WO1998051662A3 - Compounds and methods for the inhibition of the expression of vcam-1 - Google Patents

Compounds and methods for the inhibition of the expression of vcam-1 Download PDF

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Publication number
WO1998051662A3
WO1998051662A3 PCT/US1998/009781 US9809781W WO9851662A3 WO 1998051662 A3 WO1998051662 A3 WO 1998051662A3 US 9809781 W US9809781 W US 9809781W WO 9851662 A3 WO9851662 A3 WO 9851662A3
Authority
WO
WIPO (PCT)
Prior art keywords
vcam
inhibition
expression
methods
compounds
Prior art date
Application number
PCT/US1998/009781
Other languages
French (fr)
Other versions
WO1998051662A2 (en
Inventor
Patricia K Somers
Lee K Hoong
Charles Q Meng
Original Assignee
Atherogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA002289851A priority Critical patent/CA2289851C/en
Priority to JP54950298A priority patent/JP3930056B2/en
Priority to IL15707898A priority patent/IL157078A/en
Priority to EP98922264A priority patent/EP0994853B1/en
Priority to DE69829966T priority patent/DE69829966T2/en
Priority to AT98922264T priority patent/ATE294158T1/en
Priority to AU74851/98A priority patent/AU750041B2/en
Priority to IL15707798A priority patent/IL157077A/en
Priority to DK98922264T priority patent/DK0994853T3/en
Priority to PL343904A priority patent/PL207885B1/en
Priority to BR9809819-5A priority patent/BR9809819A/en
Priority to SI9830885T priority patent/SI1464639T1/en
Application filed by Atherogenics Inc filed Critical Atherogenics Inc
Priority to KR1019997010458A priority patent/KR100882335B1/en
Priority to HU0004592A priority patent/HUP0004592A3/en
Priority to EA199901026A priority patent/EA009370B1/en
Priority to SK50038-2007A priority patent/SK286766B6/en
Priority to IL13279798A priority patent/IL132797A0/en
Priority to IL16456898A priority patent/IL164568A0/en
Priority to SK1532-99A priority patent/SK286392B6/en
Publication of WO1998051662A2 publication Critical patent/WO1998051662A2/en
Priority to NO19995544A priority patent/NO316221B1/en
Publication of WO1998051662A3 publication Critical patent/WO1998051662A3/en
Priority to HK00105042A priority patent/HK1025947A1/en
Priority to NO20032254A priority patent/NO319855B1/en
Priority to IL164568A priority patent/IL164568A/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/06—Antipsoriatics
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    • A61P19/00—Drugs for skeletal disorders
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/06—Antihyperlipidemics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/21—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with the sulfur atom of the thio group bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/66—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfo, esterified sulfo or halosulfonyl groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
    • C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton

