) AU739375B2 (en)
CA (1) CA2270633A1 (en)
WO (1) WO1998020162A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6753143B2 (en) 2000-05-01 2004-06-22 Clinical Micro Sensors, Inc. Target analyte detection using asymmetrical self-assembled monolayers
US7655129B2 (en) 1998-06-23 2010-02-02 Osmetech Technology Inc. Binding acceleration techniques for the detection of analytes
US8012743B2 (en) 1998-10-27 2011-09-06 Osmetech Technology Inc. Detection of target analytes using particles and electrodes
US8486247B2 (en) 1999-04-21 2013-07-16 Osmetch Technology, Inc. Use of microfluidic systems in the electrochemical detection of target analytes
US9340567B2 (en) 2011-11-04 2016-05-17 Ohmx Corporation Chemistry used in biosensors

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6071699A (en) 1996-06-07 2000-06-06 California Institute Of Technology Nucleic acid mediated electron transfer
US5824473A (en) 1993-12-10 1998-10-20 California Institute Of Technology Nucleic acid mediated electron transfer
US6127127A (en) * 1995-06-27 2000-10-03 The University Of North Carolina At Chapel Hill Monolayer and electrode for detecting a label-bearing target and method of use thereof
US6387625B1 (en) 1995-06-27 2002-05-14 The University Of North Carolina At Chapel Hill Monolayer and electrode for detecting a label-bearing target and method of use thereof
US7014992B1 (en) 1996-11-05 2006-03-21 Clinical Micro Sensors, Inc. Conductive oligomers attached to electrodes and nucleoside analogs
US7160678B1 (en) 1996-11-05 2007-01-09 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7393645B2 (en) 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7045285B1 (en) 1996-11-05 2006-05-16 Clinical Micro Sensors, Inc. Electronic transfer moieties attached to peptide nucleic acids
US6013459A (en) * 1997-06-12 2000-01-11 Clinical Micro Sensors, Inc. Detection of analytes using reorganization energy
JP2002500897A (en) * 1998-01-27 2002-01-15 クリニカル・マイクロ・センサーズ・インコーポレイテッド Amplification of electronic nucleic acid detection
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
EP1075549B1 (en) 1998-05-06 2008-09-03 Clinical Micro Sensors, Inc. Electronic methods for the detection of analytes utilizing monolayers
EP1075541A1 (en) * 1998-05-06 2001-02-14 Clinical Micro Sensors Electronic detection of nucleic acids using monolayers
US6653462B2 (en) 1998-05-29 2003-11-25 Applera Corporation Nucleotide compounds including a rigid linker
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
JP2002518998A (en) * 1998-06-24 2002-07-02 セラセンス、インク． Multi-sensor array and method for electrochemical recognition of nucleotide sequences
JP4530541B2 (en) * 1998-09-17 2010-08-25 クリニカル・マイクロ・センサーズ・インコーポレイテッド Signal detection method for analyte detection
US6740518B1 (en) 1998-09-17 2004-05-25 Clinical Micro Sensors, Inc. Signal detection techniques for the detection of analytes
DE19964220C2 (en) 1998-11-23 2003-07-03 Friz Biochem Gmbh Modified nucleic acid oligomer, useful for sequencing by hybridization, is substituted by redox agent to allow electrical detection of hybridization
WO2000038836A1 (en) * 1998-12-30 2000-07-06 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
US6833267B1 (en) 1998-12-30 2004-12-21 Clinical Micro Sensors, Inc. Tissue collection devices containing biosensors
WO2000042217A2 (en) * 1999-01-18 2000-07-20 Fritz, Biochem Gmbh Method for electrochemically detecting nucleic acid-oligomer hybridisation events
US6432723B1 (en) 1999-01-22 2002-08-13 Clinical Micro Sensors, Inc. Biosensors utilizing ligand induced conformation changes
CA2363141C (en) 1999-02-26 2010-04-06 Chiron Corporation Microemulsions with adsorbed macromolecules and microparticles
GB2347746A (en) * 1999-03-05 2000-09-13 Azur Env Ltd Detecting analytes, particularly nucleic acids, in a sample
AU5267800A (en) 1999-05-03 2000-11-17 Gen-Probe Incorporated Polynucleotide probes for detection and quantitation of bacteria in the family enterobacteriaceae
US6821770B1 (en) 1999-05-03 2004-11-23 Gen-Probe Incorporated Polynucleotide matrix-based method of identifying microorganisms
US6376186B1 (en) 1999-05-03 2002-04-23 Gen-Probe Incorporated Polynucleotide probes for detection and quantitation of staphylococcus
CA2370123C (en) 1999-05-03 2010-09-14 Gen-Probe Incorporated Polynucleotide probes for detection and quantitation of actinomycetes
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
