WO1998030883A3 - Analysis of genetic polymorphisms and gene copy number - Google Patents

Analysis of genetic polymorphisms and gene copy number Download PDF

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Publication number
WO1998030883A3
WO1998030883A3 PCT/US1998/006414 US9806414W WO9830883A3 WO 1998030883 A3 WO1998030883 A3 WO 1998030883A3 US 9806414 W US9806414 W US 9806414W WO 9830883 A3 WO9830883 A3 WO 9830883A3
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WO
WIPO (PCT)
Prior art keywords
analysis
copy number
gene copy
genetic polymorphisms
variations
Prior art date
Application number
PCT/US1998/006414
Other languages
French (fr)
Other versions
WO1998030883A2 (en
WO1998030883A9 (en
Inventor
Maureen T Cronin
Charles G Miyada
Earl A Hubbell
Mark Chee
Stephen P A Fodor
Xiaohua C Huang
Robert J Lipshutz
Peter E Lobban
Macdonald S Morris
Edward L Sheldon
Original Assignee
Affymetrix Inc
Maureen T Cronin
Charles G Miyada
Earl A Hubbell
Mark Chee
Stephen P A Fodor
Xiaohua C Huang
Robert J Lipshutz
Peter E Lobban
Macdonald S Morris
Edward L Sheldon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affymetrix Inc, Maureen T Cronin, Charles G Miyada, Earl A Hubbell, Mark Chee, Stephen P A Fodor, Xiaohua C Huang, Robert J Lipshutz, Peter E Lobban, Macdonald S Morris, Edward L Sheldon filed Critical Affymetrix Inc
Priority to US09/341,399 priority Critical patent/US6468744B1/en
Priority to EP98947218A priority patent/EP0970251A4/en
Publication of WO1998030883A2 publication Critical patent/WO1998030883A2/en
Publication of WO1998030883A3 publication Critical patent/WO1998030883A3/en
Publication of WO1998030883A9 publication Critical patent/WO1998030883A9/en

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    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
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    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • B01J2219/00277—Apparatus
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
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    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
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    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
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    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

The invention provides methods for detecting variations in polymorphic sites and/or variations in gene copy number. The methods are particularly useful for analysis of biotransformation genes, such as cytochromes P450.
PCT/US1998/006414 1997-01-03 1998-01-02 Analysis of genetic polymorphisms and gene copy number WO1998030883A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US09/341,399 US6468744B1 (en) 1997-01-03 1998-01-02 Analysis of genetic polymorphisms and gene copy number
EP98947218A EP0970251A4 (en) 1997-01-03 1998-01-02 Analysis of genetic polymorphisms and gene copy number

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/778,794 1997-01-03
US08/778,794 US6309823B1 (en) 1993-10-26 1997-01-03 Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same

Publications (3)

Publication Number Publication Date
WO1998030883A2 WO1998030883A2 (en) 1998-07-16
WO1998030883A3 true WO1998030883A3 (en) 1998-10-29
WO1998030883A9 WO1998030883A9 (en) 1998-12-17

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PCT/US1998/006414 WO1998030883A2 (en) 1997-01-03 1998-01-02 Analysis of genetic polymorphisms and gene copy number

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US (3) US6309823B1 (en)
EP (1) EP0970251A4 (en)
WO (1) WO1998030883A2 (en)

Families Citing this family (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7115364B1 (en) 1993-10-26 2006-10-03 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US6027880A (en) * 1995-08-02 2000-02-22 Affymetrix, Inc. Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis
