WO1998031415A1 - Drug delivery balloon catheter device - Google Patents

Drug delivery balloon catheter device Download PDF

Info

Publication number
WO1998031415A1
WO1998031415A1 PCT/US1998/000373 US9800373W WO9831415A1 WO 1998031415 A1 WO1998031415 A1 WO 1998031415A1 US 9800373 W US9800373 W US 9800373W WO 9831415 A1 WO9831415 A1 WO 9831415A1
Authority
WO
WIPO (PCT)
Prior art keywords
balloon
sheath
drug
tab
opening
Prior art date
Application number
PCT/US1998/000373
Other languages
French (fr)
Inventor
Vladimir Tsukernik
Original Assignee
Boston Scientific Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Corporation filed Critical Boston Scientific Corporation
Priority to EP98902444A priority Critical patent/EP1007135B1/en
Priority to DE69824011T priority patent/DE69824011T2/en
Priority to CA002277770A priority patent/CA2277770A1/en
Priority to AT98902444T priority patent/ATE267029T1/en
Publication of WO1998031415A1 publication Critical patent/WO1998031415A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes

Definitions

  • Balloon catheters may be used to deliver drugs to tissue at a desired location of a body lumen or cavity.
  • the balloon is positioned at the desired location for drug delivery by sliding it through portions of the body lumen or cavity where no drug delivery is desired. Consequently, it may be difficult to avoid undesired drug release during the positioning of the balloon, particularly when the body lumen or cavity transports bodily fluids into which the drug may be released.
  • U.S. Patent No. 5,304,121 describes a drug delivery system that uses a hydrogel coating.
  • the '121 patent discloses a rigid sheath member extendable over
  • One aspect of the invention generally features a medical device for delivering a drug internally to a patient's body.
  • the device includes a catheter with a catheter shaft and a balloon attached to a distal end of the catheter shaft and a flexible, thin-walled sheath extending over the balloon.
  • the sheath helps to prevent the premature release of the drug during the positioning of the balloon at the desired location for drug delivery. Because the sheath is flexible and thin-walled, the flexibility and outer diameter of the catheter are only minimally affected by the addition of the sheath.
  • the sheath includes a balloon-enveloping portion having an inner diameter sized to fit closely around the balloon and a collar distal to, and having an inner diameter slightly smaller than the inner diameter of, the balloon-enveloping portion.
  • the collar terminates in an opening.
  • the collar has a slightly smaller inner diameter to help prevent the balloon from sliding out of the opening during the positioning of the balloon at the desired location for drug delivery.
  • a tab extends distally from the wall of the sheath.
  • the tab also may be a continuation of part of the wall of the sheath.
  • the tab is used to adjust the sheath with respect to the catheter. Because the tab should be removed before the device is inserted into the patient's body, the sheath may have pre-formed cuts located where the tab is attached to the sheath. The tab is detachable from the sheath by tearing the sheath along the pre-formed cuts.
  • the sheath also may have indentations located at the balloon-enveloping portion to engage the balloon.
  • the indentations are transverse to the balloon axis and help to prevent the balloon from sliding out of the opening during the positioning of the balloon at the desired location for drug delivery.
  • the wall of the sheath has a thickness of no more than 0.04 French.
  • the sheath may be made from polyester, nylon or polyethylene terephthalate (PET) .
  • PET polyethylene terephthalate
  • the invention generally features a device in which the balloon is coated with a hydrogel polymer matrix having a drug embedded therein.
  • the invention generally features a method for delivering a drug internally to a patient's body by providing the above-described device; uncovering the balloon by pushing the balloon out of the opening of the sheath; preparing the balloon by introducing the drug to the surface of the balloon; and covering the balloon by pulling the balloon back through the opening of the sheath until the balloon is proximal of the sheath opening.
  • the method also may include steps such as inserting the device into the body to position the balloon at a desired location of drug delivery; delivering the drug to the body; and removing the device from the body.
  • the outer surface of the balloon may be covered with a hydrogel coating before the uncovering step, and the preparing step may comprise introducing the drug to the hydrogel coating.
  • the outer surface of the balloon may be covered with both a hydrogel coating and the drug during the preparing step.
  • the balloon also may be expanded within the sheath to form a seal between the outer surface of the balloon and the inner surface of the sheath. This helps to prevents bodily fluids from flowing into the sheath.
  • the method may include the steps of covering the balloon by holding the tab and pulling the balloon back through the opening of the sheath until the balloon is proximal of the sheath opening and detaching the tab from the sheath.
  • the detaching step may include tearing the sheath along the pre-formed cuts located where the tab is attached to the sheath.
  • Fig. 1 is a side view, partially in section, of a device for delivering a drug internally to a patient's body.
  • Fig. 1(a) is a cross-sectional view along lines l(a)-l(a) in Fig. 1.
  • Fig. 2 is a cross-sectional view along lines 2-2 in Fig. 1.
  • Fig. 3 is a cross-sectional view along lines 3-3 in Fig. 1.
  • Figs. 4-9 show the steps of delivering a drug internally to the patient's body using the device in Fig. 1.
  • a drug delivery balloon catheter device 1 includes a catheter 4 with a catheter shaft 5 and an expandable balloon 6 attached to a distal end of catheter shaft 5.
  • Device 1 also includes a flexible, thin-walled sheath 10 extending over balloon 6. Sheath 10 helps to prevent the premature release of the drug during the positioning of balloon 6 at the desired location for drug delivery, for example, when sliding balloon 6 through a blood vessel.
  • Catheter shaft 5 is preferably very small in diameter and flexible.
  • Catheter shaft 5 may be formed of hollow tubing to which balloon 6 is attached.
  • Balloon 6 is preferably made from a compliant material such as polyethylene which conforms to the shape of the body lumen wall. Balloon 6 may also be made from other materials used in angioplasty, e.g., a nondistending material, such as polyethylene terephthalate (PET) .
  • PET polyethylene terephthalate
  • Balloon 6 has a swellable hydrogel polymer coating which can absorb a substantial amount of the drug, typically in aqueous solution form.
  • the hydrogel polymer coating is swellable and, in use, the hydrogel releases the drug.
  • the hydrogel may itself be released from the surface of the balloon, or it may release the drug while generally remaining adhered to the balloon (see the '121 patent) .
  • suitable hydrogel polymers such as cross-linked polymer materials formed from the combination of a colloid and water.
  • the drug is preferably water soluble so that it may be easily absorbed into the hydrogel polymer coating.
  • the hydrogel polymer and drug preferably are not complexed, i.e., they are held together primarily if not exclusively through non-covalent association that results when the hydrogel polymer swells and absorbs the drug. In other embodiments, however, it may be advantageous to select a hydrogel polymer coating for a particular drug such that the drug is not substantially released into bodily fluids before expanding balloon 6. Binding of the drug may be accomplished by electrostatic attraction of the drug to the coating or a coating additive or by mechanical binding, e.g., using a coating having a pore size that inhibits inward flow of bodily fluids or outward flow of the drug.
  • the drug may be an antithrombogenic drug or an antiproliferative drug.
  • Antithrombogenic drugs include heparin, PPack (dextrophenylalanine proline arginine chloromethylketone) , enoxaprin, aspirin and hirudin.
  • Antiproliferative drugs include monoclonal antibodies capable of blocking smooth muscle cell proliferation, heparin, angiopeptin and exoxaprin.
  • the dosage applied to the tissue may be controlled by regulating the time of presoaking the drug into the hydrogel polymer coating to determine the amount of absorption of the drug solution by the hydrogel polymer coating.
  • Other factors affecting the dosage are the concentration of the drug in the solution applied to the coating and the releasability of the hydrogel polymer coating determined by, for example, the thickness of the hydrogel polymer coating, its resiliency, porosity and the ability of the hydrogel polymer coating to retain the drug.
  • sheath 10 is covered by sheath 10 during the positioning of balloon 6 at the desired location for drug delivery.
  • Sheath 10 is flexible and has a thickness of no more than 0.04 French. Thus, sheath 10 increases the outer diameter of catheter 4 by only approximately 0.1 French.
  • sheath 10 is preferably made from polyethylene terephthalate (PET)
  • PET polyethylene terephthalate
  • sheath 10 also may be made from nylon or polyester. Thus, the flexibility and outer diameter of catheter 4 are only minimally affected by the addition of sheath 10.
  • Sheath 10 has a balloon-enveloping portion 12 and a collar 14.
  • Balloon-enveloping portion 12 has an inner diameter sized to fit closely around folded balloon 6.
  • Collar 14 is distal to, and has an inner diameter slightly smaller than the inner diameter of, the balloon- enveloping portion 12.
  • Collar 14 terminates in an opening 16. The slightly smaller inner diameter of collar 14 helps to prevent balloon 6 from sliding out of opening 16 during the positioning of balloon 6 at the desired location for drug delivery.
  • Sheath 10 also has indentations 20 in the wall of sheath 10 located at a distal end of balloon-enveloping portion 12. Indentations 20 help to prevent balloon 6 from sliding out of opening 16 during the positioning of balloon 6 at the desired location for drug delivery. Indentations 20 are molded into the wall of sheath 10 and are transverse to the balloon axis. Indentations 20 may be straightened out temporarily by pulling on the wall of sheath 10.
  • Sheath 10 also includes a tab 22 extending distally from the wall of sheath 10.
  • Tab 22 may be used to adjust sheath 10 with respect to catheter 4. As described below, tab 22 should be removed from sheath 10 before insertion into the patient's body. Removal is achieved by tearing along pre-formed cuts 24 in the wall of sheath 10, located where tab 22 is attached to sheath 10.
  • device 1 may include a relatively stiff tubing 26 and adapter 28 disposed at the proximal end (outside the patient's body) for a better seal between sheath 10 and catheter 4.
  • a drug may be delivered internally to the patient's body using device 1 as follows.
  • Drug and hydrogel coating typically are added to the balloon surface shortly before the device is inserted into the patient's body.
  • balloon 6 is exposed by pushing it out of opening 16 of sheath 10.
  • Balloon 6 is expanded, and a drug in an aqueous solution is absorbed into the hydrogel polymer coating, for example by immersing it in a small vial 7 containing the drug, as shown in Fig. 4.
  • the drug may be applied to the balloon in the form of droplets from an eyedropper, or it may be precipitated into the hydrogel polymer coating before sterilization and the coated balloon catheter is sold as a finished device.
  • balloon 6 After balloon 6 is dried and deflated, balloon 6 is covered with sheath 10 by pulling balloon 6 back into sheath 10 while holding tab 22, as shown in Fig. 5. Balloon 6 is positioned within sheath 10, so that balloon 6 is proximal of collar 14 of sheath 10. Tab 22 is detached from sheath 10 by tearing or cutting along pre- formed cuts 24 (Fig. 6) before inserting the device into the patient.
  • tab 22 is helpful in manipulating the flexible, thin-walled sheath
  • other embodiments of the invention may describe other ways for adjusting the relative positions of the sheath and balloon.
  • the balloon may be pulled back into the sheath by using forceps to hold the sheath.
  • the balloon may be covered with the sheath by unrolling the sheath over the balloon.
  • balloon may be slightly expanded so that the outer surface of balloon 6 contacts with the inner surface of sheath 10, thereby forming a seal between the outer surface of balloon 6 with the inner surface of sheath 10. This helps to prevent bodily fluids from flowing into sheath 10. Balloon 6 is then deflated.
  • device 1 is inserted into a blood vessel having a region to be treated, such as an occlusion due to deposits of plaque on the vessel wall tissue.
  • Device 1 is moved along the vessel to position balloon 6 at the desired location for drug delivery.
  • balloon 6 is uncovered by pulling on sheath 10 while maintaining balloon 6 in position. Balloon.6 slides out of opening 16 of sheath 10. As balloon 6 is expanded, the drug is released for transfer into the plaque and tissue. As shown in Fig. 9, the pressure applied to the plaque and tissue by the expansion of balloon 6 enhances the transfer of the drug into the plaque and tissue. After the drug is delivered to the tissue, balloon 6 is deflated and removed from the patient's body.

