WO1998041854A1 - High dynamic range apparatus for separation and detection of polynucleotide fragments - Google Patents
High dynamic range apparatus for separation and detection of polynucleotide fragments Download PDFInfo
- Publication number
- WO1998041854A1 WO1998041854A1 PCT/CA1998/000239 CA9800239W WO9841854A1 WO 1998041854 A1 WO1998041854 A1 WO 1998041854A1 CA 9800239 W CA9800239 W CA 9800239W WO 9841854 A1 WO9841854 A1 WO 9841854A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- excitation
- dynamic range
- detection
- detectors
- intensity
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/86—Signal analysis
- G01N30/8603—Signal analysis with integration or differentiation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
- G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Pure & Applied Mathematics (AREA)
- Mathematical Optimization (AREA)
- Mathematical Analysis (AREA)
- Algebra (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98910550A EP1012593B1 (en) | 1997-03-18 | 1998-03-18 | High dynamic range apparatus for separation and detection of polynucleotide fragments |
AU64919/98A AU6491998A (en) | 1997-03-18 | 1998-03-18 | High dynamic range apparatus for separation and detection of polynucleotide fragments |
CA002284888A CA2284888A1 (en) | 1997-03-18 | 1998-03-18 | High dynamic range apparatus for separation and detection of polynucleotide fragments |
DE69830412T DE69830412T2 (en) | 1997-03-18 | 1998-03-18 | DEVICE FOR SEPARATING AND DETECTING POLYNUCLEOTIDE FRAGMENTS IN THE HIGH DYNAMIC RANGE |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/819,910 US6014213A (en) | 1994-12-12 | 1997-03-18 | High dynamic range apparatus for separation and detection of polynucleotide fragments |
US08/819,910 | 1997-03-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998041854A1 true WO1998041854A1 (en) | 1998-09-24 |
WO1998041854A9 WO1998041854A9 (en) | 1999-03-04 |
Family
ID=25229414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA1998/000239 WO1998041854A1 (en) | 1997-03-18 | 1998-03-18 | High dynamic range apparatus for separation and detection of polynucleotide fragments |
Country Status (6)
Country | Link |
---|---|
US (1) | US6014213A (en) |
EP (1) | EP1012593B1 (en) |
AU (1) | AU6491998A (en) |
CA (1) | CA2284888A1 (en) |
DE (1) | DE69830412T2 (en) |
WO (1) | WO1998041854A1 (en) |
Cited By (9)
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EP1481234A2 (en) * | 2001-10-24 | 2004-12-01 | Beckman-Coulter, Inc. | Method and apparatus for increasing the dynamic range and accuracy of binding assays |
EP1488208A2 (en) * | 2001-02-23 | 2004-12-22 | Genicon Sciences Corporation | Methods for providing extended dynamic range in analyte assays |
US8735064B2 (en) | 2007-12-24 | 2014-05-27 | Bergenbio As | Methods for creating and identifying functional RNA interference elements |
US9414777B2 (en) | 2004-07-13 | 2016-08-16 | Dexcom, Inc. | Transcutaneous analyte sensor |
EP3093649A3 (en) * | 1998-05-16 | 2017-04-26 | Life Technologies Corporation | An optical instrument monitoring dna polymerase chain reactions |
US9823195B2 (en) | 1998-05-16 | 2017-11-21 | Life Technologies Corporation | Optical instrument comprising multi-notch beam splitter |
US9986942B2 (en) | 2004-07-13 | 2018-06-05 | Dexcom, Inc. | Analyte sensor |
US10610135B2 (en) | 2005-03-10 | 2020-04-07 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US10813577B2 (en) | 2005-06-21 | 2020-10-27 | Dexcom, Inc. | Analyte sensor |
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US6361672B1 (en) * | 1996-06-10 | 2002-03-26 | Transgenomic, Inc. | Multiple laser diode electromagnetic radiation source in multiple electrophoresis channel systems |
US6793790B1 (en) | 2001-06-06 | 2004-09-21 | The Regents Of The University Of California | Sample collection system for gel electrophoresis |
AU2003280470A1 (en) * | 2002-07-01 | 2004-01-19 | Guava Technologies, Inc. | Fluorescent dyes, energy transfer couples and methods |
US6894264B2 (en) * | 2002-10-15 | 2005-05-17 | Applera Corporation | System and methods for dynamic range extension using variable length integration time sampling |
CN101495656B (en) | 2006-06-07 | 2017-02-08 | 纽约哥伦比亚大学理事会 | DNA sequencing by nanopore using modified nucleotides |
