WO1999008720A1 - Apparatus and method of sterilization using propylene oxide - Google Patents
Apparatus and method of sterilization using propylene oxide Download PDFInfo
- Publication number
- WO1999008720A1 WO1999008720A1 PCT/US1998/016777 US9816777W WO9908720A1 WO 1999008720 A1 WO1999008720 A1 WO 1999008720A1 US 9816777 W US9816777 W US 9816777W WO 9908720 A1 WO9908720 A1 WO 9908720A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- propylene oxide
- pressurized
- sterilization machine
- chamber
- sterilization
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/20—Gaseous substances, e.g. vapours
- A61L2/206—Ethylene oxide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/22—Phase substances, e.g. smokes, aerosols or sprayed or atomised substances
Definitions
- This invention pertains to an apparatus and a method for sterilizing materials with propylene oxide.
- the materials may be hospital associated equipment, such as medical devices, tools, band aids, gauze, fabrics, dishes, laundry, etc.
- ethylene oxide is used to sterilize materials in hospitals.
- Ethylene oxide is injected into a sterilization machine, such as a washing machine or a gas sterilizer, from pressurized, aerosol type cans.
- the ethylene oxide at room temperature and pressure is a gas. In the pressurized can, it is a liquid.
- the ethylene oxide vaporizes but is dissolved in the water.
- the equipment in the washing machine is sterilized by the ethylene oxide solution in water.
- a gas sterilizer using gaseous washing medium the ethylene oxide remains in the gas phase.
- Ethylene oxide is a very dangerous material. Ethylene oxide is explosive, highly irritating, toxic, and probably carcinogenic. The decomposition product of ethylene oxide with water is ethylene glycol. Ethylene glycol is toxic when ingested and is probably dangerous when merely in contact with the skin. Moreover, in the manufacture and/or packaging of ethylene oxide, numerous explosions are known to have occurred. Ethylene oxide, C 2 H 4 0, has a molecular weight of 44.05 and is a flammable gas at room temperature and pressure. Its boiling point of 12°C (53.6°F). It is soluble in both water and alcohol. Its decomposition product in water is ethylene glycol, C 2 H 6 0 2 . Both ethylene oxide and ethylene glycol are toxic when ingested. Ethylene glycol is lethal to humans at a concentration of 1.4 milliliters per kilogram.
- the present invention provides an apparatus and method for sterilizing equipment without the dangers and drawbacks associated with the use of ethylene oxide as the sterilizing agent.
- the present invention provides an apparatus and method for sterilizing equipment which employs propylene oxide as the sterilization agent.
- the apparatus of this invention comprises a sterilization machine for sterilizing material detachably coupled to a pressurized can filled with propylene oxide, and a means for admitting the propylene oxide contents of the pressurized can into the sterilization machine.
- This invention also concerns a method for sterilizing material comprising the steps of loading the material into a sterilization machine which is filled with a washing medium, and injecting propylene oxide into the sterilization machine.
- the figure is a schematic illustration of a portion of an apparatus according to this invention.
- the apparatus has an injection port 1 mounted in the wall 2 of a chamber 7.
- the chamber may be part of a washing machine.
- the injection port comprises a check valve 3 which is activated by the nozzle 4 of the pressurized dispensing can 5 containing the propylene oxide. Once activated, the injection port allows the propylene oxide to enter the chamber.
- a washing medium 6 may be additionally present in the chamber.
- the pressurized dispensing can 5 is filled with propylene oxide and may also include a propellent.
- the pressurized dispensing can may be an aerosol can.
- the propellent may be compressed gas or liquified gas.
- the pressurized can shown in the figure is shown with a male valve, and the injection port on the washing machine is shown as a female valve. However, this can be reversed if necessary, i.e. the pressurized dispensing can could have a female valve and the injection port on the washing machine could have a male valve. Either design may be used. For instance, an advantage of having a female valve on the pressurized can is that the can may be transported without an overcap.
- the dispensing can be a barrier type or a non-barrier type.
- a non-barrier type can, the propylene oxide is in contact with the propellent.
- a barrier type can, the propylene oxide is separated from the propellent. Either design may be used.
- Propylene oxide is a liquid having a boiling point at 34.23°C (93.61°F) at atmospheric pressure. Propylene oxide, therefore, is liquid at normal room temperatures and pressures. Propylene oxide, C 3 H 6 0, has a molecular weight of 58.08. It is a flammable liquid at room temperature and pressure. It is miscible with alcohol and soluble in water up to an amount of 40.5% by weight.
