WO1998026763A1 - Active substance carrier for releasing apomorphine into the buccal cavity - Google Patents
Active substance carrier for releasing apomorphine into the buccal cavity Download PDFInfo
- Publication number
- WO1998026763A1 WO1998026763A1 PCT/EP1997/006529 EP9706529W WO9826763A1 WO 1998026763 A1 WO1998026763 A1 WO 1998026763A1 EP 9706529 W EP9706529 W EP 9706529W WO 9826763 A1 WO9826763 A1 WO 9826763A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- apomorphine
- pharmaceutical preparation
- preparation according
- active ingredient
- active substance
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
Definitions
- the present invention relates to a medicament preparation for the application of active substances in the area of the oral cavity or the oral mucosa. It relates in particular to a preparation that is flat and designed as a film, paper or wafer-like dosage form.
- DE-OS 27 46 414 which describes a film-like band of active substance, binder and other auxiliaries, in which, due to homogeneous thickness and density, there is a direct connection between a unit length of the band and the dose of active substance contained therein, can be regarded as fundamental for this dosage form .
- the advantages of continuous dosing were also recognized by other applicants and described in special individual variants.
- DE-PS 36 30 603 claims a flat carrier material e.g. in the form of a release paper with a coating containing the active substance, the latter being subtracted from the carrier material in doses after being divided up into dose units.
- a flat, film-like or paper-like active ingredient carrier enables a faster onset of action than the application of conventional dosage forms, such as tablets.
- Tablets are usually designed for drug release after swallowing in the gastrointestinal tract. Ordinary, rapidly disintegrating tablets release their active ingredient in the stomach. The disintegration of the dosage form is a prerequisite for the release of the active ingredient.
- the disintegration of a tablet in the fluids of the gastrointestinal tract is often a multi-stage process. If the tablet has a coating, it must first disintegrate and expose the compact.
- the latter are suitable for introducing active substances into the organism more quickly than with tablets, and can advantageously be used when a quick onset of action is necessary or particularly desirable, for example when administering analgesics, antiallergics, antitussives, antiemetics, active substances against Angina, migraines, hypotension, etc.
- the object of the present invention is therefore to create a medicinal preparation based on and with the general advantages of flat, film-like or paper-like active substance carriers, which, however, in addition, through the combination with a special active substance, also have additional economic and / or therapeutic advantages over medicament preparations thereof Active ingredient based on conventional dosage forms such as tablets.
- a medicinal preparation is provided on the basis of a flat, film, paper or wafer-like active ingredient carrier which contains apomorphine or one of its therapeutically suitable salts as the active ingredient.
- a pharmaceutical preparation according to claim 1 is, as will be explained in the following, a conventional oral dosage form for the administration of apomorphine far superior both from an economic as well as from a therapeutic point of view and is particularly suitable for the therapy of Parkinson's disease.
- apomorphine a potent dopamine agonist
- apomorphine must be injected subcutaneously for this purpose, since it is hardly bioavailable after oral administration, i.e. it only appears to a very small extent in the bloodstream of a few percent of the dose taken.
- the reason for the lack of bioavailability probably lies in the extensive breakdown of the substance during the first passage through the liver after gastrointestinal absorption ("first pass effect").
- One way to circumvent the first-pass effect in the case of oral administration is to induce the active ingredient to be absorbed on the oral mucosa.
- Active substance that enters the blood here does not first have to pass through the portal vein system and thus in concentrated form through the liver metabolizing the active substance in order to get into the central body circulation.
- a prerequisite for buccal or sublingual application is the sufficient permeability of the oral mucosa for the active substance, taking into account the necessary dose. The permeability in turn depends to a large extent on the physicochemical properties of the active ingredient.
- buccal or sublingual administration of apomorphine appears to be very desirable for the patients because of the injections to be avoided.
- apomorphine with the aid of a pharmaceutical preparation according to claim 1 is completely different.
- This dosage form can be brought into direct contact with the oral mucosa during application. Due to the flat design, about half of the already large surface of the dosage form is immediately on the mucosa immediately after application.
- the released apomorphine therefore finds two particularly favorable factors for entry into the body, namely a short diffusion distance and a large diffusion area. This reduces the amount of apomorphine that is swallowed, which would not be particularly problematic with other active ingredients. In the case of apomorphine, however, the swallowing of active ingredient should be avoided or reduced as far as possible, since swallowed apomorphine remains ineffective for the reasons set out above.