Abstract

This invention is in the area of methods and compositions for the inhibition of the expression of VCAM-1 and, in particular, for the treatment of diseases mediated by VCAM-1, including cardiovascular and inflammatory diseases.
PCT/US1998/009781 1997-05-14 1998-05-14 Compounds and methods for the inhibition of the expression of vcam-1 WO1998051662A2 (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
KR1019997010458A KR100882335B1 (en) 1997-05-14 1998-05-14 Compounds and methods for the inhibition of the expression of vcam-1
JP54950298A JP3930056B2 (en) 1997-05-14 1998-05-14 Compounds and methods for inhibiting VCAM-1 expression
HU0004592A HUP0004592A3 (en) 1997-05-14 1998-05-14 Compounds and methods for the inhibition of the expression of vcam-1
DE69829966T DE69829966T2 (en) 1997-05-14 1998-05-14 A MONOETHER OF PROBUCOL AND METHODS FOR INHIBITING THE VCAM-1 EXPRESSION
AT98922264T ATE294158T1 (en) 1997-05-14 1998-05-14 A MONOETHER OF PROBUCOL AND METHODS OF INHIBITING VCAM-1 EXPRESSION
AU74851/98A AU750041B2 (en) 1997-05-14 1998-05-14 Compounds and methods for the inhibition of the expression of VCAM-1
IL15707798A IL157077A (en) 1997-05-14 1998-05-14 Compounds and pharmaceutical compositions for the inhibition of the expression of vcam-1
DK98922264T DK0994853T3 (en) 1998-05-14 1998-05-14 Monoether of probucol and methods for inhibiting expression of VCAM-1
PL343904A PL207885B1 (en) 1997-05-14 1998-05-14 Compounds and methods for the inhibition of the expression of vcam-1
BR9809819-5A BR9809819A (en) 1997-05-14 1998-05-14 Compounds and methods for inhibiting vcam-1 expression
SI9830885T SI1464639T1 (en) 1997-05-14 1998-05-14 Succinic acid ester of probucol for the inhibition of the expression of VCAM-1
CA002289851A CA2289851C (en) 1997-05-14 1998-05-14 Compounds and methods for the inhibition of the expression of vcam-1
IL15707898A IL157078A (en) 1997-05-14 1998-05-14 Compounds and pharmaceutical compositions for the inhibition of the expression of vcam-1
EP98922264A EP0994853B1 (en) 1997-05-14 1998-05-14 A monoether of probucol and methods for the inhibition of the expression of vcam-1
EA199901026A EA009370B1 (en) 1997-05-14 1998-05-14 Compound and pharmaceutical composition for the inhibition of the expression of vcam-1
SK50038-2007A SK286766B6 (en) 1997-05-14 1998-05-14 Composition and their use for treatment cardiovascular and inflammatory diseases
IL13279798A IL132797A0 (en) 1997-05-14 1998-05-14 Compounds and methods for the inhibition of the expression of vcam-1
IL16456898A IL164568A0 (en) 1997-05-14 1998-05-14 Compounds and methods for the inhibition of the expression of vcam-1
SK1532-99A SK286392B6 (en) 1997-05-14 1998-05-14 Succinic acid ester of probucol for the inhibition of the expression of VCAM-1 and use for treatment cardiovascular and inflammatory diseases
NO19995544A NO316221B1 (en) 1997-05-14 1999-11-12 Compounds for Inhibition of Expression of VCAM-1, Pharmaceutical Composition Including Same and Use of Same for Preparation of the Drug
HK00105042A HK1025947A1 (en) 1997-05-14 2000-08-14 A monoether of probucol and methods for the inhibition of the expression of vcam-1.
NO20032254A NO319855B1 (en) 1997-05-14 2003-05-19 Use of Compounds for the Preparation of Drug for Inhibition of Expression of VCAM-1.
IL164568A IL164568A (en) 1997-05-14 2004-10-14 Compounds and pharmaceutical compositions for treating diseases mediated by vcam-1

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4702097P 1997-05-14 1997-05-14
US60/047,020 1997-05-14

Publications (2)

Publication Number Publication Date
WO1998051662A2 WO1998051662A2 (en) 1998-11-19
WO1998051662A3 true WO1998051662A3 (en) 2000-03-02

Family

ID=21946634

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US1998/009773 WO1998051289A2 (en) 1997-05-14 1998-05-14 Monoesters of probucol for the treatment of cardiovascular and inflammatory disease
PCT/US1998/009781 WO1998051662A2 (en) 1997-05-14 1998-05-14 Compounds and methods for the inhibition of the expression of vcam-1

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US1998/009773 WO1998051289A2 (en) 1997-05-14 1998-05-14 Monoesters of probucol for the treatment of cardiovascular and inflammatory disease

Country Status (26)

Country Link
US (9) US6121319A (en)
EP (2) EP0994853B1 (en)
JP (4) JP3930056B2 (en)
KR (5) KR20010012504A (en)
CN (7) CN1287783C (en)
AT (3) ATE294158T1 (en)
AU (2) AU747801C (en)
BR (2) BR9809793A (en)
CA (3) CA2292388C (en)
CY (1) CY1107645T1 (en)
CZ (4) CZ301183B6 (en)
DE (3) DE69831566T2 (en)
DK (2) DK0981343T3 (en)
EA (5) EA200800375A1 (en)
ES (3) ES2248901T3 (en)
HK (2) HK1024629A1 (en)
HU (2) HUP0004592A3 (en)
ID (2) ID23877A (en)
IL (7) IL132797A0 (en)
NO (3) NO327603B1 (en)
NZ (2) NZ528906A (en)
PL (2) PL207885B1 (en)
PT (1) PT1464639E (en)
SK (4) SK285695B6 (en)
TR (2) TR199902802T2 (en)
WO (2) WO1998051289A2 (en)

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