- the decomposition product of propylene oxide in water is propylene glycol, C 3 H 8 0 2 , which has a molecular weight of 76.09. Both propylene oxide and propylene glycol have health hazards substantially lower than ethylene oxide. Propylene glycol is not considered toxic even is ingested internally.
- propylene oxide in the same sterilization machine that uses ethylene oxide.
- the washing medium is aqueous
- the propylene oxide would simply mix in at room temperature.
- propylene oxide boils at a temperature of 34.23 °C, it is possible to raise the temperature of the sterilization machine to above 34.23°C where the propylene oxide would be vaporized and used in its gas phase.
- the gas phase of propylene oxide can be used to sterilize medical devices, band aids, gauze and other equipment for which sterilization by a gas is preferred.
- the gas phase of propylene oxide may be used in the same sterilization machine that uses ethylene oxide. Thus, there is no need for users, such as hospitals, to purchase new equipment.
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU87822/98A AU8782298A (en) | 1997-08-14 | 1998-08-13 | Apparatus and method of sterilization using propylene oxide |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5576997P | 1997-08-14 | 1997-08-14 | |
US60/055,769 | 1997-08-14 | ||
US5836497P | 1997-09-10 | 1997-09-10 | |
US60/058,364 | 1997-09-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1999008720A1 true WO1999008720A1 (en) | 1999-02-25 |
Family
ID=26734607
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/016777 WO1999008720A1 (en) | 1997-08-14 | 1998-08-13 | Apparatus and method of sterilization using propylene oxide |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU8782298A (en) |
WO (1) | WO1999008720A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7723108B2 (en) | 2005-03-16 | 2010-05-25 | Musculoskeletal Transplant Foundation | Soft tissue processing |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1060529A (en) * | 1964-11-30 | 1967-03-01 | American Sterilizer Co | Method of sterilizing |
BE691324A (en) * | 1964-01-10 | 1967-05-29 | ||
JPS5819259A (en) * | 1981-07-25 | 1983-02-04 | 日機装株式会社 | Pasturization of medical tool |
JPH0217069A (en) * | 1988-07-02 | 1990-01-22 | Nippon Medical Supply Corp | Sterilizing method and sterilized package |
JPH0326615B2 (en) * | 1983-12-28 | 1991-04-11 | Takeda Chemical Industries Ltd | |
EP0566892A2 (en) * | 1992-04-21 | 1993-10-27 | Hoechst Aktiengesellschaft | Sterilisant gas mixture |
-
1998
- 1998-08-13 AU AU87822/98A patent/AU8782298A/en not_active Abandoned
- 1998-08-13 WO PCT/US1998/016777 patent/WO1999008720A1/en active Application Filing
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE691324A (en) * | 1964-01-10 | 1967-05-29 | ||
GB1060529A (en) * | 1964-11-30 | 1967-03-01 | American Sterilizer Co | Method of sterilizing |
DE1492461A1 (en) * | 1964-11-30 | 1970-02-12 | American Sterilizer Co | Sterilization process |
JPS5819259A (en) * | 1981-07-25 | 1983-02-04 | 日機装株式会社 | Pasturization of medical tool |
JPH0326615B2 (en) * | 1983-12-28 | 1991-04-11 | Takeda Chemical Industries Ltd | |
JPH0217069A (en) * | 1988-07-02 | 1990-01-22 | Nippon Medical Supply Corp | Sterilizing method and sterilized package |
EP0566892A2 (en) * | 1992-04-21 | 1993-10-27 | Hoechst Aktiengesellschaft | Sterilisant gas mixture |
Non-Patent Citations (3)
Title |
---|
DATABASE WPI Section Ch Week 8311, Derwent World Patents Index; Class D22, AN 83-26075K, XP002088340 * |
DATABASE WPI Section Ch Week 9009, Derwent World Patents Index; Class D22, AN 90-063642, XP002088341 * |
DATABASE WPI Section Ch Week 9119, Derwent World Patents Index; Class D22, AN 91-138361, XP002088342 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7723108B2 (en) | 2005-03-16 | 2010-05-25 | Musculoskeletal Transplant Foundation | Soft tissue processing |
US8557581B2 (en) | 2005-03-16 | 2013-10-15 | Musculoskeletal Transplant Foundation | Soft tissue processing |
Also Published As
Publication number | Publication date |
---|---|
AU8782298A (en) | 1999-03-08 |
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