US20060229824A1 (en) * 1993-10-26 2006-10-12 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes
US6309823B1 (en) * 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
US7582421B2 (en) * 1993-11-01 2009-09-01 Nanogen, Inc. Methods for determination of single nucleic acid polymorphisms using a bioelectronic microchip
US5830645A (en) 1994-12-09 1998-11-03 The Regents Of The University Of California Comparative fluorescence hybridization to nucleic acid arrays
US6953663B1 (en) * 1995-11-29 2005-10-11 Affymetrix, Inc. Polymorphism detection
US6391550B1 (en) 1996-09-19 2002-05-21 Affymetrix, Inc. Identification of molecular sequence signatures and methods involving the same
AU1366299A (en) 1997-10-27 1999-05-17 Boston Probes, Inc. Methods, kits and compositions pertaining to pna molecular beacons
US6485901B1 (en) 1997-10-27 2002-11-26 Boston Probes, Inc. Methods, kits and compositions pertaining to linear beacons
US6361942B1 (en) 1998-03-24 2002-03-26 Boston Probes, Inc. Method, kits and compositions pertaining to detection complexes
WO2000039345A1 (en) * 1998-12-30 2000-07-06 Dana-Farber Cancer Institute, Inc. Mutation scanning array, and methods of use thereof
US6142681A (en) 1999-02-22 2000-11-07 Vialogy Corporation Method and apparatus for interpreting hybridized bioelectronic DNA microarray patterns using self-scaling convergent reverberant dynamics
US20040111219A1 (en) * 1999-02-22 2004-06-10 Sandeep Gulati Active interferometric signal analysis in software
US6245511B1 (en) * 1999-02-22 2001-06-12 Vialogy Corp Method and apparatus for exponentially convergent therapy effectiveness monitoring using DNA microarray based viral load measurements
US6136541A (en) 1999-02-22 2000-10-24 Vialogy Corporation Method and apparatus for analyzing hybridized biochip patterns using resonance interactions employing quantum expressor functions
ATE408025T1 (en) * 1999-03-25 2008-09-15 Serono Genetics Inst Sa BIALLELIC MARKERS RELATED TO GENES INVOLVED IN DRUG METABOLISM
US6528260B1 (en) 1999-03-25 2003-03-04 Genset, S.A. Biallelic markers related to genes involved in drug metabolism
CA2372909A1 (en) * 1999-03-30 2000-10-05 Nanogen, Inc. Single nucleotide polymorphic discrimination by electronic dot blot assay on semiconductor microchips
US6692916B2 (en) * 1999-06-28 2004-02-17 Source Precision Medicine, Inc. Systems and methods for characterizing a biological condition or agent using precision gene expression profiles
US6960439B2 (en) * 1999-06-28 2005-11-01 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
AU1075701A (en) 1999-10-08 2001-04-23 Protogene Laboratories, Inc. Method and apparatus for performing large numbers of reactions using array assembly
US20020164634A1 (en) * 2000-08-26 2002-11-07 Perlegen Sciences, Inc. Methods for reducing complexity of nucleic acid samples
JP2002071687A (en) * 2000-08-31 2002-03-12 Canon Inc Screening method for variant gene
US7117095B2 (en) * 2000-11-21 2006-10-03 Affymetrix, Inc. Methods for selecting nucleic acid probes
US20020143768A1 (en) * 2000-12-21 2002-10-03 Berno Anthony Berno Probe array data storage and retrieval
CA2440146A1 (en) * 2001-03-30 2002-10-24 Amersham Biosciences Ab P450 single nucleotide polymorphism biochip analysis
US20030009294A1 (en) * 2001-06-07 2003-01-09 Jill Cheng Integrated system for gene expression analysis
WO2002101031A1 (en) * 2001-06-11 2002-12-19 I.N.S.E.R.M. Cyp450-specific dna probes and primers, and biological applications thereof
US7195877B2 (en) * 2001-07-20 2007-03-27 Bioventures, Inc. Cytochrome P450 genetic variations