WO2001006016A2 (en) * 1999-07-20 2001-01-25 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
WO2001007665A2 (en) * 1999-07-26 2001-02-01 Clinical Micro Sensors, Inc. Sequence determination of nucleic acids using electronic detection
DE19945398A1 (en) * 1999-09-22 2001-04-05 Friz Biochem Gmbh Electrochemical detection of sequence specific nucleic acid oligomer hybridization events
DE19950969A1 (en) * 1999-10-22 2001-05-10 Aventis Res & Tech Gmbh & Co Double-stranded nucleic acid probes and their use
GB9928232D0 (en) * 1999-12-01 2000-01-26 Skelton Stephen Detection system
US6518024B2 (en) 1999-12-13 2003-02-11 Motorola, Inc. Electrochemical detection of single base extension
DE19960076C2 (en) * 1999-12-13 2002-12-05 November Ag Molekulare Medizin Method and device for the detection and quantification of biomolecules
CA2410240A1 (en) * 2000-05-26 2001-12-06 Minerva Biotechnologies Corporation Metallocenes as signal-transducer for detection of chemical or biological events
US6787339B1 (en) 2000-10-02 2004-09-07 Motorola, Inc. Microfluidic devices having embedded metal conductors and methods of fabricating said devices
ATE349011T1 (en) 2000-10-03 2007-01-15 Minerva Biotechnologies Corp MAGNETIC IN SITU DILUTION PROCESS
US7112366B2 (en) * 2001-01-05 2006-09-26 The Ohio State University Chemical monolayer and micro-electronic junctions and devices containing same
JP3670972B2 (en) 2001-02-01 2005-07-13 日立ソフトウエアエンジニアリング株式会社 Biopolymer detector
JP4057967B2 (en) * 2002-07-31 2008-03-05 株式会社東芝 Automatic nucleotide sequence analyzer
US7745203B2 (en) 2002-07-31 2010-06-29 Kabushiki Kaisha Toshiba Base sequence detection apparatus and base sequence automatic analyzing apparatus
WO2005016115A2 (en) 2003-01-23 2005-02-24 Montana State University Biosensors utilizing dendrimer-immobilized ligands and their use thereof
US20070099211A1 (en) * 2005-07-15 2007-05-03 Vissarion Aivazachvili Detection of nucleic acid amplification
CA2651815A1 (en) 2006-05-10 2007-11-22 Dxterity Diagnostics Detection of nucleic acid targets using chemically reactive oligonucleotide probes
US7820391B2 (en) 2007-11-06 2010-10-26 Osmetech Molecular Diagnostics Baseless nucleotide analogues and uses thereof
JP5181386B2 (en) * 2008-02-01 2013-04-10 国立大学法人 新潟大学 Chemical biosensor
US8329647B2 (en) 2008-07-17 2012-12-11 Ikfe Institut Fur Klinische Forschung Und Entwicklung Gmbh Method of treating a subject according to biomarkers for insulin resistance
AU2009272369B2 (en) 2008-07-17 2016-04-14 Ikfe Institut Fur Klinische Forschung Und Entwicklung Gmbh Biomarkers for cardiodiabetes
US20100256196A1 (en) 2008-12-04 2010-10-07 Ikfe Biomarkers for Atherosclerosis
US20110118134A1 (en) 2008-12-11 2011-05-19 Ikfe Gmbh Biomarkers for insulin sensitizer drug response
WO2010076655A1 (en) 2008-12-30 2010-07-08 Ikfe Gmbh Biomarkers for adipose tissue activity
EP2382475A2 (en) 2009-01-07 2011-11-02 IKFE GmbH Biomarkers for appetite regulation
WO2010114599A1 (en) 2009-04-01 2010-10-07 Dx Terity Diagnostics Inc. Chemical ligation dependent probe amplification (clpa)
EP2642291B1 (en) 2009-08-07 2015-10-07 Ohmx Corporation Enzyme triggered redox altering chemical elimination (E-trace) immunoassay
JPWO2011087130A1 (en) * 2010-01-18 2013-05-20 株式会社クラレ Acetylene compound and organic semiconductor material containing the same
CN103228796B (en) 2010-08-11 2016-06-01 赛路拉公司 Gene typing DNA
WO2012100078A1 (en) 2011-01-19 2012-07-26 Ohmx Corporation Enzyme triggered redox altering chemical elimination (e-trace) immmunoassay
EP2710145B1 (en) 2011-05-17 2015-12-09 Dxterity Diagnostics Incorporated Methods and compositions for detecting target nucleic acids
WO2013059293A1 (en) 2011-10-17 2013-04-25 Ohmx Corporation Single, direct detection of hemoglobin a1c percentage using enzyme triggered redox altering chemical elimination (e-trace) immunoassay
US9250203B2 (en) 2012-01-09 2016-02-02 Ohmx Corporation Enzyme cascade methods for E-TRACE assay signal amplification
CA2889415C (en) 2012-10-24 2020-06-02 Genmark Diagnostics, Inc. Integrated multiplex target analysis
AU2015274660B2 (en) 2014-06-10 2020-07-16 Dxterity Diagnostics Incorporated Devices and methods for collecting and stabilizing biological samples
US20190062809A1 (en) 2017-08-24 2019-02-28 Clinical Micro Sensors, Inc. (dba GenMark Diagnostics, Inc.) Electrochemical detection of bacterial and/or fungal infections