Abstract

This invention is a medical device for delivering a drug internally to a patient's body. The medical device includes a catheter (4) with a catheter shaft (5) and a balloon (6) attached to a distal end of the catheter shaft (5), and a flexible, thin-walled sheath (10) extending over the balloon (6). The sheath (10) includes a balloon enveloping portion (12) having an inner diameter sized to fit closely around the balloon (6) and a collar (14) distal to, and having an inner diameter slightly smaller than the inner diameter of the balloon enveloping portion (12). The collar (14) terminates in an opening, and a tab (22) extends distally from a wall of the sheath (10).

Description

DRUG DELIVERY BALLOON CATHETER DEVICE This application relates to delivering drugs internally to a patient's body. Background of the Invention
Balloon catheters may be used to deliver drugs to tissue at a desired location of a body lumen or cavity. Typically, the balloon is positioned at the desired location for drug delivery by sliding it through portions of the body lumen or cavity where no drug delivery is desired. Consequently, it may be difficult to avoid undesired drug release during the positioning of the balloon, particularly when the body lumen or cavity transports bodily fluids into which the drug may be released.
U.S. Patent No. 5,304,121 describes a drug delivery system that uses a hydrogel coating. The '121 patent discloses a rigid sheath member extendable over
I the hydrogel coating to help prevent the release of the drug into bodily fluids. The entire disclosure of the ' 121 patent is hereby incorporated herein by reference.
Summary of the Invention One aspect of the invention generally features a medical device for delivering a drug internally to a patient's body. The device includes a catheter with a catheter shaft and a balloon attached to a distal end of the catheter shaft and a flexible, thin-walled sheath extending over the balloon. The sheath helps to prevent the premature release of the drug during the positioning of the balloon at the desired location for drug delivery. Because the sheath is flexible and thin-walled, the flexibility and outer diameter of the catheter are only minimally affected by the addition of the sheath.
The sheath includes a balloon-enveloping portion having an inner diameter sized to fit closely around the balloon and a collar distal to, and having an inner diameter slightly smaller than the inner diameter of, the balloon-enveloping portion. The collar terminates in an opening. The collar has a slightly smaller inner diameter to help prevent the balloon from sliding out of the opening during the positioning of the balloon at the desired location for drug delivery.
To facilitate the use of a flexible, thin-walled sheath which might otherwise be difficult to manipulate in certain operations described below in which the relative positions of the sheath and balloon are adjusted, a tab extends distally from the wall of the sheath. The tab also may be a continuation of part of the wall of the sheath. The tab is used to adjust the sheath with respect to the catheter. Because the tab should be removed before the device is inserted into the patient's body, the sheath may have pre-formed cuts located where the tab is attached to the sheath. The tab is detachable from the sheath by tearing the sheath along the pre-formed cuts.
The sheath also may have indentations located at the balloon-enveloping portion to engage the balloon. The indentations are transverse to the balloon axis and help to prevent the balloon from sliding out of the opening during the positioning of the balloon at the desired location for drug delivery.
The wall of the sheath has a thickness of no more than 0.04 French. Also, the sheath may be made from polyester, nylon or polyethylene terephthalate (PET) . In another aspect, the invention generally features a device in which the balloon is coated with a hydrogel polymer matrix having a drug embedded therein.
In yet another aspect, the invention generally features a method for delivering a drug internally to a patient's body by providing the above-described device; uncovering the balloon by pushing the balloon out of the opening of the sheath; preparing the balloon by introducing the drug to the surface of the balloon; and covering the balloon by pulling the balloon back through the opening of the sheath until the balloon is proximal of the sheath opening. The method also may include steps such as inserting the device into the body to position the balloon at a desired location of drug delivery; delivering the drug to the body; and removing the device from the body.
Moreover, the outer surface of the balloon may be covered with a hydrogel coating before the uncovering step, and the preparing step may comprise introducing the drug to the hydrogel coating. In another embodiment, the outer surface of the balloon may be covered with both a hydrogel coating and the drug during the preparing step. The balloon also may be expanded within the sheath to form a seal between the outer surface of the balloon and the inner surface of the sheath. This helps to prevents bodily fluids from flowing into the sheath.
If the sheath has a tab, the method may include the steps of covering the balloon by holding the tab and pulling the balloon back through the opening of the sheath until the balloon is proximal of the sheath opening and detaching the tab from the sheath. The detaching step may include tearing the sheath along the pre-formed cuts located where the tab is attached to the sheath.
Other features and advantages will be apparent from the following drawings, description of the preferred embodiments and claims. Brief Description of the Drawing Fig. 1 is a side view, partially in section, of a device for delivering a drug internally to a patient's body. Fig. 1(a) is a cross-sectional view along lines l(a)-l(a) in Fig. 1.
Fig. 2 is a cross-sectional view along lines 2-2 in Fig. 1.
Fig. 3 is a cross-sectional view along lines 3-3 in Fig. 1.
Figs. 4-9 show the steps of delivering a drug internally to the patient's body using the device in Fig. 1.
Description of the Preferred Embodiments Referring to Figs. 1-3, a drug delivery balloon catheter device 1 includes a catheter 4 with a catheter shaft 5 and an expandable balloon 6 attached to a distal end of catheter shaft 5. Device 1 also includes a flexible, thin-walled sheath 10 extending over balloon 6. Sheath 10 helps to prevent the premature release of the drug during the positioning of balloon 6 at the desired location for drug delivery, for example, when sliding balloon 6 through a blood vessel.
Catheter shaft 5 is preferably very small in diameter and flexible. Catheter shaft 5 may be formed of hollow tubing to which balloon 6 is attached. Balloon 6 is preferably made from a compliant material such as polyethylene which conforms to the shape of the body lumen wall. Balloon 6 may also be made from other materials used in angioplasty, e.g., a nondistending material, such as polyethylene terephthalate (PET) .
Balloon 6 has a swellable hydrogel polymer coating which can absorb a substantial amount of the drug, typically in aqueous solution form. The hydrogel polymer coating is swellable and, in use, the hydrogel releases the drug. The hydrogel may itself be released from the surface of the balloon, or it may release the drug while generally remaining adhered to the balloon (see the '121 patent) . Those of ordinary skill in the art will understand that there are a number of suitable hydrogel polymers that can be used, such as cross-linked polymer materials formed from the combination of a colloid and water. The drug is preferably water soluble so that it may be easily absorbed into the hydrogel polymer coating. The hydrogel polymer and drug preferably are not complexed, i.e., they are held together primarily if not exclusively through non-covalent association that results when the hydrogel polymer swells and absorbs the drug. In other embodiments, however, it may be advantageous to select a hydrogel polymer coating for a particular drug such that the drug is not substantially released into bodily fluids before expanding balloon 6. Binding of the drug may be accomplished by electrostatic attraction of the drug to the coating or a coating additive or by mechanical binding, e.g., using a coating having a pore size that inhibits inward flow of bodily fluids or outward flow of the drug. The drug may be an antithrombogenic drug or an antiproliferative drug. Antithrombogenic drugs include heparin, PPack (dextrophenylalanine proline arginine chloromethylketone) , enoxaprin, aspirin and hirudin. Antiproliferative drugs include monoclonal antibodies capable of blocking smooth muscle cell proliferation, heparin, angiopeptin and exoxaprin.
The dosage applied to the tissue may be controlled by regulating the time of presoaking the drug into the hydrogel polymer coating to determine the amount of absorption of the drug solution by the hydrogel polymer coating. Other factors affecting the dosage are the concentration of the drug in the solution applied to the coating and the releasability of the hydrogel polymer coating determined by, for example, the thickness of the hydrogel polymer coating, its resiliency, porosity and the ability of the hydrogel polymer coating to retain the drug.
To protect against premature release of the drug and hydrogel, catheter 4 is covered by sheath 10 during the positioning of balloon 6 at the desired location for drug delivery. Sheath 10 is flexible and has a thickness of no more than 0.04 French. Thus, sheath 10 increases the outer diameter of catheter 4 by only approximately 0.1 French. Although sheath 10 is preferably made from polyethylene terephthalate (PET) , sheath 10 also may be made from nylon or polyester. Thus, the flexibility and outer diameter of catheter 4 are only minimally affected by the addition of sheath 10.
Sheath 10 has a balloon-enveloping portion 12 and a collar 14. Balloon-enveloping portion 12 has an inner diameter sized to fit closely around folded balloon 6. Collar 14 is distal to, and has an inner diameter slightly smaller than the inner diameter of, the balloon- enveloping portion 12. Collar 14 terminates in an opening 16. The slightly smaller inner diameter of collar 14 helps to prevent balloon 6 from sliding out of opening 16 during the positioning of balloon 6 at the desired location for drug delivery.
Sheath 10 also has indentations 20 in the wall of sheath 10 located at a distal end of balloon-enveloping portion 12. Indentations 20 help to prevent balloon 6 from sliding out of opening 16 during the positioning of balloon 6 at the desired location for drug delivery. Indentations 20 are molded into the wall of sheath 10 and are transverse to the balloon axis. Indentations 20 may be straightened out temporarily by pulling on the wall of sheath 10.
Sheath 10 also includes a tab 22 extending distally from the wall of sheath 10. Tab 22 may be used to adjust sheath 10 with respect to catheter 4. As described below, tab 22 should be removed from sheath 10 before insertion into the patient's body. Removal is achieved by tearing along pre-formed cuts 24 in the wall of sheath 10, located where tab 22 is attached to sheath 10.
Finally, device 1 may include a relatively stiff tubing 26 and adapter 28 disposed at the proximal end (outside the patient's body) for a better seal between sheath 10 and catheter 4. II. Use
Referring to Figs. 4-9, a drug may be delivered internally to the patient's body using device 1 as follows. Drug and hydrogel coating typically are added to the balloon surface shortly before the device is inserted into the patient's body. First, balloon 6 is exposed by pushing it out of opening 16 of sheath 10. Balloon 6 is expanded, and a drug in an aqueous solution is absorbed into the hydrogel polymer coating, for example by immersing it in a small vial 7 containing the drug, as shown in Fig. 4. Alternatively, the drug may be applied to the balloon in the form of droplets from an eyedropper, or it may be precipitated into the hydrogel polymer coating before sterilization and the coated balloon catheter is sold as a finished device. After balloon 6 is dried and deflated, balloon 6 is covered with sheath 10 by pulling balloon 6 back into sheath 10 while holding tab 22, as shown in Fig. 5. Balloon 6 is positioned within sheath 10, so that balloon 6 is proximal of collar 14 of sheath 10. Tab 22 is detached from sheath 10 by tearing or cutting along pre- formed cuts 24 (Fig. 6) before inserting the device into the patient.
Although tab 22 is helpful in manipulating the flexible, thin-walled sheath, other embodiments of the invention may describe other ways for adjusting the relative positions of the sheath and balloon. For example, the balloon may be pulled back into the sheath by using forceps to hold the sheath. In another embodiment, the balloon may be covered with the sheath by unrolling the sheath over the balloon.
After balloon 6 is positioned within sheath 10, balloon may be slightly expanded so that the outer surface of balloon 6 contacts with the inner surface of sheath 10, thereby forming a seal between the outer surface of balloon 6 with the inner surface of sheath 10. This helps to prevent bodily fluids from flowing into sheath 10. Balloon 6 is then deflated.
In Fig. 7, device 1 is inserted into a blood vessel having a region to be treated, such as an occlusion due to deposits of plaque on the vessel wall tissue. Device 1 is moved along the vessel to position balloon 6 at the desired location for drug delivery.
Referring to Fig. 8, after balloon 6 is positioned at desired location for drug delivery, balloon 6 is uncovered by pulling on sheath 10 while maintaining balloon 6 in position. Balloon.6 slides out of opening 16 of sheath 10. As balloon 6 is expanded, the drug is released for transfer into the plaque and tissue. As shown in Fig. 9, the pressure applied to the plaque and tissue by the expansion of balloon 6 enhances the transfer of the drug into the plaque and tissue. After the drug is delivered to the tissue, balloon 6 is deflated and removed from the patient's body.

