WO1998030205A1 - Emulsion vehicle for poorly soluble drugs - Google Patents
Emulsion vehicle for poorly soluble drugs Download PDFInfo
- Publication number
- WO1998030205A1 WO1998030205A1 PCT/US1998/000103 US9800103W WO9830205A1 WO 1998030205 A1 WO1998030205 A1 WO 1998030205A1 US 9800103 W US9800103 W US 9800103W WO 9830205 A1 WO9830205 A1 WO 9830205A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tocopherol
- composition
- emulsion
- paclitaxel
- tpgs
- Prior art date
Links
- GELBSEMIFYIVKE-UHFFFAOYSA-N CCC(C(C=C(c1nc2ccccc2cc1C1)N1C1)=C1C(O1)=O)(C1=O)O Chemical compound CCC(C(C=C(c1nc2ccccc2cc1C1)N1C1)=C1C(O1)=O)(C1=O)O GELBSEMIFYIVKE-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
- Y10S977/775—Nanosized powder or flake, e.g. nanosized catalyst
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
- Y10S977/797—Lipid particle
- Y10S977/798—Lipid particle having internalized material
- Y10S977/799—Containing biological material
- Y10S977/801—Drug
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/906—Drug delivery
- Y10S977/907—Liposome
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE69837328T DE69837328T2 (en) | 1997-01-07 | 1998-01-06 | COMPOSITION FOR THE FORMATION OF AN EMULSION FOR A TAXOID SUBSTANCE |
AU57314/98A AU5731498A (en) | 1997-01-07 | 1998-01-06 | Emulsion vehicle for poorly soluble drugs |
SI9830881T SI0981328T1 (en) | 1997-01-07 | 1998-01-06 | Composition forming an emulsion for a taxoid compound |
CA002276730A CA2276730C (en) | 1997-01-07 | 1998-01-06 | Emulsion vehicle for poorly soluble drugs |
DK98901173T DK0981328T3 (en) | 1997-01-07 | 1998-01-06 | Composition for forming an emulsion for a taxoid compound |
IL13073798A IL130737A0 (en) | 1997-01-07 | 1998-01-06 | Emulsion vehicle for poorly soluble drugs |
EP98901173A EP0981328B1 (en) | 1997-01-07 | 1998-01-06 | Composition forming an emulsion for a taxoid compound |
KR1019997006086A KR100612528B1 (en) | 1997-01-07 | 1998-01-06 | Emulsion vehicle for poorly soluble drugs |
JP53100698A JP2001508445A (en) | 1997-01-07 | 1998-01-06 | Emulsion vehicle for poorly soluble drugs |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3418897P | 1997-01-07 | 1997-01-07 | |
US60/034,188 | 1997-01-07 | ||
US4884097P | 1997-06-06 | 1997-06-06 | |
US60/048,840 | 1997-06-06 | ||
US09/003,173 US6458373B1 (en) | 1997-01-07 | 1998-01-05 | Emulsion vehicle for poorly soluble drugs |
US09/003,173 | 1998-01-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998030205A1 true WO1998030205A1 (en) | 1998-07-16 |
WO1998030205A9 WO1998030205A9 (en) | 1998-12-30 |
Family
ID=27357338
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/000103 WO1998030205A1 (en) | 1997-01-07 | 1998-01-06 | Emulsion vehicle for poorly soluble drugs |
Country Status (15)
Country | Link |
---|---|
US (10) | US6458373B1 (en) |
EP (1) | EP0981328B1 (en) |
JP (2) | JP2001508445A (en) |
KR (1) | KR100612528B1 (en) |
AR (1) | AR011518A1 (en) |
AT (1) | ATE356611T1 (en) |
CA (1) | CA2276730C (en) |
DE (1) | DE69837328T2 (en) |
DK (1) | DK0981328T3 (en) |
ES (1) | ES2285753T3 (en) |
IL (1) | IL130737A0 (en) |
IN (1) | IN183539B (en) |
PT (1) | PT981328E (en) |
TW (2) | TW200425913A (en) |
WO (1) | WO1998030205A1 (en) |
Cited By (61)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1999004787A1 (en) * | 1997-07-26 | 1999-02-04 | West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited | Taxol emulsion |
WO1999045918A1 (en) * | 1998-03-10 | 1999-09-16 | Napro Biotherapeutics, Inc. | Methods and compositions for delivery of taxanes |