- test person showed the superiority of an apomorphine-containing film over an apomorphine-containing tablet.
- An improved contact of the pharmaceutical preparation according to the invention with the oral mucosa can be brought about by the selection of the auxiliary substances.
- pharmaceutically customary, orally administrable auxiliaries have mucosal properties.
- mucoadhesive substances are polyacrylic acid, carboxylmethyl cellulose, tragacanth, alginic acid, gelatin, hydroxymethyl cellulose, methyl cellulose and gum arabic.
- various non-mucoadhesive substances are known to also form mucoadhesive properties in certain mixing ratios.
- An example of such a mixture is glycerol monooleate / water in the ratio 84:16 (Engström et al., Pharm. Tech. Eur. 7 [1995], No. 2, pages 14-17).
- a two- or multi-layer structure of the dosage form of the medicinal preparation according to the invention is to be preferred, only one layer, which should come into contact with the mucous membrane when the preparation is applied, to be provided with mucoadhesive properties. This prevents the preparation from sticking together different parts of the mucous membrane, which would lead to considerable discomfort during use.
- the amount of active ingredient or the proportion of the administered active ingredient dose which is absorbed in the preparation according to the invention depends not only on the contact area and the perme bailiness of the mucous membrane, but also on the contact time.
- auxiliaries can be, for example, film-forming polymers with low water solubility, such as ethyl cellulose, cellulose acetate, highly hydrolyzed polyvinyl alcohol and many others.
- apomorphine usually leads to undesirable side effects. First of all there are nausea, vomiting and a drop in blood pressure. These side effects can be seen as serious and therapy-limiting. However, it is known that the simultaneous administration of antiemetic dopamine antagonists such as metoclopramide, but especially domperidone, can prevent or alleviate the occurrence of these side effects without losing the anti-Parkinson effect of apomorphine.
- antiemetic dopamine antagonists such as metoclopramide, but especially domperidone
- a further preferred embodiment of the present invention therefore contains apomorphine in combination with a dopamine antagonist in a combination as active ingredients.
- Production examples of the pharmaceutical preparation according to the invention are given below:
- H 2 0 Place H 2 0 in a heatable, evacuable batch vessel and disperse Ti0 2 in it.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97952795A EP0959875A1 (en) | 1996-12-16 | 1997-11-21 | Active substance carrier for releasing apomorphine into the buccal cavity |
AU56547/98A AU746373B2 (en) | 1996-12-16 | 1997-11-21 | Active substance carrier for releasing apomorphine into the buccal cavity |
CA002274893A CA2274893A1 (en) | 1996-12-16 | 1997-11-21 | Active substance carrier for releasing apomorphine into the buccal cavity |
JP52593498A JP2001506612A (en) | 1996-12-16 | 1997-11-21 | Active substance carrier for release of apomorphine into the oral cavity |
NO992944A NO992944L (en) | 1996-12-16 | 1999-06-16 | Active ingredient for the delivery of apomorphine in the oral cavity |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19652268.4 | 1996-12-16 | ||
DE19652268A DE19652268C2 (en) | 1996-12-16 | 1996-12-16 | Medicinal preparation for the release of apomorphine in the oral cavity |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998026763A1 true WO1998026763A1 (en) | 1998-06-25 |
Family
ID=7814859
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1997/006529 WO1998026763A1 (en) | 1996-12-16 | 1997-11-21 | Active substance carrier for releasing apomorphine into the buccal cavity |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0959875A1 (en) |
JP (1) | JP2001506612A (en) |
KR (1) | KR20000057627A (en) |
AU (1) | AU746373B2 (en) |
CA (1) | CA2274893A1 (en) |
DE (1) | DE19652268C2 (en) |
NO (1) | NO992944L (en) |