Claims

What is claimed is:
1. A medical device for delivering a drug internally to a patient's body comprising: a catheter with a catheter shaft and a balloon attached to a distal end of the catheter shaft; and a flexible, thin-walled sheath extending over the balloon, wherein the sheath includes a balloon-enveloping portion having an inner diameter sized to fit closely around the balloon, and a collar distal to, and having an inner diameter slightly smaller than the inner diameter of, the balloon-enveloping portion, the collar terminating in an opening.
2. The device of claim 1 further comprising a tab extending distally from the wall of the sheath.
3. The device of claim 2 wherein the tab is a continuation of part of the wall of the sheath.
4. The device of claim 2 wherein the sheath has pre-formed cuts located where the tab is attached to the sheath.
5. The device of claim 4 wherein the tab is detachable from the sheath by tearing the sheath along the pre-formed cuts.
6. The device of claim 1 wherein the sheath has indentations located at the balloon-enveloping portion to engage the balloon.
7. The device of claim 1 wherein the wall of the sheath has a thickness of no more than 0.04 French.
8. The device of claim 1 wherein the sheath is made from polyester, nylon or polyethylene terephthalate (PET) .
9. The device of claim 1 wherein the balloon is coated with a hydrogel polymer matrix having a drug embedded therein.
10. A method for delivering a drug internally to a patient's body comprising: providing the device of claim 1; uncovering the balloon by pushing the balloon out of the opening of the sheath; preparing the balloon by introducing the drug to the surface of the balloon; and covering the balloon by pulling the balloon back through the opening of the sheath until the balloon is proximal of the sheath opening.
11. The method of claim 10 further comprising: inserting the device into the body to position the balloon at a desired location of drug delivery; delivering the drug to the body; and removing the device from the body.
12. The method of claim 10 wherein the outer surface of the balloon is covered with a hydrogel coating before the uncovering step, and the preparing step comprises introducing the drug to the hydrogel coating.
13. The method of claim 10 wherein the outer surface of the balloon is covered with both a hydrogel coating and the drug during the preparing step.
14. The method of claim 10 further comprising expanding the balloon within the sheath to form a seal between the outer surface of the balloon and the inner surface of the sheath.
15. A method for delivering a drug internally to a patient's body comprising: providing the device of claim 2; uncovering the balloon by pushing the balloon out of the opening of the sheath; preparing the balloon by introducing a drug to the surface of the balloon; covering the balloon by holding the tab and pulling the balloon back through the opening of the sheath until the balloon is proximal of the sheath opening; and detaching the tab from the sheath.
16. The method of claim 14 wherein the detaching step comprises tearing the sheath along pre-formed cuts located where the tab is attached to the sheath.
PCT/US1998/000373 1997-01-15 1998-01-12 Drug delivery balloon catheter device WO1998031415A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP98902444A EP1007135B1 (en) 1997-01-15 1998-01-12 Drug delivery balloon catheter device
DE69824011T DE69824011T2 (en) 1997-01-15 1998-01-12 BALLON CATHETER FOR DRUG DELIVERY
CA002277770A CA2277770A1 (en) 1997-01-15 1998-01-12 Drug delivery balloon catheter device
AT98902444T ATE267029T1 (en) 1997-01-15 1998-01-12 BALLOON CATHETER FOR MEDICINAL DELIVERY

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/782,684 1997-01-15
US08/782,684 US5868719A (en) 1997-01-15 1997-01-15 Drug delivery balloon catheter device

Publications (1)

Publication Number Publication Date
WO1998031415A1 true WO1998031415A1 (en) 1998-07-23

Family

ID=25126855

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/000373 WO1998031415A1 (en) 1997-01-15 1998-01-12 Drug delivery balloon catheter device

Country Status (6)

Country Link
US (1) US5868719A (en)
EP (1) EP1007135B1 (en)
AT (1) ATE267029T1 (en)
CA (1) CA2277770A1 (en)
DE (1) DE69824011T2 (en)
WO (1) WO1998031415A1 (en)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395208B1 (en) 1999-01-25 2002-05-28 Atrium Medical Corporation Method of making an expandable fluoropolymer device
US7654264B2 (en) 2006-07-18 2010-02-02 Nellcor Puritan Bennett Llc Medical tube including an inflatable cuff having a notched collar
EP2231254A2 (en) * 2007-12-11 2010-09-29 Massachusetts Institute of Technology Implantable drug delivery device and methods for treatment of the bladder and other body vesicles or lumens
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US9017312B2 (en) 2009-09-10 2015-04-28 Taris Biomedical Llc Implantable device for controlled drug delivery
US9050442B2 (en) 1999-01-25 2015-06-09 Atrium Medical Corporation Expandable fluoropolymer device for delivery of therapeutic agents and method of making
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
US9066990B2 (en) 2001-03-26 2015-06-30 Bayer Intellectual Property Gmbh Preparation for restenosis prevention
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US9283361B2 (en) 2010-08-05 2016-03-15 Taris Biomedical Llc Implantable drug delivery devices for genitourinary sites
US9649476B2 (en) 2002-09-20 2017-05-16 Bayer Intellectual Property Gmbh Medical device for dispersing medicaments
US9730820B2 (en) 2008-09-25 2017-08-15 Abbott Cardiovascular Systems Inc. Stent delivery system having a fibrous matrix covering with improved stent retention
US10080821B2 (en) 2009-07-17 2018-09-25 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
US10137078B2 (en) 2009-06-26 2018-11-27 Taris Biomedical Llc Methods for intravesical drug delivery and methods and systems for loading devices with drug tablets
US10286199B2 (en) 2013-03-15 2019-05-14 Taris Biomedical Llc Drug delivery devices with drug-permeable component and methods
US10369256B2 (en) 2009-07-10 2019-08-06 Boston Scientific Scimed, Inc. Use of nanocrystals for drug delivery from a balloon
US10729823B2 (en) 2013-08-19 2020-08-04 Taris Biomedical Llc Multi-unit drug delivery devices and methods
US10894150B2 (en) 2015-04-23 2021-01-19 Taris Biomedical Llc Drug delivery devices with drug-permeable component and methods

