WO1998043739A3 - Diagnostic devices and apparatus for the controlled movement of reagents without membranes - Google Patents

Diagnostic devices and apparatus for the controlled movement of reagents without membranes Download PDF

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Publication number
WO1998043739A3
WO1998043739A3 PCT/US1998/005681 US9805681W WO9843739A3 WO 1998043739 A3 WO1998043739 A3 WO 1998043739A3 US 9805681 W US9805681 W US 9805681W WO 9843739 A3 WO9843739 A3 WO 9843739A3
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WO
WIPO (PCT)
Prior art keywords
elements
membranes
assay
devices
reagents
Prior art date
Application number
PCT/US1998/005681
Other languages
French (fr)
Other versions
WO1998043739A2 (en
WO1998043739A9 (en
Inventor
Kenneth Francis Buechler
Original Assignee
Biosite Diagnostics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosite Diagnostics Inc filed Critical Biosite Diagnostics Inc
Priority to DE1998615365 priority Critical patent/DE69815365T2/en
Priority to JP54172898A priority patent/JP3531941B2/en
Priority to EP98911959A priority patent/EP1019193B1/en
Priority to AU65790/98A priority patent/AU6579098A/en
Priority to CA 2284801 priority patent/CA2284801C/en
Priority to AT98911959T priority patent/ATE242054T1/en
Publication of WO1998043739A2 publication Critical patent/WO1998043739A2/en
Publication of WO1998043739A9 publication Critical patent/WO1998043739A9/en
Publication of WO1998043739A3 publication Critical patent/WO1998043739A3/en

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    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
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    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • G01N35/085—Flow Injection Analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Abstract

The assay devices, assay systems and device components of this invention comprise at least two opposing surfaces disposed a capillary distance apart, at least one of which is capable of immobilizing at least one target ligand or a conjugate in an amount related to the presence or amount of target ligand in the sample from a fluid sample in a zone for controlled fluid movement to, through or away from the zone. The inventive device components may be incorporated into conventional assay devices with membranes or may be used in the inventive membrane-less devices herein described and claimed. These components include flow control elements, measurement elements, time gates, elements for the elimination of pipetting steps, and generally, elements for the controlled flow, timing, delivery, incubation, separation, washing and other steps of the assay process.
PCT/US1998/005681 1997-03-27 1998-03-24 Diagnostic devices and apparatus for the controlled movement of reagents without membranes WO1998043739A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE1998615365 DE69815365T2 (en) 1997-03-27 1998-03-24 DIAGNOSTIC DEVICE FOR CONTROLLED MOVEMENT OF REAGENTS WITHOUT MEMBRANES
JP54172898A JP3531941B2 (en) 1997-03-27 1998-03-24 Diagnostic devices and equipment that control and move reagents without using membranes
EP98911959A EP1019193B1 (en) 1997-03-27 1998-03-24 Diagnostic devices and apparatus for the controlled movement of reagents without membranes
AU65790/98A AU6579098A (en) 1997-03-27 1998-03-24 Diagnostic devices and apparatus for the controlled movement of reagents withoutmembranes
CA 2284801 CA2284801C (en) 1997-03-27 1998-03-24 Diagnostic devices and apparatus for the controlled movement of reagents without membranes
AT98911959T ATE242054T1 (en) 1997-03-27 1998-03-24 DIAGNOSTIC DEVICE FOR THE CONTROLLED MOVEMENT OF REAGENTS WITHOUT MEMBRANES

Applications Claiming Priority (2)

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US08/828,041 US6156270A (en) 1992-05-21 1997-03-27 Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US08/828,041 1997-03-27

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WO1998043739A9 WO1998043739A9 (en) 1999-03-04
WO1998043739A3 true WO1998043739A3 (en) 2001-06-07

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EP (1) EP1019193B1 (en)
JP (1) JP3531941B2 (en)
AT (1) ATE242054T1 (en)
AU (1) AU6579098A (en)
CA (1) CA2284801C (en)
DE (1) DE69815365T2 (en)
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Families Citing this family (214)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524456B1 (en) 1992-05-21 2009-04-28 Biosite Incorporated Diagnostic devices for the controlled movement of reagents without membranes
US6767510B1 (en) * 1992-05-21 2004-07-27 Biosite, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6905882B2 (en) * 1992-05-21 2005-06-14 Biosite, Inc. Diagnostic devices and apparatus for the controlled movement of reagents without membranes
US6113855A (en) * 1996-11-15 2000-09-05 Biosite Diagnostics, Inc. Devices comprising multiple capillarity inducing surfaces
US6037186A (en) * 1997-07-16 2000-03-14 Stimpson; Don Parallel production of high density arrays
US6194222B1 (en) * 1998-01-05 2001-02-27 Biosite Diagnostics, Inc. Methods for monitoring the status of assays and immunoassays
US7713703B1 (en) 2000-11-13 2010-05-11 Biosite, Inc. Methods for monitoring the status of assays and immunoassays
GB9808836D0 (en) * 1998-04-27 1998-06-24 Amersham Pharm Biotech Uk Ltd Microfabricated apparatus for cell based assays
US20040202579A1 (en) * 1998-05-08 2004-10-14 Anders Larsson Microfluidic device
GB9809943D0 (en) * 1998-05-08 1998-07-08 Amersham Pharm Biotech Ab Microfluidic device
US7640083B2 (en) 2002-11-22 2009-12-29 Monroe David A Record and playback system for aircraft
EP1039291A1 (en) * 1999-03-26 2000-09-27 Sony International (Europe) GmbH Optochemical sensor and method for its construction
GB9913560D0 (en) * 1999-06-10 1999-08-11 Cortecs Diagnostics Limited Mixing apparatus and method of mixing
US6319719B1 (en) * 1999-10-28 2001-11-20 Roche Diagnostics Corporation Capillary hematocrit separation structure and method
US6361958B1 (en) 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
EP2889611B1 (en) 1999-11-15 2019-09-04 PHC Holdings Corporation Biosensor and measurement apparatus.
