WO1998026286A3 - Sandwich assays for collagen type i fragments - Google Patents

Sandwich assays for collagen type i fragments Download PDF

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Publication number
WO1998026286A3
WO1998026286A3 PCT/EP1997/006803 EP9706803W WO9826286A3 WO 1998026286 A3 WO1998026286 A3 WO 1998026286A3 EP 9706803 W EP9706803 W EP 9706803W WO 9826286 A3 WO9826286 A3 WO 9826286A3
Authority
WO
WIPO (PCT)
Prior art keywords
fragments
sandwich assays
collagen type
antibody
sandwich
Prior art date
Application number
PCT/EP1997/006803
Other languages
French (fr)
Other versions
WO1998026286A2 (en
Inventor
Christian Rosenquist
Per Qvist
Original Assignee
Osteometer Biotech As
Christian Rosenquist
Per Qvist
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625559.1A external-priority patent/GB9625559D0/en
Priority claimed from GBGB9705687.3A external-priority patent/GB9705687D0/en
Application filed by Osteometer Biotech As, Christian Rosenquist, Per Qvist filed Critical Osteometer Biotech As
Priority to DE69705423T priority Critical patent/DE69705423T2/en
Priority to AU57542/98A priority patent/AU5754298A/en
Priority to JP52618698A priority patent/JP3913787B2/en
Priority to EP97953745A priority patent/EP0944833B1/en
Priority to AT97953745T priority patent/ATE202632T1/en
Priority to US09/319,539 priority patent/US6660481B2/en
Publication of WO1998026286A2 publication Critical patent/WO1998026286A2/en
Publication of WO1998026286A3 publication Critical patent/WO1998026286A3/en
Priority to US10/730,070 priority patent/US7195883B2/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/10—Musculoskeletal or connective tissue disorders
    • G01N2800/108—Osteoporosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds

Abstract

Sandwich assays for collagen degradation products are conducted using an antibody of the same specificity on both sides of the sandwich or using a first antibody reactive with an epitope contained in the sequence Glu-Lys-ala-his-asp-gly-gly-arg (EKAHDGGR) and a second antibody which may be the same or different.
PCT/EP1997/006803 1996-12-09 1997-12-05 Sandwich assays for collagen type i fragments WO1998026286A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DE69705423T DE69705423T2 (en) 1996-12-09 1997-12-05 SANDWEIGHT TEST FOR DETECTING COLLAGEN FRAGMENTS
AU57542/98A AU5754298A (en) 1996-12-09 1997-12-05 Sandwich assays for collagen type i fragments
JP52618698A JP3913787B2 (en) 1996-12-09 1997-12-05 Method for sandwich measurement of type I collagen fragments
EP97953745A EP0944833B1 (en) 1996-12-09 1997-12-05 Sandwich assays for collagen fragments
AT97953745T ATE202632T1 (en) 1996-12-09 1997-12-05 SANDWIGHT TEST FOR DETECTING COLLAGEN FRAGMENTS
US09/319,539 US6660481B2 (en) 1996-12-09 1997-12-05 Sandwich assays for collagen type I fragments
US10/730,070 US7195883B2 (en) 1996-12-09 2003-12-09 Sandwich assays for collagen fragments

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9625559.1 1996-12-09
GBGB9625559.1A GB9625559D0 (en) 1996-12-09 1996-12-09 Sandwish assays for collagen type I fragments
GBGB9705687.3A GB9705687D0 (en) 1997-03-19 1997-03-19 Sandwich assays for collagen type i fragments
GB9705687.3 1997-03-19

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US09319539 A-371-Of-International 1997-12-05
US09/319,539 A-371-Of-International US6660481B2 (en) 1996-12-09 1997-12-05 Sandwich assays for collagen type I fragments
US10/730,070 Continuation-In-Part US7195883B2 (en) 1996-12-09 2003-12-09 Sandwich assays for collagen fragments

Publications (2)

Publication Number Publication Date
WO1998026286A2 WO1998026286A2 (en) 1998-06-18
WO1998026286A3 true WO1998026286A3 (en) 1998-08-13

Family

ID=26310589

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/006803 WO1998026286A2 (en) 1996-12-09 1997-12-05 Sandwich assays for collagen type i fragments

Country Status (8)

Country Link
US (2) US6660481B2 (en)
EP (1) EP0944833B1 (en)
JP (1) JP3913787B2 (en)
AT (1) ATE202632T1 (en)
AU (1) AU5754298A (en)
DE (1) DE69705423T2 (en)
ES (1) ES2160985T3 (en)
WO (1) WO1998026286A2 (en)