WO2003012126A2 (en) * 2001-08-03 2003-02-13 Diversa Corporation Epoxide hydrolases, nucleic acids encoding them and methods for making and using them
WO2003016484A2 (en) * 2001-08-17 2003-02-27 Affymetrix, Inc. Gleason grade 4/5 prostate cancer genes
US20030068655A1 (en) * 2001-09-12 2003-04-10 Protiveris, Inc. Microcantilever apparatus and methods for detection of enzymes
WO2003027264A2 (en) * 2001-09-27 2003-04-03 University Of Delaware Coisogenic eukaryotic cell collections
WO2003040404A1 (en) 2001-11-09 2003-05-15 Source Precision Medicine, Inc. Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
US20110151438A9 (en) * 2001-11-19 2011-06-23 Affymetrix, Inc. Methods of Analysis of Methylation
DE10214788A1 (en) * 2002-04-04 2003-10-23 Universitaetsklinikum Hamburg Method for detecting a mutation in a gene predisposed to hereditary colorectal tumors
US20050196771A1 (en) * 2002-04-11 2005-09-08 Matt Neville Characterization of CYP 2D6 genotypes
US20040096874A1 (en) * 2002-04-11 2004-05-20 Third Wave Technologies, Inc. Characterization of CYP 2D6 genotypes
US7687256B2 (en) * 2002-04-11 2010-03-30 Spire Corporation Surface activated biochip
EP1502098B1 (en) * 2002-05-03 2008-09-17 ViaLogy, LLC Method for characterizing microarray output data
US7097976B2 (en) 2002-06-17 2006-08-29 Affymetrix, Inc. Methods of analysis of allelic imbalance
US9388459B2 (en) * 2002-06-17 2016-07-12 Affymetrix, Inc. Methods for genotyping
KR100442832B1 (en) * 2002-07-10 2004-08-02 삼성전자주식회사 Primer sets for MODY2 gene amplification by multiplex polymerase chain reaction
AU2003247948A1 (en) * 2002-07-18 2004-02-09 Bioventures, Inc. Cytochrome p450 genetic variations
US7601493B2 (en) * 2002-07-26 2009-10-13 Nanogen, Inc. Methods and apparatus for screening and detecting multiple genetic mutations
EP1535242A1 (en) 2002-08-20 2005-06-01 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US20060147924A1 (en) * 2002-09-11 2006-07-06 Ramsing Neils B Population of nucleic acids including a subpopulation of lna oligomers
WO2004031351A2 (en) * 2002-10-01 2004-04-15 Nimblegen Systems, Inc. Microarrays having multiple oligonucleotides in single array features
US20040219565A1 (en) * 2002-10-21 2004-11-04 Sakari Kauppinen Oligonucleotides useful for detecting and analyzing nucleic acids of interest
US10229244B2 (en) 2002-11-11 2019-03-12 Affymetrix, Inc. Methods for identifying DNA copy number changes using hidden markov model based estimations
JP2006519977A (en) * 2002-11-11 2006-08-31 アフィメトリックス インコーポレイテッド Method for identifying DNA copy number changes
US7822555B2 (en) 2002-11-11 2010-10-26 Affymetrix, Inc. Methods for identifying DNA copy number changes
US8232055B2 (en) * 2002-12-23 2012-07-31 Agilent Technologies, Inc. Comparative genomic hybridization assays using immobilized oligonucleotide features and compositions for practicing the same
US20090124514A1 (en) * 2003-02-26 2009-05-14 Perlegen Sciences, Inc. Selection probe amplification
US20060183132A1 (en) * 2005-02-14 2006-08-17 Perlegen Sciences, Inc. Selection probe amplification
CA2458085A1 (en) 2003-03-21 2004-09-21 F. Hoffmann-La Roche Ag Transcriptional activity assay
US7534561B2 (en) * 2003-04-02 2009-05-19 Agilent Technologies, Inc. Nucleic acid array in situ fabrication methods and arrays produced using the same
US7833714B1 (en) 2003-04-11 2010-11-16 Affymetrix, Inc. Combinatorial affinity selection
JP4850698B2 (en) 2003-04-25 2012-01-11 ノース・キャロライナ・ステイト・ユニヴァーシティ Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses thereof
EP2322540A1 (en) 2003-06-23 2011-05-18 North Carolina State University Lactobacillus acidophilus nucleic acids encoding fructo-oligosaccharide utilization compounds and uses thereof
US20050059024A1 (en) 2003-07-25 2005-03-17 Ambion, Inc. Methods and compositions for isolating small RNA molecules