US6406672B1 (en) * 2000-01-28 2002-06-18 Roche Diagnostics Plasma retention structure providing internal flow
WO2001062887A1 (en) * 2000-02-23 2001-08-30 Zyomyx, Inc. Chips having elevated sample surfaces
US6610499B1 (en) 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
US7615340B2 (en) * 2000-10-03 2009-11-10 Minerva Biotechnologies Corporation Electronic detection of interaction and detection of interaction based on the interruption of flow
EP2388586B1 (en) * 2000-11-30 2018-01-10 Panasonic Healthcare Holdings Co., Ltd. Method of quantifying substrate
GB0030929D0 (en) * 2000-12-19 2001-01-31 Inverness Medical Ltd Analyte measurement
US20040099310A1 (en) * 2001-01-05 2004-05-27 Per Andersson Microfluidic device
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
EP1384076B1 (en) 2001-03-19 2012-07-25 Gyros Patent Ab Characterization of reaction variables
US6572745B2 (en) 2001-03-23 2003-06-03 Virotek, L.L.C. Electrochemical sensor and method thereof
EP1251345A1 (en) * 2001-04-12 2002-10-23 Fuji Photo Film Co., Ltd. Measuring sensor utilizing attenuated total reflection and measuring chip assembly
US7476533B2 (en) 2002-04-19 2009-01-13 Adhesives Research, Inc. Diagnostic devices for use in the assaying of biological fluids
DE10125018A1 (en) * 2001-05-22 2002-12-05 Infineon Technologies Ag Detecting molecules in liquid, e.g. DNA analysis, involves fixing receptor molecules to substrate and determining flow characteristics of reference liquid and liquid for analysis
US7776608B2 (en) * 2001-07-09 2010-08-17 Bayer Healthcare Llc Volume meter testing device and method of use
EP1483052B1 (en) * 2001-08-28 2010-12-22 Gyros Patent Ab Retaining microfluidic microcavity and other microfluidic structures
US6919058B2 (en) * 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US6755949B1 (en) * 2001-10-09 2004-06-29 Roche Diagnostics Corporation Biosensor
US20030119203A1 (en) 2001-12-24 2003-06-26 Kimberly-Clark Worldwide, Inc. Lateral flow assay devices and methods for conducting assays
US8367013B2 (en) 2001-12-24 2013-02-05 Kimberly-Clark Worldwide, Inc. Reading device, method, and system for conducting lateral flow assays
US20030173223A1 (en) * 2002-01-04 2003-09-18 Board Of Regents,The University Of Texas System Wall-less channels for fluidic routing and confinement
WO2003066191A1 (en) * 2002-02-04 2003-08-14 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
US7459127B2 (en) 2002-02-26 2008-12-02 Siemens Healthcare Diagnostics Inc. Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
US7223371B2 (en) * 2002-03-14 2007-05-29 Micronics, Inc. Microfluidic channel network device
US7524462B2 (en) * 2002-03-29 2009-04-28 Agilent Technologies, Inc. Capillary flow for a heterogenous assay in a micro-channel environment
SE0201738D0 (en) * 2002-06-07 2002-06-07 Aamic Ab Micro-fluid structures
KR100480338B1 (en) * 2002-08-08 2005-03-30 한국전자통신연구원 Microfluidic devices for the controlled movements of solution
US7285424B2 (en) 2002-08-27 2007-10-23 Kimberly-Clark Worldwide, Inc. Membrane-based assay devices
EP2359689B1 (en) 2002-09-27 2015-08-26 The General Hospital Corporation Microfluidic device for cell separation and use thereof
KR100444751B1 (en) * 2002-11-11 2004-08-16 한국전자통신연구원 Device of Controlling Fluid using Surface Tension
US7094354B2 (en) * 2002-12-19 2006-08-22 Bayer Healthcare Llc Method and apparatus for separation of particles in a microfluidic device
US7247500B2 (en) 2002-12-19 2007-07-24 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in membrane-based assay devices
US7125711B2 (en) * 2002-12-19 2006-10-24 Bayer Healthcare Llc Method and apparatus for splitting of specimens into multiple channels of a microfluidic device
US7935539B2 (en) * 2003-02-14 2011-05-03 Siemens Healthcare Diagnostics, Inc. Generic method for latex agglutination assays
US20040166551A1 (en) * 2003-02-24 2004-08-26 John Moulds Detection of agglutination of assays
GB0306098D0 (en) 2003-03-18 2003-04-23 Platform Diagnostics Group Ltd Sample testing device
SE0300823D0 (en) 2003-03-23 2003-03-23 Gyros Ab Preloaded Microscale Devices
WO2004083108A1 (en) * 2003-03-23 2004-09-30 Gyros Patent Ab Preloaded microscale devices
