WO1998036679A2 - Method and system for forming an ultrasound image of a tissue while simultaneously ablating the tissue - Google Patents
Method and system for forming an ultrasound image of a tissue while simultaneously ablating the tissue Download PDFInfo
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- WO1998036679A2 WO1998036679A2 PCT/US1998/003409 US9803409W WO9836679A2 WO 1998036679 A2 WO1998036679 A2 WO 1998036679A2 US 9803409 W US9803409 W US 9803409W WO 9836679 A2 WO9836679 A2 WO 9836679A2
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- tissue
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- ultrasonic
- current
- imaging system
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00791—Temperature
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
- A61B2090/378—Surgical systems with images on a monitor during operation using ultrasound
- A61B2090/3782—Surgical systems with images on a monitor during operation using ultrasound transmitter or receiver in catheter or minimal invasive instrument
Definitions
- Radiofrequency energy can be applied to tissue in order to heat and thereby affect the tissue. This most often results in a region of necrotic or ablated tissue.
- a therapy is, for example, applied to the ablation of liver cancer, as described in "Radiofrequency Tissue Ablation: Increased Lesion Diameter with a Perfusion Electrode,” by S.N. Goldberg, G.S. Gazelle, L. Solbiati, W.J. Rittman, and P.R. Mueller, published in Academic Radiology, 3(8):636-44. It is also applied to the ablation of myocardium when the patient is suffering from tachycardia, as described in "Biophysics and Pathology of Catheter Energy Delivery Systems," by S. Nath and D.E. Haines, published in Progress in Cardiovascular Diseases, 37(4): 185-204.
- This therapy is performed by passing a high-frequency (typically 200-500 kHz), high-amplitude (typically 0.5-1 A) electrical current through the tissue to be ablated.
- a high-frequency typically 200-500 kHz
- high-amplitude typically 0.5-1 A
- the therapy current is generated by placing one or more metal therapy electrodes against the tissue to be ablated. When a single therapy electrode is used, therapy current is passed from this electrode into the tissue and then to a larger counter electrode contacting the tissue elsewhere. When more than one therapy electrode is used, the therapy current can be passed between these electrodes through the tissue.
- Ionic transport carries the current within the tissue and generates heat proportional to the square of the local current density.
- the maximum heating and the maximum temperature rise occur adjacent to the therapy electrode(s). This temperature rise will, if maintained for a sufficient time, alter the function of or kill the tissue.
- a description of the relationship between tissue temperature and the time required to cause thermal damage can be found in "Thermal Dose Determination in Cancer Therapy," by S.A. Sapareto and W.C. Dewey, published m IntemationalJoumal of Radiation Oncology, Biology and Physics, 10(6):787-800.
- Ultrasound can be used to guide radiofrequency ablation therapies. Because the location of the regions to be treated either can be identified by ultrasound (often the case with liver tumors) or can be indicated by or referenced to known anatomic references (as in the case of cardiac ablation), ultrasound is increasingly being used in conjunction with ablation procedures to guide the placement of the therapy devices. Further, as heating tissue to therapeutic temperatures alters the echogenic nature of the tissue, ultrasound is now also being used to monitor the growth of the treated region. A description of ultrasound's role in cardiac radiofrequency ablation can be found in "Ultrasound Cardioscopy: Embarking on a New Journey," by J.B. Seward, D.L. Packer, R.C. Chan, M.G. Curley, and A.J. Tajik, published in Mayo Clinic Proceedings, 71(7) (1996).
- the present invention is directed to a method and system for forming an ultrasound image of a tissue while simultaneously ablating the tissue.
- the application of therapy current is sequenced with the performance of ultrasonic detection, resulting in essentially simultaneous application of current and ultrasonic detection. This avoids electrical interference on the ultrasound image caused by the radiofrequency therapy current without adding to the size of the transducer or to the cost of the transducer or system.
- Figure 1 is a block diagram of a preferred embodiment of a system of the present invention.
- Figure 2 is an illustration of a communication protocol of a second preferred embodiment.
- Figure 3 is an illustration of a communication protocol of a third preferred embodiment.
- Figure 4 is an illustration of a communication protocol of a fourth preferred embodiment.
- Figure 5 is an illustration of an alternative communication protocol of the fourth preferred embodiment.