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US5962639A (en) * 1987-11-06 1999-10-05 Washington Research Foundation Synthetic peptides corresponding to telopeptide sequences of cross-linked type I collagen metabolites
ATE202632T1 (en) * 1996-12-09 2001-07-15 Osteometer Biotech As SANDWIGHT TEST FOR DETECTING COLLAGEN FRAGMENTS
US7354723B2 (en) 1999-11-26 2008-04-08 Nordic Bioscience Dagnostics A/S Assay of isomerised and/or optically inverted proteins and protein fragments
GB9928052D0 (en) * 1999-11-26 2000-01-26 Osteometer Biotech As Assay of isomerised and/or optically inverted proteins and protein fragments
AU2001276395A1 (en) * 2000-07-12 2002-02-05 Werner Naser Direct assessment of relative concentrations of variants of an epitope on a dimeric molecule
JP4365216B2 (en) * 2001-11-01 2009-11-18 レンセレアー ポリテクニック インスティテュート Biocatalytic sol-gel microarray
US20050124071A1 (en) * 2003-09-30 2005-06-09 Kraus Virginia B. Methods and compositions for diagnosing musculoskeletal, arthritic and joint disorders by biomarker dating
EP1943330A4 (en) * 2005-11-01 2009-12-09 Rensselaer Polytech Inst Three-dimensional cellular array chip and platform for toxicology assays
WO2009038771A2 (en) * 2007-09-19 2009-03-26 Massachusetts Institute Of Technology Tolperisone and tolperisone-like drugs for the treatment of k-ras associated cancers
EP2223112A2 (en) * 2007-12-21 2010-09-01 Siemens Healthcare Diagnostics Inc. Circulating epha2 receptor
US8796184B2 (en) 2008-03-28 2014-08-05 Sentilus, Inc. Detection assay devices and methods of making and using the same
USRE49477E1 (en) 2012-04-20 2023-03-28 Thomas Jefferson University Engineered antibody for inhibition of fibrosis
US9753030B2 (en) * 2013-03-06 2017-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Degradable carbon nanotube-containing biosensors and methods for target clinical marker detection
ES2687220B1 (en) * 2017-03-23 2019-08-08 Servicio Andaluz De Salud Method of obtaining useful data for the screening and diagnosis of osteoporosis
EP4317172A1 (en) * 2021-03-24 2024-02-07 Sekisui Medical Co., Ltd. Immunological analysis method for type-i collagen c-terminal telopeptide
WO2023068249A1 (en) * 2021-10-20 2023-04-27 積水メディカル株式会社 Measuring reagent for cross-linked n-telopeptide of type i collagen, preparation method thereof, and immunoassay method using same

Citations (8)

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WO1994014844A1 (en) * 1992-12-28 1994-07-07 Baylink David J Bone resorption assay
WO1995008115A1 (en) * 1993-09-17 1995-03-23 Osteometer Biotech As A method of assaying collagen fragments in body fluids, a test kit and means for carrying out the method and use of the method to diagnose the presence of disorders associated with the metabolism of collagen
WO1996012193A1 (en) * 1994-10-17 1996-04-25 Osteometer Bio Tech A/S Estimation of the fragmentation pattern of collagen in body fluids and the diagnosis of disorders associated with the metabolism of collagen
EP0718309A1 (en) * 1994-12-23 1996-06-26 Roche Diagnostics GmbH Antigens and antibodies for the detection of collagen I
WO1996030765A1 (en) * 1995-03-24 1996-10-03 Osteometer Biotech A/S Assaying protein fragments in body fluids
WO1996036645A1 (en) * 1995-05-19 1996-11-21 Washington Research Foundation Synthetic peptide analogs of cross-linked n-telopeptides of type i collagen
WO1998008098A2 (en) * 1996-08-22 1998-02-26 Osteometer Biotech A/S Assaying d-amino acids in body fluids
EP0829724A1 (en) * 1996-09-17 1998-03-18 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Assay for detecting collagen degradation

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US4376110A (en) * 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
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WO1994014844A1 (en) * 1992-12-28 1994-07-07 Baylink David J Bone resorption assay
WO1995008115A1 (en) * 1993-09-17 1995-03-23 Osteometer Biotech As A method of assaying collagen fragments in body fluids, a test kit and means for carrying out the method and use of the method to diagnose the presence of disorders associated with the metabolism of collagen
WO1996012193A1 (en) * 1994-10-17 1996-04-25 Osteometer Bio Tech A/S Estimation of the fragmentation pattern of collagen in body fluids and the diagnosis of disorders associated with the metabolism of collagen
EP0718309A1 (en) * 1994-12-23 1996-06-26 Roche Diagnostics GmbH Antigens and antibodies for the detection of collagen I
WO1996030765A1 (en) * 1995-03-24 1996-10-03 Osteometer Biotech A/S Assaying protein fragments in body fluids
WO1996036645A1 (en) * 1995-05-19 1996-11-21 Washington Research Foundation Synthetic peptide analogs of cross-linked n-telopeptides of type i collagen
WO1998008098A2 (en) * 1996-08-22 1998-02-26 Osteometer Biotech A/S Assaying d-amino acids in body fluids
EP0829724A1 (en) * 1996-09-17 1998-03-18 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Assay for detecting collagen degradation

Also Published As

Publication number Publication date
JP2001506000A (en) 2001-05-08
WO1998026286A2 (en) 1998-06-18
DE69705423T2 (en) 2002-05-16
US20030148272A1 (en) 2003-08-07
JP3913787B2 (en) 2007-05-09
ATE202632T1 (en) 2001-07-15
ES2160985T3 (en) 2001-11-16
EP0944833B1 (en) 2001-06-27
AU5754298A (en) 1998-07-03
EP0944833A2 (en) 1999-09-29
DE69705423D1 (en) 2001-08-02
US6660481B2 (en) 2003-12-09
US7195883B2 (en) 2007-03-27
US20040224375A1 (en) 2004-11-11

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