JP4991252B2 (en) * | 2006-11-10 | 2012-08-01 | 株式会社日立ハイテクノロジーズ | Electrophoresis apparatus and electrophoretic analysis method |
US9605307B2 (en) | 2010-02-08 | 2017-03-28 | Genia Technologies, Inc. | Systems and methods for forming a nanopore in a lipid bilayer |
US20110192723A1 (en) * | 2010-02-08 | 2011-08-11 | Genia Technologies, Inc. | Systems and methods for manipulating a molecule in a nanopore |
US9678055B2 (en) | 2010-02-08 | 2017-06-13 | Genia Technologies, Inc. | Methods for forming a nanopore in a lipid bilayer |
US8324914B2 (en) | 2010-02-08 | 2012-12-04 | Genia Technologies, Inc. | Systems and methods for characterizing a molecule |
WO2012088341A2 (en) | 2010-12-22 | 2012-06-28 | Genia Technologies, Inc. | Nanopore-based single dna molecule characterization, identification and isolation using speed bumps |
US9581563B2 (en) | 2011-01-24 | 2017-02-28 | Genia Technologies, Inc. | System for communicating information from an array of sensors |
US9110478B2 (en) | 2011-01-27 | 2015-08-18 | Genia Technologies, Inc. | Temperature regulation of measurement arrays |
US8986629B2 (en) | 2012-02-27 | 2015-03-24 | Genia Technologies, Inc. | Sensor circuit for controlling, detecting, and measuring a molecular complex |
US9494554B2 (en) | 2012-06-15 | 2016-11-15 | Genia Technologies, Inc. | Chip set-up and high-accuracy nucleic acid sequencing |
US9605309B2 (en) | 2012-11-09 | 2017-03-28 | Genia Technologies, Inc. | Nucleic acid sequencing using tags |
US9759711B2 (en) | 2013-02-05 | 2017-09-12 | Genia Technologies, Inc. | Nanopore arrays |
US9551697B2 (en) | 2013-10-17 | 2017-01-24 | Genia Technologies, Inc. | Non-faradaic, capacitively coupled measurement in a nanopore cell array |
US9567630B2 (en) | 2013-10-23 | 2017-02-14 | Genia Technologies, Inc. | Methods for forming lipid bilayers on biochips |
CA2926138A1 (en) | 2013-10-23 | 2015-04-30 | Genia Technologies, Inc. | High speed molecular sensing with nanopores |
WO2020023443A1 (en) * | 2018-07-23 | 2020-01-30 | The Brigham And Women's Hospital, Inc. | Magnetic levitation techniques to separate and analyze molecular entities |
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-
1997
- 1997-03-18 US US08/819,910 patent/US6014213A/en not_active Expired - Fee Related
-
1998
- 1998-03-18 DE DE69830412T patent/DE69830412T2/en not_active Expired - Fee Related
- 1998-03-18 CA CA002284888A patent/CA2284888A1/en not_active Abandoned
- 1998-03-18 EP EP98910550A patent/EP1012593B1/en not_active Expired - Lifetime
- 1998-03-18 AU AU64919/98A patent/AU6491998A/en not_active Abandoned
- 1998-03-18 WO PCT/CA1998/000239 patent/WO1998041854A1/en active IP Right Grant
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EP0592060A1 (en) * | 1992-10-09 | 1994-04-13 | The Board of Regents of the University of Nebraska | Digital DNA typing |
WO1996018892A1 (en) * | 1994-12-12 | 1996-06-20 | Visible Genetics Inc. | Automated electrophoresis and fluorescence detection apparatus and method |
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Title |
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US9823195B2 (en) | 1998-05-16 | 2017-11-21 | Life Technologies Corporation | Optical instrument comprising multi-notch beam splitter |
EP3093649A3 (en) * | 1998-05-16 | 2017-04-26 | Life Technologies Corporation | An optical instrument monitoring dna polymerase chain reactions |
EP1488208A2 (en) * | 2001-02-23 | 2004-12-22 | Genicon Sciences Corporation | Methods for providing extended dynamic range in analyte assays |
EP1488208A4 (en) * | 2001-02-23 | 2008-05-28 | Invitrogen Corp | Methods for providing extended dynamic range in analyte assays |
EP1481234A4 (en) * | 2001-10-24 | 2007-08-08 | Beckman Coulter Inc | Method and apparatus for increasing the dynamic range and accuracy of binding assays |
EP1481234A2 (en) * | 2001-10-24 | 2004-12-01 | Beckman-Coulter, Inc. | Method and apparatus for increasing the dynamic range and accuracy of binding assays |
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Also Published As
Publication number | Publication date |
---|---|
US6014213A (en) | 2000-01-11 |
DE69830412D1 (en) | 2005-07-07 |
EP1012593B1 (en) | 2005-06-01 |
CA2284888A1 (en) | 1998-09-24 |
DE69830412T2 (en) | 2006-01-26 |
AU6491998A (en) | 1998-10-12 |
EP1012593A1 (en) | 2000-06-28 |
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