- Figure 6 is an illustration of another alternative communication protocol of the fourth preferred embodiment.
- Figure 7 is a block diagram of an alternative embodiment of the system of Figure 1.
- Figure 8 is a block diagram of another alternative embodiment of the system of Figure 1.
- a therapeutic delivery device 14 contains a therapeutic electrode 28 and a temperature sensor 30.
- the therapeutic delivery device 14 connects to a therapy system 16, which contains a voltage generator 32 responsive to a voltage controller 34 and coupled to a current detector 36.
- the therapy system 16 also contains a temperature monitoring system 38 coupled to the voltage controller 34 and responsive to the temperature sensor 30.
- one component can be "responsive” or “coupled” to another component either directly (as when two components are connected by a conductor) or indirectly (as when there is intermediate signal processing between two components).
- a communication link 18 connects the therapy system 16 to an ultrasonic imaging system 20.
- the ultrasonic imaging system 20 includes a central controller 41, a beam former 40 responsive to the central controller 41, and receiving circuitry and amplifiers 42 responsive to the central controller 41.
- the receiving circuitry and amplifiers 42 are coupled to a scan converter 44, which is coupled to a display 46.
- the imaging system 20 attaches to an ultrasound delivery device 22 containing an ultrasound transducer 24 responsive to the beam former 40 and coupled to the receiving circuitry and amplifiers 42. The function of these components will be described below.
- the voltage generator 32 in the therapy system 16 generates a voltage and sends the resulting current to the therapy electrode 28.
- the voltage controller 34 sets the frequency and amplitude of the voltage produced by the generator 32, as well as its sequencing in time. The voltage controller 34 makes this determination based on information received from the user via an input interface or from the temperature monitoring system 38 and the current detector 36.
- the temperature monitoring system 38 receives thermal information from the temperature sensor 30 in the therapeutic delivery device 14, while the current detector 36 determines the amount of current sent to the therapy electrode 28.
- the current flowing from the therapy system 16 to the therapy electrode 28 passes to the tissue 26 when the electrode 28 is placed adjacent to the tissue 26. This current spreads as it penetrates into the tissue 26 and propagates either to a second therapy electrode or to a distant, larger counter electrode (not shown). As it passes through the tissue 26, the current generates heat according to the local current density, ablating ⁇ i.e., causing thermal damage to) the tissue 26. As used herein, the term "ablation" refers to the process that affects the tissue by thermal means.
- the communication link 18 connects the therapy system 16 to the ultrasonic imaging system 20 and is capable of sending signals between the two systems 16, 20.
- the ultrasonic imaging system 20 controls the time during which the ultrasound transducer 24 is performing ultrasonic visualization of the tissue 26.
- the imaging system 20 allows the user to adjust parameters which affect the time needed for ultrasonic visualization. As is well known in the art, these parameters include, but are not limited to, image depth, image width, and frame-rate, the number of frames per second that will be displayed to the user.
- the central controller 41 interprets the setup information entered by the user and configures the other components of the ultrasonic imaging system 20 accordingly.
- the term "ultrasonic visualization” refers to the well-known interrogating-and-imaging process which includes ultrasound generation, ultrasonic detection, image reconstruction, and image presentation phases.
- the beam former 40 applies a voltage to the transducer 24 to cause it to vibrate and emit ultrasonic energy.
- the receiving circuitry 42 measures the voltages created by the transducer 24 when ultrasonic energy reflected by the structures in the tissue 26 impinge on the transducer 24, creating a scan line. Additional ultrasonic energy is transmitted and received until enough scan lines are formed to create a frame.
- the image reconstruction phase begins.
- the scan converter 44 processes the amplified, sensed voltages to create an image of the tissue 26.
- the display 46 presents the image to the user during the presentation phase.
- the desired frame-rate is usually 10-60 frames per second. Accordingly, the image is presented to the user in 1/10 to 1/60 of a second.
- the therapy current need not be applied throughout the entire ablation process. That is, continuous ablation of the tissue (i.e., continuous thermal damage to the tissue) will be maintained even if the therapy current is interrupted during the ablation process.