Families Citing this family (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6958059B2 (en) 1996-05-20 2005-10-25 Medtronic Ave, Inc. Methods and apparatuses for drug delivery to an intravascular occlusion
US6165158A (en) 1998-10-14 2000-12-26 Advanced Cardiovascular Systems, Inc. Lubricious catheter shaft
US7637886B2 (en) * 1999-01-25 2009-12-29 Atrium Medical Corporation Expandable fluoropolymer device and method of making
US6364867B2 (en) * 1999-07-01 2002-04-02 Catheter Innovations, Inc. Anti-clotting methods and apparatus for indwelling catheter tubes
US8172783B1 (en) 1999-12-30 2012-05-08 Advanced Cardiovascular Systems, Inc Conduit system for isolation of fluids in biological tissues
US20050271701A1 (en) * 2000-03-15 2005-12-08 Orbus Medical Technologies, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en) * 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US8088060B2 (en) * 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US6471968B1 (en) 2000-05-12 2002-10-29 Regents Of The University Of Michigan Multifunctional nanodevice platform
US7481790B2 (en) * 2000-12-27 2009-01-27 Advanced Cardiovascular Systems, Inc. Vessel enlargement by arteriogenic factor delivery
US6796960B2 (en) * 2001-05-04 2004-09-28 Wit Ip Corporation Low thermal resistance elastic sleeves for medical device balloons
ATE426427T1 (en) 2001-11-09 2009-04-15 Angioscore Inc BALLOON CATHETER WITH NON-DELIVEABLE STENT
US20040111108A1 (en) 2001-11-09 2004-06-10 Farnan Robert C. Balloon catheter with non-deployable stent
US20050267407A1 (en) * 2002-02-01 2005-12-01 Vascular Designs, Inc. Multi-function catheter and use thereof
WO2003065872A2 (en) * 2002-02-01 2003-08-14 Goldman Robert J Multi-function catheter and use thereof
US8062251B2 (en) * 2002-02-01 2011-11-22 Vascular Designs, Inc. Multi-function catheter and use thereof
US20030236506A1 (en) * 2002-06-20 2003-12-25 Eric Schofield Dual outside diameter cannula for insertion into bone
EP1521603B1 (en) * 2002-07-12 2011-01-19 Cook Incorporated Coated medical device
US7686824B2 (en) * 2003-01-21 2010-03-30 Angioscore, Inc. Apparatus and methods for treating hardened vascular lesions
US8080026B2 (en) 2003-01-21 2011-12-20 Angioscore, Inc. Apparatus and methods for treating hardened vascular lesions
US8740844B2 (en) * 2003-08-20 2014-06-03 Boston Scientific Scimed, Inc. Medical device with drug delivery member
EP1663343B8 (en) * 2003-09-15 2019-12-04 Atrium Medical Corporation Application of a therapeutic substance to a tissue location using an expandable medical device
US9078570B2 (en) * 2003-10-10 2015-07-14 Sierra Scientific Instruments, Inc. High resolution solid state pressure sensor
US9241735B2 (en) * 2003-12-05 2016-01-26 Onset Medical Corporation Expandable percutaneous sheath
US7349971B2 (en) * 2004-02-05 2008-03-25 Scenera Technologies, Llc System for transmitting data utilizing multiple communication applications simultaneously in response to user request without specifying recipient's communication information
US20090104119A1 (en) * 2004-08-25 2009-04-23 Majoros Istvan J Dendrimer Based Compositions And Methods Of Using The Same
US7892203B2 (en) 2004-09-09 2011-02-22 Onset Medical Corporation Expandable transluminal sheath
US20060135981A1 (en) 2004-09-09 2006-06-22 Jay Lenker Expandable transluminal sheath
US20060083770A1 (en) * 2004-10-15 2006-04-20 Specialty Coating Systems, Inc. Medical devices and methods of preparation and use
US10076641B2 (en) * 2005-05-11 2018-09-18 The Spectranetics Corporation Methods and systems for delivering substances into luminal walls
US20070041934A1 (en) * 2005-08-12 2007-02-22 Regents Of The University Of Michigan Dendrimer based compositions and methods of using the same
US20070148390A1 (en) * 2005-12-27 2007-06-28 Specialty Coating Systems, Inc. Fluorinated coatings
US20080243068A1 (en) * 2005-12-29 2008-10-02 Kamal Ramzipoor Methods and apparatus for treatment of venous insufficiency
US20070296125A1 (en) * 2006-06-22 2007-12-27 Joel Colburn Thin cuff for use with medical tubing and method and apparatus for making the same
US20070295337A1 (en) * 2006-06-22 2007-12-27 Nelson Donald S Endotracheal cuff and technique for using the same
US8434487B2 (en) * 2006-06-22 2013-05-07 Covidien Lp Endotracheal cuff and technique for using the same
US8196584B2 (en) 2006-06-22 2012-06-12 Nellcor Puritan Bennett Llc Endotracheal cuff and technique for using the same
PL2386322T3 (en) * 2006-07-03 2018-06-29 Hemoteq Ag Production, method and use of medical products which release agents for opening blood vessels on a permanent basis
US20080053454A1 (en) * 2006-09-01 2008-03-06 Nellcor Puritan Bennett Incorporated Endotracheal tube including a partially inverted cuff collar
US8684175B2 (en) 2006-09-22 2014-04-01 Covidien Lp Method for shipping and protecting an endotracheal tube with an inflated cuff
US8561614B2 (en) * 2006-09-28 2013-10-22 Covidien Lp Multi-layer cuffs for medical devices
US20080078405A1 (en) * 2006-09-29 2008-04-03 Crumback Gary L Self-sizing adjustable endotracheal tube
US20080078401A1 (en) * 2006-09-29 2008-04-03 Nellcor Puritan Bennett Incorporated Self-sizing adjustable endotracheal tube
US8807136B2 (en) * 2006-09-29 2014-08-19 Covidien Lp Self-sizing adjustable endotracheal tube
US20080078399A1 (en) 2006-09-29 2008-04-03 O'neil Michael P Self-sizing adjustable endotracheal tube
US7950393B2 (en) * 2006-09-29 2011-05-31 Nellcor Puritan Bennett Llc Endotracheal cuff and technique for using the same
US8307830B2 (en) 2006-09-29 2012-11-13 Nellcor Puritan Bennett Llc Endotracheal cuff and technique for using the same
US8414910B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US8430055B2 (en) * 2008-08-29 2013-04-30 Lutonix, Inc. Methods and apparatuses for coating balloon catheters
US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
US9700704B2 (en) 2006-11-20 2017-07-11 Lutonix, Inc. Drug releasing coatings for balloon catheters
US8414526B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Medical device rapid drug releasing coatings comprising oils, fatty acids, and/or lipids
US8425459B2 (en) 2006-11-20 2013-04-23 Lutonix, Inc. Medical device rapid drug releasing coatings comprising a therapeutic agent and a contrast agent