WO (1) | WO1998026763A1 (en) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6291471B1 (en) | 1998-12-17 | 2001-09-18 | Abb Holdings, Inc. | Use of apomorphine for the treatment of organic erectile dysfunction in males |
US6596298B2 (en) | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
US7067116B1 (en) | 2000-03-23 | 2006-06-27 | Warner-Lambert Company Llc | Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1 |
US7314716B2 (en) | 1999-11-19 | 2008-01-01 | Mount Sinai School Of Medicine | Gustducin γ subunit materials and methods |
USRE40594E1 (en) | 1998-12-23 | 2008-12-02 | Mount Sinai School Of Medicine Of New York University | Inhibitors of the bitter taste response |
WO2010144817A1 (en) | 2009-06-12 | 2010-12-16 | Adagio Pharmaceuticals Ltd. | Sublingual apomorphine |
US7910132B2 (en) | 1998-09-24 | 2011-03-22 | Orexo Ab | Pharmaceutical composition for the treatment of acute disorders |
WO2012083269A1 (en) | 2010-12-16 | 2012-06-21 | Cynapsus Therapeutics, Inc. | Sublingual films |
US8481071B2 (en) | 2001-05-01 | 2013-07-09 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
US8481059B2 (en) | 2001-05-01 | 2013-07-09 | A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Sciences | Hydrogel compositions |
US8541021B2 (en) | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
US8617647B2 (en) | 2001-05-01 | 2013-12-31 | A.V. Topchiev Institutes of Petrochemical Synthesis, Russian Academy of Sciences | Water-absorbent adhesive compositions and associated methods of manufacture and use |
US8658201B2 (en) * | 2004-01-30 | 2014-02-25 | Corium International, Inc. | Rapidly dissolving film for delivery of an active agent |
US8784879B2 (en) | 2009-01-14 | 2014-07-22 | Corium International, Inc. | Transdermal administration of tamsulosin |
US8840918B2 (en) | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
USRE45666E1 (en) | 2000-07-07 | 2015-09-08 | A.V. Topchiev Institute Of Petrochemical Synthesis | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties |
US10449146B2 (en) | 2015-04-21 | 2019-10-22 | Sunovion Pharmaceuticals Inc. | Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10252726B4 (en) * | 2002-11-13 | 2008-05-08 | Lts Lohmann Therapie-Systeme Ag | Multilayer transmucosal therapeutic system |
US20060035008A1 (en) * | 2002-11-14 | 2006-02-16 | Givaudan Sa | Edible film containing food acid |
KR100945741B1 (en) * | 2003-01-16 | 2010-03-05 | 부광약품 주식회사 | Oral spray preparation of apomorphine hydrochloride |
US20050281757A1 (en) * | 2004-06-17 | 2005-12-22 | Sayed Ibrahim | Oral care film |
US10806703B2 (en) | 2012-01-20 | 2020-10-20 | Lts Lohmann Therapie-System Ag | Transmucosal administration system for a pharmaceutical drug |
JP2016535794A (en) * | 2013-11-11 | 2016-11-17 | インパックス ラボラトリーズ,インコーポレーテッド | Rapidly disintegrating preparations and methods of use |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3972995A (en) * | 1975-04-14 | 1976-08-03 | American Home Products Corporation | Dosage form |
WO1995028930A1 (en) * | 1994-04-22 | 1995-11-02 | Pentech Pharmaceuticals, Inc. | Dosage forms and method for ameliorating male erectile dysfunction |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2746414A1 (en) * | 1977-10-15 | 1979-04-26 | Gerlach Eduard Chem Fab | Foil-like tape for dispensing measured amts. of substance - consisting of the substance, binding agent and adjuvants, tape length being proportional to weight of substance |
FR2732896B1 (en) * | 1995-04-11 | 1997-06-13 | Prographarm Lab | TRANSDERMAL PHARMACEUTICAL FORM FOR PERCUTANEOUS ADMINISTRATION OF APOMORPHINE |
-
1996
- 1996-12-16 DE DE19652268A patent/DE19652268C2/en not_active Expired - Fee Related
-
1997
- 1997-11-21 EP EP97952795A patent/EP0959875A1/en not_active Withdrawn
- 1997-11-21 AU AU56547/98A patent/AU746373B2/en not_active Ceased
- 1997-11-21 CA CA002274893A patent/CA2274893A1/en not_active Abandoned
- 1997-11-21 WO PCT/EP1997/006529 patent/WO1998026763A1/en not_active Application Discontinuation
- 1997-11-21 JP JP52593498A patent/JP2001506612A/en active Pending
- 1997-11-21 KR KR1019990705422A patent/KR20000057627A/en not_active Application Discontinuation
-
1999
