WO1998048838B1 - Compounds - Google Patents

Compounds

Info

Publication number
WO1998048838B1
WO1998048838B1 PCT/GB1998/001244 GB9801244W WO9848838B1 WO 1998048838 B1 WO1998048838 B1 WO 1998048838B1 GB 9801244 W GB9801244 W GB 9801244W WO 9848838 B1 WO9848838 B1 WO 9848838B1
Authority
WO
WIPO (PCT)
Prior art keywords
contrast agent
optical
imaging
microscopy
polyalkylene oxide
Prior art date
Application number
PCT/GB1998/001244
Other languages
French (fr)
Other versions
WO1998048838A8 (en
WO1998048838A1 (en
Filing date
Publication date
Priority claimed from GBGB9727124.1A external-priority patent/GB9727124D0/en
Application filed filed Critical
Priority to AU72212/98A priority Critical patent/AU7221298A/en
Priority to EP98919335A priority patent/EP0979103B1/en
Priority to AT98919335T priority patent/ATE257014T1/en
Priority to DE1998620867 priority patent/DE69820867T2/en
Priority to JP54674998A priority patent/JP4699575B2/en
Publication of WO1998048838A1 publication Critical patent/WO1998048838A1/en
Publication of WO1998048838B1 publication Critical patent/WO1998048838B1/en
Priority to US09/429,347 priority patent/US6350431B1/en
Publication of WO1998048838A8 publication Critical patent/WO1998048838A8/en

Links

Abstract

This invention provides a physiologically tolerable light imaging contrast agent compound having a molecular weight in the range 500 to 500000 and containing at least two chromophores having delocalized electron systems as well as at least one polyalkylene oxide (PAO) moiety having a molecular weight in the range 60 to 100000.

Claims

151
AMENDED CLAIMS
[received by the International Bureau on 23 November 1998 (23.11.98); new claim 32 added; remaining claims unchanged (1 page)]
diagnosis of a human or animal (e.g. mammalian, avian or reptilian) body which involves generation by a confocal scanning laser microscopy (CSL ) , optical coherence tomography (OCT) , photoacoustic, acousto-optical , diffusive wave, time-resolved imaging, endoscopic, multiphoton excitation microscopy or visual observation technique, an image of a part of said body to which said material distributes.
31. A pharmaceutical composition comprising a physiologically tolerable light-imaging contrast agent compound as claimed in any of claims 1 to 24 together with at least one physiologically acceptable carrier or excipient, in a sterile, pyrogen free aqueous carrier medium.
32. A contrast agent as claimed in any one of claims 1 to 6 wherein said PAO moiety comprises a branched polyalkylene oxide .
PCT/GB1998/001244 1997-04-29 1998-04-28 Compounds WO1998048838A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU72212/98A AU7221298A (en) 1997-04-29 1998-04-28 Compounds
EP98919335A EP0979103B1 (en) 1997-04-29 1998-04-28 Light imaging contrast agents
AT98919335T ATE257014T1 (en) 1997-04-29 1998-04-28 LIGHT IMAGING CONTRAST AGENTS
DE1998620867 DE69820867T2 (en) 1997-04-29 1998-04-28 LIGHT IMAGING CONTRAST AGENTS
JP54674998A JP4699575B2 (en) 1997-04-29 1998-04-29 Compound
US09/429,347 US6350431B1 (en) 1997-04-29 1999-10-28 Compounds

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US84858697A 1997-04-29 1997-04-29
US08/848,586 1997-04-29
GB9727124.1 1997-12-22
GBGB9727124.1A GB9727124D0 (en) 1997-12-22 1997-12-22 Compounds
US3528598A 1998-03-05 1998-03-05
US09/035,285 1998-03-05

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US3528598A Continuation-In-Part 1997-04-29 1998-03-05

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US09/429,347 Continuation US6350431B1 (en) 1997-04-29 1999-10-28 Compounds

Publications (3)

Publication Number Publication Date
WO1998048838A1 WO1998048838A1 (en) 1998-11-05
WO1998048838B1 true WO1998048838B1 (en) 1998-12-30
WO1998048838A8 WO1998048838A8 (en) 2000-04-27

Family

ID=27269147

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/GB1998/001245 WO1998048845A1 (en) 1997-04-29 1998-04-28 Method of demarcating tissue
PCT/GB1998/001244 WO1998048838A1 (en) 1997-04-29 1998-04-28 Compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/001245 WO1998048845A1 (en) 1997-04-29 1998-04-28 Method of demarcating tissue

Country Status (8)

Country Link
US (1) US6350431B1 (en)
EP (1) EP0979103B1 (en)
JP (1) JP4699575B2 (en)
AT (1) ATE257014T1 (en)
AU (2) AU7221298A (en)
DE (1) DE69820867T2 (en)
ES (1) ES2213899T3 (en)
WO (2) WO1998048845A1 (en)

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