US20080276935A1 (en) 2006-11-20 2008-11-13 Lixiao Wang Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
US8998846B2 (en) 2006-11-20 2015-04-07 Lutonix, Inc. Drug releasing coatings for balloon catheters
US20080175887A1 (en) 2006-11-20 2008-07-24 Lixiao Wang Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs
US8414525B2 (en) 2006-11-20 2013-04-09 Lutonix, Inc. Drug releasing coatings for medical devices
US20080140002A1 (en) * 2006-12-06 2008-06-12 Kamal Ramzipoor System for delivery of biologically active substances with actuating three dimensional surface
US20080140022A1 (en) * 2006-12-08 2008-06-12 Warsaw Orthopedic, Inc. Coated Cannula with Protective Tip for Insertion Into a Patient
KR101144984B1 (en) * 2007-01-21 2012-05-21 헤모텍 아게 Medical product for treating stenosis of body passages and for preventing threatening restenosis
US20080215034A1 (en) * 2007-03-02 2008-09-04 Jessica Clayton Endotracheal cuff and technique for using the same
US20080210243A1 (en) * 2007-03-02 2008-09-04 Jessica Clayton Endotracheal cuff and technique for using the same
US20090088376A1 (en) * 2007-04-19 2009-04-02 The Regents Of The University Of Michigan Dendrimer based compositions and methods of using the same
US9370642B2 (en) 2007-06-29 2016-06-21 J.W. Medical Systems Ltd. Adjustable-length drug delivery balloon
US8750978B2 (en) * 2007-12-31 2014-06-10 Covidien Lp System and sensor for early detection of shock or perfusion failure and technique for using the same
US8252834B2 (en) 2008-03-12 2012-08-28 The Regents Of The University Of Michigan Dendrimer conjugates
US8049061B2 (en) 2008-09-25 2011-11-01 Abbott Cardiovascular Systems, Inc. Expandable member formed of a fibrous matrix having hydrogel polymer for intraluminal drug delivery
US8226603B2 (en) * 2008-09-25 2012-07-24 Abbott Cardiovascular Systems Inc. Expandable member having a covering formed of a fibrous matrix for intraluminal drug delivery
US8076529B2 (en) * 2008-09-26 2011-12-13 Abbott Cardiovascular Systems, Inc. Expandable member formed of a fibrous matrix for intraluminal drug delivery
US8889635B2 (en) 2008-09-30 2014-11-18 The Regents Of The University Of Michigan Dendrimer conjugates
WO2010054321A2 (en) 2008-11-07 2010-05-14 The Regents Of The University Of Michigan Methods of treating autoimmune disorders and/or inflammatory disorders
US8590534B2 (en) * 2009-06-22 2013-11-26 Covidien Lp Cuff for use with medical tubing and method and apparatus for making the same
US8828040B2 (en) * 2009-07-07 2014-09-09 Thomas G. Goff Device and methods for delivery and transfer of temporary radiopaque element
US8945508B2 (en) 2009-10-13 2015-02-03 The Regents Of The University Of Michigan Dendrimer compositions and methods of synthesis
US8912323B2 (en) 2009-10-30 2014-12-16 The Regents Of The University Of Michigan Multifunctional small molecules
US8900603B2 (en) * 2009-12-18 2014-12-02 Interface Biologics, Inc. Local delivery of drugs from self assembled coatings
US9199066B2 (en) * 2010-03-12 2015-12-01 Quattro Vascular Pte Ltd. Device and method for compartmental vessel treatment
EP2380604A1 (en) 2010-04-19 2011-10-26 InnoRa Gmbh Improved coating formulations for scoring or cutting balloon catheters
US9943668B2 (en) 2010-07-16 2018-04-17 Sub3 Vascular, Llc Guidewire and catheter system and method for treating a blood clot
US8632559B2 (en) 2010-09-21 2014-01-21 Angioscore, Inc. Method and system for treating valve stenosis
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US9402911B2 (en) 2011-12-08 2016-08-02 The Regents Of The University Of Michigan Multifunctional small molecules
KR20140114856A (en) 2012-02-01 2014-09-29 콰트로 배스큘러 피티이 리미티드 Device for compartmental dilatation of blood vessels
EP2811947B1 (en) 2012-02-08 2019-03-27 TriReme Medical, LLC Constraining structure with non-linear axial struts
US9216033B2 (en) 2012-02-08 2015-12-22 Quattro Vascular Pte Ltd. System and method for treating biological vessels
EP2991718B1 (en) 2013-05-03 2019-11-13 C.R. Bard, Inc. Peelable protective sheath
US10117668B2 (en) 2013-10-08 2018-11-06 The Spectranetics Corporation Balloon catheter with non-deployable stent having improved stability
WO2015077545A1 (en) 2013-11-24 2015-05-28 Cordis Corporation Drug delivery system
RU2635557C2 (en) 2014-01-13 2017-11-14 Хафид БЕЛХАДЖ-ТАХАР Dendrimeric compositions, methods for their synthesis and their application
US20170119892A1 (en) 2014-04-04 2017-05-04 President And Fellows Of Harvard College Refillable drug delivery devices and methods of use thereof
CN107106822B (en) 2014-11-17 2021-05-04 特里雷米医疗有限责任公司 Balloon catheter system
AU2016238290B9 (en) 2015-03-25 2019-06-13 The Regents Of The University Of Michigan Compositions and methods for delivery of biomacromolecule agents
WO2017158436A1 (en) 2016-03-17 2017-09-21 Oslo Universitetssykehus Hf Fusion proteins targeting tumour associated macrophages for treating cancer
US20190358263A1 (en) 2016-12-07 2019-11-28 Oslo Universitetssykehus Hf Compositions and Methods for Cell Therapy
CN109381783A (en) * 2017-08-02 2019-02-26 杭州唯强医疗科技有限公司 Drug coated balloon catheter
US10688287B2 (en) 2018-01-19 2020-06-23 Medtronic, Inc. Sheath including sheath body and sheath insert
US10737071B2 (en) 2018-01-19 2020-08-11 Medtronic, Inc. Splittable sheath
US10682492B2 (en) 2018-01-19 2020-06-16 Medtronic Vascular, Inc. Expandable balloon sheath
US10668255B2 (en) 2018-01-19 2020-06-02 Medtronic Vascular, Inc. Sheath for medically expandable balloon
US10702673B2 (en) 2018-01-19 2020-07-07 Medtronic Vascular, Inc. Expandable balloon sheaths
US10851072B2 (en) 2018-04-06 2020-12-01 The Regents Of The University Of Michigan Inhibitors of Rho/MRTF/SRF-mediated gene transcription and methods for use of the same
CN112638436A (en) 2018-05-22 2021-04-09 界面生物公司 Compositions and methods for drug delivery to vessel walls
US11389627B1 (en) 2018-10-02 2022-07-19 Lutonix Inc. Balloon protectors, balloon-catheter assemblies, and methods thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5730734A (en) * 1996-11-14 1998-03-24 Scimed Life Systems, Inc. Catheter systems with interchangeable parts