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005732A1 (en) * 1988-11-07 1990-05-31 The Trustees Of Columbia University In The City Ofnew York Mixed ligand complexes and uses thereof as binding agents and probres to dna
WO1993010267A1 (en) * 1991-11-15 1993-05-27 Igen, Inc. Rapid assays for amplification products
WO1994022889A1 (en) * 1993-03-31 1994-10-13 Cis Bio International Electronically conductive polymer/nucleotide copolymer, preparation method therefor and use thereof
WO1995015971A2 (en) * 1993-12-10 1995-06-15 California Institute Of Technology Nucleic acid mediated electron transfer
WO1996040712A1 (en) * 1995-06-07 1996-12-19 California Institute Of Technology Nucleic acid mediated electron transfer

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005732A1 (en) * 1988-11-07 1990-05-31 The Trustees Of Columbia University In The City Ofnew York Mixed ligand complexes and uses thereof as binding agents and probres to dna
WO1993010267A1 (en) * 1991-11-15 1993-05-27 Igen, Inc. Rapid assays for amplification products
WO1994022889A1 (en) * 1993-03-31 1994-10-13 Cis Bio International Electronically conductive polymer/nucleotide copolymer, preparation method therefor and use thereof
WO1995015971A2 (en) * 1993-12-10 1995-06-15 California Institute Of Technology Nucleic acid mediated electron transfer
US5591578A (en) * 1993-12-10 1997-01-07 California Institute Of Technology Nucleic acid mediated electron transfer
WO1996040712A1 (en) * 1995-06-07 1996-12-19 California Institute Of Technology Nucleic acid mediated electron transfer