- 1999-06-16 NO NO992944A patent/NO992944L/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3972995A (en) * | 1975-04-14 | 1976-08-03 | American Home Products Corporation | Dosage form |
WO1995028930A1 (en) * | 1994-04-22 | 1995-11-02 | Pentech Pharmaceuticals, Inc. | Dosage forms and method for ameliorating male erectile dysfunction |
Cited By (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8454996B2 (en) | 1998-09-24 | 2013-06-04 | Orexo Ab | Pharmaceutical composition for the treatment of acute disorders |
US8512747B2 (en) | 1998-09-24 | 2013-08-20 | Orexo Ab | Pharmaceutical composition for the treatment of acute disorders |
US7910132B2 (en) | 1998-09-24 | 2011-03-22 | Orexo Ab | Pharmaceutical composition for the treatment of acute disorders |
EP1676557A2 (en) | 1998-09-25 | 2006-07-05 | Warner-Lambert Company LLC | Fast dissolving orally consumable films |
US7025983B2 (en) | 1998-09-25 | 2006-04-11 | Warner-Lambert Company Llc | Fast dissolving orally consumable films |
US7491406B2 (en) | 1998-09-25 | 2009-02-17 | Mcneil-Ppc, Inc. | Fast dissolving orally consumable films |
US6923981B2 (en) | 1998-09-25 | 2005-08-02 | Warner-Lambert Company | Fast dissolving orally consumable films |
US6596298B2 (en) | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
US6291471B1 (en) | 1998-12-17 | 2001-09-18 | Abb Holdings, Inc. | Use of apomorphine for the treatment of organic erectile dysfunction in males |
USRE40594E1 (en) | 1998-12-23 | 2008-12-02 | Mount Sinai School Of Medicine Of New York University | Inhibitors of the bitter taste response |
US7314716B2 (en) | 1999-11-19 | 2008-01-01 | Mount Sinai School Of Medicine | Gustducin γ subunit materials and methods |
US7067116B1 (en) | 2000-03-23 | 2006-06-27 | Warner-Lambert Company Llc | Fast dissolving orally consumable solid film containing a taste masking agent and pharmaceutically active agent at weight ratio of 1:3 to 3:1 |
EP1674078A2 (en) | 2000-03-23 | 2006-06-28 | Warner-Lambert Company LLC | Fast dissolving orally consumable filsm containing an ion exchange resin as a taste masking agent |
US7648712B2 (en) | 2000-03-23 | 2010-01-19 | Mcneil-Ppc, Inc. | Fast dissolving orally consumable films containing a taste masking agent |
USRE45666E1 (en) | 2000-07-07 | 2015-09-08 | A.V. Topchiev Institute Of Petrochemical Synthesis | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties |
US9687428B2 (en) | 2001-05-01 | 2017-06-27 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
US9532935B2 (en) | 2001-05-01 | 2017-01-03 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
US10179096B2 (en) | 2001-05-01 | 2019-01-15 | Corium International, Inc. | Hydrogel compositions for tooth whitening |
US8481071B2 (en) | 2001-05-01 | 2013-07-09 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
US8481059B2 (en) | 2001-05-01 | 2013-07-09 | A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Sciences | Hydrogel compositions |
US10869947B2 (en) | 2001-05-01 | 2020-12-22 | Corium, Inc. | Hydrogel compositions |
US8541021B2 (en) | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
US8617647B2 (en) | 2001-05-01 | 2013-12-31 | A.V. Topchiev Institutes of Petrochemical Synthesis, Russian Academy of Sciences | Water-absorbent adhesive compositions and associated methods of manufacture and use |
US9127140B2 (en) | 2001-05-01 | 2015-09-08 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Water-absorbent adhesive compositions and associated methods of manufacture and use |
US8741331B2 (en) | 2001-05-01 | 2014-06-03 | A. V. Topchiev Institute of Petrochemicals Synthesis, Russian Academy of Sciences | Hydrogel compositions with an erodible backing member |
US9259504B2 (en) | 2001-05-01 | 2016-02-16 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Non-electrically conductive hydrogel composition |
US8840918B2 (en) | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
US10835454B2 (en) | 2001-05-01 | 2020-11-17 | Corium, Inc. | Hydrogel compositions with an erodible backing member |
US9089481B2 (en) | 2001-05-01 | 2015-07-28 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