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE380205C (en) * 1921-09-29 1924-01-19 Julius Frankenstein Dr Device for the therapeutic treatment of human body cavities with an airtight rubber jacket on an air supply tube
DE1196327B (en) * 1963-04-06 1965-07-08 Willy Ruesch Fa catheter
US3699956A (en) * 1970-10-01 1972-10-24 Tecna Corp Percutaneous lead device
CS173836B1 (en) * 1974-03-19 1977-03-31
JPS5950335B2 (en) * 1976-07-06 1984-12-07 東洋紡績株式会社 Manufacturing method of anti-blood coagulation medical soft material
JPS5435036A (en) * 1977-08-13 1979-03-14 Sumitomo Electric Industries Irrigation device
US4299226A (en) * 1979-08-08 1981-11-10 Banka Vidya S Coronary dilation method
US4481323A (en) * 1980-05-07 1984-11-06 Medical Research Associates, Ltd. #2 Hydrocarbon block copolymer with dispersed polysiloxane
US4364392A (en) * 1980-12-04 1982-12-21 Wisconsin Alumni Research Foundation Detachable balloon catheter
US4330497A (en) * 1981-01-19 1982-05-18 Sherwood Medical Industries Inc. Method of making grooved plastic medical tubing
US4448195A (en) * 1981-05-08 1984-05-15 Leveen Harry H Reinforced balloon catheter
US4515593A (en) * 1981-12-31 1985-05-07 C. R. Bard, Inc. Medical tubing having exterior hydrophilic coating for microbiocide absorption therein and method for using same
CA1191064A (en) * 1981-12-31 1985-07-30 Bard (C. R.), Inc. Catheter with selectively rigidified portion
US4417576A (en) * 1982-02-25 1983-11-29 Baran Ostap E Double-wall surgical cuff
US4423725A (en) * 1982-03-31 1984-01-03 Baran Ostap E Multiple surgical cuff
US4636195A (en) * 1982-04-02 1987-01-13 Harvey Wolinsky Method and apparatus for removing arterial constriction
US4769013A (en) * 1982-09-13 1988-09-06 Hydromer, Inc. Bio-effecting medical material and device
SU1069826A1 (en) * 1982-09-17 1984-01-30 Запорожский медицинский институт Endotracheal tube
DE3381238D1 (en) * 1982-10-08 1990-04-05 David Hardcastle BALLOON CATHETER AND METHOD FOR THE PRODUCTION THEREOF.
US4603152A (en) * 1982-11-05 1986-07-29 Baxter Travenol Laboratories, Inc. Antimicrobial compositions
US4693243A (en) * 1983-01-14 1987-09-15 Buras Sharon Y Conduit system for directly administering topical anaesthesia to blocked laryngeal-tracheal areas
US4714460A (en) * 1983-07-29 1987-12-22 Reynaldo Calderon Methods and systems for retrograde perfusion in the body for curing it of the disease or immume deficiency
US4592340A (en) * 1984-05-02 1986-06-03 Boyles Paul W Artificial catheter means
US4589873A (en) * 1984-05-29 1986-05-20 Becton, Dickinson And Company Method of applying a hydrophilic coating to a polymeric substrate and articles prepared thereby
DE3582754D1 (en) * 1984-06-04 1991-06-13 Terumo Corp MEDICAL TOOL AND PRODUCTION METHOD.
US4732930A (en) * 1985-05-20 1988-03-22 Massachusetts Institute Of Technology Reversible, discontinuous volume changes of ionized isopropylacrylamide cells
JPS62236560A (en) * 1986-04-09 1987-10-16 テルモ株式会社 Catheter for repairing blood vessel
US4784647A (en) * 1986-07-30 1988-11-15 The Kendal Company Catheter meatal pad device
JPS6415056A (en) * 1987-07-09 1989-01-19 Hanarou Maeda Body indwelling tube
JPH01171571A (en) * 1987-12-28 1989-07-06 Yoshiharu Yamawaki Balloon catheter
US4950256A (en) * 1988-04-07 1990-08-21 Luther Medical Products, Inc. Non-thrombogenic intravascular time release catheter
JP2683750B2 (en) * 1988-06-06 1997-12-03 住友電気工業株式会社 Catheter balloon
DE3821544C2 (en) * 1988-06-25 1994-04-28 H Prof Dr Med Just Dilatation catheter
US4909258A (en) * 1988-08-08 1990-03-20 The Beth Israel Hospital Association Internal mammary artery (IMA) catheter
US5213580A (en) * 1988-08-24 1993-05-25 Endoluminal Therapeutics, Inc. Biodegradable polymeric endoluminal sealing process
US5575815A (en) * 1988-08-24 1996-11-19 Endoluminal Therapeutics, Inc. Local polymeric gel therapy
CH676426A5 (en) * 1988-09-27 1991-01-31 Schneider Shiley Ag
US5091205A (en) * 1989-01-17 1992-02-25 Union Carbide Chemicals & Plastics Technology Corporation Hydrophilic lubricious coatings
US5021044A (en) * 1989-01-30 1991-06-04 Advanced Cardiovascular Systems, Inc. Catheter for even distribution of therapeutic fluids
US5087244A (en) * 1989-01-31 1992-02-11 C. R. Bard, Inc. Catheter and method for locally applying medication to the wall of a blood vessel or other body lumen
US5328470A (en) * 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5047045A (en) * 1989-04-13 1991-09-10 Scimed Life Systems, Inc. Multi-section coaxial angioplasty catheter
US5041100A (en) * 1989-04-28 1991-08-20 Cordis Corporation Catheter and hydrophilic, friction-reducing coating thereon
US4994033A (en) * 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US5026607A (en) * 1989-06-23 1991-06-25 C. R. Bard, Inc. Medical apparatus having protective, lubricious coating
US4993412A (en) * 1989-08-02 1991-02-19 Eclipse Surgical Technologies, Inc. Method and apparatus for removal of obstructive substance from body channels
JPH05501276A (en) * 1989-10-23 1993-03-11 マサチユセツツ・インスチチユート・オブ・テクノロジー Photoinduced reversible discontinuous volume change of gels
US5439446A (en) * 1994-06-30 1995-08-08 Boston Scientific Corporation Stent and therapeutic delivery system
US5304121A (en) * 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
US5674192A (en) * 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
US5135516A (en) * 1989-12-15 1992-08-04 Boston Scientific Corporation Lubricious antithrombogenic catheters, guidewires and coatings
US5049132A (en) * 1990-01-08 1991-09-17 Cordis Corporation Balloon catheter for delivering therapeutic agents
EP0441516B1 (en) * 1990-02-08 1995-03-29 Howmedica Inc. Inflatable stent
US5120322A (en) * 1990-06-13 1992-06-09 Lathrotec, Inc. Method and apparatus for treatment of fibrotic lesions
US5180366A (en) * 1990-10-10 1993-01-19 Woods W T Apparatus and method for angioplasty and for preventing re-stenosis
WO1992011895A1 (en) * 1990-12-28 1992-07-23 Boston Scientific Corporation Balloon drug delivery system
JP3372950B2 (en) * 1990-12-28 2003-02-04 ボストン サイエンティフィック コーポレーション Drug delivery system
US5102402A (en) * 1991-01-04 1992-04-07 Medtronic, Inc. Releasable coatings on balloon catheters
US5324261A (en) * 1991-01-04 1994-06-28 Medtronic, Inc. Drug delivery balloon catheter with line of weakness
WO1992013566A1 (en) * 1991-01-31 1992-08-20 Massachusetts Institute Of Technology Interpenetrating-polymer network phase-transition gels
US5171217A (en) * 1991-02-28 1992-12-15 Indiana University Foundation Method for delivery of smooth muscle cell inhibitors
US5213576A (en) * 1991-06-11 1993-05-25 Cordis Corporation Therapeutic porous balloon catheter
EP0572624A4 (en) * 1991-12-18 1994-07-06 Scimed Life Systems Inc Lubricous polymer network
US5336615A (en) * 1992-01-06 1994-08-09 Yale University Genetically engineered endothelial cells exhibiting enhanced migration and plasminogen activator activity
US5254089A (en) * 1992-04-02 1993-10-19 Boston Scientific Corp. Medication dispensing balloon catheter
US5246437A (en) * 1992-04-10 1993-09-21 Abela George S Cell treatment apparatus and method
US5304120A (en) * 1992-07-01 1994-04-19 Btx Inc. Electroporation method and apparatus for insertion of drugs and genes into endothelial cells
US5336178A (en) * 1992-11-02 1994-08-09 Localmed, Inc. Intravascular catheter with infusion array
US5634901A (en) * 1992-11-02 1997-06-03 Localmed, Inc. Method of using a catheter sleeve
CA2186870A1 (en) * 1994-04-01 1995-10-12 Aaron V. Kaplan Method and apparatus for performing multiple procedures
US5462752A (en) * 1994-07-28 1995-10-31 Prp, Inc. Inhibition of platelet binding
ES1030202Y (en) * 1995-02-20 1996-01-16 Medina Fernandez Aceytuno Alfo BALL CATHETER WITH IMPROVED TUBULAR DEVICE FOR USE IN THE TREATMENT OF VASCULAR STENOSIS.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5730734A (en) * 1996-11-14 1998-03-24 Scimed Life Systems, Inc. Catheter systems with interchangeable parts