WO2000032186A2 (en) * | 1998-12-02 | 2000-06-08 | Mylan Pharmaceuticals, Inc. | Stabilized injectable pharmaceutical compositions containing taxoid anti-neoplastic agents |
WO2000059488A2 (en) * | 1999-04-02 | 2000-10-12 | Washington State University Research Foundation | Enhanced tissue and subcellular delivery of vitamin e compounds |
WO2000061112A2 (en) * | 1999-04-13 | 2000-10-19 | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) | Solubilized pharmaceutical composition for parenteral administration |
WO2000071163A1 (en) * | 1999-05-24 | 2000-11-30 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
WO2000061189A3 (en) * | 1999-04-02 | 2001-01-11 | Ca Nat Research Council | Water-soluble compositions of bioactive lipophilic compounds |
WO2001022937A1 (en) * | 1999-09-27 | 2001-04-05 | Sonus Pharmaceuticals, Inc. | Compositions of tocol-soluble therapeutics |
WO2001030319A1 (en) * | 1999-10-25 | 2001-05-03 | Supergen, Inc. | New and improved formulation for paclitaxel |
FR2803203A1 (en) * | 1999-12-31 | 2001-07-06 | Fournier Ind & Sante | NEW GALENIC FORMULATIONS OF FENOFIBRATE |
EP1135150A1 (en) * | 1998-12-11 | 2001-09-26 | Pharmasolutions, Inc. | Self-emulsifying compositions for drugs poorly soluble in water |
WO2002026208A2 (en) * | 2000-09-27 | 2002-04-04 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
WO2002045709A1 (en) * | 2000-12-07 | 2002-06-13 | Bharat Serums & Vaccines Ltd. | Clear propofol compositions |
JP2002519318A (en) * | 1998-06-26 | 2002-07-02 | エルデイエス・テクノロジーズ・インコーポレーテツド | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
JP2003520227A (en) * | 2000-01-20 | 2003-07-02 | スプラテック ファーマ インコーポレイテッド | Novel podophyllotoxin composition |
US6589968B2 (en) | 2001-02-13 | 2003-07-08 | Kosan Biosciences, Inc. | Epothilone compounds and methods for making and using the same |
EP1340497A1 (en) * | 2002-03-01 | 2003-09-03 | Novagali Sas | Self emulsifying drug delivery systems for poorly soluble drugs |
WO2003074027A2 (en) * | 2002-03-01 | 2003-09-12 | Novagali Pharma Sa | Self emulsifying drug delivery systems for poorly soluble drugs |
US6632443B2 (en) | 2000-02-23 | 2003-10-14 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
US6727280B2 (en) | 1997-01-07 | 2004-04-27 | Sonus Pharmaceuticals, Inc. | Method for treating colorectal carcinoma using a taxane/tocopherol formulation |
JP2004514690A (en) * | 2000-11-29 | 2004-05-20 | リオトロピック セラピュティックス アイエヌシー. | Drug solvent system |
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US6828346B2 (en) * | 1999-10-25 | 2004-12-07 | Supergen, Inc. | Methods for administration of paclitaxel |
US6858227B1 (en) | 2001-11-21 | 2005-02-22 | Sonus Pharmaceuticals, Inc. | Vitamin E conjugates |
WO2005035606A1 (en) | 2003-10-10 | 2005-04-21 | Samyang Corporation | Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery |
US6893859B2 (en) | 2001-02-13 | 2005-05-17 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
US6919370B2 (en) | 2000-11-28 | 2005-07-19 | Transform Pharmaceuticals, Inc. | Pharmaceutical formulations comprising paclitaxel, derivatives, and pharmaceutically acceptable salts thereof |
US6964946B1 (en) | 1995-10-26 | 2005-11-15 | Baker Norton Pharmaceuticals, Inc. | Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same |
US6982281B1 (en) | 2000-11-17 | 2006-01-03 | Lipocine Inc | Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs |
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KR100754352B1 (en) * | 1999-05-24 | 2007-08-31 | 소너스파머슈티칼즈인코포레이티드 | The method of preparing emulsion vehicle for poorly soluble drugs |
US7307104B2 (en) | 2003-05-16 | 2007-12-11 | Velocys, Inc. | Process for forming an emulsion using microchannel process technology |