CN1882688B (en) 2003-07-25 2014-07-16 安比恩股份有限公司 Methods and compositions for isolating small RNA molecules
US20050100911A1 (en) * 2003-08-06 2005-05-12 Perlegen Sciences, Inc. Methods for enriching populations of nucleic acid samples
US7824857B2 (en) * 2003-12-02 2010-11-02 Musc Foundation For Research Development Methods and compositions for diagnosing epithelial cell cancer
US20050233354A1 (en) * 2004-01-22 2005-10-20 Affymetrix, Inc. Genotyping degraded or mitochandrial DNA samples
WO2005084254A2 (en) * 2004-02-27 2005-09-15 Musc Foundation For Research Development Enhanced detection of rna using a panel of truncated gene-specific primers for reverse transcription
US20070031883A1 (en) * 2004-03-04 2007-02-08 Kincaid Robert H Analyzing CGH data to identify aberrations
US8321138B2 (en) * 2005-07-29 2012-11-27 Agilent Technologies, Inc. Method of characterizing quality of hybridized CGH arrays
US7459289B2 (en) 2004-03-08 2008-12-02 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor
EP1732537A1 (en) * 2004-04-09 2006-12-20 Aryx Therapeutics Benzofuranyl derivatives useful for the treatment of cardiac arrhythmia
US20060008823A1 (en) * 2004-05-12 2006-01-12 Kemp Jennifer T DNA profiling and SNP detection utilizing microarrays
US7636637B2 (en) * 2004-06-18 2009-12-22 Roche Nimblegen, Inc. Variable length probe selection
AU2005271960B2 (en) 2004-07-09 2011-12-08 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Identification of markers in lung and breast cancer
US8484000B2 (en) * 2004-09-02 2013-07-09 Vialogy Llc Detecting events of interest using quantum resonance interferometry
US7495092B2 (en) 2005-01-14 2009-02-24 North Carolina State University Compositions comprising promoter sequences and methods of use
US20060166224A1 (en) * 2005-01-24 2006-07-27 Norviel Vernon A Associations using genotypes and phenotypes
WO2006089046A2 (en) 2005-02-18 2006-08-24 Monogram Biosciences, Inc. Methods and compositions for determining anti-hiv drug susceptibility and replication capacity of hiv
US8178291B2 (en) 2005-02-18 2012-05-15 Monogram Biosciences, Inc. Methods and compositions for determining hypersusceptibility of HIV-1 to non-nucleoside reverse transcriptase inhibitors
US20060204600A1 (en) * 2005-03-11 2006-09-14 Paul Konz Dragon's blood anti-viral materials and methods
WO2006110314A2 (en) 2005-03-25 2006-10-19 Ambion, Inc. Methods and compositions for depleting abundant rna transcripts
US20070072175A1 (en) * 2005-05-13 2007-03-29 Biogen Idec Ma Inc. Nucleotide array containing polynucleotide probes complementary to, or fragments of, cynomolgus monkey genes and the use thereof
EP2458019A3 (en) 2005-05-27 2012-07-25 Monogram BioSciences, Inc. Methods and compositions for determining resistance of HIV-1 to protease inhibitors
US9506121B2 (en) * 2005-06-06 2016-11-29 Monogram Biosciences, Inc. Methods for determining resistance or susceptibility to HIV entry inhibitors
US8071284B2 (en) * 2005-06-06 2011-12-06 Monogram Biosciences, Inc. Methods and compositions for determining altered susceptibility of HIV-1 to anti-HIV drugs
US20060292585A1 (en) * 2005-06-24 2006-12-28 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
US7962291B2 (en) 2005-09-30 2011-06-14 Affymetrix, Inc. Methods and computer software for detecting splice variants
US20070092904A1 (en) * 2005-10-19 2007-04-26 Biogen Idec Ma Inc. Method for preparing limiting quantities of nucleic acids
CA2626977A1 (en) * 2005-10-27 2007-05-03 Rosetta Inpharmatics Llc Nucleic acid amplification using non-random primers
WO2007067907A1 (en) 2005-12-06 2007-06-14 Ambion, Inc. Reverse transcription primers and methods of design
US11306351B2 (en) 2005-12-21 2022-04-19 Affymetrix, Inc. Methods for genotyping