US7851209B2 (en) 2003-04-03 2010-12-14 Kimberly-Clark Worldwide, Inc. Reduction of the hook effect in assay devices
US20040197819A1 (en) 2003-04-03 2004-10-07 Kimberly-Clark Worldwide, Inc. Assay devices that utilize hollow particles
US7300802B2 (en) * 2003-04-25 2007-11-27 Biodigit Laboratories Corp. Membrane strip biosensor system for point-of-care testing
SE527896C2 (en) * 2003-05-20 2006-07-04 Aamic Ab Optical test device for biological samples, as well as a microarray for the device and the method for its use
KR100509254B1 (en) * 2003-05-22 2005-08-23 한국전자통신연구원 Micro-fluidic device to control flow time of micro-fluid
US8153081B2 (en) * 2003-05-29 2012-04-10 Bayer Healthcare Llc Test sensor and method for manufacturing the same
DE10325110B3 (en) * 2003-05-30 2005-01-13 Universität Freiburg Fluid channel, for use e.g. in biotechnology, is filled with liquid using capillary action, and comprises two sections separated by barrier preventing migration of liquid between sections, except at closed end
DE10326607A1 (en) * 2003-06-13 2005-01-05 Steag Microparts Gmbh Microstructure, for minimal- and non-invasive diagnostics, analysis and therapy, has base plate whose surface is sub-divided into zones with different capillary characteristics
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
DE10352535A1 (en) * 2003-11-07 2005-06-16 Steag Microparts Gmbh A microstructured separator and method of separating liquid components from a liquid containing particles
US7169933B2 (en) * 2003-11-14 2007-01-30 3M Innovative Properties Company N-sulfonylaminocarbonyl containing compounds
US7423155B2 (en) 2003-11-14 2008-09-09 3M Innovative Properties Company N-sulfonyldicarboximide containing tethering compounds
US7943388B2 (en) * 2003-11-14 2011-05-17 3M Innovative Properties Company Acoustic sensors and methods
US7361767B2 (en) * 2003-11-14 2008-04-22 3M Innovative Properties Company N-sulfonyldicarboximide containing tethering compounds
WO2005049590A2 (en) * 2003-11-14 2005-06-02 3M Innovative Properties Company N-sulfonylaminocarbonyl containing compounds
DE10354806A1 (en) * 2003-11-21 2005-06-02 Boehringer Ingelheim Microparts Gmbh sample carrier
US7713748B2 (en) 2003-11-21 2010-05-11 Kimberly-Clark Worldwide, Inc. Method of reducing the sensitivity of assay devices
US7943395B2 (en) 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
US20050112703A1 (en) 2003-11-21 2005-05-26 Kimberly-Clark Worldwide, Inc. Membrane-based lateral flow assay devices that utilize phosphorescent detection
US7943089B2 (en) 2003-12-19 2011-05-17 Kimberly-Clark Worldwide, Inc. Laminated assay devices
DE10360220A1 (en) * 2003-12-20 2005-07-21 Steag Microparts Gmbh Fine structure arrangement in fluid ejection system, has predetermined region in transitional zone between inlet and discharge ports, at which capillary force is maximum
KR100540143B1 (en) 2003-12-22 2006-01-10 한국전자통신연구원 Microfluidic control device and method for controlling microfluidic
JP4880478B2 (en) * 2003-12-30 2012-02-22 スリーエム イノベイティブ プロパティズ カンパニー Surface acoustic wave sensor assembly
EP1700127A1 (en) * 2003-12-30 2006-09-13 3M Innovative Properties Company Method of enhancing signal detection of cell-wall components of cells
US20070281369A1 (en) * 2003-12-30 2007-12-06 Carter Chad J Acousto-Mechanical Detection Systems and Methods of Use
US7402678B2 (en) * 2004-12-17 2008-07-22 3M Innovative Properties Company Multifunctional amine capture agents
US7399609B2 (en) * 2003-12-30 2008-07-15 3M Innovative Properties Company Staphylococcus detection
US7342082B2 (en) * 2004-12-17 2008-03-11 3M Innovative Properties Company Soluble polymers as amine capture agents and methods
DE102004007567A1 (en) * 2004-02-17 2005-09-01 Boehringer Ingelheim Microparts Gmbh Microstructured platform and method for handling a liquid
WO2005083390A1 (en) * 2004-02-20 2005-09-09 Research Foundation Of The State University Of New York Method and device for manipulating liquids in microfluidic systems
EP1733232A1 (en) 2004-03-23 2006-12-20 Quidel Corporation Hybrid phase lateral flow assay