US9084723B2 (en) | 2001-05-01 | 2015-07-21 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions with an erodible backing member |
US9144552B2 (en) | 2004-01-30 | 2015-09-29 | A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Sciences | Rapidly dissolving film for delivery of an active agent |
US8658201B2 (en) * | 2004-01-30 | 2014-02-25 | Corium International, Inc. | Rapidly dissolving film for delivery of an active agent |
US9610253B2 (en) | 2009-01-14 | 2017-04-04 | Corium International, Inc. | Transdermal administration of tamsulosin |
US8784879B2 (en) | 2009-01-14 | 2014-07-22 | Corium International, Inc. | Transdermal administration of tamsulosin |
US10238612B2 (en) | 2009-01-14 | 2019-03-26 | Corium International, Inc. | Transdermal administration of tamsulosin |
CN102480958B (en) * | 2009-06-12 | 2015-08-19 | Cynapsus疗法有限公司 | sublingual apomorphine |
EP2442650A4 (en) * | 2009-06-12 | 2012-11-14 | Adagio Pharmaceuticals Inc | Sublingual apomorphine |
EP2442650B1 (en) | 2009-06-12 | 2015-08-26 | Cynapsus Therapeutics Inc. | Sublingual apomorphine |
WO2010144817A1 (en) | 2009-06-12 | 2010-12-16 | Adagio Pharmaceuticals Ltd. | Sublingual apomorphine |
US9326981B2 (en) | 2009-06-12 | 2016-05-03 | Cynapsus Therapeutics, Inc. | Sublingual apomorphine |
AU2019200308B2 (en) * | 2009-06-12 | 2020-11-26 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
EP2442650A1 (en) * | 2009-06-12 | 2012-04-25 | Adagio Pharmaceuticals Inc. | Sublingual apomorphine |
AU2010259971B2 (en) * | 2009-06-12 | 2016-10-27 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
US9044475B2 (en) | 2009-06-12 | 2015-06-02 | Cynapsus Therapeutics, Inc. | Sublingual apomorphine |
AU2010259971C1 (en) * | 2009-06-12 | 2017-02-16 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
US10420763B2 (en) | 2009-06-12 | 2019-09-24 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
US9669020B2 (en) | 2009-06-12 | 2017-06-06 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
US9669021B2 (en) | 2009-06-12 | 2017-06-06 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
US9669018B2 (en) | 2009-06-12 | 2017-06-06 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
US9669019B2 (en) | 2009-06-12 | 2017-06-06 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
EP2952191A1 (en) * | 2009-06-12 | 2015-12-09 | Cynapsus Therapeutics Inc. | Sublingual apomorphine |
AU2017200329B2 (en) * | 2009-06-12 | 2018-11-08 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
CN102480958A (en) * | 2009-06-12 | 2012-05-30 | Adagio制药有限公司 | Sublingual apomorphine |
EP3434270A1 (en) * | 2009-06-12 | 2019-01-30 | Sunovion Pharmaceuticals Inc. | Sublingual apomorphine |
WO2012083269A1 (en) | 2010-12-16 | 2012-06-21 | Cynapsus Therapeutics, Inc. | Sublingual films |
US10285953B2 (en) | 2010-12-16 | 2019-05-14 | Sunovion Pharmaceuticals Inc. | Sublingual films |
US8846074B2 (en) | 2010-12-16 | 2014-09-30 | Cynapsus Therapeutics, Inc. | Sublingual films |
EP3735988A1 (en) * | 2010-12-16 | 2020-11-11 | Sunovion Pharmaceuticals Inc. | Sublingual films |
US9427412B2 (en) | 2010-12-16 | 2016-08-30 | Cynapsus Therapeutics, Inc. | Sublingual films |
EP2651357A4 (en) * | 2010-12-16 | 2016-07-20 | Cynapsus Therapeutics Inc | Sublingual films |
US9283219B2 (en) | 2010-12-16 | 2016-03-15 | Cynapsus Therapeutics, Inc. | Sublingual films |
US11419769B2 (en) | 2010-12-16 | 2022-08-23 | Sunovion Pharmaceuticals Inc. | Sublingual films |
US10449146B2 (en) | 2015-04-21 | 2019-10-22 | Sunovion Pharmaceuticals Inc. | Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa |
US10959943B2 (en) | 2015-04-21 | 2021-03-30 | Sunovion Pharmaceuticals Inc. | Methods of treating Parkinson's disease by administration of apomorphine to an oral mucosa |
Also Published As
Publication number | Publication date |
---|---|
NO992944D0 (en) | 1999-06-16 |
AU746373B2 (en) | 2002-04-18 |
CA2274893A1 (en) | 1998-06-25 |
KR20000057627A (en) | 2000-09-25 |
DE19652268A1 (en) | 1998-06-18 |
JP2001506612A (en) | 2001-05-22 |
NO992944L (en) | 1999-06-16 |
AU5654798A (en) | 1998-07-15 |
DE19652268C2 (en) | 2000-06-29 |
EP0959875A1 (en) | 1999-12-01 |
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