WO1998046277A2 - Humidity compensation for fuel cell zeroing in respiratory gas measurement - Google Patents
Humidity compensation for fuel cell zeroing in respiratory gas measurement Download PDFInfo
- Publication number
- WO1998046277A2 WO1998046277A2 PCT/US1998/006254 US9806254W WO9846277A2 WO 1998046277 A2 WO1998046277 A2 WO 1998046277A2 US 9806254 W US9806254 W US 9806254W WO 9846277 A2 WO9846277 A2 WO 9846277A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- respiratory gas
- gas
- sample
- respiratory
- humidity
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
Definitions
- electrochemical fuel cells are used in conjunction with additional circuitry to measure the amount of a specific gas within a respiratory gas stream.
- a monitor for measuring the concentration of nitric oxide and nitrogen dioxide electrochemical fuel cells are used to generate an electrical signal indicative of the respective concentrations of nitric oxide and nitrogen dioxide.
- Such a monitor is useful during the administration of nitric oxide to a patient for medical purposes.
- United States Patent No. 5,485,827, Zapol et al. which discusses the method of treating patients with nitric oxide and United States Patent No. 5,558,083, Bathe et al., which discloses a nitric oxide delivery system of which a gas monitor is one element.
- the accuracy of respiratory gas measurements taken by electrochemical fuel cells is affected by changes in humidity. Such changes come more apparent after a monitoring bench containing fuel cells has been zeroed and then returned to the sampling mode where a measurement is taken of a respiratory gas sample. The difference in humidity between the sampling gas stream and the zeroing gas stream causes a zero drift in the fuel cell readings.
- a six inch piece of Nafion® tubing is used in the present invention after the pneumatics manifold which switches between the two gas streams and the fuel cell bench in order to equilibrate the humidity in both the sample and zero gas streams. The addition of this Nafion® tubing eliminates the zero drift between the two gas sources allowing for an accurate zeroing of the nitrogen oxide and nitrogen dioxide fuel cells.
- FIG. 1 is a diagram of the gas stream flow components of a respiratory gas monitor according to the present invention.
- FIG. 1 depicts the major components of a respiratory gas monitor according to the present invention through which the sample and zero gases flow.
- the pneumatic manifold 10 controls the source of the gas stream input to the bench 20 containing the electrochemical fuel cells for the measurement of nitric oxide, nitrogen dioxide and oxygen.
- the manifold 10 enables the monitor control to select between inputting a sample of the respiratory gas stream into the sample inlet 40 or a sample of a calibration gas into scrubber 30.
- a Nafion® tube or other hydrophilic tube 50 is placed between manifold 10 to bench 20 to reduce the amount of moisture in the gas stream.
- Vacuum pump 60 provides the Vacuum necessary to draw the sample or calibration (zeroing) gases through the system.
- the next configuration tested used humidified sample gas and dry room air gas.
- the system was zeroed in each of four configurations: (1) no Nafion; (2) 4 inches of Nafion; (3) 6 inches of Nafion; and (4) 16 inches of Nafion. After zeroing the system was switched to humid sample gas and the variance in the relative humidity of the gas readings taken on the far side of the bench was recorded as set forth in the following Table 2.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Physics & Mathematics (AREA)
- Obesity (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Physiology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Fuel Cell (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU68726/98A AU6872698A (en) | 1997-04-16 | 1998-03-30 | Humidity compensation for fuel cell zeroing in respiratory gas measurement |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4325097P | 1997-04-16 | 1997-04-16 | |
US60/043,250 | 1997-04-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1998046277A2 true WO1998046277A2 (en) | 1998-10-22 |
WO1998046277A3 WO1998046277A3 (en) | 1999-03-04 |
Family
ID=21926239
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/006254 WO1998046277A2 (en) | 1997-04-16 | 1998-03-30 | Humidity compensation for fuel cell zeroing in respiratory gas measurement |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU6872698A (en) |
WO (1) | WO1998046277A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003017837A1 (en) * | 2001-08-28 | 2003-03-06 | Phase-In Ab | Device at quantitative analysis of respiratory gases |
WO2010030226A1 (en) * | 2008-09-15 | 2010-03-18 | Phasein Ab | Gas sampling line for respiratory gases |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5038792A (en) * | 1988-06-29 | 1991-08-13 | Mault James R | Oxygen consumption meter |