SE0400662D0 (en) * 2004-03-24 2004-03-24 Aamic Ab Assay device and method
SE527036C2 (en) * 2004-06-02 2005-12-13 Aamic Ab Controlled flow analysis device and corresponding procedure
DE102004027422A1 (en) * 2004-06-04 2005-12-29 Boehringer Ingelheim Microparts Gmbh Device for receiving blood and separating blood components
US7169617B2 (en) * 2004-08-19 2007-01-30 Fujitsu Limited Device and method for quantitatively determining an analyte, a method for determining an effective size of a molecule, a method for attaching molecules to a substrate, and a device for detecting molecules
JP2007523355A (en) * 2004-08-21 2007-08-16 エルジー・ライフ・サイエンシズ・リミテッド Microfluidic device and diagnostic and analytical apparatus including the same
GB0423885D0 (en) 2004-10-28 2004-12-01 Platform Diagnostics Ltd Blood analysis
US7682817B2 (en) * 2004-12-23 2010-03-23 Kimberly-Clark Worldwide, Inc. Microfluidic assay devices
US20060171846A1 (en) * 2005-01-10 2006-08-03 Marr David W M Microfluidic systems incorporating integrated optical waveguides
US20090136982A1 (en) * 2005-01-18 2009-05-28 Biocept, Inc. Cell separation using microchannel having patterned posts
US8158410B2 (en) 2005-01-18 2012-04-17 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
KR20070116585A (en) 2005-01-18 2007-12-10 바이오셉트 인코포레이티드 Cell separation using microchannel having patterned posts
US20060252087A1 (en) * 2005-01-18 2006-11-09 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
DE102005003961A1 (en) * 2005-01-27 2006-08-10 Boehringer Ingelheim Microparts Gmbh Device for testing sample liquids, e.g. blood, plasma or urine, comprises a capillary channel, a reagent-containing zone with a device for holding liquid during reaction, and a test zone with a detection chemical
WO2006080021A2 (en) 2005-01-31 2006-08-03 Realbio Technologies Ltd. Multistep reaction lateral flow capillary device
US7189522B2 (en) 2005-03-11 2007-03-13 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
WO2006098804A2 (en) 2005-03-11 2006-09-21 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US7611908B2 (en) 2005-05-02 2009-11-03 Bioscale, Inc. Method and apparatus for therapeutic drug monitoring using an acoustic device
US7300631B2 (en) 2005-05-02 2007-11-27 Bioscale, Inc. Method and apparatus for detection of analyte using a flexural plate wave device and magnetic particles
US7749445B2 (en) 2005-05-02 2010-07-06 Bioscale, Inc. Method and apparatus for analyzing bioprocess fluids
US7648844B2 (en) 2005-05-02 2010-01-19 Bioscale, Inc. Method and apparatus for detection of analyte using an acoustic device
SE529254C2 (en) * 2005-06-17 2007-06-12 Aamic Ab Optical test system
SE0501418L (en) 2005-06-20 2006-09-26 Aamic Ab Method and means for effecting liquid transport
EP1896180B1 (en) 2005-06-23 2011-11-23 Biocartis SA Cartridge, system and method for automated medical diagnostics
EP1904234B1 (en) * 2005-06-30 2011-10-19 Biocartis SA Cartridge for automated medical diagnostics
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US7544754B2 (en) 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
US7544756B2 (en) * 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
US7544755B2 (en) * 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
JPWO2007052648A1 (en) * 2005-11-02 2009-04-30 パナソニック株式会社 Sample analysis disc
TW200734641A (en) * 2005-12-26 2007-09-16 Inst Of Microchemical Technology Microchip for immunoassay, kit for immunoassay and immunoassay method
US9885644B2 (en) 2006-01-10 2018-02-06 Colorado School Of Mines Dynamic viscoelasticity as a rapid single-cell biomarker
US9487812B2 (en) 2012-02-17 2016-11-08 Colorado School Of Mines Optical alignment deformation spectroscopy
US9878326B2 (en) * 2007-09-26 2018-01-30 Colorado School Of Mines Fiber-focused diode-bar optical trapping for microfluidic manipulation
US8119976B2 (en) * 2007-07-03 2012-02-21 Colorado School Of Mines Optical-based cell deformability
US7695956B2 (en) * 2006-01-12 2010-04-13 Biocept, Inc. Device for cell separation and analysis and method of using
EP1808696B1 (en) 2006-01-14 2009-03-11 Roche Diagnostics GmbH Immunological test element with improved control zone