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9050442B2 (en) 1999-01-25 2015-06-09 Atrium Medical Corporation Expandable fluoropolymer device for delivery of therapeutic agents and method of making
US6395208B1 (en) 1999-01-25 2002-05-28 Atrium Medical Corporation Method of making an expandable fluoropolymer device
US9066990B2 (en) 2001-03-26 2015-06-30 Bayer Intellectual Property Gmbh Preparation for restenosis prevention
US9649476B2 (en) 2002-09-20 2017-05-16 Bayer Intellectual Property Gmbh Medical device for dispersing medicaments
US7654264B2 (en) 2006-07-18 2010-02-02 Nellcor Puritan Bennett Llc Medical tube including an inflatable cuff having a notched collar
US8096299B2 (en) 2006-07-18 2012-01-17 Nellcor Puritan Bennett Llc Medical tube including an inflatable cuff having a notched collar
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US11612718B2 (en) 2007-12-11 2023-03-28 Massachusetts Institute Of Technology Intravesical drug delivery devices
US10646691B2 (en) 2007-12-11 2020-05-12 Massachusetts Institute Of Technology Intravesical drug delivery methods and devices
EP2231254B1 (en) * 2007-12-11 2014-05-07 Massachusetts Institute of Technology Implantable drug delivery device
US9586035B2 (en) 2007-12-11 2017-03-07 Massachusetts Institute Of Technology Implantable drug delivery device and methods for treatment of the bladder and other body vesicles or lumens
EP2231254A2 (en) * 2007-12-11 2010-09-29 Massachusetts Institute of Technology Implantable drug delivery device and methods for treatment of the bladder and other body vesicles or lumens
US9730820B2 (en) 2008-09-25 2017-08-15 Abbott Cardiovascular Systems Inc. Stent delivery system having a fibrous matrix covering with improved stent retention
US10137078B2 (en) 2009-06-26 2018-11-27 Taris Biomedical Llc Methods for intravesical drug delivery and methods and systems for loading devices with drug tablets
US10543166B2 (en) 2009-06-26 2020-01-28 Taris Biomedical Llc Implantable drug delivery devices and methods of making the same
US11596595B2 (en) 2009-06-26 2023-03-07 Taris Biomedical Llc Intravesical drug delivery device with retention frame and drug tablets
US10369256B2 (en) 2009-07-10 2019-08-06 Boston Scientific Scimed, Inc. Use of nanocrystals for drug delivery from a balloon
US11278648B2 (en) 2009-07-10 2022-03-22 Boston Scientific Scimed, Inc. Use of nanocrystals for drug delivery from a balloon
US10080821B2 (en) 2009-07-17 2018-09-25 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
US9017312B2 (en) 2009-09-10 2015-04-28 Taris Biomedical Llc Implantable device for controlled drug delivery
US11135161B2 (en) 2009-09-10 2021-10-05 Taris Biomedical Llp Intravesical device for controlled drug delivery
US11129973B2 (en) 2010-08-05 2021-09-28 Taris Biomedical Llc Drug delivery devices for deployment in genitourinary sites
US10058689B2 (en) 2010-08-05 2018-08-28 Taris Biomedical Llc Implantable drug delivery devices for genitourinary sites
US9283361B2 (en) 2010-08-05 2016-03-15 Taris Biomedical Llc Implantable drug delivery devices for genitourinary sites
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
US11285304B2 (en) 2013-03-15 2022-03-29 Taris Biomedical Llc Drug delivery devices with drug-permeable component and methods
US10315019B2 (en) 2013-03-15 2019-06-11 Taris Biomedical Llc Drug delivery devices with drug-permeable component and methods
US10286199B2 (en) 2013-03-15 2019-05-14 Taris Biomedical Llc Drug delivery devices with drug-permeable component and methods
US10729823B2 (en) 2013-08-19 2020-08-04 Taris Biomedical Llc Multi-unit drug delivery devices and methods
US10894150B2 (en) 2015-04-23 2021-01-19 Taris Biomedical Llc Drug delivery devices with drug-permeable component and methods
US11744998B2 (en) 2015-04-23 2023-09-05 Taris Biomedical Llc Drug delivery devices with drug-permeable component and methods

