WO1998029744A3 - Method to classify gene products - Google Patents
Method to classify gene products Download PDFInfo
- Publication number
- WO1998029744A3 WO1998029744A3 PCT/US1997/023762 US9723762W WO9829744A3 WO 1998029744 A3 WO1998029744 A3 WO 1998029744A3 US 9723762 W US9723762 W US 9723762W WO 9829744 A3 WO9829744 A3 WO 9829744A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- proteins
- collection
- methods
- gene products
- contained
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1089—Design, preparation, screening or analysis of libraries using computer algorithms
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B30/00—Methods of screening libraries
- C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
Abstract
Methods for classifying large numbers of proteins contained in a collection of interest are described. The collection may represent the repertoire of proteins encoded by the genome of an organism including a higher organism or those expressed by a particular tissue or type of cell. Classification is based on ability to bind ligands contained in a panel representative of the range of physiological interactions. The methods of the invention may also be used to evaluate relative binding of proteins in a set of proteins with respect to a physiologically significant ligand so as to permit the modification of specificity of a desired ligand/receptor interaction.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU59020/98A AU5902098A (en) | 1997-01-03 | 1997-12-23 | Method to classify gene products |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78536097A | 1997-01-03 | 1997-01-03 | |
US08/785,360 | 1997-01-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998029744A2 WO1998029744A2 (en) | 1998-07-09 |
WO1998029744A3 true WO1998029744A3 (en) | 1998-11-12 |
Family
ID=25135248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/023762 WO1998029744A2 (en) | 1997-01-03 | 1997-12-23 | Method to classify gene products |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU5902098A (en) |
WO (1) | WO1998029744A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9816514D0 (en) * | 1998-07-29 | 1998-09-30 | Smithkline Beecham Plc | Novel method |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993006121A1 (en) * | 1991-09-18 | 1993-04-01 | Affymax Technologies N.V. | Method of synthesizing diverse collections of oligomers |
WO1995018969A1 (en) * | 1994-01-06 | 1995-07-13 | Terrapin Technologies, Inc. | Surrogates for targets and improved reference panels |
-
1997
- 1997-12-23 WO PCT/US1997/023762 patent/WO1998029744A2/en active Application Filing
- 1997-12-23 AU AU59020/98A patent/AU5902098A/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1993006121A1 (en) * | 1991-09-18 | 1993-04-01 | Affymax Technologies N.V. | Method of synthesizing diverse collections of oligomers |
WO1995018969A1 (en) * | 1994-01-06 | 1995-07-13 | Terrapin Technologies, Inc. | Surrogates for targets and improved reference panels |
Non-Patent Citations (3)
Title |
---|
H. BRIEM ET AL.: "Molecular similarity based on DOCK-generated fingerprints", JOURNAL OF MEDICINAL CHEMISTRY., vol. 39, no. 17, 1996, WASHINGTON US, pages 3401 - 3408, XP002078005 * |
M. J. MAHAN ET AL.: "Antibiotic-based selection for bacterial genes that are specifically induced during infection of a host", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 92, January 1995 (1995-01-01), WASHINGTON US, pages 669 - 673, XP002078004 * |
S. LI ET AL.: "A computer screening approach to immunoglobulin superfamily structures and interactions: Discovery of small non-peptidic CD4 inhibitors as novel immunotherapeutics", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 94, January 1997 (1997-01-01), WASHINGTON US, pages 73 - 78, XP000619663 * |
Also Published As
Publication number | Publication date |
---|---|
AU5902098A (en) | 1998-07-31 |
WO1998029744A2 (en) | 1998-07-09 |
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