- Therapy current can be interrupted without significant effect on tissue heating if the resulting time-averaged current is sufficient to cause heating to therapeutic temperatures. This can be achieved by increasing the magnitude of the therapy current during its application or by increasing the duration of the ablation process to compensate for the interruption in therapy current. See S.A. Sapareto and W.C. Dewey, supra. If a sufficient amount of heat is generated within the tissue 26 before the therapy current is interrupted, ablation of the tissue 26 will continue-even though therapy current is momentarily interrupted. It is preferable that the time the therapy current is off is short compared to the natural decay time of the heating field. This time scale is approximately equal to the length scale of the heating field squared divided by the thermal diffusivity of tissue, or
- L - ⁇ a '
- L is the length scale of the heating field
- ⁇ is the approximate time scale for cooling
- thermal diffusivity of tissue typically 1.5 x 10 " " cm 2 /sec.
- the length scale can be taken as the diameter of the electrode, and so the time scale for cooling is about 106 seconds. Therefore, as long as the interruption of therapy current to the heating field is significantly less than 100 seconds and as long as the therapy current is increased during the "on" periods to compensate for the brief loss of heating energy, ablation of the tissue 26 will continue even though therapy current is interrupted. Instead of increasing the therapy current, the duration of the ablation process can be increased to compensate for the slight diminution in temperature resulting from the brief pauses in the application of the therapy current, if the resulting time-averaged current is sufficient to cause heating to therapeutic temperatures.
- This temporal averaging of the therapeutic heating may be used in a method and system for forming an ultrasound image of a tissue while simultaneously ablating the tissue, as will be illustrated below.
- Ultrasonic detection can be performed simultaneously with the ablation of tissue 26 if the application of therapy current is sequenced with ultrasonic detection. With this approach, no ultrasonic detection takes place while therapy current passes, and no therapy current passes while ultrasonic detection takes place. By sequencing these steps, the application of therapy current occurs virtually simultaneously with the performance of ultrasonic detection.
- a sufficient amount of therapy current is applied to the tissue 26 to generate enough heat for ablation to continue during an interruption in therapy current, as can be detected by the temperature sensor 30 and the temperature monitoring system 38.
- ultrasonic detection is performed by the ultrasonic imaging system 20 during an interruption in the application of the therapy current.
- the cycle begins again, and therapy current is reapplied to the tissue 26, as before, to generate enough heat for continuous ablation.
- This method allows the tissue 26 to be ultrasonically monitored while being simultaneously ablated without the previously mentioned problem of electrical interference on the ultrasound image.
- ultrasonic detection occurs in this method, no therapy current is flowing to the tissue (hence, no interference), yet the tissue is being ablated (from the heat built up before the therapy current was interrupted).
- this solution does not significantly add to the size or cost of the transducer 24.
- Sequencing may be implemented with a communication protocol, as described below, to determine when therapy current should be applied and when ultrasonic detection should be performed.
- each system 16, 20 can use information entered by a user to determine when therapy current should be applied and when ultrasonic detection should be performed, without the use of a communication protocol between the systems 16, 20.
- FIG. 2 illustrates the communication protocol used in the method of the second preferred embodiment.
- both the ultrasonic imaging system 20 and the therapy system 16 signal each other, via the communication link 18, when done performing their functions.
- control is passed between the two systems 16, 20. Once one system indicates that it is done with its function, it cannot proceed until it receives a signal from the other system signaling that the other system is done.
- the ultrasonic imaging system 20 begins performing ultrasonic detection. When detection is complete, the ultrasonic imaging system 20 stops performing ultrasonic detection and signals the therapy system 16 that it is done with its function.
- the therapy system 16 begins to apply therapy current to the tissue 26.
- the therapy system 16 stops applying the therapy current to the tissue 26 and signals the ultrasonic imaging system 20 that it is done with its function. This would occur, for example, when a sufficient amount of heat is generated within the tissue 26 to continue ablation during the time when the therapy current is interrupted, as can be detected by the temperature sensor 30 and the temperature monitoring system 38. Ultrasonic detection of the tissue 26 resumes after the ultrasonic imaging system 20 receives the signal from the therapy system 16.
- FIG. 3 illustrates the communication protocol used in the method of the third preferred embodiment.
- the ultrasonic imaging system 20 retains exclusive control over when therapy current should be applied and when detection should be performed.
- the ultrasonic imaging system 20 begins performing ultrasonic detection. When detection is complete, the ultrasonic imaging system 20 stops performing ultrasonic detection and signals the therapy system 16 that therapy current may be applied. Next, the therapy system 16 begins to apply therapy current to the tissue 26.