US7794656B2 (en) 2006-01-23 2010-09-14 Quidel Corporation Device for handling and analysis of a biological sample
US7871568B2 (en) 2006-01-23 2011-01-18 Quidel Corporation Rapid test apparatus
US8460878B2 (en) 2006-02-21 2013-06-11 The Trustees Of Tufts College Methods and arrays for detecting cells and cellular components in small defined volumes
US11237171B2 (en) 2006-02-21 2022-02-01 Trustees Of Tufts College Methods and arrays for target analyte detection and determination of target analyte concentration in solution
SE529711C2 (en) * 2006-03-22 2007-11-06 Aamic Ab Fluorescence Readers
EP2023802A2 (en) * 2006-05-08 2009-02-18 Bayer Healthcare, LLC Test sensor with under-fill protection
DE102006024355B4 (en) * 2006-05-19 2008-04-03 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Microfluidic arrangement for the detection of chemical, biochemical molecules and / or particles contained in samples
EP2589668A1 (en) 2006-06-14 2013-05-08 Verinata Health, Inc Rare cell analysis using sample splitting and DNA tags
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
EP2029779A4 (en) 2006-06-14 2010-01-20 Living Microsystems Inc Use of highly parallel snp genotyping for fetal diagnosis
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
WO2007149043A1 (en) * 2006-06-20 2007-12-27 Åmic AB Assay device
SE531948C2 (en) * 2006-06-20 2009-09-15 Aamic Ab Liquid sample analyzer including filters in direct contact with projections
KR100824209B1 (en) * 2006-06-22 2008-04-24 부산대학교 산학협력단 Device for passive microfluidic washing using capillary force
US20080021364A1 (en) * 2006-07-17 2008-01-24 Industrial Technology Research Institute Fluidic device
US7959876B2 (en) * 2006-07-17 2011-06-14 Industrial Technology Research Institute Fluidic device
US7794665B2 (en) * 2006-07-17 2010-09-14 Industrial Technology Research Institute Fluidic device
EP2500723B1 (en) 2006-11-14 2015-07-08 Alere San Diego, Inc. Methods for monitoring and risk prediction in cardiorenal syndrome
US8524462B2 (en) 2006-11-14 2013-09-03 Alere San Diego, Inc. Methods and compositions for diagnosis and prognosis of renal artery stenosis
US8202491B2 (en) 2006-11-21 2012-06-19 Bioscale, Inc. Apparatus for analyte processing
US20080118402A1 (en) * 2006-11-21 2008-05-22 David Brancazio Method and apparatus for analyte processing
EP2100130A1 (en) * 2006-12-29 2009-09-16 3M Innovative Properties Company Method of detection of bioanalytes by acousto-mechanical detection systems comprising the addition of liposomes
DE502007006595D1 (en) 2007-01-10 2011-04-14 Hoffmann La Roche Apparatus for determining an analyte in a liquid and method
SE0700930L (en) * 2007-04-16 2008-01-22 Aamic Ab Assay device for liquid samples
EP2011630A1 (en) * 2007-07-03 2009-01-07 F. Hoffmann-La Roche AG Method for manufacturing an analytical element
EP2011629A1 (en) * 2007-07-03 2009-01-07 F. Hoffman-la Roche AG Method for manufacturing a microfluid system on a polymer surface
ES2556627T3 (en) 2007-08-30 2016-01-19 Trustees Of Tufts College Methods to determine the concentration of an analyte in solution
US20090062828A1 (en) * 2007-09-04 2009-03-05 Colorado School Of Mines Magnetic field-based colloidal atherectomy
US10722250B2 (en) 2007-09-04 2020-07-28 Colorado School Of Mines Magnetic-field driven colloidal microbots, methods for forming and using the same
US8354280B2 (en) 2007-09-06 2013-01-15 Bioscale, Inc. Reusable detection surfaces and methods of using same
WO2009034563A2 (en) 2007-09-14 2009-03-19 Nanocomms Patents Limited An analysis system
KR100890988B1 (en) * 2007-10-29 2009-03-31 주식회사 아이센스 Electrochemical biosensor equipped with sampling port which enables uniform introduction of a small amount of sample
KR100878229B1 (en) 2007-11-22 2009-01-12 주식회사 디지탈바이오테크놀러지 Chip for analysis of fluidic liquid
US8008032B2 (en) * 2008-02-25 2011-08-30 Cellective Dx Corporation Tagged ligands for enrichment of rare analytes from a mixed sample
AU2009218752B2 (en) * 2008-02-27 2014-07-10 Boehringer Ingelheim Microparts Gmbh Apparatus for the separation of plasma
KR100968524B1 (en) * 2008-04-11 2010-07-08 인싸이토 주식회사 Micoro-nano fluidic biochip for assaying biomass