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EP2135868A1 (en) | 2002-11-07 | 2009-12-23 | Kosan Biosciences Incorporated | Trans-9, 10-dehydroepothilone c and d, analogs thereof and methods of making the same |
WO2010007252A2 (en) * | 2008-07-18 | 2010-01-21 | Yvery | Formulation for improving the bioavailability of a hydrophobic molecule |
WO2010009075A1 (en) * | 2008-07-14 | 2010-01-21 | The University Of North Carolina At Chapel Hill | Methods and compositions comprising crystalline nanoparticles of hydrophobic compounds |
US7691392B2 (en) | 2005-04-29 | 2010-04-06 | Kosan Biosciences Incorporated | Method of treating multiple myeloma using 17-AAG or 17-AG or a prodrug of either |
US7691838B2 (en) | 2003-05-30 | 2010-04-06 | Kosan Biosciences Incorporated | Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics |
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- 1998-01-06 TW TW087100121A patent/TW579297B/en not_active IP Right Cessation
- 1998-01-06 AT AT98901173T patent/ATE356611T1/en not_active IP Right Cessation
- 1998-01-06 IL IL13073798A patent/IL130737A0/en unknown
- 1998-01-06 EP EP98901173A patent/EP0981328B1/en not_active Expired - Lifetime
- 1998-01-06 IN IN26CA1998 patent/IN183539B/en unknown
- 1998-01-06 KR KR1019997006086A patent/KR100612528B1/en not_active IP Right Cessation
- 1998-01-06 PT PT98901173T patent/PT981328E/en unknown
- 1998-01-06 ES ES98901173T patent/ES2285753T3/en not_active Expired - Lifetime
- 1998-01-06 WO PCT/US1998/000103 patent/WO1998030205A1/en active IP Right Grant
- 1998-01-07 AR ARP980100062A patent/AR011518A1/en not_active Application Discontinuation
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1999
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- 1999-07-27 US US09/361,935 patent/US6667048B1/en not_active Expired - Fee Related
-
2002
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- 2002-05-17 US US10/151,064 patent/US20030027858A1/en not_active Abandoned
- 2002-06-28 US US10/187,055 patent/US20030109575A1/en not_active Abandoned
- 2002-11-19 US US10/299,626 patent/US20030147959A1/en not_active Abandoned
- 2002-11-19 US US10/299,649 patent/US20030170279A1/en not_active Abandoned
-
2004
- 2004-04-28 US US10/833,619 patent/US20040202712A1/en not_active Abandoned
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2005
- 2005-02-25 US US11/067,217 patent/US20050142189A1/en not_active Abandoned
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2007
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Also Published As
Publication number | Publication date |
---|---|
EP0981328A1 (en) | 2000-03-01 |
DE69837328D1 (en) | 2007-04-26 |
AR011518A1 (en) | 2000-08-30 |
DE69837328T2 (en) | 2007-12-20 |
US20030027858A1 (en) | 2003-02-06 |
IN183539B (en) | 2000-02-05 |
JP2007332157A (en) | 2007-12-27 |
KR20000069893A (en) | 2000-11-25 |
US6982282B2 (en) | 2006-01-03 |
KR100612528B1 (en) | 2006-08-11 |
US20050142189A1 (en) | 2005-06-30 |
US20040202712A1 (en) | 2004-10-14 |
TW579297B (en) | 2004-03-11 |
DK0981328T3 (en) | 2007-07-02 |
PT981328E (en) | 2007-05-31 |
TW200425913A (en) | 2004-12-01 |
US6667048B1 (en) | 2003-12-23 |
EP0981328B1 (en) | 2007-03-14 |
JP2001508445A (en) | 2001-06-26 |
CA2276730C (en) | 2004-10-26 |
US6458373B1 (en) | 2002-10-01 |
US20030147959A1 (en) | 2003-08-07 |
CA2276730A1 (en) | 1998-07-16 |
US20030109575A1 (en) | 2003-06-12 |
ES2285753T3 (en) | 2007-11-16 |
IL130737A0 (en) | 2000-06-01 |
ATE356611T1 (en) | 2007-04-15 |
US20030170279A1 (en) | 2003-09-11 |
US20030104015A1 (en) | 2003-06-05 |
US6660286B1 (en) | 2003-12-09 |
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