- the ultrasonic imaging system 20 determines that a new ultrasound image needs to be formed, it sends a signal to the therapy system 16 to indicate that the therapy current should be turned off. This determination can be based on a minimum frame- rate entered by the user. For example, in cardiac ablation applications, the minimum frame-rate is usually 10-60 frames per second. The application of therapy current is then interrupted, and ultrasonic detection is performed.
- the method using this protocol can be used, for example, when careful monitoring of the growth of the treated tissue 26 is considered important.
- the ultrasonic imaging system 20 ensures that the imaging is sufficiently continuous for tracking the growth of a lesion.
- Figure 4 illustrates the communication protocol used in the method of the fourth preferred embodiment.
- the therapy system 16 retains exclusive control by determining when ultrasonic detection should begin and end. This protocol can be used to ensure a particular therapy current delivery.
- the therapy system 16 begins applying therapy current to the tissue 26.
- the therapy system 16 interrupts the application of therapy current to the tissue 26 and signals the ultrasonic imaging system 20 that detection may be performed. This would occur, for example, when a sufficient amount of heat is generated within the tissue 26 for ablation to continue during the time when the therapy current is interrupted, as can be detected by the temperature sensor 30 and the temperature monitoring system 38.
- the ultrasonic imaging system 20 performs ultrasonic detection.
- the therapy system 16 determines that therapy current needs to be applied to the tissue 26, it sends a signal to the ultrasonic imaging system 20 to interrupt ultrasonic detection. This would happen, for example, when more therapy current is needed to generate additional heat to maintain a continued ablation of the tissue 26.
- Ultrasonic detection is then interrupted, and therapy current is applied to the tissue 26.
- This protocol may produce a sub-optimal result given the complexity of the detection of ultrasound and given the delay needed for the ultrasound waves to travel into and return from the tissue 26. That is, the detection may not be complete when the therapy system 16 determines that detection must be interrupted and therapy current must be applied.
- the therapy system 16 can apply current while the detection phase continues (see Figure 5). Although there will be interference on the image caused by the simultaneous application of current and detection, this alternative allows the user to receive an image, even though it is of lesser quality.
- an alternative embodiment can be used in which instead of sending two signals (one indicating that detection should begin and one indicating that it should be interrupted), the therapy system 16 sends only one signal, as shown in Figure 6.
- This single signal gives the ultrasonic imaging system 20 a preset time interval to complete detection.
- the ultrasonic imaging system 20 would then adjust imaging parameters (including, but not limited to, image depth and width) to ensure that detection is complete in the given amount of time.
- the detection phase would be complete and therapy current would be applied automatically, without the need to send a second signal from the therapy system 16 to the ultrasonic imaging system 20.
- the application of therapy current is sequenced with the performance of the ultrasonic detection because it is during the detection phase that the ultrasound system 20 is most susceptible to noise.
- the other phases of the ultrasonic visualization process i.e., ultrasound generation, image reconstruction, and image presentation
- the application of therapy current can be interrupted throughout the entire ultrasonic visualization process. This can be done for simplicity since the detection phase can consume the largest fraction of time for the entire ultrasonic visualization process.
- Ultrasound delivery devices include all types of devices that contain a transducer. These devices include, but are not limited to, transthorasic, transabdominal, transesophageal, endorectal, endovaginal, and transluminal surgical devices and catheters.
- Therapy delivery devices include several devices that contain an electrode. For example, in cardiac application, the therapy electrodes can be delivered using a catheter, while for liver tumor applications, the therapy electrodes can be delivered using a catheter or a needle. Additionally, the therapy electrode can be a separate device delivered through an introducer needle or sheath.
- the ultrasound transducer can be of any type (e.g., mechanical array, ultrasound array, synthesized B-mode) as long as the ultrasonic imaging system 20 has the ability to control the time during which ultrasound energy is being generated or detected. While the ultrasonic imaging system can have duplicate receivers and amplifiers, it can also have a single receiver and amplifier.
- an additional communication may be sent from the ultrasonic imaging system 20 to the therapy system 16.
- the ultrasonic imaging system 20 may communicate its duty cycle to the therapy system 16.
- the duty cycle comprises the amount of time required for ultrasonic detection (or for completion of the entire ultrasonic visualization process) and the frame-rate.