SE533514C2 (en) * 2008-06-16 2010-10-12 Aamic Ab Analytical apparatus and method
US8974749B2 (en) * 2008-06-16 2015-03-10 Johnson & Johnson Ab Assay device and method
EP2326419B1 (en) 2008-06-29 2021-04-07 Realbio Technologies Ltd. Liquid transfer device particularly useful as a capturing device in a biological assay process
US20100022916A1 (en) 2008-07-24 2010-01-28 Javanbakhsh Esfandiari Method and Apparatus for Collecting and Preparing Biological Samples for Testing
DE102008036639A1 (en) * 2008-08-06 2010-02-11 Volker Lob Cell-chip system for examining living cells in its natural environment, comprises inlet chamber, main chamber, in which cell culture chamber is present with sensor chip at its bottom area, outlet chamber, inlet channel, and outlet channel
HUE031849T2 (en) 2008-09-20 2017-08-28 Univ Leland Stanford Junior Noninvasive diagnosis of fetal aneuploidy by sequencing
US20100075439A1 (en) * 2008-09-23 2010-03-25 Quanterix Corporation Ultra-sensitive detection of molecules by capture-and-release using reducing agents followed by quantification
US8222047B2 (en) 2008-09-23 2012-07-17 Quanterix Corporation Ultra-sensitive detection of molecules on single molecule arrays
EP2213364A1 (en) 2009-01-30 2010-08-04 Albert-Ludwigs-Universität Freiburg Phase guide patterns for liquid manipulation
US20120107811A1 (en) * 2009-02-06 2012-05-03 Kelso David M Burstable liquid packaging and uses thereof
JP4962658B2 (en) * 2009-03-31 2012-06-27 凸版印刷株式会社 Sample analysis chip, sample analysis apparatus using the same, sample analysis method and gene analysis method, and sample analysis chip manufacturing method
EP2269737B1 (en) * 2009-07-02 2017-09-13 Amic AB Assay device comprising serial reaction zones
EP2281632B1 (en) * 2009-07-02 2013-11-13 Amic AB Capillary driven assay device and its manufacture
KR101312090B1 (en) 2009-12-18 2013-09-25 한국전자통신연구원 The lab-on a chip and method of driving the same
EP2534494A4 (en) * 2010-02-12 2016-05-04 Univ Northwestern Assay card for sample acquisition, treatment and reaction
US8236574B2 (en) 2010-03-01 2012-08-07 Quanterix Corporation Ultra-sensitive detection of molecules or particles using beads or other capture objects
ES2544635T3 (en) 2010-03-01 2015-09-02 Quanterix Corporation Methods to extend the dynamic range in assays for the detection of molecules or particles
US9678068B2 (en) 2010-03-01 2017-06-13 Quanterix Corporation Ultra-sensitive detection of molecules using dual detection methods
US8415171B2 (en) 2010-03-01 2013-04-09 Quanterix Corporation Methods and systems for extending dynamic range in assays for the detection of molecules or particles
KR100961874B1 (en) * 2010-04-05 2010-06-09 주식회사 나노엔텍 Chip for analyzing fluids without outer powersource
EP2555871B1 (en) 2010-04-07 2021-01-13 Biosensia Patents Limited Flow control device for assays
CN103370619B (en) 2010-11-29 2016-01-20 美艾利尔圣地亚哥有限公司 The method of diagnosis or risk profile heart failure and reagent
US9952237B2 (en) 2011-01-28 2018-04-24 Quanterix Corporation Systems, devices, and methods for ultra-sensitive detection of molecules or particles
US8603835B2 (en) 2011-02-10 2013-12-10 Chembio Diagnostic Systems, Inc. Reduced step dual path immunoassay device and method
CN102680441A (en) * 2011-03-16 2012-09-19 罗姆股份有限公司 Analysis chip, analysis system, and analysis method
JP2012202925A (en) * 2011-03-28 2012-10-22 Rohm Co Ltd Analytical chip, analytical system and analytical method
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
GB201109203D0 (en) 2011-06-01 2011-07-13 Carclo Technical Plastics Ltd Fluid flow control
KR101911435B1 (en) 2011-09-26 2018-10-25 삼성전자주식회사 Apparatus for controlling fluid, filter and bio-chip including the same
KR101257700B1 (en) * 2011-12-05 2013-04-24 삼성전자주식회사 Microfluidic device and microfluidic system including thereof
CN105833925B (en) 2011-12-22 2018-11-13 瑞尔比奥技术有限公司 sequential lateral flow capillary device for analyte determination
CN103217519B (en) 2012-01-20 2017-06-20 奥索临床诊断有限公司 Measure device with multiple reagents
EP2618153B1 (en) * 2012-01-20 2015-03-18 Ortho-Clinical Diagnostics, Inc. Controlling fluid flow through an assay device
