WO1999007354A3 - Compositions, apparatus and methods for facilitating surgical procedures - Google Patents

Compositions, apparatus and methods for facilitating surgical procedures Download PDF

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Publication number
WO1999007354A3
WO1999007354A3 PCT/US1998/016469 US9816469W WO9907354A3 WO 1999007354 A3 WO1999007354 A3 WO 1999007354A3 US 9816469 W US9816469 W US 9816469W WO 9907354 A3 WO9907354 A3 WO 9907354A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
patient
surgical
blocker
Prior art date
Application number
PCT/US1998/016469
Other languages
French (fr)
Other versions
WO1999007354A2 (en
Inventor
Francis G Duhaylongsod
Original Assignee
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Duke filed Critical Univ Duke
Priority to DE69833665T priority Critical patent/DE69833665T2/en
Priority to AU90156/98A priority patent/AU758370B2/en
Priority to JP2000506946A priority patent/JP2001513495A/en
Priority to EP98942013A priority patent/EP1051168B1/en
Priority to CA002300049A priority patent/CA2300049C/en
Publication of WO1999007354A2 publication Critical patent/WO1999007354A2/en
Publication of WO1999007354A3 publication Critical patent/WO1999007354A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/12—Blood circulatory system
    • A61M2210/125—Heart

Abstract

Methods are provided for conducting surgical procedures in a patient wherein, during the surgical procedure, autonomous ventricular electrical conductivity and escape beats are reversibly and transiently suppressed to facilitate the surgical procedure. Also provided are compositions which are capable of inducing ventricular asystole in a patient. The compositions may include an AV node blocker. In one embodiment, compositions including an atrioventricular (AV) node blocker and a β-blocker are provided, wherein the β-blocker is present in an amount sufficient to substantially reduce the amount of AV node blocker required to induce ventricular asystole in the patient. The compositions and methods may be used for inducing temporary ventricular asystole in a beating heart, and to facilitate the performance of a variety of surgical techniques, including minimally invasive microsurgical techniques. Methods for performing a surgical procedure on a human patient are provided wherein a composition capable of inducing transient reversible ventricular asystole is administered to the heart, for example by intracoronary injection. The heart then is electrically paced using an electrical pacing system, thereby to maintain the patient's blood circulation. The electrical pacing is then selectively intermittently stopped to allow ventricular asystole to occur, and the steps of the surgical or therapeutic procedure, such as suturing, are conducted during the time that the electrical pacing is intermittently stopped. The methods and compositions advantageoulsy may be used in a range of different surgical procedures including cardiac, vascular and neurosurgical procedures.
PCT/US1998/016469 1997-08-08 1998-08-07 Compositions, apparatus and methods for facilitating surgical procedures WO1999007354A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE69833665T DE69833665T2 (en) 1997-08-08 1998-08-07 COMPOSITIONS FOR SIMPLIFYING SURGICAL PROCEDURES
AU90156/98A AU758370B2 (en) 1997-08-08 1998-08-07 Compositions, apparatus and methods for facilitating surgical procedures
JP2000506946A JP2001513495A (en) 1997-08-08 1998-08-07 Compositions, devices and methods that facilitate surgical procedures
EP98942013A EP1051168B1 (en) 1997-08-08 1998-08-07 Compositions for facilitating surgical procedures
CA002300049A CA2300049C (en) 1997-08-08 1998-08-07 Compositions, apparatus and methods for facilitating surgical procedures

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5512797P 1997-08-08 1997-08-08
US60/055,127 1997-08-08

Publications (2)

Publication Number Publication Date
WO1999007354A2 WO1999007354A2 (en) 1999-02-18
WO1999007354A3 true WO1999007354A3 (en) 1999-04-29

Family

ID=21995793

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/016469 WO1999007354A2 (en) 1997-08-08 1998-08-07 Compositions, apparatus and methods for facilitating surgical procedures

Country Status (8)

Country Link
US (7) US6060454A (en)
EP (1) EP1051168B1 (en)
JP (1) JP2001513495A (en)
AT (1) ATE318595T1 (en)
AU (1) AU758370B2 (en)
CA (1) CA2300049C (en)
DE (1) DE69833665T2 (en)
WO (1) WO1999007354A2 (en)

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