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
AIZAWA M ET AL: "INTEGRATED MOLECULAR SYSTEMS FOR BIOSENSORS*", SENSORS AND ACTUATORS B, vol. B24, no. 1/03, PART 01, March 1995 (1995-03-01), pages 1 - 5, XP000521315 *
J.R.REIMERS ET AL.: "Towards Efficient Molecular Wires and Switches : The Brooker Ions.", BIOSYSTEMS, vol. 35, 1995, pages 107 - 111, XP002077969 *
MURPHY C J ET AL: "LONG-RANGE PHOTOINDUCED ELECTRON TRANSFER THROUGH A DNA HELIX", SCIENCE, vol. 262, 12 November 1993 (1993-11-12), pages 1025 - 1029, XP002041920 *
P.LINCOLN ET AL.: "Short-Circuiting the Molecular Wire.", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY., vol. 119, no. 6, 1997, DC US, pages 1454 - 1455, XP002077971 *
R.P.HSUNG ET AL.: "Synthesis and CHaracterization of Unsymmetric Ferrocene-Terminated Phenylethynyl Oligomers.", ORGANOMETALLICS, vol. 14, no. 10, 1995, pages 4808 - 4815, XP002077968 *
TURRO N J ET AL: "PHOTOELECTRON TRANSFER BETWEEN MOLECULES ADSORBED IN RESTICTED SPACES", PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON PHOTOCHEMICAL CONVERSION AND STORAGE OF SOLAR ENERGY, 1990, pages 121 - 139, XP002041921 *
W.M.ALBERS ET AL.: "Design of Novel Molecular Wires for Realizing Long-Distance Electron Transfer.", BIOCHEMISTRY AND BIOENERGETICS, vol. 42, 1997, pages 25-33, XP002077970 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7655129B2 (en) 1998-06-23 2010-02-02 Osmetech Technology Inc. Binding acceleration techniques for the detection of analytes
US8012743B2 (en) 1998-10-27 2011-09-06 Osmetech Technology Inc. Detection of target analytes using particles and electrodes
US8486247B2 (en) 1999-04-21 2013-07-16 Osmetch Technology, Inc. Use of microfluidic systems in the electrochemical detection of target analytes
US9151746B2 (en) 1999-04-21 2015-10-06 Osmetech Technology, Inc. Use of microfluidic systems in the electrochemical detection of target analytes
US9557295B2 (en) 1999-04-21 2017-01-31 Osmetech Technology, Inc. Use of microfluidic systems in the electrochemical detection of target analytes
US6753143B2 (en) 2000-05-01 2004-06-22 Clinical Micro Sensors, Inc. Target analyte detection using asymmetrical self-assembled monolayers
US9340567B2 (en) 2011-11-04 2016-05-17 Ohmx Corporation Chemistry used in biosensors

Also Published As

Publication number Publication date
JP4072206B2 (en) 2008-04-09
EP0939762A2 (en) 1999-09-08
AU739375B2 (en) 2001-10-11
WO1998020162A2 (en) 1998-05-14
AU5196798A (en) 1998-05-29
CA2270633A1 (en) 1998-05-14
JP2001507930A (en) 2001-06-19

Similar Documents

Publication Publication Date Title
WO1998020162A3 (en) Electrodes linked via conductive oligomers to nucleic acids
AU5245998A (en) Production and recovery of organic acids
CA2232242A1 (en) Long wavelength engineered fluorescent proteins
CA2258502A1 (en) Modified factor viii
EP0982378A4 (en) Carbon black and process for producing the same
AU2851597A (en) Spray-drying process
AU2827895A (en) Purified polyporus laccases and nucleic acids encoding same
WO2000018914A3 (en) Novel dkr polypeptides
AU3172997A (en) Process for producing multi-coat paints on electrically conductive substrates
PL332720A1 (en) Novel derivatives of piperydinketone carboxylic acids, their production and application
CA2150100A1 (en) Electrical connection for track lighting
AU8562898A (en) Thienopyridine derivatives, intermediates thereof, and process for producing theboth
ZA989329B (en) Process to produce low color trimethylolpropane.
WO2000018212A8 (en) Platelet-derived growth factor c, dna coding therefor, and uses thereof
AU2978697A (en) Novel peptide, process for the production of the same, and use of the same
PL329238A1 (en) Novel derivatives of alpha-hydroxycarboxylic acids, their production and application
AU1719300A (en) Pasted positive electrode and process for its production
ZA983697B (en) Production of L(+)-Lactate.
AU1757299A (en) Polyamide production process
PL329240A1 (en) Novel derivatives of carboxylic acid, their production and application
AU4456497A (en) Process for the production of substituted phenylpyridines
AU2764497A (en) Alpha-glucuronidases of aspergillus, production thereof and their uses
AU2877897A (en) Long-life egg-based product and preparative process
AU1137699A (en) Novel reovirus-derived proteins, nucleic acids encoding same, and uses therefor
ZA961424B (en) Method for production of carbon electrodes.

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH KE LS MW SD SZ UG ZW AT BE CH DE DK ES FI FR GB GR IE IT LU MC

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 51967/98

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 1997946876

Country of ref document: EP

ENP Entry into the national phase

Ref country code: JP

Ref document number: 1998 521668

Kind code of ref document: A

Format of ref document f/p: F

ENP Entry into the national phase

Ref document number: 2270633

Country of ref document: CA

Ref country code: CA

Ref document number: 2270633

Kind code of ref document: A

Format of ref document f/p: F

WWP Wipo information: published in national office

Ref document number: 1997946876

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWG Wipo information: grant in national office

Ref document number: 51967/98

Country of ref document: AU