CA2802258A1 (en) * 2012-01-20 2013-07-20 Ortho-Clinical Diagnostics, Inc. Low volume assay device having increased sensitivity
KR101175594B1 (en) 2012-05-14 2012-08-21 주식회사 나노엔텍 A chip for analyzing sample
US20140093980A1 (en) * 2012-10-01 2014-04-03 University Of Washington Through Its Center For Commercialization Dissolvable bridges for manipulating fluid volumes and associated devices, systems and methods
WO2014078790A1 (en) * 2012-11-16 2014-05-22 Lightstat Llc A micro-pillar array method and apparatus
US9932626B2 (en) 2013-01-15 2018-04-03 Quanterix Corporation Detection of DNA or RNA using single molecule arrays and other techniques
WO2014116756A1 (en) 2013-01-22 2014-07-31 University Of Washington Through Its Center For Commercialization Sequential delivery of fluid volumes and associated devices, systems and methods
CA2841692C (en) 2013-02-12 2023-08-22 Zhong Ding Reagent zone deposition pattern
US9304120B2 (en) * 2013-11-24 2016-04-05 Kemira Oyj Method and system for analyzing a liquid sample containing particles of solid matter and the use of such a method and system
JP5933518B2 (en) * 2013-12-26 2016-06-08 富士フイルム株式会社 Bonding method and manufacturing method of microchannel device
DK3126486T3 (en) 2014-04-02 2019-10-14 Chembio Diagnostic Systems Inc IMMUNASSAY USING THE Catch Conjugate
US20160116466A1 (en) 2014-10-27 2016-04-28 Chembio Diagnostic Systems, Inc. Rapid Screening Assay for Qualitative Detection of Multiple Febrile Illnesses
JP6726104B2 (en) * 2014-12-15 2020-07-22 デンカ株式会社 Liquid sample inspection kit and method for producing liquid sample inspection kit
JP6640998B2 (en) 2015-06-05 2020-02-05 ミメタス ビー．ブイ． Micro fluid plate
NL2015130B1 (en) 2015-07-09 2017-02-01 Mimetas B V Barrier function measurements.
JP6868639B2 (en) * 2016-03-18 2021-05-12 クイデル カーディオバスキュラー インコーポレイテッド Microfluidic devices, systems, and methods
DE102016210010B4 (en) * 2016-06-07 2020-02-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for producing a device with components that are movable relative to one another and spaced apart in the micrometer range, provided device and uses thereof
KR101982670B1 (en) * 2017-04-13 2019-05-29 주식회사 인지바이오 Lateral flow immunoassay sensor comprising a bridge structure for enhancing of detection sensitivity
JP2019007956A (en) * 2017-06-28 2019-01-17 積水化学工業株式会社 Micro flow passage chip, method for mixing reagent, and optical inspection system
CN108593939B (en) * 2018-07-18 2023-11-14 瑞博奥(广州)生物科技股份有限公司 Full-automatic protein chip and application thereof
WO2020178947A1 (en) * 2019-03-04 2020-09-10 Enplas Corporation Fluid handling device
WO2020178951A1 (en) * 2019-03-04 2020-09-10 Enplas Corporation Fluid handling device
DE102019210697A1 (en) * 2019-07-19 2021-01-21 Robert Bosch Gmbh Lab-on-chip system with at least one functionalized section
US20220387993A1 (en) * 2019-11-01 2022-12-08 Redbud Labs, Inc. Active surface devices for and methods of providing dried reagents in microfluidic applications
KR102474790B1 (en) * 2020-03-17 2022-12-07 주식회사 나노엔텍 chip for analyzing fluids

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4591570A (en) * 1983-02-02 1986-05-27 Centocor, Inc. Matrix of antibody-coated spots for determination of antigens
US4829010A (en) * 1987-03-13 1989-05-09 Tanox Biosystems, Inc. Immunoassay device enclosing matrixes of antibody spots for cell determinations
US4911782A (en) * 1988-03-28 1990-03-27 Cyto-Fluidics, Inc. Method for forming a miniaturized biological assembly
US5202268A (en) * 1988-12-30 1993-04-13 Environmental Diagnostics, Inc. Multi-layered test card for the determination of substances in liquids
WO1994009366A1 (en) * 1992-10-08 1994-04-28 Abbott Laboratories Assay devices using subsurface flow
US5486335A (en) * 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
EP0695941A2 (en) * 1994-06-08 1996-02-07 Affymax Technologies N.V. Method and apparatus for packaging a chip
WO1997000442A1 (en) * 1995-06-16 1997-01-03 The University Of Washington Microfabricated differential extraction device and method
WO1997002357A1 (en) * 1995-06-29 1997-01-23 Affymetrix, Inc. Integrated nucleic acid diagnostic device