US7901882B2 (en) 2006-03-31 2011-03-08 Affymetrix, Inc. Analysis of methylation using nucleic acid arrays
US20080102453A1 (en) * 2006-10-31 2008-05-01 Jayati Ghosh Methods and systems and analysis of CGH data
DK2099935T3 (en) * 2006-11-30 2014-04-07 Univ California ARRAY FOR DETECTION OF MICROBES
JP4331216B2 (en) * 2007-02-09 2009-09-16 株式会社東芝 Detection method of gene mutation
WO2008106115A2 (en) 2007-02-26 2008-09-04 Monogram Biosciences, Inc. Compositions and methods for determining whether a subject would benefit from co-receptor inhibitor therapy
US20080274458A1 (en) * 2007-05-01 2008-11-06 Latham Gary J Nucleic acid quantitation methods
US8200440B2 (en) 2007-05-18 2012-06-12 Affymetrix, Inc. System, method, and computer software product for genotype determination using probe array data
US8685642B2 (en) * 2007-07-30 2014-04-01 Agilent Technologies, Inc. Allele-specific copy number measurement using single nucleotide polymorphism and DNA arrays
JP5723154B2 (en) 2007-09-19 2015-05-27 アプライド バイオシステムズ リミテッド ライアビリティー カンパニー SiRNA sequence-independent modification format for reducing the influence of off-target phenotype in RNAi and its stabilized form
US20090233809A1 (en) * 2008-03-04 2009-09-17 Affymetrix, Inc. Resequencing methods for identification of sequence variants
EP2982437B1 (en) 2008-06-25 2017-12-06 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale fet arrays
WO2010138908A1 (en) 2009-05-29 2010-12-02 Ventana Medical Systems, Inc. Igfir gene copy number as a prognostic marker in a non-small cell lung cancer
AU2010253978B2 (en) 2009-05-29 2014-12-11 Ventana Medical Systems, Inc. Methods of scoring gene copy number in a biological sample using in situ hybridization
SI3133070T1 (en) 2009-11-27 2019-11-29 Genzyme Corp Eliglustat (genz 112638) as inhibitor of glucosylceramide synthase for use in a method of treating fabry's or gaucher's disease, the method comprising adjusting the individual therapeutical dose to the p-450 metabolism of the patient
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
US9315857B2 (en) 2009-12-15 2016-04-19 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse label-tags
US20130058915A1 (en) 2010-03-02 2013-03-07 Children's Medica Center Corporation Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
EP2576823A1 (en) 2010-06-04 2013-04-10 Institut National De La Sante Et De La Recherche Medicale (Inserm) Constitutively active prolactin receptor variants as prognostic markers and therapeutic targets to prevent progression of hormone-dependent cancers towards hormone-independence
US8530157B2 (en) 2010-07-01 2013-09-10 Agilent Technologies, Inc. SNP-dependent end labeling method
ES2690753T3 (en) 2010-09-21 2018-11-22 Agilent Technologies, Inc. Increased confidence in allele identifications with molecular count
WO2012145574A2 (en) 2011-04-20 2012-10-26 Life Technologies Corporation Methods, compositions and systems for sample deposition
WO2013003112A1 (en) 2011-06-27 2013-01-03 The Jackson Laboratory Methods and compositions for treatment of cancer and autoimmune disease
US20150087539A1 (en) 2011-07-14 2015-03-26 Traslational Cancer Drugs Pharma, S.L. Method for predicting outcome of cancer in a subject
EP2820174B1 (en) 2012-02-27 2019-12-25 The University of North Carolina at Chapel Hill Methods and uses for molecular tags
WO2013130674A1 (en) 2012-02-27 2013-09-06 Cellular Research, Inc. Compositions and kits for molecular counting
US9670529B2 (en) 2012-02-28 2017-06-06 Population Genetics Technologies Ltd. Method for attaching a counter sequence to a nucleic acid sample
US20130253839A1 (en) * 2012-03-23 2013-09-26 International Business Machines Corporation Surprisal data reduction of genetic data for transmission, storage, and analysis