US5042500A (en) * | 1990-06-18 | 1991-08-27 | Medical Graphics Corporation | Drying sample line |
US5284160A (en) * | 1991-11-13 | 1994-02-08 | Dryden Gale E | Consolidated anesthesia circuit |
US5485827A (en) * | 1990-12-05 | 1996-01-23 | The General Hospital Corporation | Methods and devices for treating plumonary vasoconstriction and asthma |
US5558083A (en) * | 1993-11-22 | 1996-09-24 | Ohmeda Inc. | Nitric oxide delivery system |
-
1998
- 1998-03-30 AU AU68726/98A patent/AU6872698A/en not_active Abandoned
- 1998-03-30 WO PCT/US1998/006254 patent/WO1998046277A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5038792A (en) * | 1988-06-29 | 1991-08-13 | Mault James R | Oxygen consumption meter |
US5042500A (en) * | 1990-06-18 | 1991-08-27 | Medical Graphics Corporation | Drying sample line |
US5485827A (en) * | 1990-12-05 | 1996-01-23 | The General Hospital Corporation | Methods and devices for treating plumonary vasoconstriction and asthma |
US5284160A (en) * | 1991-11-13 | 1994-02-08 | Dryden Gale E | Consolidated anesthesia circuit |
US5558083A (en) * | 1993-11-22 | 1996-09-24 | Ohmeda Inc. | Nitric oxide delivery system |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003017837A1 (en) * | 2001-08-28 | 2003-03-06 | Phase-In Ab | Device at quantitative analysis of respiratory gases |
WO2010030226A1 (en) * | 2008-09-15 | 2010-03-18 | Phasein Ab | Gas sampling line for respiratory gases |
US9861298B2 (en) | 2008-09-15 | 2018-01-09 | Masimo Corporation | Gas sampling line |
US10952641B2 (en) | 2008-09-15 | 2021-03-23 | Masimo Corporation | Gas sampling line |
US11564593B2 (en) | 2008-09-15 | 2023-01-31 | Masimo Corporation | Gas sampling line |
Also Published As
Publication number | Publication date |
---|---|
AU6872698A (en) | 1998-11-11 |
WO1998046277A3 (en) | 1999-03-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU2002253206B2 (en) | Method and measuring equipment for measuring nitric oxide concentration in exhaled air | |
US5042500A (en) | Drying sample line | |
Tissot et al. | Clinical validation of the Deltatrac monitoring system in mechanically ventilated patients | |
US5303712A (en) | Calibration method for single-breath carbon monoxide lung diffusing capacity test system | |
CA2633235C (en) | Calibration method of metabolic gas analyzers | |
EP0747675A2 (en) | Method for measuring the flow rate of a species contained in an exhaust gas stream of a combustion process | |
Kader | Methods of gas mixing, sampling and analysis | |
AU2002253206A1 (en) | Method and measuring equipment for measuring nitric oxide concentration in exhaled air | |
GB2114890A (en) | Method and apparatus for measuring the concentration of one or more given components in a gas inhaled and/or exhaled by a patient | |
Shephard | A critical examination of the Douglas bag technique | |
Sackner et al. | Determination of tissue volume and carbon dioxide dissociation slope of the lungs in man | |
CN101500482B (en) | Method and apparatus for analyzing pulmonary performance | |
Linderholm et al. | Determination of carbon monoxide in small gas volumes | |
WO1998046277A2 (en) | Humidity compensation for fuel cell zeroing in respiratory gas measurement | |
CN110554028A (en) | Gas detection method and gas detection system based on same | |
Maas et al. | Evaluation of ampouled tonometered buffer solutions as a quality-control system for pH, pCO2, and pO2 measurement. | |
JP2946800B2 (en) | Carbon dioxide measuring device | |
Green et al. | Water vapor pressure of end-tidal air of normals and chronic bronchitics. | |
Colquhoun et al. | An evaluation of the Datex Normac anaesthetic agent monitor | |
Douglas et al. | Measurement of saturation time and saturation tension with Millikan oximeter, in subjects with normal pulmonary function | |
Snider et al. | Carbon dioxide transfer rate in artificial lungs. | |
CN210803283U (en) | Double-mechanism cooperative gas detection device | |
CN213749512U (en) | Measuring device of special ventilation rate standard rod of tobacco | |
Severinghaus et al. | A gas mixer for computer calibration of an anesthetic mass spectrometer | |
SU824998A1 (en) | Respiration examination device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
AK | Designated states |
Kind code of ref document: A3 Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH GM GW HU ID IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT UA UG US UZ VN YU ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): GH GM KE LS MW SD SZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
122 | Ep: pct application non-entry in european phase | ||
NENP | Non-entry into the national phase in: |
Ref country code: CA |
|
NENP | Non-entry into the national phase in: |
Ref country code: JP Ref document number: 1998543944 Format of ref document f/p: F |