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4233029A (en) 1978-10-25 1980-11-11 Eastman Kodak Company Liquid transport device and method
US4426451A (en) * 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
US4435504A (en) 1982-07-15 1984-03-06 Syva Company Immunochromatographic assay with support having bound "MIP" and second enzyme
US4883688A (en) 1984-03-16 1989-11-28 Syntex (U.S.A) Inc. Method for producing chromatographic devices having modified edges
US4757004A (en) * 1984-03-16 1988-07-12 Syntex (U.S.A.) Inc. Chromatographic devices having modified edges
US4756828A (en) 1984-04-12 1988-07-12 Syntex (U.S.A.) Inc. Chromatographic strip having non-compressed edges
US4945205A (en) 1984-04-12 1990-07-31 Syntex (U.S.A.) Inc. Chromatographic strip having non-compressed edges
US4632901A (en) 1984-05-11 1986-12-30 Hybritech Incorporated Method and apparatus for immunoassays
US4740468A (en) 1985-02-14 1988-04-26 Syntex (U.S.A.) Inc. Concentrating immunochemical test device and method
US4963498A (en) * 1985-08-05 1990-10-16 Biotrack Capillary flow device
US4756884A (en) 1985-08-05 1988-07-12 Biotrack, Inc. Capillary flow device
US4916056A (en) 1986-02-18 1990-04-10 Abbott Laboratories Solid-phase analytical device and method for using same
US4906439A (en) * 1986-03-25 1990-03-06 Pb Diagnostic Systems, Inc. Biological diagnostic device and method of use
US4960691A (en) * 1986-09-29 1990-10-02 Abbott Laboratories Chromatographic test strip for determining ligands or receptors
US4857453A (en) 1987-04-07 1989-08-15 Syntex (U.S.A.) Inc. Immunoassay device
US5137808A (en) 1987-04-07 1992-08-11 Syntex (U.S.A.) Inc. Immunoassay device
US5006309A (en) 1988-04-22 1991-04-09 Abbott Laboratories Immunoassay device with liquid transfer between wells by washing
US5051237A (en) * 1988-06-23 1991-09-24 P B Diagnostic Systems, Inc. Liquid transport system
US4877586A (en) 1988-07-27 1989-10-31 Eastman Kodak Company Sliding test device for assays
JP2685544B2 (en) 1988-11-11 1997-12-03 株式会社日立製作所 Blood filter, blood test method, and blood test apparatus
US5028535A (en) 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
US5087556A (en) 1989-05-17 1992-02-11 Actimed Laboratories, Inc. Method for quantitative analysis of body fluid constituents
IE903118A1 (en) 1989-09-21 1991-03-27 Becton Dickinson Co Test device including flow control means
WO1993022058A1 (en) * 1992-05-01 1993-11-11 Trustees Of The University Of Pennsylvania Polynucleotide amplification analysis using a microfabricated device
US5458852A (en) * 1992-05-21 1995-10-17 Biosite Diagnostics, Inc. Diagnostic devices for the controlled movement of reagents without membranes
US5458582A (en) 1992-06-15 1995-10-17 Nakao; Naomi L. Postoperative anesthetic delivery device and associated method for the postoperative treatment of pain
US5707799A (en) * 1994-09-30 1998-01-13 Abbott Laboratories Devices and methods utilizing arrays of structures for analyte capture

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4591570A (en) * 1983-02-02 1986-05-27 Centocor, Inc. Matrix of antibody-coated spots for determination of antigens
US4829010A (en) * 1987-03-13 1989-05-09 Tanox Biosystems, Inc. Immunoassay device enclosing matrixes of antibody spots for cell determinations
US4911782A (en) * 1988-03-28 1990-03-27 Cyto-Fluidics, Inc. Method for forming a miniaturized biological assembly
US5202268A (en) * 1988-12-30 1993-04-13 Environmental Diagnostics, Inc. Multi-layered test card for the determination of substances in liquids
US5486335A (en) * 1992-05-01 1996-01-23 Trustees Of The University Of Pennsylvania Analysis based on flow restriction
WO1994009366A1 (en) * 1992-10-08 1994-04-28 Abbott Laboratories Assay devices using subsurface flow
EP0695941A2 (en) * 1994-06-08 1996-02-07 Affymax Technologies N.V. Method and apparatus for packaging a chip
WO1997000442A1 (en) * 1995-06-16 1997-01-03 The University Of Washington Microfabricated differential extraction device and method
WO1997002357A1 (en) * 1995-06-29 1997-01-23 Affymetrix, Inc. Integrated nucleic acid diagnostic device

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