US8812243B2 (en) 2012-05-09 2014-08-19 International Business Machines Corporation Transmission and compression of genetic data
US10353869B2 (en) 2012-05-18 2019-07-16 International Business Machines Corporation Minimization of surprisal data through application of hierarchy filter pattern
US8855938B2 (en) 2012-05-18 2014-10-07 International Business Machines Corporation Minimization of surprisal data through application of hierarchy of reference genomes
US9002888B2 (en) 2012-06-29 2015-04-07 International Business Machines Corporation Minimization of epigenetic surprisal data of epigenetic data within a time series
US8972406B2 (en) 2012-06-29 2015-03-03 International Business Machines Corporation Generating epigenetic cohorts through clustering of epigenetic surprisal data based on parameters
US10876152B2 (en) 2012-09-04 2020-12-29 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
CA3190199A1 (en) 2012-09-04 2014-03-13 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
US11913065B2 (en) 2012-09-04 2024-02-27 Guardent Health, Inc. Systems and methods to detect rare mutations and copy number variation
EP2813571A1 (en) 2013-06-13 2014-12-17 Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) Method for the treatment of lung cancer
WO2015031691A1 (en) 2013-08-28 2015-03-05 Cellular Research, Inc. Massively parallel single cell analysis
CN105745528A (en) 2013-10-07 2016-07-06 赛卢拉研究公司 Methods and systems for digitally counting features on arrays
JP6706206B2 (en) 2013-11-11 2020-06-03 ライフ テクノロジーズ コーポレーション Rotor assembly and method for using same
ES2784450T3 (en) 2013-12-28 2020-09-25 Guardant Health Inc Methods and systems to detect genetic variants
TW201702218A (en) 2014-12-12 2017-01-16 美國杰克森實驗室 Compositions and methods relating to the treatment of cancer, autoimmune disease, and neurodegenerative disease
EP3259371B1 (en) 2015-02-19 2020-09-02 Becton, Dickinson and Company High-throughput single-cell analysis combining proteomic and genomic information
US9727810B2 (en) 2015-02-27 2017-08-08 Cellular Research, Inc. Spatially addressable molecular barcoding
CN107406888A (en) 2015-03-30 2017-11-28 赛卢拉研究公司 For combining the method and composition of bar coding
EP3286326A1 (en) 2015-04-23 2018-02-28 Cellular Research, Inc. Methods and compositions for whole transcriptome amplification
WO2016196229A1 (en) 2015-06-01 2016-12-08 Cellular Research, Inc. Methods for rna quantification
JP6940484B2 (en) 2015-09-11 2021-09-29 セルラー リサーチ， インコーポレイテッド Methods and compositions for library normalization
WO2017106768A1 (en) 2015-12-17 2017-06-22 Guardant Health, Inc. Methods to determine tumor gene copy number by analysis of cell-free dna
EP3452614B1 (en) 2016-05-02 2023-06-28 Becton, Dickinson and Company Accurate molecular barcoding
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
CN109074430B (en) 2016-05-26 2022-03-29 贝克顿迪金森公司 Molecular marker counting adjustment method
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
US10640763B2 (en) 2016-05-31 2020-05-05 Cellular Research, Inc. Molecular indexing of internal sequences
AU2017331459B2 (en) 2016-09-26 2023-04-13 Becton, Dickinson And Company Measurement of protein expression using reagents with barcoded oligonucleotide sequences
AU2017359047A1 (en) 2016-11-08 2019-05-02 Becton, Dickinson And Company Methods for cell label classification
CN109952612B (en) 2016-11-08 2023-12-01 贝克顿迪金森公司 Method for classifying expression profiles
US10722880B2 (en) 2017-01-13 2020-07-28 Cellular Research, Inc. Hydrophilic coating of fluidic channels
CN110382708A (en) 2017-02-01 2019-10-25 赛卢拉研究公司 Selective amplification is carried out using blocking property oligonucleotides
CN110719959B (en) 2017-06-05 2021-08-06 贝克顿迪金森公司 Sample indexing for single cells
JP7265537B2 (en) 2017-09-11 2023-04-26 サイティアー セラピューティクス，インコーポレイティド RAD51 inhibitor