Also Published As

Publication number Publication date
ATE267029T1 (en) 2004-06-15
DE69824011T2 (en) 2005-06-16
CA2277770A1 (en) 1998-07-23
EP1007135A1 (en) 2000-06-14
EP1007135A4 (en) 2000-12-06
US5868719A (en) 1999-02-09
EP1007135B1 (en) 2004-05-19
DE69824011D1 (en) 2004-06-24

Similar Documents

Publication Publication Date Title
US5868719A (en) Drug delivery balloon catheter device
CA2032689C (en) Catheter
CA2201342C (en) Polymeric medical device systems having shape memory
JP4691734B2 (en) Device for selectively supplying a drug to a target position on the wall of a patient's body cavity, blood vessel or the like
JP4330805B2 (en) System for removably attaching a stent to a catheter assembly and method of use thereof
JP4436761B2 (en) Device with expandable potion for drug release
CA2098984C (en) Drug delivery system
US6673058B2 (en) Temporary dilating tip for gastro-intestinal tubes
JP2930422B2 (en) Expandable drug delivery catheter
US6527740B1 (en) Medical regrooming and drug delivery device
CA2229325A1 (en) Delivery device for a medical device having a constricted region
JPH11178929A (en) Balloon expansion drug delivery catheter and stent deployment drug delivery catheter in rapid exchange configuration
WO2003045275A3 (en) Medical device delivery system
KR20060010827A (en) Stent supplying device
WO2005011533A1 (en) Self-expandable stent
JP2003526449A (en) Incontinence prevention equipment for women
JPH08252321A (en) Treatment tool carrying catheter
EP1366731B1 (en) A catheter for treating an intimal dissection
JP2022153949A (en) Obstruction-loaded catheter and obstruction
US20030004534A1 (en) Balloon transporter
WO2002100473A1 (en) Stent and delivery catheter
WO2023054320A1 (en) Medical device and delivery system
JPH10502269A (en) Urinary incontinence prevention device and incontinence prevention law
JP2022149382A (en) Obstruction loaded catheter and medical instrument set
MXPA96004820A (en) A catheter for the release of farmaco pordilatac

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2277770

Country of ref document: CA

Ref country code: CA

Ref document number: 2277770

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 1998902444

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

Ref document number: 1998534443

Format of ref document f/p: F

WWP Wipo information: published in national office

Ref document number: 1998902444

Country of ref document: EP

WWG Wipo information: grant in national office

Ref document number: 1998902444

Country of ref document: EP