- the time required for detection (or visualization) allows the therapy system 16 to know how long it must be off, while the frame-rate allows the therapy system 16 to know how long it can be on before another image needs to be generated.
- the voltage controller 34 may then alter the intensity of therapy current or increase the duration of the ablation process accordingly to ensure that the time-average of the square of the therapy current, as determined by the current detector 36, is sufficient to generate enough heat for continuous ablation of the tissue 26.
- the duration of the ablation process increasing, the number of times that the application of current and the performance of ultrasonic visualization (or detection) are sequenced is increased.
- the additional communication can be sent directly between the systems 16, 20, or it can be manually entered by the operator.
- the current detector 36 can monitor the time-average of the square of the therapy current it is generating, and the voltage controller 34 can adjust the therapy current in real-time to maintain a particular value. Additionally, the voltage controller 34 can increase the duration of the ablation process.
- a combination of the therapy current-control alternatives described above can also be used. As mentioned earlier, the number of times that the application of current and the performance of ultrasonic visualization (or detection) are sequenced is increased as a result of the duration of the ablation process increasing.
- the temperature of the tissue can be monitored by the temperature sensor 30 and the temperature monitoring system 38.
- the voltage controller 34 or the user can increase the duration of the ablation process, instead of increasing the magnitude of the current, to ensure continuous ablation.
- the temperature sensor 30 and the temperature monitoring system 38 are not strictly needed. For example, a user can use his experience to set the voltage or current level based on the electrode and tissue type.
- the sequencing described in the embodiments can begin with either application of therapy current or ultrasonic detection. While the above preferred embodiments show the ultrasound delivery device 22 and ultrasonic imaging system 20 as being separate components, it should be understood that they may be combined into one component. This is also true for the therapy delivery device 14 and the therapy system 16. Also, while the above preferred embodiments show the therapy system 16 and the ultrasonic imaging system 20 as being separate components, it should be understood that they may be subsystems of an integrated therapy/visualization system (See Figure 7). Additionally, while two separate delivery devices 14, 22 are described above, a single delivery device can house the therapy electrode 28, the ultrasound transducer 24, and the temperature sensor 30 (See Figure 8).
- the communication between the systems 16, 20 can use conventional digital communication techniques - a short period of a high voltage to communicate that control is being passed. Other, possibly more sophisticated, communication modalities can also be used.
- communication link is meant in its broadest sense to be any suitable communication technology and can include, but is not limited to, communication by wire, fiber optics, and radio waves, and it can be effected using either hardware or software.
- the communication protocols of the above embodiments and alternatives need not be maintained throughout a particular therapy session.
- a communication protocol can vary among any of the embodiments and alternatives as necessary or desired during a therapy session.
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Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19882137T DE19882137T1 (en) | 1997-02-25 | 1998-02-23 | Method and system for forming an ultrasound image of a tissue while ablating the tissue |
JP53692298A JP2001513664A (en) | 1997-02-25 | 1998-02-23 | Method and system for forming ultrasound images while simultaneously cutting tissue |
AU64376/98A AU6437698A (en) | 1997-02-25 | 1998-02-23 | Method and system for forming an ultrasound image of a tissue while simultaneously ablating the tissue |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US08/805,473 US5788636A (en) | 1997-02-25 | 1997-02-25 | Method and system for forming an ultrasound image of a tissue while simultaneously ablating the tissue |
US08/805,473 | 1997-02-25 |
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WO1998036679A2 true WO1998036679A2 (en) | 1998-08-27 |
WO1998036679A3 WO1998036679A3 (en) | 1998-10-01 |
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PCT/US1998/003409 WO1998036679A2 (en) | 1997-02-25 | 1998-02-23 | Method and system for forming an ultrasound image of a tissue while simultaneously ablating the tissue |
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US (1) | US5788636A (en) |
JP (1) | JP2001513664A (en) |
AU (1) | AU6437698A (en) |
DE (1) | DE19882137T1 (en) |
WO (1) | WO1998036679A2 (en) |
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Also Published As
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JP2001513664A (en) | 2001-09-04 |
DE19882137T1 (en) | 2000-05-18 |
WO1998036679A3 (en) | 1998-10-01 |
US5788636A (en) | 1998-08-04 |
AU6437698A (en) | 1998-09-09 |
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