WO2019126209A1 (en) 2017-12-19 2019-06-27 Cellular Research, Inc. Particles associated with oligonucleotides
JP7358388B2 (en) 2018-05-03 2023-10-10 ベクトン・ディキンソン・アンド・カンパニー Molecular barcoding at opposite transcript ends
AU2019262048A1 (en) 2018-05-03 2020-11-12 Becton, Dickinson And Company High throughput multiomics sample analysis
WO2020072380A1 (en) 2018-10-01 2020-04-09 Cellular Research, Inc. Determining 5' transcript sequences
JP2022506546A (en) 2018-11-08 2022-01-17 ベクトン・ディキンソン・アンド・カンパニー Single-cell whole transcriptome analysis using random priming
US11492660B2 (en) 2018-12-13 2022-11-08 Becton, Dickinson And Company Selective extension in single cell whole transcriptome analysis
US11371076B2 (en) 2019-01-16 2022-06-28 Becton, Dickinson And Company Polymerase chain reaction normalization through primer titration
EP4242322A3 (en) 2019-01-23 2023-09-20 Becton, Dickinson and Company Oligonucleotides associated with antibodies
TW202104198A (en) 2019-03-12 2021-02-01 美商賽堤爾醫療公司 Rad51 inhibitors
SG11202109844QA (en) 2019-03-25 2021-10-28 Cyteir Therapeutics Inc Combinations of rad51 and parp inhibitors
EP3986402A1 (en) 2019-06-21 2022-04-27 Cyteir Therapeutics, Inc. Methods of using rad51 inhibitors for treatment of pancreatic cancer
US11939622B2 (en) 2019-07-22 2024-03-26 Becton, Dickinson And Company Single cell chromatin immunoprecipitation sequencing assay
WO2021092386A1 (en) 2019-11-08 2021-05-14 Becton Dickinson And Company Using random priming to obtain full-length v(d)j information for immune repertoire sequencing
EP4090763A1 (en) 2020-01-13 2022-11-23 Becton Dickinson and Company Methods and compositions for quantitation of proteins and rna
TW202146014A (en) 2020-03-03 2021-12-16 美商賽堤爾醫療公司 Targeting homologous recombination: a new synthetic lethal therapeutic paradigm
CN115605614A (en) 2020-05-14 2023-01-13 贝克顿迪金森公司（Us） Primers for immune repertoire profiling
US11932901B2 (en) 2020-07-13 2024-03-19 Becton, Dickinson And Company Target enrichment using nucleic acid probes for scRNAseq
EP4247967A1 (en) 2020-11-20 2023-09-27 Becton, Dickinson and Company Profiling of highly expressed and lowly expressed proteins

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472842A (en) * 1993-10-06 1995-12-05 The Regents Of The University Of California Detection of amplified or deleted chromosomal regions
US5670314A (en) * 1994-02-22 1997-09-23 Regents Of The University Of California Genetic alterations that correlate with lung carcinomas
US5690894A (en) * 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8311018D0 (en) 1983-04-22 1983-05-25 Amersham Int Plc Detecting mutations in dna
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US5002867A (en) 1988-04-25 1991-03-26 Macevicz Stephen C Nucleic acid sequence determination by multiple mixed oligonucleotide probes
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
DE68928853T2 (en) 1988-05-20 1999-08-05 Cetus Corp FASTENING OF SEQUENCE-SPECIFIC SAMPLES
AU3869289A (en) 1988-07-14 1990-02-05 Baylor College Of Medicine Solid phase assembly and reconstruction of biopolymers
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US5527676A (en) 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
US5527681A (en) 1989-06-07 1996-06-18 Affymax Technologies N.V. Immobilized molecular synthesis of systematically substituted compounds
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5620848A (en) 1990-06-27 1997-04-15 Trustees Of Princeton University Methods for detecting mutant p53
EP0834576B1 (en) 1990-12-06 2002-01-16 Affymetrix, Inc. (a Delaware Corporation) Detection of nucleic acid sequences
ES2155822T3 (en) 1990-12-06 2001-06-01 Affymetrix Inc COMPOUNDS AND ITS USE IN A BINARY SYNTHESIS STRATEGY.
