WO1998030883A3 - Analysis of genetic polymorphisms and gene copy number - Google Patents

Analysis of genetic polymorphisms and gene copy number Download PDF

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Publication number
WO1998030883A3
WO1998030883A3 PCT/US1998/006414 US9806414W WO9830883A3 WO 1998030883 A3 WO1998030883 A3 WO 1998030883A3 US 9806414 W US9806414 W US 9806414W WO 9830883 A3 WO9830883 A3 WO 9830883A3
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WO
WIPO (PCT)
Prior art keywords
analysis
copy number
gene copy
genetic polymorphisms
variations
Prior art date
Application number
PCT/US1998/006414
Other languages
French (fr)
Other versions
WO1998030883A2 (en
WO1998030883A9 (en
Inventor
Maureen T Cronin
Charles G Miyada
Earl A Hubbell
Mark Chee
Stephen P A Fodor
Xiaohua C Huang
Robert J Lipshutz
Peter E Lobban
Macdonald S Morris
Edward L Sheldon
Original Assignee
Affymetrix Inc
Maureen T Cronin
Charles G Miyada
Earl A Hubbell
Mark Chee
Stephen P A Fodor
Xiaohua C Huang
Robert J Lipshutz
Peter E Lobban
Macdonald S Morris
Edward L Sheldon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Affymetrix Inc, Maureen T Cronin, Charles G Miyada, Earl A Hubbell, Mark Chee, Stephen P A Fodor, Xiaohua C Huang, Robert J Lipshutz, Peter E Lobban, Macdonald S Morris, Edward L Sheldon filed Critical Affymetrix Inc
Priority to EP98947218A priority Critical patent/EP0970251A4/en
Priority to US09/341,399 priority patent/US6468744B1/en
Publication of WO1998030883A2 publication Critical patent/WO1998030883A2/en
Publication of WO1998030883A3 publication Critical patent/WO1998030883A3/en
Publication of WO1998030883A9 publication Critical patent/WO1998030883A9/en

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    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
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    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • B01J2219/00277—Apparatus
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    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
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    • B01J2219/00603—Making arrays on substantially continuous surfaces
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    • B01J2219/00639—Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
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    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
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    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Abstract

The invention provides methods for detecting variations in polymorphic sites and/or variations in gene copy number. The methods are particularly useful for analysis of biotransformation genes, such as cytochromes P450.
PCT/US1998/006414 1997-01-03 1998-01-02 Analysis of genetic polymorphisms and gene copy number WO1998030883A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP98947218A EP0970251A4 (en) 1997-01-03 1998-01-02 Analysis of genetic polymorphisms and gene copy number
US09/341,399 US6468744B1 (en) 1997-01-03 1998-01-02 Analysis of genetic polymorphisms and gene copy number

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/778,794 1997-01-03
US08/778,794 US6309823B1 (en) 1993-10-26 1997-01-03 Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same

Publications (3)

Publication Number Publication Date
WO1998030883A2 WO1998030883A2 (en) 1998-07-16
WO1998030883A3 true WO1998030883A3 (en) 1998-10-29
WO1998030883A9 WO1998030883A9 (en) 1998-12-17

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PCT/US1998/006414 WO1998030883A2 (en) 1997-01-03 1998-01-02 Analysis of genetic polymorphisms and gene copy number

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US (3) US6309823B1 (en)
EP (1) EP0970251A4 (en)
WO (1) WO1998030883A2 (en)

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