US5220004A (en) * 1991-05-07 1993-06-15 Cetus Corporation Methods and reagents for G -65 -globin typing
CA2130562A1 (en) 1992-02-19 1993-09-02 Alexander B. Chetverin Novel oligonucleotide arrays and their use for sorting, isolating, sequencing, and manipulating nucleic acids
WO1994003638A1 (en) * 1992-07-30 1994-02-17 Applied Biosystems, Inc. Method of detecting aneuploidy by amplified short tandem repeats
US5273632A (en) 1992-11-19 1993-12-28 University Of Utah Research Foundation Methods and apparatus for analysis of chromatographic migration patterns
US5861242A (en) * 1993-06-25 1999-01-19 Affymetrix, Inc. Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
WO1995011995A1 (en) 1993-10-26 1995-05-04 Affymax Technologies N.V. Arrays of nucleic acid probes on biological chips
US6309823B1 (en) * 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
NZ283660A (en) 1994-03-30 1998-07-28 Mitokor Diagnosis and therapy for diseases associated with mitochondrial defects such as alzheimers
US5861127A (en) * 1997-07-11 1999-01-19 Yeh; Kuo Chung Portable air purifying apparatus

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472842A (en) * 1993-10-06 1995-12-05 The Regents Of The University Of California Detection of amplified or deleted chromosomal regions
US5670314A (en) * 1994-02-22 1997-09-23 Regents Of The University Of California Genetic alterations that correlate with lung carcinomas
US5690894A (en) * 1995-05-23 1997-11-25 The Regents Of The University Of California High density array fabrication and readout method for a fiber optic biosensor

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CHEE M., ET AL.: "ACCESSING GENETIC INFORMATION WITH HIGH-DENSITY DNA ARRAYS.", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, vol. 274., 25 October 1996 (1996-10-25), US, pages 610 - 614., XP002914032, ISSN: 0036-8075, DOI: 10.1126/science.274.5287.610 *
HACIA J. G., ET AL.: "DETECTION OF HETEROZYGOUS MUTATIONS IN BRCA1 USING HIGH DENSITY OLIGONUCLEOTIDE ARRAYS AND TWO-COLOUR FLUORESCENCE ANALYSIS.", NATURE GENETICS., NATURE PUBLISHING GROUP, NEW YORK, US, vol. 14., 1 December 1996 (1996-12-01), NEW YORK, US, pages 441 - 447., XP002914035, ISSN: 1061-4036, DOI: 10.1038/ng1296-441 *
LAAN M., ET AL.: "SOLID-PHASE MINISEQUENCING CONFIRMED BY FISH ANALYSIS IN DETERMINATION OF GENE COPY NUMBER.", HUMAN GENETICS, SPRINGER, BERLIN, DE, vol. 96., 1 January 1995 (1995-01-01), BERLIN, DE, pages 275 - 280., XP002914029, ISSN: 0340-6717, DOI: 10.1007/BF00210406 *
LIPSHUTZ R. J., ET AL.: "USING OLIGONUCLEOTIDE PROBE ARRAYS TO ACCESS GENETIC DIVERSITY.", BIOTECHNIQUES, INFORMA HEALTHCARE, US, vol. 19., no. 03., 1 January 1995 (1995-01-01), US, pages 442 - 447., XP002914033, ISSN: 0736-6205 *
RUDERT W. A., ET AL.: "RAPID DETECTION OF SEQUENCE VARIATIONS USING POLYMERS OF SPECIFIC OLIGONUCLEOTIDES.", NUCLEIC ACIDS RESEARCH, INFORMATION RETRIEVAL LTD., GB, vol. 20., no. 05., 11 March 1992 (1992-03-11), GB, pages 1146., XP002914034, ISSN: 0305-1048 *
See also references of EP0970251A4 *
STICKLAND B., ET AL.: "QUANTIFICATION OF ONCOGENE DOSAGE IN TUMOURS BY SIMULTANEOUS DUAL-LABEL HYBRIDIZATION.", ONCOGENE, NATURE PUBLISHING GROUP, GB, vol. 08., 1 January 1993 (1993-01-01), GB, pages 223 - 227., XP002914030, ISSN: 0950-9232 *
TULLY G., ET AL.: "ANALYSIS OF 6 VNTR LOCI BY "MULTIPLEX" PCR AND AUTOMATED FLUORESCENT DETECTION.", HUMAN GENETICS, SPRINGER, BERLIN, DE, vol. 92., 1 January 1993 (1993-01-01), BERLIN, DE, pages 554 - 562., XP002914031, ISSN: 0340-6717, DOI: 10.1007/BF00420938 *

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